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ChangeLog

Charles Pence edited this page Apr 24, 2013 · 1 revision

MTBindingSim Revision History

Version 0.13

  • Add an info button which opens a box with information about the currently selected binding model.

Version 0.12

  • Fixes to the MTBindingSim installation system.

Version 0.11

  • Added a new pseudo-cooperativity model.
  • Added a new two-sites binding model.

Version 0.10

  • Removed the cooperativity binding model.
  • Added ability to save Scatchard plots.

Version 0.9

  • Changed calculation method for the binding ratio.
  • New way to save graphs and data.

Version 0.8.1

  • Fixed an urgent calculation bug.

Version 0.8

  • Changed terminology for the various dissociation constants.
  • Various bug fixes, including a calculation error.

Version 0.7

  • Complete documentation is now available for MTBindingSim.
  • Various bug fixes.

Version 0.6.1

  • Various bug fixes.

Version 0.6

  • Added a new model where a microtubule binding protein can bind to microtubules either as a monomer or as a dimer with different affinities.
  • Inputs now default to zero when the experimental mode or model are changed. The ratio parameter defaults to one.
  • Various bug fixes.

Version 0.5

  • Supports the following binding models:

    • First-order binding of microtubule binding protein to microtubules
    • "Classical" cooperativity
    • A model where a protein binds the microtubule at the seam and the lattice with different affinities
    • A model where a microtubule binding protein can bind either the microtubule or a microtubule bound protein, allowing two total layers of microtubule bound proteins.
    • A model where a microtubule binding protein can bind either the microtubule or a microtubule bound protein, allowing up to three layers of microtubule binding proteins on the microtubule.
  • Three different modes of collecting binding data:

    • Holding the protein of interest constant and varying the microtubule concentration
    • Holding the microtubule concentration constant and varying the concentration of the protein of interest
    • An experiment with two different microtubule binding proteins, where one microtubule binding protein and microtubule concentration are held constant and the concentration of the other microtubule binding protein is varied. In this mode, both microtubule binding proteins are assumed to follow first-order binding.
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