Interaction with screen readers and other assistive technology?

[caraya]

Has there any research been done on how the TTS portion of the API interacts with screen readers and other forms of assistive technology?

[LJWatson]

There is no relationship. The TTS interface of the API produces synthetic speech in the browser, a screen reader uses specific installed TTS engines to produce synthetic speech at the OS level/application level. A screen reader won't respond to anything created using the API.