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<ul> | ||
<li>Release of the new Biased Signalling resource</li> | ||
<li>Release of the new Biased Signaling resource</li> | ||
<ul> | ||
<li>Bias calculations according to the recently published <a href="https://doi.org/10.1111/bph.15811" target="_blank">Community Guidelines for GPCR Ligand Bias</a></li> | ||
<li>In-depth browsing and plotting of biased signalling data for individual receptors on transducer family and subtype level</li> | ||
<li>Visualisation of the trends in the signalling data via the <a href="https://gpcrdb.org/biased_signalling/bias_statistics"> statistics</a> pages</li> | ||
<li>In-depth browsing and plotting of biased signaling data for individual receptors on transducer family and subtype level</li> | ||
<li>Visualisation of the trends in the signaling data via the <a href="https://biasedsignalingatlas.org/biased_signalling/bias_coverage"> statistics</a> pages</li> | ||
<li>Annotation of endogenous ligands via the Guide to Pharmacology for identifying physiology-biased ligands</li> | ||
<li>Comparison of receptor-signalling profiles between any ligand with signalling data for a given receptor</li> | ||
<li>Comparison of receptor-signaling profiles between any ligand with signaling data for a given receptor</li> | ||
</ul> | ||
<li>Revamped ligand handling in GPCRdb</li> | ||
<ul> | ||
<li>Improved ligand identification, processing, curation, integration, and crosslinking</li> | ||
<li>Updated GPCR ligand and bioactivity data from ChEMBL</li> | ||
<li>Updated ligand vendor data from PubChem</li> | ||
<li>Linking ligands to external sources (<a href="https://www.guidetopharmacology.org" target="_blank">Guide to Pharmacology</a>, <a href="https://www.ebi.ac.uk/chembl/" target="_blank">ChEMBL</a>, <a href="https://pubchem.ncbi.nlm.nih.gov" target="_blank">PubChem</a>, <a href="https://drugcentral.org" target="_blank">Drug Central</a>, and <a href="https://www.drugbank.ca" target="_blank">DrugBank</a>). </li> | ||
<li>Linking ligands to external sources (<a href="https://www.guidetopharmacology.org" target="_blank">Guide to Pharmacology</a>, <a href="https://www.ebi.ac.uk/chembl/" target="_blank">ChEMBL</a>, <a href="https://pubchem.ncbi.nlm.nih.gov" target="_blank">PubChem</a>, <a href="https://drugcentral.org" target="_blank">Drug Central</a>, and <a href="https://www.drugbank.ca" target="_blank">DrugBank</a>)</li> | ||
</ul> | ||
<li>Updated <a href="https://gpcrdb.org/structure/">GPCR</a> and <a href="https://gproteindb.org/structure/g_protein_structure_browser">G protein</a> structures</li> | ||
<li>Updated GPCR <a href="https://gpcrdb.org/structure/homology_models">homology</a> and <a href="https://gpcrdb.org/structure/">refined</a> structure models</li> | ||
<li>Minor bug and performance fixes</li> | ||
</ul> | ||
</ul> |