XBB.1.16 with ORF1b:Q1546H, ORF3a:L41F, ORF1a:Q2660H, ORF1b:A1620V, ORF1b:T284I and S:K304Q (31 seqs, 8 countries)

[NkRMnZr]

Taken from Branch 2 of Multitask sars-cov-2-variants/lineage-proposals#517

Defining Mutations: XBB.1.16 > G18105T(ORF1b:Q1546H/nsp14_Q22H) > T16209C, C25513T(ORF3a:L41F) > A8245C(ORF1a:Q2660H/nsp3_Q1842H), C16608T > C18326T(ORF1b:A1620V/nsp14_A96V) > C14318T(ORF1b:T284I/nsp12_T293I) > A22472C(S:K304Q)
Query: C14318T, C18326T, A22472C
Earliest seq: 2023-04-28 (EPI_ISL_17625420, Shanghai, China, travel history to: Singapore)
Latest seq: 2023-08-23 (EPI_ISL_18211080, New York, USA)
Sampled Countries: China (12: Heilongjiang/3, Shanghai/3, Shanxi/1, Hubei/1, Jiangsu/1, Sichuan/1), USA (6, New York/5, New Jersey/1), South Korea (2), Laos (1), Singapore (1), Switzerland (1)

Genomes:

EPI_ISL_17625420, EPI_ISL_17850378, EPI_ISL_17850453, EPI_ISL_17951213, EPI_ISL_17989079, EPI_ISL_18022610, EPI_ISL_18034134, EPI_ISL_18038504, EPI_ISL_18047554, EPI_ISL_18055693, EPI_ISL_18057798, EPI_ISL_18067375, EPI_ISL_18080211, EPI_ISL_18104523, EPI_ISL_18105848, EPI_ISL_18105951, EPI_ISL_18127506, EPI_ISL_18138323, EPI_ISL_18162986, EPI_ISL_18208537, EPI_ISL_18211080

UShER:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_2c34d_31d7f0.json?f_userOrOld=uploaded%20sample&label=id:node_6823117

view from ORF1b:Q1546H branch

details

[corneliusroemer]

How does this relate to XBB.1.16.23?

[FedeGueli]

This = > XBB.1.16 > G18105T(ORF1b:Q1546H/nsp14_Q22H) > T16209C, C25513T(ORF3a:L41F) > A8245C(ORF1a:Q2660H/nsp3_Q1842H), C16608T > C18326T(ORF1b:A1620V/nsp14_A96V) > C14318T(ORF1b:T284I/nsp12_T293I) > A22472C(S:K304Q)

XBB.1.16.23 =>XBB.1.16 > A22472C(S:K304Q)

[NkRMnZr]

Tracking updates:

09-08, 2 seqs from South Korea and Sweden: EPI_ISL_18221519, EPI_ISL_18237050

[corneliusroemer]

Too small, doesn't seem to grow and doesn't have novel RBD haplotype either