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mutSignatures

Thank you for your interest in mutSignatures!

  • version: latest (dev) version, 2.1.3
  • previous versions are available as alternative branches

Notes about the R library

  • integrated R-based computational framework aimed at deciphering DNA mutational signatures

  • provides advanced functions for importing DNA variants, computing mutation types, and extracting mutational signatures via non-negative matrix factorization (NMF)

  • I/O: accepts multiple types of input data (VCF, MAF), is compatible with non-human genomes, and supports the analysis of non-standard mutation types, such as tetra-nucleotide mutation types.

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Installation from GitHub

In R, you can run:

devtools::install_github("dami82/mutSignatures", force = TRUE, build_vignettes = TRUE)

Authors

  • Damiano Fantini, Vania Vidimar, Yanni Yu, Salvatore Condello, Joshua J Meeks
  • The package was developed at Northwestern University, Chicago, IL (Department of Urology, 2017-2020)

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mutSignatures R package - updated (dev) version - 2.1.3

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