voronoi-diagram biomarker-discovery breast-cancer prostate-cancer sobel-filter drug-response-prediction circulating-tumor-cells circular-hough-transform difference-of-gaussian gastric-cancer tubulin-inhibitors intensity-histogram-thresholding tubulin-bundling tubulin-tyrosination transcription-factor-localization stationary-wavelet-transform feature-eccentricity microfluidics-chip-enrichment brca1-drug-resistance paclitaxel-therapy