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Closes #3043 NTR neuroendocrine system #3045
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@@ -135206,6 +135206,7 @@ is_a: UBERON:0000061 {source="MP"} ! anatomical structure | |
relationship: contributes_to_morphology_of UBERON:0000115 ! lung epithelium | ||
relationship: has_part CL:1000223 ! lung neuroendocrine cell | ||
relationship: part_of UBERON:0000115 ! lung epithelium | ||
relationship: part_of UBERON:8600018 ! neuroendocrine system | ||
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[Term] | ||
id: UBERON:0010005 | ||
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@@ -136303,8 +136304,9 @@ subset: pheno_slim | |
synonym: "neuroendocrine system gland" EXACT [] | ||
xref: MA:0000720 | ||
intersection_of: UBERON:0002368 ! endocrine gland | ||
intersection_of: part_of UBERON:0001016 ! nervous system | ||
intersection_of: part_of UBERON:8600018 ! neuroendocrine system | ||
relationship: has_part CL:0000165 ! neuroendocrine cell | ||
relationship: overlaps UBERON:0001016 ! nervous system | ||
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[Term] | ||
id: UBERON:0010134 | ||
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@@ -224439,6 +224441,18 @@ relationship: dc-contributor https://orcid.org/0000-0002-9185-3994 | |
relationship: part_of UBERON:0000101 ! lobe of lung | ||
property_value: dcterms-date "2023-07-20T12:43:29Z" xsd:dateTime | ||
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[Term] | ||
id: UBERON:8600018 | ||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Consider using the term "neurohormone" as the current definition does not capture all neurohormones (e.g., steroid hormones). There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Consider the following definition, although I haven't found no-cost access to the online reference: Neuroendocrine systems can be defined as the sets of neurons, glands and non-endocrine tissues, and the neurochemicals, hormones, and humoral signals they produce and receive, that function in an integrated manner to collectively regulate a physiological or behavioral state. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Thank you for your comments and providing this reference.
https://doi.org/10.1016/B978-0-12-375097-6.10001-0 There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. The second sentence: "involves" and "various organs" are vague. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Beware that this definition (specifically the part “involves […] cells primarily located in the hypothalamus, pituitary gland, and various organs”) makes the term vertebrate-specific. Invertebrates may lack a hypothalamus or a pituitary gland but they do have a “neuroendocrine system” (see for example Hartenstein 2006), so if it is intended that this term should be vertebrate-specific then this should be clearly stated; otherwise the definition should avoid referring to vertebrate-specific structures or at least use precautions around them. There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. Thank you @gouttegd, the intention is that is not vertebrate-specific, and anything that is vertebrate-specific will be in a comment. |
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name: neuroendocrine system | ||
def: "A regulatory system of the body that integrates the nervous system and the endocrine system. This system is formed by specialized neuroendocrine cells located mainly in the nervous system and neuroendocrine glands. However, they can also be found as either single cells or small clusters of cells dispersed throughout the surface epithelium of different tissues. The neuroendocrine system functions through the release of neurotransmitters and neurohormones, enabling communication between the endocrine and nervous systems to govern vitally important processes that include growth, reproduction, metabolism and energy homeostasis, electrolyte and water balance, and responses to stress." [doi:10.1016/B978-0-12-375097-6.10001-0, PMID:15481802, PMID:17003257, PMID:25905254, Wikipedia:endocrinology] | ||
comment: In vertebrates, the hypothalamic-pituitary-target organ axis (H-P axis), the autonomic nervous system (ANS) and the diffuse neuroendocrine or APUD system contribute to the neuroendocrine system. {xref="PMID:15481802"} | ||
synonym: "NES" RELATED ABBREVIATION [PMID:15481802] | ||
is_a: UBERON:0000467 ! anatomical system | ||
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 | ||
relationship: overlaps UBERON:0000949 ! endocrine system | ||
relationship: overlaps UBERON:0001016 ! nervous system | ||
property_value: dcterms-date "2023-08-29T10:49:45Z" xsd:dateTime | ||
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[Typedef] | ||
id: aboral_to | ||
name: aboral to | ||
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With the updated logical definition, would this be redundant?
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I don't think so. If K overlaps T, that means there is C that is the overlapping part. If B is part of K, it does not mean that it is part of C (overlapping T).
![image](https://private-user-images.githubusercontent.com/94959119/265036323-83f0d497-211c-47af-8559-1aab6546ab0a.png?jwt=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.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.XZEbj3xmLwuyaVjwfjCSOmGFvOdVTgPKo0Rm4UccLQk)
For clarification I have added a diagram and changed the letters:
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Is there a plan to revise 'neuroendocrine cell'?
If not, this may still be redundant if keeping
'has part' some 'neuroendocrine cell'
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yes, neuroendocrine cell will not be a neuron after the revision.