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Some encoders like CRAMtools write empty blocks, i.e., a block with an uncompressed size of 0. This is rather unconventional, but the CRAM spec does not define whether this is legal or not. The question is posed in samtools/hts-specs#680.
Some encoders like CRAMtools write empty blocks, i.e., a block with an uncompressed size of 0. This is rather unconventional, but the CRAM spec does not define whether this is legal or not. The question is posed in samtools/hts-specs#680.
An example of data like this can be seen with
SAMEA3302751.alt_bwamem_GRCh38DH.20200922.Finnish.simons.cram
.This was originally reported by @claymcleod.
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