Life-span elongation target - AMPK ?

[jehoons]

AMPK는 다우어와 유사한 식이제한상태와 비슷한 상태를 유도합니다. 그러므로 AMPK를 조절하는 Metformin이 식이제한상태를 유도할 수 있을 것입니다. 관련논문

1. Petrascheck M, Ye X, Buck LB. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 2007;450:553-6.

2. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-42.

3. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365: 1415-1428.

4. Scarpello JH. Improving survival with metformin: the evidence base today. Diabetes Metab 2003;29:6S36-43.

5. Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiol Genomics 2005;23:343?350.

6. Zhou G, Myers R, Li Y, Chen Y, Shen X, et al. Role of AMPactivated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167?1174.

7. Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 2002;277: 25226?25232.

8. Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotideindependent mechanism. Diabetes 2002;51: 2420?2425.

9. Katic M, and Kahn CR. The role of insulin and IGF-1 signaling in longevity. Cell Mol Life Sci 2005;62:320-343.

10. Salih DA, and Brunet A. FOXO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 2008;20:126-136.

11. Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S, and Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 2009;106:2700-5.

12. Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, and Curb JD. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 2008;105:13987-13992

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