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Addresses #1892 NTR for respiratory new terms #1896
Addresses #1892 NTR for respiratory new terms #1896
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Unsure if there is a specific reason "lung" is used here and "airway" used in other terms. Ref describes "PC-fibro around the airway cartilage".
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Thank you for your comment, @bvarner-ebi. Initially I was considering airway for this same reason, however in the text you are quoting it is describing the localisation of PC-fibro in an image showing an airway. That doesn't exclude that it is also present in other pulmonary parts, as this cell is "enriched in the airways", but that doesn't mean it is exclusive, as cartilage it is not exclusive around the airways: "Cartilage (hyaline type) has the function of maintaining airway patency and it also serves for the attachment of local muscle and connective tissue."
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If this cell type does exist in lung tissue, would you please add that reference to the term. The quote mentioned above refers to the airways as well.
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Looking at the scRNA-seq data, the majority of cells identified as PC-fibro came from airway tissue, but a small proportion (~0'4%) was found in parenchymal tissue:
Of course the number of cells is very small and they can be false positives (in the umap they don't map with the PC-fibro cluster) or a different kind of perichondrial cells. In the later case, it makes more sense to use 'lung perichondrial fibroblast' to encompass all PC-fibro found in the lung.
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If that is from the dbxref, and if Par stands for parenchyma, it seems reasonable.