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fatty aldehyde dehydrogenase activity #28142

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sjm41 opened this issue Jun 14, 2024 · 0 comments
Closed
4 tasks done

fatty aldehyde dehydrogenase activity #28142

sjm41 opened this issue Jun 14, 2024 · 0 comments

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@sjm41
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sjm41 commented Jun 14, 2024

id: GO:0102673
name: fatty aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde = NADH(2-) + 2 H+ + a fatty acid." [EC:1.2.1.3, GOC:pz]
xref: MetaCyc:RXN-4142
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

This term corresponds to RHEA:49832:
a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH

That term is part of a small hierarchy in RHEA that includes the following:

RHEA:16185 an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH (= GO:0004029)
    |_RHEA:49832 a fatty aldehyde + H2O + NAD+ = a fatty acid + 2 H+ + NADH (= GO:0102673)
	|_ RHEA:69763 a medium-chain fatty aldehyde + H2O + NAD+ = a medium chain fatty acid + 2 H+ + NADH (GO:0052814)
	|_ RHEA:10652 a long-chain fatty aldehyde + H2O + NAD+ = a long-chain fatty acid + 2 H+ + NADH (GO:0050061)

  • add RHEA:49832 to GO:0102673 as term and def xref
  • change parent of GO:0102673 to GO:0004029
  • change parents of GO:0052814 and GO:0050061 to GO:0102673
  • change names of GO:0052814 and GO:0050061 to include 'fatty'
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