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Make sure you have the latest Biostrings i.e. version 2.71.5. Note that pwalign requires Biostrings >= 2.71.5. However, a serious design flaw in R CMD INSTALL is that it checks for version requirements after compilation, when it should actually do this before doing anything else.
When I install the package, I got call to undeclared function 'get_XStringSet_width'.
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