mutSignatures

Thank you for your interest in mutSignatures!

• version: latest (dev) version, 2.1.3
• previous versions are available as alternative branches

Notes about the R library

• integrated R-based computational framework aimed at deciphering DNA mutational signatures

• provides advanced functions for importing DNA variants, computing mutation types, and extracting mutational signatures via non-negative matrix factorization (NMF)

• I/O: accepts multiple types of input data (VCF, MAF), is compatible with non-human genomes, and supports the analysis of non-standard mutation types, such as tetra-nucleotide mutation types.

Links

• Vignette on CRAN: https://cran.r-project.org/web/packages/mutSignatures/vignettes/get_sarted_with_mutSignatures.html

• Peer-reviewed paper (Sci Rep. 2020 Oct 26;10(1):18217): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589488/

Installation from GitHub

In R, you can run:

devtools::install_github("dami82/mutSignatures", force = TRUE, build_vignettes = TRUE)

Authors

• Damiano Fantini, Vania Vidimar, Yanni Yu, Salvatore Condello, Joshua J Meeks
• The package was developed at Northwestern University, Chicago, IL (Department of Urology, 2017-2020)