July 2014

This release contains enhancements in speed and functionality of the LiFE software.

The new version of LiFE uses a different fitting procedure to solve the non-negative least square problem (see feFitModel.m). The new code is faster than the previous version and by eliminating the stochastic gradient descent method used in v0.1 it does not require two diffusion data sets to solve the minimization and determine the fascicle weights.

Furthermore, the new code comprises new functions to compute:

• Strength of Evidence
• Earth Movers Distance
• Virtual Lesions

Finally, the help and in-line documentation of many of the functions has been improved and expanded.

Franco Pestilli, PhD, Stanford University 2014

Validation and statistical inference of white-matter connectomes

This is the main release of the software. The software allows for validating the network of large-scale brain connection identified by using Diffusion MR imaging and fiber tractography.

It runs in Matlab and it requires Vistasoft.