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summarizeMolecularProfiles not working #124
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Hi @shwetha141, Please provide the code you are trying to run so I can help you debug. Best, |
Hi Chris, apologies for the delay. I was trying to follow with a tutorial that was posted and some of the function didn't seem to be working. I do see that there is an updated vignette for this package. I will try to refer it for my analysis. |
Hi @shwetha141, That workshop is pretty old and we have made a number of changes to PharmacoGx since it was published. One key different is that we changed the nomenclature of our PharmacoSet objects in the If you view the From the error your included previously, it looks like the PSets are not being downloaded. If you update the data set names for the downloads the rest of the code should (theoretically) work. Best, |
Thank you so much. I am sorry for asking such redundant questions. I am
quite new to bioinformatics and assessing drug response is even newer to
me. I was wondering if you can suggest something for the kind of analysis I
would like to do.
I am looking at the drug sensitivity of cell lines with specific mutations,
e.g TP53 mutations. I did try to assess the sensitivity cut-off using the
waterfall analysis but I am not sure how to interpret it. The paper
suggests that I use the inflection point of the curve to be the cut-off but
the Coregx mentions something else. Do you have any suggestions?
Conversely, I can also cell lines that are sensitive to a p53 pathway
target (https://www.cancerrxgene.org/cellline/22RV1/924100) and assess
their molecular profiles, something like this (
https://cellmodelpassports.sanger.ac.uk/passports/SIDM01240).
Is there a way I can do this for a group of cell lines.
Thank you, sorry for the long email.
Shwetha
…On Thu, Nov 3, 2022 at 10:32 AM Christopher Eeles ***@***.***> wrote:
Hi @shwetha141 <https://github.com/shwetha141>,
That workshop is pretty old and we have made a number of changes to
PharmacoGx since it was published.
One key different is that we changed the nomenclature of our PharmacoSet
objects in the downloadPSet function to allow for new releases of the
same data (i.e., data versioning).
If you view the availablePSets() table, the "PSet Name" column indicates
the value that should be passed to downloadPSet to retrieve the
associated data object.
From the error your included previously, it looks like the PSets are not
being downloaded. If you update the data set names for the downloads the
rest of the code should (theoretically) work.
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I am running the codes posted Error in (function (classes, fdef, mtable) : _session info Matrix products: default locale: attached base packages: other attached packages: loaded via a namespace (and not attached): |
Hi @shwetha141, That code is very old and PharmacoGx has been updated several times since that code ran. The solution has already been discussed in #130, but the issue is the argument names for most PharmacoGx functions have changed from If you make that change it should resolve your current error. However, that code appears to be very old and we cannot guarantee backwards compatibility beyond a year or two. That being said, Bioconductor archives old package releases. As such if you cannot get the script working you can find the Bioconductor release from when that code was last updated and install the appropriate packages like: Best, |
Thank you Christopher, I am really sorry. I should have checked the prior issues. https://www.bioconductor.org/packages/devel/bioc/manuals/PharmacoGx/man/PharmacoGx.pdf |
@ChristopherEeles What is the equivalent function for the |
Hi @gadepallivs, The Best, |
Hello, I was trying to work with the code uploaded and for some reason I get this error when I run summarizeMolecularProfiles
Error in (function (classes, fdef, mtable) : unable to find an inherited method for function ‘summarizeMolecularProfiles’ for signature ‘"missing"’
The text was updated successfully, but these errors were encountered: