drug-repurposing line-intersection drug-resistance center-of-mass system-of-linear-equations diophantine-equations sensitizing-drugs mitotic-inhibitors fluorescent-speckle-microscopy dynein-targeting meiotic-spindle spindle-pole-motion microtubule-growth-trajectory end-binding-protein stathmin-oncoprotein-18 microtubule-nucleation microtubule-minus-end microtubule-dynamics microtubule-regulation minus-end-directed-motors