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intact_pubid_22094256.txt
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intact_pubid_22094256.txt
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#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B
uniprotkb:Q8IZC7 uniprotkb:P11802 intact:EBI-5278328|uniprotkb:C9JU83|uniprotkb:Q0VDG9 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:zn101_human(display_long)|uniprotkb:ZNF101(gene name)|psi-mi:ZNF101(display_short)|uniprotkb:Zinc finger protein HZF12(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283871|imex:IM-16628-36 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000318110|ensembl:ENST00000592502|reactome:REACT_12627|ensembl:ENSG00000181896|ensembl:ENSP00000319716|ensembl:ENSP00000468049|ensembl:ENSP00000400952|ensembl:ENST00000415784|refseq:NP_001287878.1|go:"GO:0046872"(metal ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_149981.2|interpro:IPR001909(Krueppel-associated box)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:mZLXs/PbWbfgLzkjwZfoE2c6jy09606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:0486DE729E5A8158|rigid:3gdrHm0coV8SrIkISsThCm64vwk false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P01106 uniprotkb:Q00534 intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283167|imex:IM-16628-35 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|rcsb pdb:2OR9|go:"GO:0005654"(nucleoplasm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|reactome:REACT_118780|reactome:REACT_120734|reactome:REACT_160243|reactome:REACT_160254|reactome:REACT_200799|reactome:REACT_9029|ensembl:ENSG00000136997|ensembl:ENSP00000367207|go:"GO:0032403"(protein complex binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051276"(chromosome organization)|go:"GO:0070491"(repressing transcription factor binding)|go:"GO:0070848"(response to growth factor)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000377970|go:"GO:0005730"(nucleolus)|go:"GO:0070888"(E-box binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0032204"(regulation of telomere maintenance)|refseq:NP_002458.2|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0015671"(oxygen transport)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0035690"(cellular response to drug)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0000165"(MAPK cascade)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043234"(protein complex)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0005829"(cytosol) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:20A3DCC8419B269E|rigid:bfSR2lJKa/lYn3qyMu9VkFJuu2U false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P28698 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-5278283|uniprotkb:M0QXU0|uniprotkb:Q7Z729|uniprotkb:Q96I71|uniprotkb:Q9NRY0|uniprotkb:Q9UBW2 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:mzf1_human(display_long)|uniprotkb:MZF1(gene name)|psi-mi:MZF1(display_short)|uniprotkb:MZF(gene name synonym)|uniprotkb:ZNF42(gene name synonym)|uniprotkb:ZSCAN6(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 6(gene name synonym)|uniprotkb:Zinc finger protein 42(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283443|imex:IM-16628-34 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000215057|ensembl:ENST00000594234|ensembl:ENST00000599369|refseq:XP_006723422.1|refseq:XP_006723423.1|ensembl:ENSG00000099326|ensembl:ENSP00000215057|ensembl:ENSP00000469378|ensembl:ENSP00000469493|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0046872"(metal ion binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_001253962.1|go:"GO:0005634"(nucleus)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0044212"(transcription regulatory region DNA binding)|refseq:NP_003413.2|refseq:NP_932172.1|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:2FI2 go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:1rq+ga/Uew705r63KlORpqBObbw9606 intact-crc:578214FA683591D0|rigid:8AADqx3NNAXF9bjpSIdFG8JREow false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:Q9H165 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283535|imex:IM-16628-33 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|ensembl:ENSG00000119866|ensembl:ENSP00000338774|ensembl:ENSP00000349300|ensembl:ENSP00000351307|ensembl:ENSP00000352648|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0005654"(nucleoplasm)|refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0016925"(protein sumoylation)|go:"GO:0050773"(regulation of dendrite development)|ensembl:ENST00000335712|ensembl:ENST00000356842|ensembl:ENST00000358510|ensembl:ENST00000359629 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606 intact-crc:F173ABFF34E61592|rigid:5u6F7IwnpEEfp4Qckmuf/sjgxJc false sufficient binding region:4-303|glutathione s tranferase tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14980 uniprotkb:Q00534 intact:EBI-521611|uniprotkb:H0YH75|uniprotkb:Q9BTE9|uniprotkb:Q14981 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:numa1_human(display_long)|uniprotkb:SP-H antigen(gene name synonym)|uniprotkb:NUMA1(gene name)|psi-mi:NUMA1(display_short)|uniprotkb:NUMA(gene name synonym)|uniprotkb:NMP22(gene name synonym)|uniprotkb:Nuclear matrix protein-22(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5291819|imex:IM-16628-32 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005737"(cytoplasm)|go:"GO:0000139"(Golgi membrane)|reactome:REACT_15510|ensembl:ENSG00000137497|ensembl:ENSP00000260051|ensembl:ENSP00000351851|ensembl:ENSP00000377298|ensembl:ENSP00000478624|ensembl:ENSP00000480172|ensembl:ENST00000613205|ensembl:ENST00000620566|go:"GO:0045177"(apical part of cell)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0016363"(nuclear matrix)|rcsb pdb:3RO2|go:"GO:0070062"(extracellular exosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0051301"(cell division)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005198"(structural molecule activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0006997"(nucleus organization)|refseq:NP_006176.2|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR026650|ensembl:ENST00000351960|ensembl:ENST00000358965|ensembl:ENST00000393695|refseq:NP_001273490.1|refseq:XP_006718625.1|refseq:XP_006718626.1|refseq:XP_006718627.1|refseq:XP_006718628.1|refseq:XP_006718629.1|refseq:XP_006718630.1|refseq:XP_006718631.1|refseq:XP_006718632.1|go:"GO:0007067"(mitotic nuclear division) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:goAKbcTz6vzGy3T7RlpGPnTCbdk9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:43D7B9AE4E55FAA0|rigid:mLhZxkGnjrpK+WheO+OxV9YTooE false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:Q08050 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283631|imex:IM-16628-31 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) ensembl:ENST00000342628|ensembl:ENST00000359843|ensembl:ENST00000361953|reactome:REACT_1006|reactome:REACT_1857|ensembl:ENSG00000111206|ensembl:ENSP00000342307|ensembl:ENSP00000352901|ensembl:ENSP00000354492|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0006281"(DNA repair)|go:"GO:2000781"(positive regulation of double-strand break repair)|refseq:NP_001230017.1|refseq:NP_001230018.1|go:"GO:0003677"(DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0007049"(cell cycle)|go:"GO:0001889"(liver development)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0071156"(regulation of cell cycle arrest)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0042127"(regulation of cell proliferation)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0001570"(vasculogenesis)|refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:3G73 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1. d|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606 intact-crc:F0616B46938B3CAC|rigid:CeZRvwXqeLZ8kCcnl1w4EW2Fgd4 false sufficient binding region:4-303|glutathione s tranferase tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9H4Z2 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2795590|uniprotkb:B4DLG7|uniprotkb:Q548D0|uniprotkb:Q9H684 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:zn335_human(display_long)|uniprotkb:ZNF335(gene name)|psi-mi:ZNF335(display_short)|uniprotkb:NRC-interacting factor 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283029|imex:IM-16628-30 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000198026|ensembl:ENSP00000325326|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_071378.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|ensembl:ENST00000322927 go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:9f3nj4Z9/YtwjpEejHkO4S791Qw9606 intact-crc:5965CFBE91F16D4E|rigid:LjcamkyM/FtTfhah1zdRI927iU0 false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q08999 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-971439|uniprotkb:B7Z913|uniprotkb:Q8NE70|uniprotkb:Q15073|uniprotkb:Q16084|uniprotkb:Q92812 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:rbl2_human(display_long)|uniprotkb:RBL2(gene name)|psi-mi:RBL2(display_short)|uniprotkb:RB2(gene name synonym)|uniprotkb:Retinoblastoma-related protein 2(gene name synonym)|uniprotkb:130 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:pRb2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5278351|imex:IM-16628-29 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000262133|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|interpro:IPR028308|interpro:IPR028309|go:"GO:0003677"(DNA binding)|go:"GO:0016568"(chromatin modification)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_005602.3|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|reactome:REACT_111214|reactome:REACT_821|ensembl:ENSG00000103479|ensembl:ENSP00000262133|go:"GO:0070062"(extracellular exosome)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:2/u/ejPv7UkPWeZYyfJpZXf9Roc9606 intact-crc:F9931AFFDD0B80E8|rigid:NcgfG+HzG7CTOYOMUhsOMZmPuIY false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8IZC7 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-5278328|uniprotkb:C9JU83|uniprotkb:Q0VDG9 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:zn101_human(display_long)|uniprotkb:ZNF101(gene name)|psi-mi:ZNF101(display_short)|uniprotkb:Zinc finger protein HZF12(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283121|imex:IM-16628-28 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000318110|ensembl:ENST00000592502|reactome:REACT_12627|ensembl:ENSG00000181896|ensembl:ENSP00000319716|ensembl:ENSP00000468049|ensembl:ENSP00000400952|ensembl:ENST00000415784|refseq:NP_001287878.1|go:"GO:0046872"(metal ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_149981.2|interpro:IPR001909(Krueppel-associated box)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:mZLXs/PbWbfgLzkjwZfoE2c6jy09606 intact-crc:9E13877DE01EEA23|rigid:ypDQ6zWFu/iLTt7/mFnanJl/epI false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:P32243 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-954480|uniprotkb:Q6GTV3|uniprotkb:Q9HAW3|uniprotkb:B2RAN5|uniprotkb:Q9P2R1 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:otx2_human(display_long)|uniprotkb:Orthodenticle homolog 2(gene name synonym)|uniprotkb:OTX2(gene name)|psi-mi:OTX2(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5278204|imex:IM-16628-27 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) ensembl:ENSG00000165588|ensembl:ENSP00000343819|ensembl:ENSP00000386185|ensembl:ENSP00000452336|go:"GO:0048664"(neuron fate determination)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0001708"(cell fate specification)|go:"GO:0005737"(cytoplasm)|go:"GO:0007492"(endoderm development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042706"(eye photoreceptor cell fate commitment)|refseq:NP_001257452.1|refseq:NP_001257453.1|refseq:NP_001257454.1|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|refseq:NP_068374.1|refseq:NP_758840.1|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR013851(Transcription factor Otx, C-terminal)|go:"GO:0030426"(growth cone)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0043234"(protein complex)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0007411"(axon guidance)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:0090009"(primitive streak formation)|go:"GO:0006461"(protein complex assembly)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|ensembl:ENST00000339475|go:"GO:0022037"(metencephalon development)|go:"GO:0048852"(diencephalon morphogenesis)|ensembl:ENST00000408990|ensembl:ENST00000555006 go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:ceYynldw4n+AnFOVi5L0PONYj609606 intact-crc:28F24D2AB93CB70E|rigid:fLOKPakfi/AaS6rmL9G9SqlDDi4 false glutathione s tranferase tag:n-n|sufficient binding region:4-303 glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28698 uniprotkb:P11802 intact:EBI-5278283|uniprotkb:M0QXU0|uniprotkb:Q7Z729|uniprotkb:Q96I71|uniprotkb:Q9NRY0|uniprotkb:Q9UBW2 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:mzf1_human(display_long)|uniprotkb:MZF1(gene name)|psi-mi:MZF1(display_short)|uniprotkb:MZF(gene name synonym)|uniprotkb:ZNF42(gene name synonym)|uniprotkb:ZSCAN6(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 6(gene name synonym)|uniprotkb:Zinc finger protein 42(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283775|imex:IM-16628-26 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000215057|ensembl:ENST00000594234|ensembl:ENST00000599369|refseq:XP_006723422.1|refseq:XP_006723423.1|ensembl:ENSG00000099326|ensembl:ENSP00000215057|ensembl:ENSP00000469378|ensembl:ENSP00000469493|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0046872"(metal ion binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042803"(protein homodimerization activity)|refseq:NP_001253962.1|go:"GO:0005634"(nucleus)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0044212"(transcription regulatory region DNA binding)|refseq:NP_003413.2|refseq:NP_932172.1|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:2FI2 ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1. g|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:1rq+ga/Uew705r63KlORpqBObbw9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:6EA45027F929B932|rigid:h4Ft2Sy8dKIl/kDtSIJM27YFUvM false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UB98 uniprotkb:Q08050 intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231 intact:EBI-866480|uniprotkb:O43258|uniprotkb:O43259|uniprotkb:O43260|uniprotkb:Q4ZGG7|uniprotkb:Q9BRL2 psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short) psi-mi:foxm1_human(display_long)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282983|imex:IM-16628-25 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101745|ensembl:ENSP00000262126|ensembl:ENSP00000382897|refseq:XP_005258149.1|refseq:XP_005258150.1|refseq:XP_005258151.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|interpro:IPR002110(Ankyrin)|interpro:IPR020683|ensembl:ENST00000262126|ensembl:ENST00000400020 ensembl:ENST00000342628|ensembl:ENST00000359843|ensembl:ENST00000361953|reactome:REACT_1006|reactome:REACT_1857|ensembl:ENSG00000111206|ensembl:ENSP00000342307|ensembl:ENSP00000352901|ensembl:ENSP00000354492|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0006281"(DNA repair)|go:"GO:2000781"(positive regulation of double-strand break repair)|refseq:NP_001230017.1|refseq:NP_001230018.1|go:"GO:0003677"(DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0007049"(cell cycle)|go:"GO:0001889"(liver development)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0071156"(regulation of cell cycle arrest)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0042127"(regulation of cell proliferation)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0001570"(vasculogenesis)|refseq:NP_068772.2|refseq:NP_973731.1|refseq:NP_973732.1|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:3G73 go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:etb60/sLQAg6in0go8JlQEGA9Os9606 rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606 intact-crc:0DDCD89669C97620|rigid:OffwTCskzTXlU8JkHxAr77CO8yI false glutathione s tranferase tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:O60902 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-5278206|uniprotkb:O60465|uniprotkb:O60467|uniprotkb:O60903 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:shox2_human(display_long)|uniprotkb:SHOX2(gene name)|psi-mi:SHOX2(display_short)|uniprotkb:OG12X(gene name synonym)|uniprotkb:SHOT(gene name synonym)|uniprotkb:Homeobox protein Og12X(gene name synonym)|uniprotkb:Paired-related homeobox protein SHOT(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282940|imex:IM-16628-24 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0043565"(sequence-specific DNA binding)|ensembl:ENSP00000397099|ensembl:ENST00000441443|ensembl:ENST00000389589|ensembl:ENST00000483851|refseq:XP_006713791.1|refseq:XP_006713792.1|ensembl:ENSG00000168779|ensembl:ENSP00000374240|ensembl:ENSP00000419362|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003170"(heart valve development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060415"(muscle tissue morphogenesis)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0031965"(nuclear membrane)|go:"GO:0007507"(heart development)|go:"GO:0007399"(nervous system development)|go:"GO:0001501"(skeletal system development)|refseq:NP_001157150.1|refseq:NP_003021.3|refseq:NP_006875.2|interpro:IPR003654(Paired-like homeodomain protein, OAR)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR000047(Helix-turn-helix motif, lambda-like repressor) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:KGs4JbbEL/J1oITNTQC3K5OF1P89606 intact-crc:DC86314E254DCCDB|rigid:KWQWUOR7zLWovf8W67w52TM0goE false sufficient binding region:4-303|glutathione s tranferase tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9P2Y4 uniprotkb:P11802 intact:EBI-3937106|uniprotkb:Q53Y57|uniprotkb:D3DS16|uniprotkb:Q8IYC1|uniprotkb:Q9BW28 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:zn219_human(display_long)|uniprotkb:ZNF219(gene name)|psi-mi:ZNF219(display_short) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282927|imex:IM-16628-23 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000360947|ensembl:ENST00000421093|ensembl:ENST00000451119|refseq:XP_006720226.1|refseq:XP_006720227.1|ensembl:ENSP00000354206|ensembl:ENSP00000388558|ensembl:ENSP00000392401|go:"GO:0046872"(metal ion binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|go:"GO:0016021"(integral component of membrane)|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0004969"(histamine receptor activity)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001095142.1|refseq:NP_001095924.1|refseq:NP_057507.2|interpro:IPR003980(Histamine H3 receptor)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|ensembl:ENSG00000165804|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0001505"(regulation of neurotransmitter levels) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:DAXqcfdII8ou11EGWuB96DmnpGI9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:3AED40CA9434400C|rigid:BfnK2B5ZxeP3vhmGStkX9rFhbDs false glutathione s tranferase tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:4-303 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q08050-1 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-866499 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5279372|imex:IM-16628-22 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) intact:EBI-866480(foxm1_human) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig 4I|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606 intact-crc:18E2A7300D129CD5|rigid:uIcwp6sePM7jmGJlr09V5SK/DtU false his tag:n-n glutathione s tranferase tag:?-?|sufficient binding region:345-537|sufficient binding region:529-763 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9BX66 uniprotkb:Q00534 intact:EBI-433642|uniprotkb:A0AED4|uniprotkb:O43857|uniprotkb:Q7LBE5|uniprotkb:Q8IVK0|uniprotkb:Q8IVQ4|uniprotkb:Q96KF3|uniprotkb:Q96KF4|uniprotkb:Q9BX64|uniprotkb:Q9BX65|uniprotkb:Q9P2Q0|uniprotkb:Q9UFT2|uniprotkb:Q9UHN7|uniprotkb:Q9Y338|uniprotkb:A7MD40|uniprotkb:Q5T924|uniprotkb:D3DR42|uniprotkb:A6NEK3|uniprotkb:A6NID8|uniprotkb:A6NJS4|uniprotkb:Q5T923|uniprotkb:Q5T927|uniprotkb:Q5T928|uniprotkb:Q5T929|uniprotkb:Q5T930|uniprotkb:Q5T931|uniprotkb:Q5T932 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:srbs1_human(display_long)|uniprotkb:KIAA0894(gene name synonym)|uniprotkb:Ponsin(gene name synonym)|uniprotkb:c-Cbl-associated protein(gene name synonym)|uniprotkb:SH3 domain protein 5(gene name synonym)|uniprotkb:SH3P12(gene name synonym)|uniprotkb:SORBS1(gene name)|psi-mi:SORBS1(display_short)|uniprotkb:KIAA1296(gene name synonym)|uniprotkb:SH3D5(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292649|imex:IM-16628-21 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006717644.1|refseq:XP_006717652.1|refseq:XP_006717654.1|refseq:XP_006717655.1|refseq:XP_006717658.1|refseq:NP_001277223.1|refseq:NP_001277224.1|refseq:NP_001277225.1|refseq:NP_001277226.1|refseq:NP_001277227.1|rcsb pdb:2MOX|rcsb pdb:4LN2|rcsb pdb:4LNP|reactome:REACT_20558|ensembl:ENSG00000095637|ensembl:ENSP00000277982|ensembl:ENSP00000277984|ensembl:ENSP00000302556|ensembl:ENSP00000355136|ensembl:ENSP00000360271|ensembl:ENSP00000360283|ensembl:ENSP00000360285|ensembl:ENSP00000360291|ensembl:ENSP00000360292|ensembl:ENSP00000360293|ensembl:ENSP00000360295|ensembl:ENSP00000475901|go:"GO:0003779"(actin binding)|go:"GO:0005070"(SH3/SH2 adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005913"(cell-cell adherens junction)|go:"GO:0005924"(cell-substrate adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0005925"(focal adhesion)|go:"GO:0016363"(nuclear matrix)|rcsb pdb:2LJ0|rcsb pdb:2LJ1|ensembl:ENST00000607232|ensembl:ENST00000277982|ensembl:ENST00000306402|ensembl:ENST00000354106|ensembl:ENST00000361941|ensembl:ENST00000371227|ensembl:ENST00000371239|ensembl:ENST00000371241|ensembl:ENST00000371245|ensembl:ENST00000371246|ensembl:ENST00000371247|ensembl:ENST00000371249|interpro:IPR001452(Src homology-3)|interpro:IPR003127(Sorbin-like)|rcsb pdb:2DL3|rcsb pdb:2ECZ|rcsb pdb:2O2W|rcsb pdb:2O31|rcsb pdb:2O9S|rcsb pdb:2O9V|go:"GO:0005829"(cytosol)|go:"GO:0045121"(membrane raft)|go:"GO:0005634"(nucleus)|go:"GO:0001725"(stress fiber)|go:"GO:0005915"(zonula adherens)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0043149"(stress fiber assembly)|refseq:NP_001030126.1|go:"GO:0015758"(glucose transport)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0006936"(muscle contraction)|go:"GO:0090004"(positive regulation of establishment of protein localization to plasma membrane)|refseq:NP_001030127.1|refseq:NP_001030128.1|refseq:NP_001030129.1|refseq:NP_006425.2|refseq:NP_056200.1|refseq:NP_079267.1|interpro:IPR011511(Variant SH3)|interpro:IPR028506 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:R2ONicSRiI7w0eCi4m4vbdPekL09606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:C817F5F11BDDED85|rigid:mWnSCC0pwNwbGFPolV93AdfD1hw false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:Q99741 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-374862|uniprotkb:Q8TB30 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283967|imex:IM-16628-20 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) ensembl:ENST00000209728|reactome:REACT_1095|reactome:REACT_111214|reactome:REACT_1156|reactome:REACT_1181|reactome:REACT_1221|reactome:REACT_1707|reactome:REACT_1949|reactome:REACT_207|reactome:REACT_2243|reactome:REACT_471|reactome:REACT_6769|reactome:REACT_683|ensembl:ENSG00000094804|ensembl:ENSP00000209728|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019900"(kinase binding)|go:"GO:0032467"(positive regulation of cytokinesis)|rcsb pdb:4I5L|rcsb pdb:4I5N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0051301"(cell division)|interpro:IPR027417|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0000076"(DNA replication checkpoint)|go:"GO:0007067"(mitotic nuclear division)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|refseq:NP_001245.1|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:2CCH|rcsb pdb:2CCI|go:"GO:0005794"(Golgi apparatus) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606 intact-crc:A2D08402C879007C|rigid:vYo0V471QIF83SLRnqrrvvVGF48 false sufficient binding region:4-303|glutathione s tranferase tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:P28749 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5278658|imex:IM-16628-19 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) interpro:IPR028310|ensembl:ENST00000344359|ensembl:ENST00000373664|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010467"(gene expression)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0005667"(transcription factor complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR028309|rcsb pdb:1H28|reactome:REACT_111214|reactome:REACT_120734|reactome:REACT_821|ensembl:ENSG00000080839|ensembl:ENSP00000343646|ensembl:ENSP00000362768|go:"GO:0016568"(chromatin modification)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0043550"(regulation of lipid kinase activity)|refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|go:"GO:0016032"(viral process)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR015030(Rb C-terminal) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606 intact-crc:478326D39E3303E8|rigid:Jg9r6WPXpV6tlM8mnh13K66qazU false sufficient binding region:4-303|glutathione s tranferase tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14493 uniprotkb:P11802 intact:EBI-2696402|uniprotkb:B3KRJ5 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5284015|imex:IM-16628-18 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029344|ensembl:ENST00000429429|ensembl:ENST00000489418|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0030529"(ribonucleoprotein complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0051028"(mRNA transport)|interpro:IPR026502|rcsb pdb:4L8R|rcsb pdb:2KJM|go:"GO:0005829"(cytosol)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0033260"(nuclear DNA replication)|go:"GO:0006398"(histone mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_006518.1|rcsb pdb:4QOZ|go:"GO:0003729"(mRNA binding)|reactome:REACT_1364|reactome:REACT_405|ensembl:ENSG00000163950|ensembl:ENSP00000406322|ensembl:ENSP00000417686 ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:57B73D946B2D2664|rigid:1d11Xjl9BOP1xCELf/vU8WUnUX0 false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:P01106 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-447544|intact:EBI-1058440|uniprotkb:P01107|uniprotkb:Q14026|uniprotkb:A8WFE7 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:myc_human(display_long)|uniprotkb:BHLHE39(gene name synonym)|uniprotkb:Transcription factor p64(gene name synonym)|uniprotkb:MYC(gene name)|psi-mi:MYC(display_short)|uniprotkb:Proto-oncogene c-Myc(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 39(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283919|imex:IM-16628-17 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|rcsb pdb:2OR9|go:"GO:0005654"(nucleoplasm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|reactome:REACT_118780|reactome:REACT_120734|reactome:REACT_160243|reactome:REACT_160254|reactome:REACT_200799|reactome:REACT_9029|ensembl:ENSG00000136997|ensembl:ENSP00000367207|go:"GO:0032403"(protein complex binding)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051276"(chromosome organization)|go:"GO:0070491"(repressing transcription factor binding)|go:"GO:0070848"(response to growth factor)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000377970|go:"GO:0005730"(nucleolus)|go:"GO:0070888"(E-box binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0090096"(positive regulation of metanephric cap mesenchymal cell proliferation)|go:"GO:0032204"(regulation of telomere maintenance)|refseq:NP_002458.2|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR003327(Leucine zipper, Myc)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|rcsb pdb:1A93|rcsb pdb:1EE4|rcsb pdb:1MV0|rcsb pdb:1NKP|rcsb pdb:2A93|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0015671"(oxygen transport)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0035690"(cellular response to drug)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0000165"(MAPK cascade)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043234"(protein complex)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0005829"(cytosol) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:CCk+p9FN7JV6cTmJDlin2hRp1tg9606 intact-crc:1CFB4BE7FE10E8E7|rigid:LwzBBxzh3G/N85ITEovJ+KJV9oc false glutathione s tranferase tag:n-n|sufficient binding region:4-303 glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H4L4 uniprotkb:P11802 intact:EBI-2880236|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283823|imex:IM-16628-16 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000161956|ensembl:ENSP00000403712|go:"GO:0008234"(cysteine-type peptidase activity)|ensembl:ENSP00000314029|ensembl:ENST00000321337|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000429205|go:"GO:0005634"(nucleus)|go:"GO:0071339"(MLL1 complex)|go:"GO:0005730"(nucleolus)|refseq:NP_056485.2|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:379BE88EC7E52061|rigid:FokwUHhfCOh1yJQv82r3Z17XfaY false glutathione s tranferase tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:4-303 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28749 uniprotkb:P11802 intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283679|imex:IM-16628-15 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028310|ensembl:ENST00000344359|ensembl:ENST00000373664|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010467"(gene expression)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0005667"(transcription factor complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR028309|rcsb pdb:1H28|reactome:REACT_111214|reactome:REACT_120734|reactome:REACT_821|ensembl:ENSG00000080839|ensembl:ENSP00000343646|ensembl:ENSP00000362768|go:"GO:0016568"(chromatin modification)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0043550"(regulation of lipid kinase activity)|refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|go:"GO:0016032"(viral process)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR015030(Rb C-terminal) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:478326D39E3303E8|rigid:Jg9r6WPXpV6tlM8mnh13K66qazU false glutathione s tranferase tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:4-303 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q08999 uniprotkb:P11802 intact:EBI-971439|uniprotkb:B7Z913|uniprotkb:Q8NE70|uniprotkb:Q15073|uniprotkb:Q16084|uniprotkb:Q92812 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:rbl2_human(display_long)|uniprotkb:RBL2(gene name)|psi-mi:RBL2(display_short)|uniprotkb:RB2(gene name synonym)|uniprotkb:Retinoblastoma-related protein 2(gene name synonym)|uniprotkb:130 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:pRb2(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283583|imex:IM-16628-14 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000262133|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|interpro:IPR028308|interpro:IPR028309|go:"GO:0003677"(DNA binding)|go:"GO:0016568"(chromatin modification)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_005602.3|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|reactome:REACT_111214|reactome:REACT_821|ensembl:ENSG00000103479|ensembl:ENSP00000262133|go:"GO:0070062"(extracellular exosome)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:2/u/ejPv7UkPWeZYyfJpZXf9Roc9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:630643F0A34FEB93|rigid:4XI2XO76oKGGE6FgSigJT99GOco false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H4Z2 uniprotkb:P11802 intact:EBI-2795590|uniprotkb:B4DLG7|uniprotkb:Q548D0|uniprotkb:Q9H684 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:zn335_human(display_long)|uniprotkb:ZNF335(gene name)|psi-mi:ZNF335(display_short)|uniprotkb:NRC-interacting factor 1(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5284063|imex:IM-16628-13 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000198026|ensembl:ENSP00000325326|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_071378.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|ensembl:ENST00000322927 ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:9f3nj4Z9/YtwjpEejHkO4S791Qw9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:C3F096B1EFB50635|rigid:2q3nlk+kLMX1xb8MI2AB7vzcpUM false glutathione s tranferase tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:4-303 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q99741 uniprotkb:Q00534 intact:EBI-374862|uniprotkb:Q8TB30 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283213|imex:IM-16628-12 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000209728|reactome:REACT_1095|reactome:REACT_111214|reactome:REACT_1156|reactome:REACT_1181|reactome:REACT_1221|reactome:REACT_1707|reactome:REACT_1949|reactome:REACT_207|reactome:REACT_2243|reactome:REACT_471|reactome:REACT_6769|reactome:REACT_683|ensembl:ENSG00000094804|ensembl:ENSP00000209728|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019900"(kinase binding)|go:"GO:0032467"(positive regulation of cytokinesis)|rcsb pdb:4I5L|rcsb pdb:4I5N|go:"GO:0000166"(nucleotide binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0051301"(cell division)|interpro:IPR027417|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0000076"(DNA replication checkpoint)|go:"GO:0007067"(mitotic nuclear division)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|refseq:NP_001245.1|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:2CCH|rcsb pdb:2CCI|go:"GO:0005794"(Golgi apparatus) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:3845DD0DB63D6B07|rigid:fvBFRLZdW3lniIuLHGCii6FWD40 false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H165 uniprotkb:Q00534 intact:EBI-765567|uniprotkb:Q86W14|uniprotkb:Q8WU92|uniprotkb:Q96JL6|uniprotkb:Q9H163|uniprotkb:Q9H164|uniprotkb:Q9H3G9|uniprotkb:Q9NWA7|uniprotkb:D6W5D7 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:bc11a_human(display_long)|uniprotkb:B-cell CLL/lymphoma 11A(gene name synonym)|uniprotkb:COUP-TF-interacting protein 1(gene name synonym)|uniprotkb:Ecotropic viral integration site 9 protein homolog(gene name synonym)|uniprotkb:BCL11A(gene name)|psi-mi:BCL11A(display_short)|uniprotkb:CTIP1(gene name synonym)|uniprotkb:EVI9(gene name synonym)|uniprotkb:KIAA1809(gene name synonym)|uniprotkb:ZNF856(gene name synonym)|uniprotkb:Zinc finger protein 856(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283489|imex:IM-16628-11 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|ensembl:ENSG00000119866|ensembl:ENSP00000338774|ensembl:ENSP00000349300|ensembl:ENSP00000351307|ensembl:ENSP00000352648|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0005654"(nucleoplasm)|refseq:NP_060484.2|refseq:NP_075044.2|refseq:NP_612569.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0016925"(protein sumoylation)|go:"GO:0050773"(regulation of dendrite development)|ensembl:ENST00000335712|ensembl:ENST00000356842|ensembl:ENST00000358510|ensembl:ENST00000359629 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:xASsLQWykg/7ZpyjLsQP8GlQ/H09606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:6BE6F2F04AA27EE9|rigid:dSjljIPbwr75r5J5Gtr9VXheC5c false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q6UB98 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283075|imex:IM-16628-10 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000101745|ensembl:ENSP00000262126|ensembl:ENSP00000382897|refseq:XP_005258149.1|refseq:XP_005258150.1|refseq:XP_005258151.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|interpro:IPR002110(Ankyrin)|interpro:IPR020683|ensembl:ENST00000262126|ensembl:ENST00000400020 go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:etb60/sLQAg6in0go8JlQEGA9Os9606 intact-crc:F91314DDAC1A7FD7|rigid:QYe9AsIs0F62jsmcSEm54mYwdaU false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P06400 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283351|imex:IM-16628-9 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0016605"(PML body)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0043433"(negative regulation of sequence-specific DNA binding transcription factor activity)|ensembl:ENST00000267163|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|reactome:REACT_1156|reactome:REACT_169121|reactome:REACT_172744|reactome:REACT_308|reactome:REACT_329|reactome:REACT_821|reactome:REACT_9029|ensembl:ENSG00000139687|ensembl:ENSP00000267163|interpro:IPR028309|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0005819"(spindle)|go:"GO:0031175"(neuron projection development)|go:"GO:0042551"(neuron maturation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|rcsb pdb:4ELJ|rcsb pdb:4ELL|go:"GO:0000075"(cell cycle checkpoint)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0019900"(kinase binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0007093"(mitotic cell cycle checkpoint)|refseq:NP_000312.2|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR015030(Rb C-terminal)|go:"GO:0000785"(chromatin)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|go:"GO:0001047"(core promoter binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016032"(viral process)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0007070"(negative regulation of transcription from RNA polymerase II promoter during mitosis)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0071922"(regulation of cohesin localization to chromatin)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0031134"(sister chromatid biorientation)|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:xidCNX96KlQzu160polvT61k4Zw9606 intact-crc:7455B43E1DE2FE7F|rigid:4dToys4au84fNLzCxDHULIBDc4g false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q14493 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2696402|uniprotkb:B3KRJ5 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283305|imex:IM-16628-8 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) interpro:IPR029344|ensembl:ENST00000429429|ensembl:ENST00000489418|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0008334"(histone mRNA metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0030529"(ribonucleoprotein complex)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0051028"(mRNA transport)|interpro:IPR026502|rcsb pdb:4L8R|rcsb pdb:2KJM|go:"GO:0005829"(cytosol)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0033260"(nuclear DNA replication)|go:"GO:0006398"(histone mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_006518.1|rcsb pdb:4QOZ|go:"GO:0003729"(mRNA binding)|reactome:REACT_1364|reactome:REACT_405|ensembl:ENSG00000163950|ensembl:ENSP00000406322|ensembl:ENSP00000417686 go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606 intact-crc:CD22649B15694D1F|rigid:peoDVG9lpJsweGN8glxUhfLe7WU false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9H4L4 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2880236|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283397|imex:IM-16628-7 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000161956|ensembl:ENSP00000403712|go:"GO:0008234"(cysteine-type peptidase activity)|ensembl:ENSP00000314029|ensembl:ENST00000321337|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000429205|go:"GO:0005634"(nucleus)|go:"GO:0071339"(MLL1 complex)|go:"GO:0005730"(nucleolus)|refseq:NP_056485.2|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606 intact-crc:AD0EB181B9A14B1A|rigid:u7tYbHVHjSVoOKvRzygSBQ7OErU false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6UB98 uniprotkb:P11802 intact:EBI-2690224|uniprotkb:Q658K1|uniprotkb:Q6QMF7|uniprotkb:Q9H784|uniprotkb:O94951|uniprotkb:Q9H231 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:anr12_human(display_long)|uniprotkb:ANCO2(gene name synonym)|uniprotkb:KIAA0874(gene name synonym)|uniprotkb:Ankyrin repeat-containing cofactor 2(gene name synonym)|uniprotkb:GAC-1 protein(gene name synonym)|uniprotkb:ANKRD12(gene name)|psi-mi:ANKRD12(display_short) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283727|imex:IM-16628-6 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101745|ensembl:ENSP00000262126|ensembl:ENSP00000382897|refseq:XP_005258149.1|refseq:XP_005258150.1|refseq:XP_005258151.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001077094.1|refseq:NP_001190985.1|refseq:NP_056023.3|interpro:IPR002110(Ankyrin)|interpro:IPR020683|ensembl:ENST00000262126|ensembl:ENST00000400020 ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:etb60/sLQAg6in0go8JlQEGA9Os9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:63864DD2D25E14AC|rigid:qu2gR+fwSjRkL7YMIL6IYT+u53A false glutathione s tranferase tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:4-303 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P28749 uniprotkb:Q00534 intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5283259|imex:IM-16628-5 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028310|ensembl:ENST00000344359|ensembl:ENST00000373664|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010467"(gene expression)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0005667"(transcription factor complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005634"(nucleus)|interpro:IPR028309|rcsb pdb:1H28|reactome:REACT_111214|reactome:REACT_120734|reactome:REACT_821|ensembl:ENSG00000080839|ensembl:ENSP00000343646|ensembl:ENSP00000362768|go:"GO:0016568"(chromatin modification)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0043550"(regulation of lipid kinase activity)|refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR013763(Cyclin-related)|interpro:IPR024599|go:"GO:0016032"(viral process)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR015030(Rb C-terminal) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:9963B61D19D3370D|rigid:tTU2mBnujIiH8wnUcw17pkvOArk false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9C0J8 uniprotkb:P11802 intact:EBI-712637|uniprotkb:Q6NUQ0|uniprotkb:Q587J1|uniprotkb:Q05DP8|uniprotkb:Q53FG9|uniprotkb:Q9NUL1|uniprotkb:Q69YF7 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:wdr33_human(display_long)|uniprotkb:WD repeat-containing protein WDC146(gene name synonym)|uniprotkb:WDR33(gene name)|psi-mi:WDR33(display_short)|uniprotkb:WDC146(gene name synonym)|uniprotkb:WD repeat-containing protein 33(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282970|imex:IM-16628-4 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000322313|ensembl:ENST00000393006|ensembl:ENST00000409658|ensembl:ENSG00000136709|ensembl:ENSP00000325377|ensembl:ENSP00000376730|ensembl:ENSP00000387186|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0044822"("poly(A) RNA binding")|refseq:NP_001006624.1|go:"GO:0005581"(collagen trimer)|go:"GO:0005634"(nucleus)|go:"GO:0006301"(postreplication repair)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001006623.1|refseq:NP_060853.3|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR017986 ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:FzGeASJyKaYaqFQfFBYby692REg9606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:E7E54BDFC8B04A11|rigid:64BbHCf03+h1e1bdvRgTLZ7Tv4Y false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P08151 uniprotkb:P11802 intact:EBI-308084|uniprotkb:F5H6H8|uniprotkb:Q8TDN9|uniprotkb:D0EUY3|uniprotkb:E9PQQ9 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 psi-mi:gli1_human(display_long)|uniprotkb:GLI1(gene name)|psi-mi:GLI1(display_short)|uniprotkb:GLI(gene name synonym)|uniprotkb:Glioma-associated oncogene(gene name synonym)|uniprotkb:Oncogene GLI(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5282953|imex:IM-16628-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000228682|ensembl:ENST00000528467|ensembl:ENST00000543426|ensembl:ENST00000546141|refseq:XP_005268856.1|ensembl:ENSG00000111087|ensembl:ENSP00000228682|ensembl:ENSP00000434408|ensembl:ENSP00000437607|ensembl:ENSP00000441006|go:"GO:0046872"(metal ion binding)|reactome:REACT_267605|reactome:REACT_267634|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0003682"(chromatin binding)|go:"GO:0003705"(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007418"(ventral midline development)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030324"(lung development)|go:"GO:0060032"(notochord regression)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001161081.1|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|rcsb pdb:4BLB|go:"GO:0048546"(digestive tract morphogenesis)|rcsb pdb:4KMD|go:"GO:0072372"(primary cilium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|refseq:NP_001153517.1|refseq:NP_005260.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:2GLI ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig S1A, Table 1.|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:XMxc3WAzq0JCpu49dMsG/I+09B09606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:8F71578DACC93EC1|rigid:rrm0QZHWmPK4GR/b668M++K7ARE false glutathione s tranferase tag:?-? sufficient binding region:4-303|glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P11802 uniprotkb:Q08050-1 intact:EBI-295644|uniprotkb:B2R9A0|uniprotkb:B4DNF9|uniprotkb:O00576|uniprotkb:Q6FG61 intact:EBI-866499 psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5279388|imex:IM-16628-2 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000257904|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_27161|reactome:REACT_27271|reactome:REACT_4|reactome:REACT_821|ensembl:ENSG00000135446|ensembl:ENSP00000257904|reactome:REACT_228108|go:"GO:0005923"(tight junction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0031100"(organ regeneration)|go:"GO:0033574"(response to testosterone)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0000785"(chromatin)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042493"(response to drug)|refseq:NP_000066.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0071157"(negative regulation of cell cycle arrest)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0006325"(chromatin organization)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0045859"(regulation of protein kinase activity) intact:EBI-866480(foxm1_human) go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation) - - figure legend:Fig 4I|comment:Cyclin D1/D3 was added as part of a complex with CDK4/6, as binding of a D-type Cyclin is necessary for enzymatic activity of these CDKs.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606 intact-crc:4AD58B2E9EC6840F|rigid:CeZRvwXqeLZ8kCcnl1w4EW2Fgd4 false sufficient binding region:4-303|glutathione s tranferase tag:n-n sufficient binding region:345-537|glutathione s tranferase tag:?-?|sufficient binding region:529-763 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P35711 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-3505701|uniprotkb:B7Z8V0|uniprotkb:F5H5B0|uniprotkb:Q86UK8|uniprotkb:Q8J017|uniprotkb:Q8J018|uniprotkb:Q8J019|uniprotkb:Q8J020|uniprotkb:Q8N1D9|uniprotkb:Q8N7E0|uniprotkb:Q8TEA4 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:sox5_human(display_long)|uniprotkb:SOX5(gene name)|psi-mi:SOX5(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292976|imex:IM-16628-38 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000381381|ensembl:ENST00000396007|ensembl:ENST00000451604|ensembl:ENST00000541536|ensembl:ENST00000545921|ensembl:ENST00000546136|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0044798"(nuclear transcription factor complex)|ensembl:ENSG00000134532|ensembl:ENSP00000370788|ensembl:ENSP00000379328|ensembl:ENSP00000398273|ensembl:ENSP00000437487|ensembl:ENSP00000441973|ensembl:ENSP00000443520|refseq:NP_001248343.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060164"(regulation of timing of neuron differentiation)|refseq:NP_001248344.1|refseq:XP_006719212.1|refseq:XP_006719213.1|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|refseq:NP_008871.3|refseq:NP_694534.1|refseq:NP_821078.1|interpro:IPR009071(High mobility group box, HMG) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:YVl5zcnqafFgRvQt8B79kMtbz+g9606 intact-crc:B448A89CB217815A|rigid:vSUGiEH5It+wiJ3ObRHkJivgDN0 false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P16415 uniprotkb:Q00534 intact:EBI-3446693|uniprotkb:B7Z8D4|uniprotkb:Q6P4A9|uniprotkb:A0PJL4 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:zn823_human(display_long)|uniprotkb:ZNF823(gene name)|psi-mi:ZNF823(display_short)|uniprotkb:ZFP36(gene name synonym)|uniprotkb:Zinc finger protein ZFP-36(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292885|imex:IM-16628-37 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197933|ensembl:ENSP00000340683|refseq:NP_001284539.1|refseq:NP_059977.1|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000341191|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_001073962.1|interpro:IPR001909(Krueppel-associated box)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:BZcGK54jkZFiEreePPL3Dt4KcZw9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:87F3CA89E9281079|rigid:0zKOccCaK3TK1AKE2TwZQJ+lPIE false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P62995 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-725485|uniprotkb:O15449|uniprotkb:Q15815|uniprotkb:Q64283|uniprotkb:B4DVK2|uniprotkb:D3DNU3 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:tra2b_human(display_long)|uniprotkb:TRA2B(gene name)|psi-mi:TRA2B(display_short)|uniprotkb:SFRS10(gene name synonym)|uniprotkb:Transformer-2 protein homolog B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 10(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293310|imex:IM-16628-85 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000342294|ensembl:ENST00000382191|ensembl:ENST00000453386|ensembl:ENST00000456380|refseq:XP_006713787.1|ensembl:ENSG00000136527|ensembl:ENSP00000343857|ensembl:ENSP00000371626|ensembl:ENSP00000416887|ensembl:ENSP00000416959|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0005634"(nucleus)|go:"GO:0003729"(mRNA binding)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|refseq:NP_004584.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:2CQC|rcsb pdb:2KXN|rcsb pdb:2RRA|rcsb pdb:2RRB|refseq:XP_005247760.1|refseq:NP_001230808.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:6uZGeHEDlIVsb2uPeo+9NoR4tDw9606 intact-crc:D5E7B6D275898FC8|rigid:EBjyylG9KS+P6X1pXp/OoitvaRM false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q01130 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-627047|uniprotkb:B3KWD5|uniprotkb:B4DN89|uniprotkb:H0YG49 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293294|imex:IM-16628-84 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0070062"(extracellular exosome)|reactome:REACT_1597|reactome:REACT_1753|reactome:REACT_1849|reactome:REACT_467|ensembl:ENSG00000161547|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|ensembl:ENSP00000441780|ensembl:ENST00000508921|ensembl:ENST00000359995|ensembl:ENST00000392485|ensembl:ENST00000452355|ensembl:ENST00000585202|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_001182356.1|refseq:NP_003007.2|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:2KN4 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606 intact-crc:47D9C9DA93A056C0|rigid:6KliDBCX1pKkGo1McPudXNXeI+Y false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8WXF0 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-5278477|uniprotkb:B2RA22|uniprotkb:Q5T7K0|uniprotkb:Q8WW25 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:srs12_human(display_long)|uniprotkb:SRSF12(gene name)|psi-mi:SRSF12(display_short)|uniprotkb:SFRS13B(gene name synonym)|uniprotkb:SFRS19(gene name synonym)|uniprotkb:SRRP35(gene name synonym)|uniprotkb:35 kDa SR repressor protein(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 13B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 19(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293278|imex:IM-16628-83 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000452027|ensembl:ENSG00000154548|ensembl:ENSP00000414302|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0050733"(RS domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0016482"(cytoplasmic transport)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|refseq:NP_542781.3|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:tTmxDmeY9WZwFAEUUFgmjP0VJW89606 intact-crc:A16F97246A3C4F5E|rigid:MKvCuPtg7wGjMjexiwP5PY/aaas false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P37275 uniprotkb:Q00534 intact:EBI-2849734|uniprotkb:Q2KJ05|uniprotkb:B4DJV0|uniprotkb:B4DUW9|uniprotkb:E9PCM7|uniprotkb:F5H4I8|uniprotkb:Q5VZ84|uniprotkb:Q8NB68|uniprotkb:Q12924|uniprotkb:Q5T968|uniprotkb:Q13800 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:zeb1_human(display_long)|uniprotkb:ZEB1(gene name)|psi-mi:ZEB1(display_short)|uniprotkb:AREB6(gene name synonym)|uniprotkb:TCF8(gene name synonym)|uniprotkb:NIL-2-A zinc finger protein(gene name synonym)|uniprotkb:Negative regulator of IL2(gene name synonym)|uniprotkb:Transcription factor 8(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293270|imex:IM-16628-82 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000320985|ensembl:ENST00000361642|ensembl:ENST00000446923|ensembl:ENST00000542815|ensembl:ENST00000560721|ensembl:ENSG00000148516|ensembl:ENSP00000319248|ensembl:ENSP00000354487|ensembl:ENSP00000391612|ensembl:ENSP00000444891|ensembl:ENSP00000452787|go:"GO:0005654"(nucleoplasm)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0090103"(cochlea morphogenesis)|interpro:IPR008598(Drought induced 19)|refseq:NP_001167564.1|refseq:NP_001167567.1|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005667"(transcription factor complex)|go:"GO:0007389"(pattern specification process)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0010464"(regulation of mesenchymal cell proliferation)|go:"GO:0014823"(response to activity)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR009057(Homeodomain-like)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0070888"(E-box binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell proliferation)|go:"GO:0006955"(immune response)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0045666"(positive regulation of neuron differentiation)|refseq:NP_001121600.1|refseq:NP_001167565.1|refseq:NP_001167566.1|refseq:NP_110378.3|interpro:IPR001356(Homeobox)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:2E19 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:2QwbT74tbgA6Jec85fGMRYg0EBI9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:1865BB27CC1842FB|rigid:a1BBunjgaV2h5iDBHEKLIA6Ja5Y false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q16629 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-398885|uniprotkb:B4DLU6|uniprotkb:G5E9M3|uniprotkb:Q564D3 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293244|imex:IM-16628-81 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0070062"(extracellular exosome)|reactome:REACT_1597|reactome:REACT_1753|reactome:REACT_1849|reactome:REACT_467|ensembl:ENSG00000115875|ensembl:ENSP00000325905|ensembl:ENSP00000398159|ensembl:ENSP00000402264|ensembl:ENSP00000402544|go:"GO:0005634"(nucleus)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0044822"("poly(A) RNA binding")|ensembl:ENST00000313117|ensembl:ENST00000431066|ensembl:ENST00000443213|ensembl:ENST00000446327|go:"GO:0005654"(nucleoplasm)|go:"GO:0000166"(nucleotide binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_001026854.1|refseq:NP_001182375.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:2HVZ|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606 intact-crc:BEE2D73F6F9ABBCA|rigid:0j2vqUpIgl2hUJAy+fBQK19WX+U false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P61371 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-3906896|uniprotkb:P47894|uniprotkb:P20663 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:isl1_human(display_long)|uniprotkb:ISL1(gene name)|psi-mi:ISL1(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292845|imex:IM-16628-80 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) reactome:REACT_23824|ensembl:ENSG00000016082|ensembl:ENSP00000230658|go:"GO:0001102"(RNA polymerase II activating transcription factor binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0016922"(ligand-dependent nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042517"(positive regulation of tyrosine phosphorylation of Stat3 protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|ensembl:ENST00000230658|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0060384"(innervation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0048880"(sensory system development)|go:"GO:0021559"(trigeminal nerve development)|refseq:NP_002193.2|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0005737"(cytoplasm)|go:"GO:0001158"(enhancer sequence-specific DNA binding)|go:"GO:0001105"(RNA polymerase II transcription coactivator activity)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0031016"(pancreas development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:1eir7wLzkoqlwl4AfQuBtjjiyd09606 intact-crc:5FC5434784A3E261|rigid:xoUpzqZOOAs/U0frteZ2O3os//I false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9UPV9 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1105048|uniprotkb:E9PDS2|uniprotkb:Q659B5|uniprotkb:J3KNT7|uniprotkb:Q96B69|uniprotkb:Q63HR0 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:trak1_human(display_long)|uniprotkb:TRAK1(gene name)|psi-mi:TRAK1(display_short)|uniprotkb:KIAA1042(gene name synonym)|uniprotkb:OIP106(gene name synonym)|uniprotkb:106 kDa O-GlcNAc transferase-interacting protein(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293219|imex:IM-16628-79 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000327628|ensembl:ENST00000341421|ensembl:ENST00000449246|ensembl:ENSG00000182606|ensembl:ENSP00000328998|ensembl:ENSP00000340702|ensembl:ENSP00000410717|go:"GO:0005737"(cytoplasm)|refseq:NP_001252537.1|refseq:NP_055780.2|refseq:NP_001252539.1|go:"GO:0005769"(early endosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005634"(nucleus)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|refseq:NP_001036111.1|interpro:IPR006933(HAP1, N-terminal)|interpro:IPR022154 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:wO1gttlJMJ/4RvsellzkZ2YHGiE9606 intact-crc:08C06EB8E9C1F05D|rigid:tx96p3bhqLOV/hhJ+wES/gO9z2U false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O75113 uniprotkb:Q00534 intact:EBI-5278391|uniprotkb:A7MD49|uniprotkb:Q2YDX1 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:n4bp1_human(display_long)|uniprotkb:N4BP1(gene name)|psi-mi:N4BP1(display_short)|uniprotkb:KIAA0615(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293211|imex:IM-16628-78 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000262384|ensembl:ENSG00000102921|ensembl:ENSP00000262384|go:"GO:0034644"(cellular response to UV)|go:"GO:0005730"(nucleolus)|go:"GO:0016605"(PML body)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_694574.3|interpro:IPR021869 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:DjuEYSvNvt5wy7oD2kareuxfDxM9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:9B6F4A5DB4027CCD|rigid:Ogi+Vtno9XFBJicYubsoddxnRDw false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q15910 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-530054|uniprotkb:Q75MG3|uniprotkb:Q15755|uniprotkb:Q92857|uniprotkb:B2RAQ1|uniprotkb:B3KS30|uniprotkb:B7Z1D6|uniprotkb:B7Z7L6|uniprotkb:Q96FI6|intact:EBI-746496 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:ezh2_human(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)|uniprotkb:EZH2(gene name)|psi-mi:EZH2(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293195|imex:IM-16628-77 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0000790"(nuclear chromatin)|go:"GO:0031490"(chromatin DNA binding)|ensembl:ENST00000320356|ensembl:ENST00000350995|ensembl:ENST00000460911|ensembl:ENST00000476773|ensembl:ENST00000478654|ensembl:ENST00000483967|go:"GO:0003723"(RNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|reactome:REACT_169436|reactome:REACT_200808|ensembl:ENSP00000223193|ensembl:ENSP00000320147|ensembl:ENSP00000417062|ensembl:ENSP00000419050|ensembl:ENSP00000419711|ensembl:ENSP00000419856|go:"GO:0001047"(core promoter binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0042127"(regulation of cell proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045120"(pronucleus)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070734"(histone H3-K27 methylation)|interpro:IPR026489|rcsb pdb:4MI0|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0032320"|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048511"(rhythmic process)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|refseq:XP_006715946.1|refseq:XP_006715948.1|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0003677"(DNA binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_001190176.1|refseq:NP_001190177.1|refseq:NP_001190178.1|refseq:NP_004447.2|refseq:NP_694543.1|ensembl:ENSG00000106462|ensembl:ENSG00000106462|interpro:IPR021654|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|go:"GO:0005737"(cytoplasm)|rcsb pdb:4MI5|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0006306"(DNA methylation)|rcsb pdb:2C6V|go:"GO:0005634"(nucleus)|go:"GO:0010467"(gene expression)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:ZjwjEGDmMsyQ/33rYN7PimxvcUk9606 intact-crc:597FFFB346E7EA39|rigid:lihLbUlJEqv3Xjls2FGEAVkcSJU false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6KC79 uniprotkb:Q00534 intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293179|imex:IM-16628-76 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000282516|ensembl:ENST00000448238|reactome:REACT_150421|ensembl:ENSG00000164190|ensembl:ENSP00000282516|ensembl:ENSP00000406266|go:"GO:0000785"(chromatin)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|refseq:XP_005248340.1|interpro:IPR026003|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070087"(chromo shadow domain binding)|interpro:IPR024986|go:"GO:0003682"(chromatin binding)|go:"GO:0019827"(stem cell maintenance)|go:"GO:0032116"(SMC loading complex)|go:"GO:0007420"(brain development)|go:"GO:0034613"(cellular protein localization)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0050890"(cognition)|go:"GO:0048589"(developmental growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0001656"(metanephros development)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0061038"(uterus morphogenesis)|refseq:NP_056199.2|refseq:NP_597677.2|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0070062"(extracellular exosome) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:71D545DEED83702B|rigid:jRPvbbzbPUw8dcFW7qk4YQhQZRY false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9BQW3 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-5278505|uniprotkb:Q1MTP7|uniprotkb:Q5JY53|uniprotkb:Q9NUB6|uniprotkb:Q9P2A6 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:coe4_human(display_long)|uniprotkb:EBF4(gene name)|psi-mi:EBF4(display_short)|uniprotkb:COE4(gene name synonym)|uniprotkb:KIAA1442(gene name synonym)|uniprotkb:Early B-cell factor 4(gene name synonym)|uniprotkb:Olf-1/EBF-like 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293171|imex:IM-16628-75 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000609451|ensembl:ENSG00000088881|ensembl:ENSP00000477023|refseq:XP_005260827.1|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0007275"(multicellular organismal development)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_001103984.1|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR003523(Transcription factor COE)|interpro:IPR018350 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:1UiTZxXqCvF6n5MDyZntgB1EBe49606 intact-crc:5A4C2A04A273AFD8|rigid:eIRo6gq0opzTAxYLyDxW6V1vF7A false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9NRA8 uniprotkb:Q00534 intact:EBI-301024|uniprotkb:B1AKL3|uniprotkb:B1AKL2|uniprotkb:Q8NCF2|uniprotkb:Q9H708|uniprotkb:B2RBF1|intact:EBI-877635 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:4et_human(display_long)|uniprotkb:EIF4ENIF1(gene name)|psi-mi:EIF4ENIF1(display_short)|uniprotkb:Eukaryotic translation initiation factor 4E nuclear import factor 1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293163|imex:IM-16628-74 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000330125|ensembl:ENST00000344710|ensembl:ENST00000397525|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000184708|ensembl:ENSP00000328103|ensembl:ENSP00000342927|ensembl:ENSP00000380659|go:"GO:0044822"("poly(A) RNA binding")|refseq:XP_005261743.1|refseq:XP_005261744.1|refseq:XP_005261745.1|go:"GO:0016020"(membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0008565"(protein transporter activity)|refseq:NP_001157973.1|refseq:NP_001157974.1|refseq:NP_062817.2|interpro:IPR018862 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:4A9mF81S/ePAraruTNYgovUdkT49606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:A164B3E051147CD7|rigid:X51tUq54eOGk2Y7TI1zMnDlibdY false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q07955 uniprotkb:Q00534 intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293155|imex:IM-16628-73 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR029538|reactome:REACT_1597|reactome:REACT_1753|reactome:REACT_1849|reactome:REACT_467|ensembl:ENSG00000136450|ensembl:ENSP00000258962|ensembl:ENSP00000462215|ensembl:ENSP00000463223|rcsb pdb:2M8D|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0044822"("poly(A) RNA binding")|rcsb pdb:2M7S|ensembl:ENST00000258962|ensembl:ENST00000581979|ensembl:ENST00000582730|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0000166"(nucleotide binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_001071634.1|refseq:NP_008855.1|rcsb pdb:1X4A|rcsb pdb:2O3D|rcsb pdb:3BEG|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003729"(mRNA binding)|rcsb pdb:4C0O|go:"GO:0060048"(cardiac muscle contraction) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:A6C5BF30F75C3102|rigid:unlg5sq722qnlmV1MHBlsgaLSBE false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q14814 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2829828|uniprotkb:Q5T9U5|uniprotkb:Q14815|uniprotkb:Q5T9U6|uniprotkb:D3DVC0 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:mef2d_human(display_long)|uniprotkb:MEF2D(gene name)|psi-mi:MEF2D(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293139|imex:IM-16628-72 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000348159|ensembl:ENST00000360595|ensembl:ENST00000464356|refseq:XP_006711393.1|refseq:XP_006711394.1|refseq:XP_006711395.1|refseq:XP_006711396.1|refseq:XP_006711397.1|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:XP_005245226.1|refseq:XP_005245227.1|reactome:REACT_200608|reactome:REACT_21402|reactome:REACT_24941|ensembl:ENSG00000116604|ensembl:ENSP00000271555|ensembl:ENSP00000353803|ensembl:ENSP00000476788|go:"GO:0005654"(nucleoplasm)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|refseq:NP_001258558.1|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0033613"(activating transcription factor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0005634"(nucleus)|go:"GO:0000977"(RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0007512"(adult heart development)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0007399"(nervous system development)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|refseq:NP_005911.1|interpro:IPR022102|interpro:IPR002100(Transcription factor, MADS-box) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:jedvDf/fMyonSO9j1epfMUuj86Y9606 intact-crc:F17543E1D1E754D9|rigid:jItS1vbUUXIFA3MTs4bKw0zwS9k false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q12968 uniprotkb:Q00534 intact:EBI-5278441|uniprotkb:O75211|uniprotkb:Q14516|uniprotkb:Q99840|uniprotkb:Q99841|uniprotkb:Q99842 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:nfac3_human(display_long)|uniprotkb:NFATC3(gene name)|psi-mi:NFATC3(display_short)|uniprotkb:NFAT4(gene name synonym)|uniprotkb:NFATx(gene name synonym)|uniprotkb:T-cell transcription factor NFAT4(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293123|imex:IM-16628-71 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0071277"(cellular response to calcium ion)|ensembl:ENST00000329524|ensembl:ENST00000346183|ensembl:ENST00000349223|reactome:REACT_163834|ensembl:ENSG00000072736|ensembl:ENSP00000264008|ensembl:ENSP00000300659|ensembl:ENSP00000331324|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0005654"(nucleoplasm)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0001569"(patterning of blood vessels)|go:"GO:0003682"(chromatin binding)|go:"GO:0007507"(heart development)|go:"GO:0045333"(cellular respiration)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0055001"(muscle cell development)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0005829"(cytosol)|go:"GO:0005730"(nucleolus)|go:"GO:0006954"(inflammatory response)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|refseq:NP_004546.1|refseq:NP_775186.1|refseq:NP_775188.1|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|rcsb pdb:2XRW|rcsb pdb:2XS0 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:YhaCvxbZKhSOtPQqf5dj5XVr8X89606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:98C88774B93D7646|rigid:P/px+NFkt9jMeXYs7Hp8PHllWvQ false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8N5Y2 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2560796|uniprotkb:A6NCU2|uniprotkb:A6NHW8|uniprotkb:A8K165|uniprotkb:B4DUV8|uniprotkb:Q9Y5Z8|uniprotkb:Q9UG70|uniprotkb:B7Z227 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:ms3l1_human(display_long)|uniprotkb:MSL3(gene name)|psi-mi:MSL3(display_short)|uniprotkb:MSL3L1(gene name synonym)|uniprotkb:Male-specific lethal-3 protein-like 1(gene name synonym)|uniprotkb:Male-specific lethal-3 homolog 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293115|imex:IM-16628-70 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) reactome:REACT_172610|ensembl:ENSG00000005302|ensembl:ENSP00000312244|ensembl:ENSP00000338078|ensembl:ENSP00000354562|ensembl:ENSP00000370069|ensembl:ENSP00000381538|refseq:XP_006724524.1|refseq:NP_001269103.1|refseq:XP_005274497.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|interpro:IPR025995|interpro:IPR026541|refseq:NP_006791.2|go:"GO:0035064"(methylated histone binding)|ensembl:ENST00000312196|ensembl:ENST00000337339|ensembl:ENST00000380693|ensembl:ENST00000398527|go:"GO:0072487"(MSL complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0007275"(multicellular organismal development)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|refseq:NP_001180199.1|refseq:NP_523352.1|refseq:NP_523353.2|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR008676(MRG)|rcsb pdb:2Y0N|rcsb pdb:3OA6|rcsb pdb:3OB9|ensembl:ENST00000361672 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:uZsUcEHPwWI+o+d7aGwhfnxVltA9606 intact-crc:EBDCD4D34E76F0A0|rigid:SzOamooGkb7qrO5u+P0o/PBAPIM false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8IZP0 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-375446|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293099|imex:IM-16628-69 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000346832|ensembl:ENST00000359188|ensembl:ENST00000376138|ensembl:ENST00000376139|ensembl:ENST00000376140|ensembl:ENST00000376142|ensembl:ENST00000376166|ensembl:ENST00000376170|ensembl:ENST00000490841|go:"GO:0035855"(megakaryocyte development)|go:"GO:0072673"(lamellipodium morphogenesis)|reactome:REACT_160086|ensembl:ENSG00000136754|ensembl:ENSP00000279599|ensembl:ENSP00000352114|ensembl:ENSP00000365308|ensembl:ENSP00000365309|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENSP00000365336|ensembl:ENSP00000365340|ensembl:ENSP00000440101|ensembl:ENSP00000365307|ensembl:ENST00000376137|reactome:REACT_228166|go:"GO:0008092"(cytoskeletal protein binding)|refseq:NP_001171587.1|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0005622"(intracellular)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0001756"(somitogenesis)|go:"GO:0030296"(protein tyrosine kinase activator activity)|refseq:NP_001171596.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030426"(growth cone)|interpro:IPR028456|interpro:IPR028457|go:"GO:0030054"(cell junction)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030175"(filopodium)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0006928"(movement of cell or subcellular component)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR001452(Src homology-3)|interpro:IPR000727(Target SNARE coiled-coil region)|go:"GO:0031209"(SCAR complex)|go:"GO:0032403"(protein complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606 intact-crc:3176ECF86D57E4B1|rigid:gtmAmTv2pkgzaCuh6MVNuKmIKtY false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14186 uniprotkb:Q00534 intact:EBI-749713|uniprotkb:B4DLQ9|uniprotkb:Q8IZL5|uniprotkb:Q5JSB4 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:tfdp1_human(display_long)|uniprotkb:E2F dimerization partner 1(gene name synonym)|uniprotkb:DRTF1-polypeptide 1(gene name synonym)|uniprotkb:TFDP1(gene name)|psi-mi:TFDP1(display_short)|uniprotkb:DP1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293091|imex:IM-16628-68 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:REACT_111214|reactome:REACT_118568|reactome:REACT_1194|reactome:REACT_120734|reactome:REACT_121|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_329|reactome:REACT_471|reactome:REACT_683|reactome:REACT_821|ensembl:ENSG00000198176|ensembl:ENSP00000364519|refseq:XP_005268383.1|refseq:XP_005268384.1|go:"GO:0008544"(epidermis development)|go:"GO:0043276"(anoikis)|go:"GO:2000278"(regulation of DNA biosynthetic process)|refseq:XP_005268388.1|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0005654"(nucleoplasm)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010467"(gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR028313|rcsb pdb:2AZE|ensembl:ENST00000375370|go:"GO:0005667"(transcription factor complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0008283"(cell proliferation)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|refseq:NP_009042.1|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR011991(Winged helix repressor DNA-binding) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:FvCKBqPptRL9BKBmt+F9kA7oU8k9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:52B8CEEB6C7CACF3|rigid:XcgeFX8o3ypoIQk4jexSq01LuNo false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WXF8 uniprotkb:Q00534 intact:EBI-5278558|uniprotkb:Q8NBR2|uniprotkb:Q8NES1|uniprotkb:Q8TAA8|uniprotkb:Q96D35 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:dedd2_human(display_long)|uniprotkb:DEDD2(gene name)|psi-mi:DEDD2(display_short)|uniprotkb:FLAME3(gene name synonym)|uniprotkb:DED-containing protein FLAME-3(gene name synonym)|uniprotkb:FADD-like anti-apoptotic molecule 3(gene name synonym)|uniprotkb:PSEC0004(orf name) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293107|imex:IM-16628-67 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000160570|ensembl:ENSP00000336972|ensembl:ENSP00000470082|ensembl:ENSP00000471512|ensembl:ENST00000336034|ensembl:ENST00000595337|ensembl:ENST00000596251|go:"GO:0030159"(receptor signaling complex scaffold activity)|refseq:NP_001257543.1|refseq:NP_001257544.1|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0003677"(DNA binding)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_579874.1|interpro:IPR011029(DEATH-like)|interpro:IPR001875(Death effector) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:KEvs0YThfzCArmJwoQF/bHHttZk9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:9E6C37D26CE88EAB|rigid:1UDOyXLFQQKJ2pjuDSs8bv7otUI false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P19419 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-726632|uniprotkb:O75606|uniprotkb:O95058|uniprotkb:Q969X8|uniprotkb:Q9UJM4|uniprotkb:B2R7H4 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:elk1_human(display_long)|uniprotkb:ELK1(gene name)|psi-mi:ELK1(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292963|imex:IM-16628-66 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSP00000483056|ensembl:ENST00000619324|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0030154"(cell differentiation)|reactome:REACT_12599|ensembl:ENSG00000126767|ensembl:ENSP00000247161|ensembl:ENSP00000345585|ensembl:ENSP00000366182|go:"GO:0001047"(core promoter binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0009416"(response to light stimulus)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|ensembl:ENST00000247161|ensembl:ENST00000343894|ensembl:ENST00000376983|go:"GO:0005654"(nucleoplasm)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|refseq:NP_001107595.1|refseq:NP_005220.2|interpro:IPR000418(Ets)|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:1DUX|go:"GO:0034146"(toll-like receptor 5 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034166"(toll-like receptor 10 signaling pathway)|go:"GO:0038123"("toll-like receptor TLR1:TLR2 signaling pathway")|go:"GO:0038124"("toll-like receptor TLR6:TLR2 signaling pathway")|refseq:NP_001244097.1|go:"GO:0005634"(nucleus)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:fhzXfUkfVKwHJ263gkK8USP+olg9606 intact-crc:FAB7264F2E8DEF0C|rigid:bGtgapFlvatXuTMVEjDlOFZoWNw false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q86U06 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-780319|uniprotkb:Q8ND16|uniprotkb:Q8TB88|uniprotkb:Q8WY40|uniprotkb:Q9BUJ1|uniprotkb:Q9NVV7|uniprotkb:D3DS32 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:rbm23_human(display_long)|uniprotkb:RNA-binding motif protein 23(gene name synonym)|uniprotkb:RNA-binding region-containing protein 4(gene name synonym)|uniprotkb:Splicing factor SF2(gene name synonym)|uniprotkb:RBM23(gene name)|psi-mi:RBM23(display_short)|uniprotkb:RNPC4(gene name synonym)|uniprotkb:PP239(orf name) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293037|imex:IM-16628-65 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000100461|ensembl:ENSP00000339220|ensembl:ENSP00000352956|ensembl:ENSP00000382806|go:"GO:0016020"(membrane)|go:"GO:0005634"(nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0006397"(mRNA processing)|refseq:NP_001070819.1|refseq:NP_001070820.1|refseq:NP_060577.3|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:2CQ4|interpro:IPR029123|ensembl:ENST00000346528|ensembl:ENST00000359890|ensembl:ENST00000399922|rcsb pdb:2DNZ psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:+u0lm/as9TcTOHwwPa2ON0HIiW49606 intact-crc:DCE782CF0BBAA497|rigid:G9pPWJPBeef9d3OWCuY7jWQMdEs false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q7Z3K3 uniprotkb:Q00534 intact:EBI-1389308|uniprotkb:B4DTP8|uniprotkb:B4DYL9|uniprotkb:B7ZBY5|uniprotkb:E9PM80|uniprotkb:O75049|uniprotkb:Q5SZS2|uniprotkb:Q5SZS3|uniprotkb:Q5SZS4|uniprotkb:Q8TDZ7|uniprotkb:Q9Y4X7|uniprotkb:Q3LIC4|uniprotkb:Q5SZS1|intact:EBI-2560449 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:pogz_human(display_long)|uniprotkb:POGZ(gene name)|psi-mi:POGZ(display_short)|uniprotkb:KIAA0461(gene name synonym)|uniprotkb:Nbla00003(orf name)|uniprotkb:SUHW5(gene name synonym)|uniprotkb:ZNF280E(gene name synonym)|uniprotkb:ZNF635(gene name synonym)|uniprotkb:Suppressor of hairy wing homolog 5(gene name synonym)|uniprotkb:Zinc finger protein 280E(gene name synonym)|uniprotkb:Zinc finger protein 635(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292943|imex:IM-16628-64 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000271715|ensembl:ENST00000368863|ensembl:ENST00000392723|ensembl:ENST00000409503|ensembl:ENST00000491586|ensembl:ENST00000531094|refseq:XP_006711300.1|go:"GO:0046872"(metal ion binding)|go:"GO:0000790"(nuclear chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0007064"(mitotic sister chromatid cohesion)|refseq:NP_001181866.1|refseq:NP_001181867.1|refseq:NP_055915.2|interpro:IPR004875(CENP-B protein)|refseq:NP_665739.3|refseq:NP_997054.1|interpro:IPR009057(Homeodomain-like)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|rcsb pdb:2E72|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051301"(cell division)|ensembl:ENSG00000143442|ensembl:ENSP00000271715|ensembl:ENSP00000357856|ensembl:ENSP00000376484|ensembl:ENSP00000386836|ensembl:ENSP00000418408|ensembl:ENSP00000431259|refseq:XP_005245056.1|refseq:XP_005245057.1|refseq:XP_005245058.1|refseq:XP_005245060.1|refseq:XP_005245061.1|refseq:XP_005245062.1|refseq:XP_005245063.1 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:sCOIY8KsHRQtfcoSA9Tixl9yIsc9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:275B0184E4F1D37D|rigid:fPJ0aycisZqwIKpisfCwRphNMW0 false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8TAD8 uniprotkb:Q00534 intact:EBI-749336|uniprotkb:Q96SP9|uniprotkb:Q9H9T7|intact:EBI-1046254 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:snip1_human(display_long)|uniprotkb:SNIP1(gene name)|psi-mi:SNIP1(display_short)|uniprotkb:FHA domain-containing protein SNIP1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292935|imex:IM-16628-63 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163877|ensembl:ENSP00000296215|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000296215|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|refseq:NP_078976.2|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:2UWnTY01RhPuUx3PepGug23l11U9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:4AD6002ACA6FC9D7|rigid:faRxnTcTFTienE3yrvScSWPPcRI false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q99941 uniprotkb:Q00534 intact:EBI-2841031|uniprotkb:Q99637|uniprotkb:Q5SSW7|uniprotkb:Q13269|uniprotkb:Q9H3W1|uniprotkb:Q9NPL0|uniprotkb:Q99635|uniprotkb:Q14345|uniprotkb:Q9H3V9|uniprotkb:B0UYX6|uniprotkb:Q14343 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:atf6b_human(display_long)|uniprotkb:ATF6B(gene name)|psi-mi:ATF6B(display_short)|uniprotkb:CREBL1(gene name synonym)|uniprotkb:G13(gene name synonym)|uniprotkb:Activating transcription factor 6 beta(gene name synonym)|uniprotkb:Protein G13(gene name synonym)|uniprotkb:cAMP response element-binding protein-related protein(gene name synonym)|uniprotkb:cAMP-responsive element-binding protein-like 1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292951|imex:IM-16628-62 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000293709|ensembl:ENST00000375201|ensembl:ENST00000375203|ensembl:ENST00000383156|ensembl:ENST00000425571|ensembl:ENST00000427136|ensembl:ENST00000435768|ensembl:ENST00000439240|ensembl:ENSG00000168468|ensembl:ENSG00000213676|ensembl:ENSG00000228628|ensembl:ENSG00000234539|ensembl:ENSP00000293709|ensembl:ENSP00000364347|ensembl:ENSP00000364349|ensembl:ENSP00000372642|ensembl:ENSP00000391131|ensembl:ENSP00000399764|ensembl:ENSP00000404725|ensembl:ENSP00000404814|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:0005622"(intracellular)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|interpro:IPR029809|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0007165"(signal transduction)|refseq:NP_001129625.1|refseq:NP_004372.3|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0035497"(cAMP response element binding) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:HEe34jikjdOE5qyUIfTFbAB5g3g9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:6ED3A4CBD3558D52|rigid:MwmChrpbpTQmAGA99PFecLmGbpI false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13118 uniprotkb:Q00534 intact:EBI-1389509|uniprotkb:L0R4P6|uniprotkb:L0R679|uniprotkb:Q503B2|uniprotkb:B2R794|intact:EBI-3962407|uniprotkb:A8MVH0|uniprotkb:O75411 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:klf10_human(display_long)|uniprotkb:Transforming growth factor-beta-inducible early growth response protein 1(gene name synonym)|uniprotkb:EGR-alpha(gene name synonym)|uniprotkb:KLF10(gene name)|psi-mi:KLF10(display_short)|uniprotkb:TIEG(gene name synonym)|uniprotkb:TIEG1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292869|imex:IM-16628-61 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000285407|ensembl:ENST00000395884|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000155090|ensembl:ENSP00000285407|ensembl:ENSP00000379222|go:"GO:0030282"(bone mineralization)|go:"GO:0035019"(somatic stem cell maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0008283"(cell proliferation)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0001501"(skeletal system development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001027453.1|refseq:NP_005646.1|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:2EPA|go:"GO:1901653"(cellular response to peptide)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:zn9npr6/dmo7T/4AiUnHQPHR4409606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:86C682E91E4AB290|rigid:Bx4hn2UG4NemB/wXqecnqlY2pQs false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8N2M8 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-751069|uniprotkb:B4DDT8|uniprotkb:F8WAG9|uniprotkb:O96026|uniprotkb:Q6UW71|uniprotkb:Q96DX2 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:clasr_human(display_long)|uniprotkb:Suppressor of white-apricot homolog 2(gene name synonym)|uniprotkb:CLASRP(gene name)|psi-mi:CLASRP(display_short)|uniprotkb:SWAP2(gene name synonym)|uniprotkb:UNQ2428/PRO4988(orf name)|uniprotkb:SFRS16(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 16(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293326|imex:IM-16628-60 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000391952|ensembl:ENSG00000104859|ensembl:ENSP00000375814|ensembl:ENSP00000375815|ensembl:ENST00000391953|refseq:NP_001265368.1|go:"GO:0005634"(nucleus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:NP_008987.2|interpro:IPR019147 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:CVO2beqWR1zvbhfgcMOOjqVXa/Y9606 intact-crc:15DF6728124180CE|rigid:8RkyZ+KmY9OsiTgrOYGy8gOflyA false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q8IYF1 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-741705|uniprotkb:Q9P2V9 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:eloa2_human(display_long)|uniprotkb:Elongin-A2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3B(gene name synonym)|uniprotkb:TCEB3B(gene name)|psi-mi:TCEB3B(display_short)|uniprotkb:TCEB3L(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293302|imex:IM-16628-59 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000332567|ensembl:ENSG00000206181|ensembl:ENSP00000331302|go:"GO:0016021"(integral component of membrane)|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|refseq:NP_057511.2|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR017923 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:DsYQKcSRh99Q2iVBnyfejSM4XZU9606 intact-crc:6B5284BF9B214B33|rigid:ifs/DlqI3AJtTuEx1yk1phsNQXk false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9UMS6 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-3453434|intact:EBI-9640076|uniprotkb:S5XAM4|uniprotkb:B2RWP6|uniprotkb:B2Y8J9|uniprotkb:Q9UK89 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:synp2_human(display_long)|uniprotkb:SYNPO2(gene name)|psi-mi:SYNPO2(display_short)|uniprotkb:Genethonin-2(gene name synonym)|uniprotkb:Myopodin(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293286|imex:IM-16628-58 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000307142|ensembl:ENST00000429713|ensembl:ENST00000434046|ensembl:ENSG00000172403|ensembl:ENSP00000306015|ensembl:ENSP00000390965|ensembl:ENSP00000395143|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0005925"(focal adhesion)|ensembl:ENSP00000484885|go:"GO:0005634"(nucleus)|go:"GO:0030018"(Z disc)|refseq:NP_001122405.1|refseq:NP_001122406.1|refseq:NP_597734.2|interpro:IPR001478(PDZ/DHR/GLGF)|refseq:NP_001273683.1|ensembl:ENST00000610556 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:/M3mn/7+FeorqW2JcdbxjylVyDU9606 intact-crc:33CCDCD78DAC8124|rigid:rB8iA8T1iI7WcadnDT4oav9d4XA false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q14693 uniprotkb:Q00534 intact:EBI-5278370|uniprotkb:B4DET9|uniprotkb:B4DGS4|uniprotkb:B4DGZ6|uniprotkb:B5MC18|uniprotkb:E7ESE7|uniprotkb:B7Z858|uniprotkb:D6W506|uniprotkb:A8MU38|uniprotkb:F5GY24|uniprotkb:Q53T25 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:lpin1_human(display_long)|uniprotkb:LPIN1(gene name)|psi-mi:LPIN1(display_short)|uniprotkb:KIAA0188(gene name synonym)|uniprotkb:Lipin-1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293262|imex:IM-16628-57 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000256720|ensembl:ENST00000396097|ensembl:ENST00000425416|refseq:XP_006711933.1|refseq:XP_006711934.1|refseq:XP_006711935.1|refseq:XP_006711936.1|refseq:XP_006711937.1|refseq:XP_006711938.1|reactome:REACT_1190|reactome:REACT_120919|reactome:REACT_121238|reactome:REACT_200828|ensembl:ENSG00000134324|ensembl:ENSP00000256720|ensembl:ENSP00000379404|ensembl:ENSP00000379405|ensembl:ENSP00000397908|ensembl:ENSP00000401522|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044281"(small molecule metabolic process)|go:"GO:0046474"(glycerophospholipid biosynthetic process)|refseq:NP_001248356.1|refseq:NP_001248357.1|refseq:NP_001248358.1|go:"GO:0006646"(phosphatidylethanolamine biosynthetic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription factor complex)|go:"GO:0005829"(cytosol)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031100"(organ regeneration)|go:"GO:0031529"(ruffle organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016311"(dephosphorylation)|ensembl:ENST00000396098|ensembl:ENST00000449576|interpro:IPR028794|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008195"(phosphatidate phosphatase activity)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0006642"(triglyceride mobilization)|refseq:NP_663731.1|interpro:IPR023214|interpro:IPR007651(Lipin, N-terminal conserved region)|interpro:IPR013209(LNS2, Lipin/Ned1/Smp2)|go:"GO:0031965"(nuclear membrane)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007077"(mitotic nuclear envelope disassembly) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:DxAi6Wqj+hqqEsnWMPWFuc6Bkx89606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:E069F75BFD54CCAA|rigid:VepgDBsEROBRiy8QIxBVBuAoBCI false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q05519 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1051785|uniprotkb:Q8IWE6|uniprotkb:Q5T758 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:srs11_human(display_long)|uniprotkb:Arginine-rich 54 kDa nuclear protein(gene name synonym)|uniprotkb:SRSF11(gene name)|psi-mi:SRSF11(display_short)|uniprotkb:SFRS11(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 11(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293236|imex:IM-16628-56 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) reactome:REACT_1597|reactome:REACT_1849|reactome:REACT_467|ensembl:ENSG00000116754|ensembl:ENSP00000359988|ensembl:ENSP00000359989|go:"GO:0005634"(nucleus)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0044822"("poly(A) RNA binding")|refseq:NP_001177916.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0000166"(nucleotide binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0006369"(termination of RNA polymerase II transcription)|refseq:NP_004759.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|ensembl:ENST00000370950|ensembl:ENST00000370951 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:F6QVk0M0PqxLXIA1dgWyoFbwFHE9606 intact-crc:D4846D7C3984C252|rigid:MUrY/KyAAKSje0zotR7Z9o+w7F8 false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q14202 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2556139|uniprotkb:Q96E26|uniprotkb:O15089|uniprotkb:D3DVV3 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:zmym3_human(display_long)|uniprotkb:DXS6673E(gene name synonym)|uniprotkb:KIAA0385(gene name synonym)|uniprotkb:ZNF261(gene name synonym)|uniprotkb:Zinc finger protein 261(gene name synonym)|uniprotkb:ZMYM3(gene name)|psi-mi:ZMYM3(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293228|imex:IM-16628-55 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) refseq:XP_006724778.1|ensembl:ENSG00000147130|ensembl:ENSP00000322845|ensembl:ENSP00000363093|ensembl:ENSP00000363110|refseq:XP_005262366.1|refseq:XP_005262367.1|refseq:NP_001164634.1|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0007275"(multicellular organismal development)|refseq:NP_001164633.1|refseq:NP_005087.1|refseq:NP_963893.1|interpro:IPR021893|interpro:IPR011017(TRASH)|interpro:IPR010507(Zinc finger, MYM-type)|ensembl:ENST00000373998|ensembl:ENST00000314425|ensembl:ENST00000373981|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0022604"(regulation of cell morphogenesis) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:pNPpauiC3Qk1EB3mevtM9L/+g0A9606 intact-crc:E8984710053359A7|rigid:WrL9adi98bk/xmEFBd52PIhWSdM false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P42568 uniprotkb:Q00534 intact:EBI-716132|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293203|imex:IM-16628-54 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000380338|ensembl:ENSG00000171843|ensembl:ENSP00000369695|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0007379"(segment specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|rcsb pdb:4TMP|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_004520.2|interpro:IPR005033(YEATS)|rcsb pdb:2LM0|refseq:NP_001273620.1|go:"GO:0070062"(extracellular exosome) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:1DCC3A9DA01FA7F7|rigid:xA64ZXfoRCs2ME5j0pWc3kGSk8o false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O43524 uniprotkb:Q00534 intact:EBI-1644164|uniprotkb:B4DVZ6|uniprotkb:Q9BZ04|uniprotkb:O15171|uniprotkb:Q5T2I7|uniprotkb:E1P5E6 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:foxo3_human(display_long)|uniprotkb:FOXO3(gene name)|psi-mi:FOXO3(display_short)|uniprotkb:FKHRL1(gene name synonym)|uniprotkb:FOXO3A(gene name synonym)|uniprotkb:Forkhead in rhabdomyosarcoma-like 1(gene name synonym)|uniprotkb:AF6q21 protein(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293187|imex:IM-16628-53 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000343882|ensembl:ENST00000406360|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|ensembl:ENSP00000446316|ensembl:ENST00000540898|refseq:XP_005266925.1|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|rcsb pdb:2LQH|rcsb pdb:2LQI|go:"GO:0016020"(membrane)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001047"(core promoter binding)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034599"(cellular response to oxidative stress)|reactome:REACT_111057|reactome:REACT_12442|reactome:REACT_147727|ensembl:ENSG00000118689|ensembl:ENSP00000339527|ensembl:ENSP00000385824|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|refseq:NP_001446.1|refseq:NP_963853.1|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:2K86|rcsb pdb:2UZK|go:"GO:0006417"(regulation of translation)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0001227"(RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell maintenance)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:kzNUkcFagA9f+Zhr7tZokroPzQQ9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:6FAEB10C255F06BC|rigid:9d08fxydjH0GLNIzBjtZzEUaMhE false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9BXM0 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1753064|uniprotkb:Q9BXL9|uniprotkb:Q9HCF2 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:prax_human(display_long)|uniprotkb:PRX(gene name)|psi-mi:PRX(display_short)|uniprotkb:KIAA1620(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293147|imex:IM-16628-52 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000105227|ensembl:ENSP00000291825|ensembl:ENSP00000326018|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008366"(axon ensheathment)|refseq:NP_066007.1|refseq:NP_870998.2|interpro:IPR001478(PDZ/DHR/GLGF)|rcsb pdb:4CMZ|ensembl:ENST00000291825|ensembl:ENST00000324001 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:r//PcVSJCIM+n38f917ORVoktFI9606 intact-crc:F2A5F4CD107E09E7|rigid:8FNjB23lkymkYC+5Q7F26ExsivY false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q00613 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293131|imex:IM-16628-51 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) reactome:REACT_200624|reactome:REACT_200744|reactome:REACT_200775|reactome:REACT_200780|ensembl:ENSG00000185122|ensembl:ENSP00000431512|interpro:IPR027072|interpro:IPR027725|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001078"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription)|go:"GO:0003682"(chromatin binding)|go:"GO:0007143"(female meiotic division)|go:"GO:0034605"(cellular response to heat)|go:"GO:0090231"(regulation of spindle checkpoint)|go:"GO:0005829"(cytosol)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:0005654"(nucleoplasm)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043234"(protein complex)|go:"GO:0045120"(pronucleus)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0006952"(defense response)|go:"GO:0005737"(cytoplasm)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|refseq:NP_005517.1|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR011991(Winged helix repressor DNA-binding)|rcsb pdb:2LDU|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|ensembl:ENST00000528838 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 intact-crc:9E3D4D7943621776|rigid:xRU4r774EQQ8ZcGDrqw7YUXhx6k false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9UDY2 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1042602|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293083|imex:IM-16628-50 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000265384|ensembl:ENST00000348208|ensembl:ENST00000377245|ensembl:ENST00000453658|ensembl:ENST00000535702|ensembl:ENST00000539225|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein binding, bridging)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|reactome:REACT_118607|reactome:REACT_13579|ensembl:ENSG00000119139|ensembl:ENSP00000265384|ensembl:ENSP00000345893|ensembl:ENSP00000366453|ensembl:ENSP00000392178|ensembl:ENSP00000438262|ensembl:ENSP00000442090|go:"GO:0006915"(apoptotic process)|go:"GO:0046939"(nucleotide phosphorylation)|go:"GO:0005886"(plasma membrane)|interpro:IPR027417|go:"GO:0005912"(adherens junction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0035329"(hippo signaling)|refseq:NP_001163886.1|refseq:NP_001163887.1|go:"GO:0005737"(cytoplasm)|go:"GO:0030054"(cell junction)|refseq:NP_001164101.1|refseq:NP_004808.2|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011511(Variant SH3)|interpro:IPR001452(Src homology-3)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|go:"GO:0005923"(tight junction)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0006921"(cellular component disassembly involved in execution phase of apoptosis)|rcsb pdb:2OSG|rcsb pdb:3E17|go:"GO:0010033"(response to organic substance) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:iN/EF8QWKtekoj5eON764eKAdpg9606 intact-crc:5A1A490791A94621|rigid:PE7d/93pMjPJvkV/M3sa+PBcEeY false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q96EB6 uniprotkb:Q00534 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:sir1_human(display_long)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293067|imex:IM-16628-49 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006325"(chromatin organization)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|interpro:IPR029035|ensembl:ENST00000212015|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|reactome:REACT_200780|reactome:REACT_200827|ensembl:ENSG00000096717|ensembl:ENSP00000212015|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:0000790"(nuclear chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"(chromatin silencing)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0042127"(regulation of cell proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of sequence-specific DNA binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|rcsb pdb:4I5I|go:"GO:0046872"(metal ion binding)|interpro:IPR026590|interpro:IPR026591|go:"GO:0005737"(cytoplasm)|go:"GO:0061647"(histone H3-K9 modification)|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0005739"(mitochondrion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:0016032"(viral process)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005719"(nuclear euchromatin)|go:"GO:0005720"(nuclear heterochromatin)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0016605"(PML body)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0070403"(NAD+ binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0007569"(cell aging)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0000183"(chromatin silencing at rDNA)|go:"GO:0006260"(DNA replication)|go:"GO:0006343"(establishment of chromatin silencing)|go:"GO:0006344"(maintenance of chromatin silencing)|go:"GO:0007517"(muscle organ development)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0031937"(positive regulation of chromatin silencing)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0033158"(regulation of protein import into nucleus, translocation)|go:"GO:0006364"(rRNA processing)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0050872"(white fat cell differentiation)|refseq:NP_001135970.1|refseq:NP_036370.2|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0006346"(methylation-dependent chromatin silencing)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032868"(response to insulin)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:0000012"(single strand break repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0001525"(angiogenesis)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0010467"(gene expression)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:1900034"(regulation of cellular response to heat) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:976FE8C3E20C679C|rigid:Y6P70WWmKSAfKS9jPvhVZWuO8ew false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9ULW0 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1037322|intact:EBI-2554635|uniprotkb:Q96RR5|uniprotkb:Q9H1R4|uniprotkb:Q9NRA3|uniprotkb:Q9UFN9|uniprotkb:Q9UL00|uniprotkb:Q9Y2M1 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:tpx2_human(display_long)|uniprotkb:TPX2(gene name)|psi-mi:TPX2(display_short)|uniprotkb:C20orf1(gene name synonym)|uniprotkb:C20orf2(gene name synonym)|uniprotkb:DIL2(gene name synonym)|uniprotkb:HCA519(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 90(gene name synonym)|uniprotkb:Restricted expression proliferation-associated protein 100(gene name synonym)|uniprotkb:Differentially expressed in cancerous and non-cancerous lung cells 2(gene name synonym)|uniprotkb:Protein fls353(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 519(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293075|imex:IM-16628-48 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0043203"(axon hillock)|rcsb pdb:4C3P|ensembl:ENSG00000088325|ensembl:ENSP00000300403|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005819"(spindle)|go:"GO:0000922"(spindle pole)|interpro:IPR027329|interpro:IPR027330|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005634"(nucleus)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell proliferation)|go:"GO:0007067"(mitotic nuclear division)|go:"GO:0060236"(regulation of mitotic spindle organization)|refseq:NP_036244.2|interpro:IPR015128(Aurora-A binding)|interpro:IPR009675(Targeting for Xklp2)|rcsb pdb:1OL5|rcsb pdb:3E5A|rcsb pdb:3HA6|go:"GO:0005654"(nucleoplasm)|go:"GO:0051301"(cell division)|ensembl:ENSP00000341145|ensembl:ENST00000340513|ensembl:ENST00000300403 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:dQbYLMi2nP9JPEbdDMk4R4arVxw9606 intact-crc:CE0FACA1006E7B19|rigid:ibwbxeTC05RsSRcLtqPkiDzqdfM false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9UBK2 uniprotkb:Q00534 intact:EBI-765486|uniprotkb:Q3LIG1|uniprotkb:Q4W5M7|uniprotkb:Q9UN32|uniprotkb:B7Z406|uniprotkb:I3RTT5|uniprotkb:I3RTT6|uniprotkb:I3RTT7|uniprotkb:I3RTT8|uniprotkb:I3RTT9|uniprotkb:G8DM16 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:prgc1_human(display_long)|uniprotkb:Ligand effect modulator 6(gene name synonym)|uniprotkb:PPARGC1A(gene name)|psi-mi:PPARGC1A(display_short)|uniprotkb:LEM6(gene name synonym)|uniprotkb:PGC1(gene name synonym)|uniprotkb:PGC1A(gene name synonym)|uniprotkb:PPARGC1(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293059|imex:IM-16628-47 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:4QJR|reactome:REACT_111118|reactome:REACT_116145|reactome:REACT_118659|reactome:REACT_118789|reactome:REACT_200608|reactome:REACT_200686|reactome:REACT_27161|ensembl:ENSG00000109819|ensembl:ENSP00000264867|ensembl:ENSP00000421632|ensembl:ENSP00000423075|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1901860"(positive regulation of mitochondrial DNA metabolic process)|go:"GO:1901863"(positive regulation of muscle tissue development)|rcsb pdb:4QK4|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:2000310"(regulation of N-methyl-D-aspartate selective glutamate receptor activity)|go:"GO:2000507"(positive regulation of energy homeostasis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0016605"(PML body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016922"(ligand-dependent nuclear receptor binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045333"(cellular respiration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:3V9T|rcsb pdb:3V9V|reactome:REACT_24941|ensembl:ENST00000264867|ensembl:ENST00000506055|ensembl:ENST00000513205|ensembl:ENSP00000481498|ensembl:ENST00000613098|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:2000272"(negative regulation of receptor activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071871"(response to epinephrine)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051552"(flavone metabolic process)|go:"GO:0071250"(cellular response to nitrite)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0009409"(response to cold)|go:"GO:0036273"(response to statin)|go:"GO:0043201"(response to leucine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045820"(negative regulation of glycolytic process)|refseq:XP_005248187.1|go:"GO:0006461"(protein complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0014850"(response to muscle activity)|go:"GO:0042594"(response to starvation)|go:"GO:0008380"(RNA splicing)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|refseq:NP_037393.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|rcsb pdb:1XB7|rcsb pdb:3B1M|rcsb pdb:3CS8|rcsb pdb:3D24|go:"GO:0005665"(DNA-directed RNA polymerase II, core complex)|go:"GO:0030374"(ligand-dependent nuclear receptor transcription coactivator activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0001104"(RNA polymerase II transcription cofactor activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0007586"(digestion)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0051091"(positive regulation of sequence-specific DNA binding transcription factor activity)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|rcsb pdb:3U9Q|go:"GO:0006996"(organelle organization)|go:"GO:0007623"(circadian rhythm) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:kZHn8pBS+XDQNNMV7vwuyaxnquI9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:EACB3AEF7863D84D|rigid:LA/0VULxo3wWD3nqPS/tBO5Bl+k false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q9Y3M2 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-947308|uniprotkb:Q66GT6|uniprotkb:Q9UIK9|uniprotkb:B2R4S2 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:cby1_human(display_long)|uniprotkb:CBY1(gene name)|psi-mi:CBY1(display_short)|uniprotkb:C22orf2(gene name synonym)|uniprotkb:CBY(gene name synonym)|uniprotkb:HRIHFB2025(orf name)|uniprotkb:ARB1(gene name synonym)|uniprotkb:PGEA1(gene name synonym)|uniprotkb:PKD2 interactor, Golgi and endoplasmic reticulum-associated 1(gene name synonym)|uniprotkb:PIGEA-14(gene name synonym)|uniprotkb:Cytosolic leucine-rich protein(gene name synonym)|uniprotkb:ARPP-binding protein(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293028|imex:IM-16628-46 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) reactome:REACT_200731|ensembl:ENSP00000216029|ensembl:ENSP00000380026|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|refseq:NP_001002880.2|go:"GO:0008013"(beta-catenin binding)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0008104"(protein localization)|refseq:NP_056188.1|ensembl:ENSG00000100211|interpro:IPR028118|ensembl:ENST00000216029|ensembl:ENST00000396811|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:RqvyVBe3nAEf0bYnToiVsM5hLhc9606 intact-crc:D63BED458ED371CD|rigid:V7Ha9t/bZFPzFOJSBMNl4N13Ggc false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q14135 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-5278589|uniprotkb:J3KN68|uniprotkb:B4DTS7|uniprotkb:Q7L5V0|uniprotkb:Q9BQ78 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:vgll4_human(display_long)|uniprotkb:VGLL4(gene name)|psi-mi:VGLL4(display_short)|uniprotkb:KIAA0121(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293020|imex:IM-16628-45 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000424529|ensembl:ENST00000451674|ensembl:ENSG00000144560|ensembl:ENSP00000402878|ensembl:ENSP00000416615|interpro:IPR028184|go:"GO:0005634"(nucleus)|refseq:NP_001121691.1|refseq:NP_001121693.1|refseq:NP_001271319.1|refseq:NP_001271320.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006351"(transcription, DNA-templated)|refseq:NP_001121692.1|refseq:NP_055482.2|interpro:IPR006627(Protein of unknown function TDU) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:uV9rqVyw0SMHZrHZTyzqkg3ovEw9606 intact-crc:288D71F4F854BFD9|rigid:2Mf2C+oaXamcCnKyWLOSH7pFABU false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8NBB4 uniprotkb:Q00534 intact:EBI-5292994|uniprotkb:Q3B798|uniprotkb:Q6WLH8|uniprotkb:Q86WS8 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:zsca1_human(display_long)|uniprotkb:ZSCAN1(gene name)|psi-mi:ZSCAN1(display_short) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292986|imex:IM-16628-44 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152467|ensembl:ENSP00000282326|go:"GO:0046872"(metal ion binding)|interpro:IPR027775|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|ensembl:ENST00000282326|go:"GO:0005634"(nucleus)|go:"GO:0003677"(DNA binding)|refseq:NP_872378.3|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0003713"(transcription coactivator activity) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:WR2G0UBcX3kvOdwdBzRYAEmtJs09606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:59415353FFE7CBC7|rigid:QNx4vIhh1OvgCai41qlIPUX/JPM false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P35638 uniprotkb:Q00534 intact:EBI-742651|uniprotkb:F8VS99 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:ddit3_human(display_long)|uniprotkb:CHOP10(gene name synonym)|uniprotkb:C/EBP-homologous protein(gene name synonym)|uniprotkb:DDIT3(gene name)|psi-mi:DDIT3(display_short)|uniprotkb:CHOP(gene name synonym)|uniprotkb:GADD153(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD153(gene name synonym)|uniprotkb:C/EBP-homologous protein 10(gene name synonym)|uniprotkb:C/EBP zeta(gene name synonym)|uniprotkb:CCAAT/enhancer-binding protein homologous protein(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292927|imex:IM-16628-43 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:REACT_18355|reactome:REACT_18423|ensembl:ENSG00000175197|ensembl:ENSP00000340671|ensembl:ENSP00000447188|ensembl:ENSP00000447803|ensembl:ENSP00000448665|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005770"(late endosome)|go:"GO:0006983"(ER overload response)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0003677"(DNA binding)|go:"GO:0043433"(negative regulation of sequence-specific DNA binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0005829"(cytosol)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|refseq:NP_001181982.1|refseq:NP_001181983.1|refseq:NP_001181984.1|go:"GO:0044324"(regulation of transcription involved in anterior/posterior axis specification)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|refseq:NP_001181986.1|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0042789"(mRNA transcription from RNA polymerase II promoter)|go:"GO:2000016"(negative regulation of determination of dorsal identity)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_004074.2|interpro:IPR016670(DNA damage-inducible transcript 3)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0001077"(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042594"(response to starvation)|ensembl:ENST00000346473|ensembl:ENST00000547303|ensembl:ENST00000551116|ensembl:ENST00000552740|go:"GO:0005654"(nucleoplasm)|go:"GO:0006987"(activation of signaling protein activity involved in unfolded protein response)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:xyMsMwPwid+S2IYb3H0K0pnUc309606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:FE512BE6D187C089|rigid:tWoK3iya3t9+6CtIEhcLUqEXbYY false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P56693 uniprotkb:Q00534 intact:EBI-1167533|uniprotkb:B4DV62|uniprotkb:Q6FHW7 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:sox10_human(display_long)|uniprotkb:SOX10(gene name)|psi-mi:SOX10(display_short) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292909|imex:IM-16628-42 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000354130|ensembl:ENSP00000380093|go:"GO:0000978"(RNA polymerase II core promoter proximal region sequence-specific DNA binding)|go:"GO:0000980"(RNA polymerase II distal enhancer sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003705"(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity)|go:"GO:0006357"(regulation of transcription from RNA polymerase II promoter)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014015"(positive regulation of gliogenesis)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048469"(cell maturation)|go:"GO:0048484"(enteric nervous system development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENST00000360880|ensembl:ENST00000396884|go:"GO:0001190"(RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription)|go:"GO:0005634"(nucleus)|go:"GO:0003713"(transcription coactivator activity)|refseq:NP_008872.1|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022151|ensembl:ENSG00000100146 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:AKrWYlZirtToU/lVD3TerSaJyWY9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:47B4C9F5110D2EC6|rigid:bBcfbfDFeXZPGhB1XFaStmQco+8 false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:P81877 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-748077|uniprotkb:B7Z1J2|uniprotkb:B7Z665|uniprotkb:D6RH18|uniprotkb:E9PB74|uniprotkb:Q8N2Q2|uniprotkb:Q9BWW6|uniprotkb:Q9Y4T7|uniprotkb:B7Z2L9|uniprotkb:E9PDA8|uniprotkb:B2R5W1 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:ssbp2_human(display_long)|uniprotkb:Sequence-specific single-stranded-DNA-binding protein 2(gene name synonym)|uniprotkb:SSBP2(gene name)|psi-mi:SSBP2(display_short)|uniprotkb:SSDP2(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292901|imex:IM-16628-41 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000145687|ensembl:ENSP00000322977|ensembl:ENSP00000422961|ensembl:ENSP00000423969|ensembl:ENSP00000424657|ensembl:ENSP00000426183|refseq:NP_001243663.1|refseq:NP_001243664.1|refseq:NP_001243662.1|ensembl:ENST00000320672|ensembl:ENST00000505980|ensembl:ENST00000509053|ensembl:ENST00000514493|ensembl:ENST00000515395|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|refseq:NP_036578.2|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR008116(Sequence-specific single-strand DNA-binding protein)|refseq:NP_001243661.1|refseq:NP_001243665.1 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:CMmZPTurp1G6Y2q7GP/pTMlFM549606 intact-crc:64317A028F4B3A27|rigid:5M2uHiAuplajFydhr0SKLp8rKzA false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8NEY8 uniprotkb:Q00534 intact:EBI-474076|uniprotkb:E9PAX8|uniprotkb:Q86YT2|uniprotkb:Q8IXN3|uniprotkb:Q8TB09|uniprotkb:Q96NB9|uniprotkb:Q9NXL4|uniprotkb:Q9P0P6|uniprotkb:Q9P0R9 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:pphln_human(display_long)|uniprotkb:Gastric cancer antigen Ga50(gene name synonym)|uniprotkb:HSPC206(orf name)|uniprotkb:HSPC232(orf name)|uniprotkb:PPHLN1(gene name)|psi-mi:PPHLN1(display_short) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292893|imex:IM-16628-40 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028851|ensembl:ENST00000358314|ensembl:ENST00000395568|ensembl:ENST00000395580|ensembl:ENST00000432191|ensembl:ENST00000449194|ensembl:ENST00000552761|ensembl:ENSP00000477681|ensembl:ENSP00000478872|ensembl:ENSP00000479913|ensembl:ENST00000610488|ensembl:ENST00000613154|ensembl:ENST00000619544|go:"GO:0005794"(Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000134283|ensembl:ENSP00000351066|ensembl:ENSP00000378935|ensembl:ENSP00000378947|ensembl:ENSP00000390681|ensembl:ENSP00000393965|ensembl:ENSP00000449331|go:"GO:0005654"(nucleoplasm)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0005737"(cytoplasm)|go:"GO:0031424"(keratinization)|refseq:NP_001137259.1|refseq:NP_001137260.1|refseq:NP_057572.5|refseq:NP_958846.1|refseq:NP_958847.1|refseq:NP_958848.1|refseq:NP_958923.1 ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:+s8KstGQ7d91qe3DDnpKYMJon7o9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:9EE2285A3BE48DB1|rigid:QMyEB6qTUWOXnaKovgt8d/96QEM false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:O15234 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-299118|uniprotkb:A8K8R0 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:casc3_human(display_long)|uniprotkb:CASC3(gene name)|psi-mi:CASC3(display_short)|uniprotkb:MLN51(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 3 protein(gene name synonym)|uniprotkb:Metastatic lymph node gene 51 protein(gene name synonym)|uniprotkb:Protein barentsz(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292877|imex:IM-16628-39 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENST00000264645|reactome:REACT_75822|ensembl:ENSG00000108349|ensembl:ENSP00000264645|go:"GO:0042802"(identical protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"("poly(A) RNA binding")|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010467"(gene expression)|go:"GO:0030529"(ribonucleoprotein complex)|refseq:XP_005257220.1|interpro:IPR028544|go:"GO:0005829"(cytosol)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0051028"(mRNA transport)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0006417"(regulation of translation)|go:"GO:0008380"(RNA splicing)|refseq:NP_031385.2|interpro:IPR018545|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:62nwK5KCrjsyaY7WKPlfUAPhohM9606 intact-crc:75B5CCF2A1FD6B9A|rigid:AjGoiwv3z6p3BPDwIprrxtrY36o false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q15697 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-1210452|uniprotkb:Q9BQ34|uniprotkb:Q53Y68 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:zn174_human(display_long)|uniprotkb:ZNF174(gene name)|psi-mi:ZNF174(display_short)|uniprotkb:ZSCAN8(gene name synonym)|uniprotkb:AW-1(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 8(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5292860|imex:IM-16628-87 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000103343|ensembl:ENSP00000268655|ensembl:ENSP00000339781|ensembl:ENSP00000460397|ensembl:ENSP00000461502|go:"GO:0046872"(metal ion binding)|interpro:IPR027778|go:"GO:0005654"(nucleoplasm)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENST00000268655|ensembl:ENST00000344823|ensembl:ENST00000571936|ensembl:ENST00000575752|go:"GO:0005634"(nucleus)|go:"GO:0044212"(transcription regulatory region DNA binding)|go:"GO:0000122"(negative regulation of transcription from RNA polymerase II promoter)|refseq:NP_001027463.1|refseq:NP_003441.1|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR007087(Zinc finger, C2H2-type)|interpro:IPR015880(Zinc finger, C2H2-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|rcsb pdb:1Y7Q|go:"GO:0000981"(sequence-specific DNA binding RNA polymerase II transcription factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|interpro:IPR027775 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:OotqJnbHr1LkdIoAnKfK0GrXhKo9606 intact-crc:A7B1FF6F434CFECC|rigid:0aF6Kb0Ja0T+N2KHUU5AequeJLM false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q00534 uniprotkb:Q13595 intact:EBI-295663|uniprotkb:A4D1G0 intact:EBI-2685506|uniprotkb:B4DUA9|uniprotkb:B4DQI6|uniprotkb:E9PD75 psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:tra2a_human(display_long)|uniprotkb:Transformer-2 protein homolog A(gene name synonym)|uniprotkb:TRA2A(gene name)|psi-mi:TRA2A(display_short) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5293318|imex:IM-16628-86 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) ensembl:ENSG00000164548|ensembl:ENSP00000297071|ensembl:ENSP00000480822|ensembl:ENST00000621813|go:"GO:0044822"("poly(A) RNA binding")|ensembl:ENSP00000441116|ensembl:ENST00000538367|refseq:NP_001269688.1|refseq:XP_005249782.1|refseq:XP_006715776.1|refseq:NP_001269686.1|refseq:NP_001269687.1|go:"GO:0005634"(nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|refseq:NP_037425.1|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0005730"(nucleolus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENST00000297071|go:"GO:0003676"(nucleic acid binding)|ensembl:ENSP00000376290|ensembl:ENST00000392502 psi-mi:"MI:0469"(intact) - - figure legend:Fig S1A, Table 1.|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rogid:JvcdzipB7mCy8eV3z8TaVjucLLM9606 intact-crc:A00FEC4042E48500|rigid:vBKFr7+Pv42FZWSEdziTdWN+eqg false his tag:n-n glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q08050-1 uniprotkb:Q00534 intact:EBI-866499 intact:EBI-295663|uniprotkb:A4D1G0 psi-mi:q08050-1(display_long)|uniprotkb:FOXM1(gene name)|psi-mi:FOXM1(display_short)|uniprotkb:FKHL16(gene name synonym)|uniprotkb:HFH11(gene name synonym)|uniprotkb:MPP2(gene name synonym)|uniprotkb:WIN(gene name synonym)|uniprotkb:Forkhead-related protein FKHL16(gene name synonym)|uniprotkb:Hepatocyte nuclear factor 3 forkhead homolog 11(gene name synonym)|uniprotkb:M-phase phosphoprotein 2(gene name synonym)|uniprotkb:MPM-2 reactive phosphoprotein 2(gene name synonym)|uniprotkb:Transcription factor Trident(gene name synonym)|uniprotkb:Winged-helix factor from INS-1 cells(gene name synonym)|uniprotkb:FOXM1-c(isoform synonym)|uniprotkb:FoxM1C(isoform synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Anders et al. (2011) pubmed:22094256|imex:IM-16628 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-5278953|imex:IM-16628-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-866480(foxm1_human) ensembl:ENST00000265734|ensembl:ENST00000424848|reactome:REACT_169168|reactome:REACT_169325|reactome:REACT_169436|reactome:REACT_821|ensembl:ENSG00000105810|ensembl:ENSP00000265734|ensembl:ENSP00000397087|rcsb pdb:4TTH|rcsb pdb:4AUA|rcsb pdb:4EZ5|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0051301"(cell division)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0009615"(response to virus)|refseq:NP_001138778.1|refseq:NP_001250.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR002290(Serine/threonine protein kinase)|rcsb pdb:1BI7|go:"GO:0014002"(astrocyte development)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0048699"(generation of neurons)|go:"GO:0021670"(lateral ventricle development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:2000145"(regulation of cell motility)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0010468"(regulation of gene expression)|refseq:XP_006715898.1|interpro:IPR028788|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0060218"(hematopoietic stem cell differentiation) go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity) - - figure legend:Fig 4H|curation depth:imex curation|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/12/01 2014/10/16 rogid:u1jKIeT/XYuwT7KzYJbwdQXq7hM9606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:3AEC6EDD9F0A2928|rigid:uIcwp6sePM7jmGJlr09V5SK/DtU false glutathione s tranferase tag:?-? his tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)