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Closes #3043 NTR neuroendocrine system #3045

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merged 5 commits into from
Sep 4, 2023
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Closes #3043 NTR neuroendocrine system #3045

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0880f5c
Closes #3043 NTR neuroendocrine system
aleixpuigb Aug 29, 2023
c7db81b
Change abbreviation annotation property
aleixpuigb Aug 29, 2023
24276c1
Update definition and add reference
aleixpuigb Aug 31, 2023
f19a78e
Update definition and references, and added 'part of' axioms to struc…
aleixpuigb Sep 1, 2023
eb4c05c
Merge branch 'master' into 3043_NTR_neuroendocrine_system
aleixpuigb Sep 4, 2023
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12 changes: 12 additions & 0 deletions src/ontology/uberon-edit.obo
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Expand Up @@ -224439,6 +224439,18 @@ relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0000101 ! lobe of lung
property_value: dcterms-date "2023-07-20T12:43:29Z" xsd:dateTime

[Term]
id: UBERON:8600018
name: neuroendocrine system
def: "A regulatory system of the body that integrates the nervous system and the endocrine system. This system consists of a set of cells organized in single organs and diffuse elements, sharing co-production of amine hormone/transmitters, peptide hormone/transmitters and specific markers of neural determination." [PMID:15481802, Wikipedia:endocrinology]
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Consider using the term "neurohormone" as the current definition does not capture all neurohormones (e.g., steroid hormones).

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Consider the following definition, although I haven't found no-cost access to the online reference:

Neuroendocrine systems can be defined as the sets of neurons, glands and non-endocrine tissues, and the neurochemicals, hormones, and humoral signals they produce and receive, that function in an integrated manner to collectively regulate a physiological or behavioral state.
From: Handbook of Neuroendocrinology, 2012

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@aleixpuigb aleixpuigb Aug 31, 2023 •
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Thank you for your comments and providing this reference.
The new updated definition is the following:

A regulatory system of the body that integrates the nervous system and the endocrine system. This system involves specialized neuroendocrine cells primarily located in the hypothalamus, pituitary gland, and various organs. The neuroendocrine system functions through the release of neurotransmitters and hormones, enabling communication between these systems to govern vitally important processes that include growth, reproduction, metabolism and energy homeostasis, electrolyte and water balance, and responses to stress.

https://doi.org/10.1016/B978-0-12-375097-6.10001-0
PMID:15481802
Wikipedia:endocrinology

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The second sentence: "involves" and "various organs" are vague.

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Beware that this definition (specifically the part “involves […] cells primarily located in the hypothalamus, pituitary gland, and various organs”) makes the term vertebrate-specific. Invertebrates may lack a hypothalamus or a pituitary gland but they do have a “neuroendocrine system” (see for example Hartenstein 2006), so if it is intended that this term should be vertebrate-specific then this should be clearly stated; otherwise the definition should avoid referring to vertebrate-specific structures or at least use precautions around them.

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Thank you @gouttegd, the intention is that is not vertebrate-specific, and anything that is vertebrate-specific will be in a comment.

comment: In vertebrates, the hypothalamic-pituitary-target organ axis (H-P axis), the autonomic nervous system (ANS) and the diffuse neuroendocrine or APUD system contribute to the neuroendocrine system. {xref="PMID:15481802"}
synonym: "NES" RELATED ABBREVIATION [PMID:15481802]
is_a: UBERON:0000467 ! anatomical system
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: overlaps UBERON:0000949 ! endocrine system
relationship: overlaps UBERON:0001016 ! nervous system
property_value: dcterms-date "2023-08-29T10:49:45Z" xsd:dateTime

[Typedef]
id: aboral_to
name: aboral to
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