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README.rst

EARM

Extrinsic Apoptosis Reaction Model

http://sorgerlab.github.com/earm

EARM is a family of models of the extrinsic apoptosis pathway written using the Python modeling framework PySB. Model variants focus on exploring alternative hypotheses for the mechanism of Mitochondrial Outer Membrane Permeabilization (MOMP), controlled by the Bcl-2 family of proteins.

Documentation

The documentation is available online at http://earm.readthedocs.org/ . The documentation source files are available locally in the doc/ subdirectory.

Download

EARM is hosted on GitHub at http://github.com/sorgerlab/earm .

The code is available via the Download link there, or you can clone the repository with Git:

git clone git://github.com/sorgerlab/earm

To use the models you'll need to install PySB and its associated dependencies. More information on using the models is available in the EARM documentation.

Authors

Carlos F. Lopez (carlito_x@yahoo.com) Jeremy L. Muhlich (jmuhlich@bitflood.org) John A. Bachman (bachmanjohn@gmail.com)

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Extrinsic Apoptosis Reaction Model

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