mesenchymal cell / mesenchymal stem cell (CL_0000134)

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http://purl.obolibrary.org/obo/CL_0000134

This class has multiple issues.  

1. It seems to confuse mesenchymal cell with 'mesenchymal stem cell'.  As far 
as I understand it, mesenchyme is simply a description of the non-polarised 
cells that make up mesenchyme: a loosely packed developing tissue with 
extensive extracellular matrix containing unpolarised cells. As many cells 
under CL_0000134 are stem cells, we should probably make a new term for 
mesenchymal cell.  I'm not sure whether the stem cell is even a subclass of 
this general class.

2. The use of cell surface markers in the definition severely limits species 
applicability.  This looks to me like a case where the cell surface marker 
axioms should be punted off into a species specific class - or perhaps into 

3. Are we really sure about all those developmental potentials?  Can't a 
mesenchymal stem cell have only some of these?

4. Is this equivalent class expression ever likely to be useful for 
auto-classification?

5. Some notes on the text definition:

"A connective tissue cell that..."
should be part of some connective tissue?

"They may further differentiate into osteoblasts, adipocytes, myocytes, 
neurons, or chondroblasts in vitro..."
in vitro?  is this in scope?

Original issue reported on code.google.com by dosu...@gmail.com on 14 Jul 2014 at 4:27

[GoogleCodeExporter]

Scratch 5a, relationship to connective tissue is already in place.

Original comment by dosu...@gmail.com on 14 Jul 2014 at 4:28

[gouttegd]

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