Dealing with 'Inf' fold change values

[kholt1993]

Hi,
After running Desingle, my fold change data contains a lot of Inf values. I cannot run a pathway analysis unless I remove the genes with an 'Inf' fold change. How should I use Desingle to fix this issue, while still allowing Desingle the ability to distinguish real zeros in my count data?
Thank you.

[miaozhun]

Hi,
The 'Inf' fold change shows for some genes because the expression values of these genes in cell group 2 compared are all zeros. So the fold change of these genes will be 'Inf'. You could just switch cell group 1 and cell group 2, then the fold change of these genes will be '0's.

Best,
Zhun