CoMorMent-Containers
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Updated
Jun 27, 2024 - R
CoMorMent-Containers
Toolkit for the efficient construction and analysis of polygenic risk scores in R.
Cross-Trait Penalized Regression using Summary Statistics
quincunx: an R package to query, download and wrangle PGS Catalog data
quincunx: an R package to query, download and wrangle PGS Catalog data
single cell informed polygenic risk scoring in Parkinson's disease
Bayesian PRS methods model uncertainty in effect size estimates and shrink small effect sizes to mitigate spurious associations and biases from sample overlap. By using full posterior distributions rather than point estimates, they effectively account for estimation errors and reduce the impact of artificially inflated associations.
Pipeline for PRS computation integrating diverse PRS algorithms into a unique Snakemake workflow.
GAUDI: a penalized regression based PRS method designed specifically for admixed individuals
power calculator for Genetic Risk Scores (GRS)
Those are the code files for producing the PheWAS analyses in the manuscript "Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer’s Disease in Electronic Health Records". Part of our analyses included sensitive genomic data. Codes to produce AD PRS were not included here.
Polygenic Risk Scores (PRS) pipeline.
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