Definition Signal to Noise Ratio
In many instances, the signal-to-noise ratio (S/N) of a chromatographic peak depends on performance of the chromatographic separation. There are four methods to calculate signal to noise ratio (S/N) for a chromatographic peak that are described here:
This method requires manual and visual inspection of a peak to select the noise regions by an expert user.
In IDSL.IPA, signal to noise ratio (S/N) are calculated after developing a hypothetical baseline for the smoothed chromatogram by connecting the local minima after removing outlier local minima using a local median absolute deviation method. This baseline facilitates calculating local noise measurement for chromatographic peaks independently from adjacent peaks.
