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[Parasite Targets] Getting MRNA and protein sequences #1141

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mzueva opened this issue Feb 5, 2024 · 0 comments
Closed

[Parasite Targets] Getting MRNA and protein sequences #1141

mzueva opened this issue Feb 5, 2024 · 0 comments
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kind/enhancement New feature or request

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@mzueva
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mzueva commented Feb 5, 2024

Background
For parasite targets protein sequences maybe unavailable in public databases, but we can get them from the gene files registered in NGB.

Approach
API method to get protein sequences for a target gene shall optionally return local gene sequences in addition to sequences from NCBI. A new option includeLocal shall be added to the request parameters. If this parameter is specified, NGB shall try to find the sequence following this approach:

  1. Find reference genomes associated with a tax id specified for the gene and get gene files associated with this genome.
  2. In the found gene file search features with matching gene id with types GENE and MRNA. Resulting protein sequences shall be reconstructed using ProteinSequenceReconstructionManager.
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