Bahadar Srichawla D.O., M.S.

Physician-Scientist

Technical Skills: Python, RStudio, MATLAB

🔗 Links

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🌟 Biography

Bahadar Srichawla is a Chief Resident Physician in the Department of Neurology at the University of Massachusetts Chan Medical School. His research interests are deeply rooted in the neurological sciences. And is particularly specialized in:

Neurocritical Care: Focusing on advanced treatments and interventions for critically ill neurological patients.

Cerebral Hemodynamics: Investigating the dynamics of blood flow in the brain and how it impacts neurological conditions.

Multimodal Neuromonitoring: Utilizing multiple forms of neurological monitoring to provide a comprehensive understanding of a patient's neurophysiological state.

Data Science & Machine Learning in ICU: Leveraging data science and machine learning techniques to advance our understanding of cerebral physiology. The aim is to employ these technologies to improve the clinical care of patients in the intensive care unit.

🎓 Education

Residency, Neurology, University of Massachusetts Chan Medical School (2022-2025)

• Department of Neurology Research Award, 2023

Internship, Medicine, University of Massachusetts Chan Medical School (2021-2022)

Doctor of Osteopathic Medicine (D.O.), Medicine, Touro College (2017-2021)

• Omega Beta Iota (ΩβΙ) Honor Society
• Sigma Sigma Phi (ΣΣΦ) Honor Society

Graduate Certificate, Clinical Research, Harvard University (2017-2019)

• Thesis Title: Efficacy of Posaconazole for Treatment of Basal Cell Carcinoma

Master of Science (M.S.), Biophysics, Stony Brook University (2016-2017)

• GPA 4.0/4.0
• Thesis Title: Effects of the Baroreflex in Response to Phenylephrine and Nitroprusside in Vagotomized and Non-Vagotomized rats
• Relevant Coursework: Statistical & Model-Based Analysis of Physiological Data

Bachelor of Science (B.S.), Neuroscience, Stony Brook University (2012-2016)

• Dean's List 2015-2016

🛠 Selected Experience

Resident Physician @ UMass Memorial Medical Center (2021-2025)

Research Associate @ Stony Brook University (2015-2017)

• Solomon Lab: Understanding the mechanisms by which central nervous system (CNS) neurons integrate peripheral and central inputs in respiratory and cardiovascular control.
• Competency in multi-channel electrode array electromyography (EMG) in both mice and rats.
• Complex physiological data analysis using MATLAB.

🔬 Clinical Trials

Sub-Investigator @ Univeristy of Massachusetts Chan Medical School (2022- )

• BOOST-3 Clinical Trial
• FASTEST Phase III Clinical Trial
• MOST Phase III Clinical Trial

📈 Selected Projects

The Effects of Catheter Ablation on Cognitive Outcomes in Atrial Fibrillation

Publication

The study, part of the SAGE-AF cohort, enrolled ambulatory patients aged 65 or older with AF eligible for oral anticoagulation from clinics in Massachusetts and Georgia between 2016 and 2018. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) at baseline, 1 year, and 2 years, with a score of 23 or less defining cognitive impairment. The study included 887 participants, with an average age of 75.2 years, and found that those who had undergone CA before enrollment were significantly less likely to experience cognitive impairment over the two-year period compared to those receiving only medical management. This was evident even after adjusting for propensity score for CA. Specifically, at the 2-year follow-up, a higher percentage of patients in the non-CA group showed cognitive impairment compared to the CA group. The study concludes that CA for AF appears to be associated with a lower likelihood of cognitive impairment in this patient population over a two-year period.

Neurological Manifestations, ICU outcomes, and Biomarkers in COVID-19

Publication 1

Publication 2

This project investigates the clinical, neurological, and laboratory markers in hospitalized COVID-19 patients based on a retrospective study of 1248 inpatients. A multivariate logistic regression analysis was completed using SAS. Key findings reveal that 31% of patients were admitted to the ICU, with a higher prevalence of male and older individuals. Neurological symptoms were observed in 41.74% of the cases, affecting the central nervous system. A mortality rate of 25.16% was noted, significantly higher among ICU-admitted patients. Elevated levels of specific biomarkers like white blood cell count, ferritin, and lactate dehydrogenase were associated with ICU admission. The study underscores the importance of these markers in predicting morbidity, ICU admission, and mortality, offering valuable insights for effective COVID-19 management.

A subgroup analysis of 387 patients admitted to the ICU was conducted. Nearly half (48.5%) of the ICU patients succumbed to COVID-19. Factors that contributed to increased mortality included being 60 years of age or older, impaired consciousness, lung disease, elevated international normalized ratio (INR) and elevated blood urea nitrogen (BUN) levels. Surprisingly, symptoms such as dizziness/lightheadedness, myalgia, and headache were associated with a higher likelihood of survival. Additionally, elevated D-dimer and aspartate aminotransferase (AST) levels, as well as lymphopenia, were more commonly observed in deceased patients.

Meta Analysis: Neuromyelitis Optica Spectrum Disorder (NMOSD) and Breast Cancer

Publication

This project focuses on the relationship between neuromyelitis optica spectrum disorder (NMOSD) and breast cancer. NMOSD is an autoimmune astrocytopathy marked by neuroinflammation and demyelination in the central nervous system, often mediated by aquaporin-4 immunoglobulin (AQP4-IgG). The meta-anlysis was completed using Python, and data visualization was completed using GraphPad Prism. Based on a systematic review and meta-analysis of 12 publications, we identified 19 cases, all in women, with an average age of 51.26 years. Neurological symptoms like speech abnormalities and myelopathy were commonly observed, and MRI scans often showed longitudinally extensive transverse myelitis involving the cervical spine. Our data reveals a complex temporal relationship between NMOSD and breast cancer diagnosis: 15.9% were diagnosed with both conditions within the same month, 26.1% had prior breast cancer diagnosis, and 42.1% were diagnosed with breast cancer following NMOSD. Given the broad time range for breast cancer diagnosis relative to NMOSD onset, our study suggests that older women newly diagnosed with NMOSD should undergo frequent breast cancer screening.

📚 Bibliography

1. Srichawla, B.S., Kaur, T., Singh, H. Corticosteroids in Posterior Reversible Encephalopathy Syndrome: Friend or Foe? A Systematic Review. World Journal of Clinical Cases. (Accepted for publication)
2. Srichawla, B.S., Garcia-Dominguez, M.A. Regional Dynamic Cerebral Autoregulation Across Anterior and Posterior Circulatory Territories: A Detailed Exploration and its Clinical Implications. World Journal of Critical Care Medicine. (Accepted for publication).
3. Srichawla, B.S., Garcia-Dominguez, M.A. Spectrum of Delayed Post-Hypoxic Leukoencephalopathy Syndrome: A Systematic Review. World Journal of Clinical Cases. 2024 October 16; 12(29): 6285-6301. PMID: 39417054
4. Srichawla, B.S., Fang, T., Kipkorir, V., Lalla, R. Critical Illness-Associated Cerebral Microbleeds Involving the Corpus Callosum Following Cardiac Arrest: A Case Report . Medicine. Aug 9;103(32):e39273. PMID: 39121333
5. Srichawla, B.S. Future of Neurocritical Care: Integrating Neurophysics, Multimodal Monitoring, and Machine Learning. World Journal of Critical Care Medidine. 2024 Jun 9;13(2):91397. PMID: 38855276
6. Găman, M.-A., Srichawla, B.S., Cheng, Y., Roy, P., Dhali, A., Nahian, A., Manan, M.R., Kipkorir, V., Suteja, R.C., Kutikuppala, L.V.S., Găman, A.M., Diaconu, C.C. An overview of Dyslipidemia and Metabolic Syndrome in Myeloproliferative Neoplasms. World Journal of Clinical Oncology. 2024 Jun 24;15(6):717-729. PMID: 38946827
7. Cozma, M.-A., Găman, M.-A., Srichawla, B.S., Dhali, A., Manan, M.R., Nahian, A., Marsool, M.D., Suteja, R.C., Kutikuppala, L.V.S., Kipkorir, V., Găman, A.M., Diaconu, C.C. Acute Cholangitis: a State-of-the-Art Review. Annals of Medicine & Surgery. 2024 May 15;86(8):4560-4574. PMID: 39118745
8. Cozma, E.-C., Banciu, L.M., Celarel, A.M., Soare, E., Srichawla, B.S., Kipkorir, V., Găman, M.-A. Molecular Mechanisms of Human Papilloma Virus Related Skin Cancers: A Review. Medicine. 2024 May 24;103(21):e38202. PMID: 38787972
9. Srichawla, B.S., Manan, M.R., Kipkorir, V., Dhali, A., Diebel, S., Sawant, T., Zia, S., Carrion-Alvarez, D., Suteja, R.C., Nurani, K., Găman, M.-A. Neuroinvasion of Emerging and Re-emerging Arboviruses: A Scoping Review. SAGE Open Medicine. 2024 May 6 12:20503121241229847. PMID: 38711470
10. Srichawla, B.S., Presti, K., Kipkorir, V., Berrios-Morales, I. Chemotherapy-Associated Hemorrhagic Posterior Reversible Encephalopathy Syndrome (PRES) with Considerations for Circle of Willis Variants on Cerebral Blood Flow and Autoregulation Medicine. 2024 Feb 23;103(8):e37250. PMID: 38394546
11. Srichawla, B.S., Hamel, A., Cook, P., Aleyadeh R., Lessard, D., Otabil, E.M., Mehawej, J., Saczynski, J.S., McManus, D., Moonis, M. Is Catheter Ablation Associated with Favorable Cognitive Function Over Time? An Analysis of the SAGE-AF Observational Cohort Study. Frontiers in Neurology. 2024 Jan 5:14:130202010.3389/fneur.2023.1302020 PMID: 38249728
12. Garcia-Dominguez, M.A., Kipkorir, V., Srichawla, B.S. Prognostic indicators for hospitalization and ICU admission in people with multiple sclerosis and COVID-19: an analysis of the COVID-19 in MS global data sharing initiative dataset. Annals of Medicine & Surgery. 2024 Jan 3;86(2):720-725. PMID: 38333271
13. Srichawla, B.S., Bose, A., Kipkorir, V. Cranial Neurolymphomatosis and Its Oncologic Counterparts: Case Series on Malignant Cranial Nerve Neuropathies. SAGE Open Medical Case Reports. 2023 Dec 30:12:2050313X231221466. PMID: 38162422
14. Srichawla, B.S., Fang, T., Kipkorir, V., Garcia-Dominguez, M. Reversible Cerebral Vasoconstriction Syndrome (RCVS) and Posterior Reversible Encephalopathy Syndrome (PRES) Following Vaccination: An Analysis of the VAERS Database and Systematic Review. Annals of Medicine & Surgery. 2023 Oct 18;86(3):1251-1260. PMID: 38463101
15. Srichawla, B.S., Kipkorir, V., Sekhon, M. Clinical Indications and Outcomes of Impella Devices for Severe Cardiogenic Shock in COVID-19 Patients: A Systematic Review. Annals of Medicine & Surgery. 2023 Nov 1;85(12):6115-6122. PMID: 38098597
16. Manan, M.R., Kipkorir, V., Nawaz, I., Waithaka, M.W., Srichawla, B.S., Găman, A.M., Diaconu, C.C., Găman, M.-A. Acute myocardial infarction in myeloproliferative neoplasms. World Journal of Cardiology. 2023; 15 (11) 571-581. 10.4330/wjc.v15.i11.571 PMID: 38058401
17. Adesola, A.A., Cozma, M.-A., Chen, Y.-F., Srichawla, B.S., Găman, M.-A. Risk of hepatitis B reactivation in patients with myeloproliferative neoplasms treated with ruxolitinib. World Journal of Hepatology 2023.; 15 (11) 1188-1195 10.4254/wjh.v15.i11.1188 PMID: 38075009
18. Srichawla, B.S., Fang, T., Bose, A., Kipkorir, V., Ferris, A. Successful Mechanical Thrombectomy of Bilateral Middle Cerebral Artery Occlusions Following Apixaban Discontinuation. Journal of Investigative Medicine High Impact Case Reports. 2023 Jan-Dec;11:23247096231206624 10.1177/23247096231206624 PMID: 37843107
19. Srichawla, B.S., Quast, J. Magnesium deficiency: An overlooked key to the puzzle of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS)? Journal of the Neurological Sciences. 2023; 453:120796 10.1016/j.jns.2023.120796 PMID: 37708589
20. Dhali, A., Kipkorir, V., Srichawla, B.S., Rathna, R.B., Cheruto, D., Ongidi, I., Chaudhry, T., Morara, G., Nurani, K., Biswas, J., Chieng, L.R., Dhali, G.K. Artificial Intelligence Assisted Endoscopic Ultrasound for Detection of Pancreatic Space Occupying Lesion: A Systematic Review and Meta-Analysis. International Journal of Surgery. 2023. 10.1097/JS9.0000000000000717 PMID: 37800594
21. Srichawla, B.S., Kipkorir, V., Hawyard, Lawrence. Heart Rate Variability Analysis in Toxic Leukoencephalopathy Induced Malignant Catatonia: A Case Report. Medicine. 2023 Nov 3;102(44):e35371 10.1097/MD.000000000003537 PMID: 37932984
22. Purwar S., Fatima A., Bhattacharyya, H., Kutikuppala, L.V.S., Cozma, M-A., Srichawla, B.S., Komer, L., Nurani, K.M., Găman, M.-A. Toxicity of Targeted Anticancer Treatments on the Liver in Myeloproliferative Neoplasms. World Journal of Hepatology. 2023; 15 (9):1021-1032. 10.4254/wjh.v15.i9.1021 PMID: 37900211
23. Srichawla, B.S., Sivakumar S., Cheraghi, S.N., Kipkorir, V., Garcia-Dominguez, M.A. Breast Cancer Associated Paraneoplastic Neuromyelitis Optica with Cervical Cord Compression and Spondylosis Requiring Laminectomy: A Case Report. SAGE Open Medical Case Reports. 2023; 11:1-4. 10.1177/2050313X231198322 PMID: 37667745
24. Srichawla, B.S., Andrade, E., Kipkorir V. Decoding Brain Calcifications: A Single-Center Descriptive Case Series and Examination of Pathophysiological Mechanisms. SAGE Open Medical Case Reports. 2023; 11:1-6. 10.1177/2050313X231197521 PMID:37663154
25. Srichawla, B.S., Quast J., Pacut, P., Sivakumar S., Garcia-Dominguez, M.A., Belgrad, J., Panda, A., Carbone, S., Sanders, D.T., Min, E., Hayes, N.T., Bose, A., Lee, V., Ghasemi, M. COVID-19 in the Intensive Care Unit: Unmasking the Critical Factors Impacting Patient Survival. Journal of Investigative Medicine. 2023 Dec;71(8):907-916 10.1177/10815589231191813 PMID: 37485922
26. Srichawla, B.S.!#, Garcia-Dominguez, M.A.!, Pacut, P., Quast, J., Sivakumar, S., Belgrad, J., Panda, A., Cabone, S., Sanders, D., Min, E., Hayes, N.T., Bose, A., Lee, V., Kipkorir, V., Ghasemi, M. A Single-Center Retrospective Study of Hospitalized COVID-19 Patients: Demographics, Laboratory Markers, Neurological Complications, ICU Admission, and Mortality. Annals of Medicine & Surgery. 2023; 85(7):3323-3333. 10.1097/MS9.0000000000000949 PMID: 37427212 (!Contributed equally; # Corresponding author)
27. Srichawla, B.S., Doshi, K, Cheraghi, S.N., Sivakumar, S. The Temporal Relationship of Paraneoplastic Aquaporin-4-IgG Seropositive Neuromyelitis Optica Spectrum Disorder (NMOSD) and Breast Cancer: A Systematic Review & Meta-Analysis. Neurological Sciences. 2023. Nov;44(11):3809-3817 10.1007/s10072-023-06952-0 PMID: 37453952
28. Srichawla, B.S., Can, H., Deeb, W. Cranio-Cervical Junction Intradural Extramedullary Meningioma with Cord Compression. BMJ Case Reports. 2023; 16 (7): e255544. 10.1136/bcr-2023-255544 PMID: 37437961
29. Srichawla, B.S., Kipkorir, V., Manan, M.R., Dhali, A., Diebel, S., Sawant, T., Zia, S., Carrion-Alvarez, D., Suteja, R.C., Nurani, K., Găman, M.-A. Stealth Invaders: Unraveling the Mystery of Neurotropic Viruses and Their Elusive Presence in Cerebrospinal Fluid - A Comprehensive Review. Annals of Medicine and Surgery. 85(6): 2 761-2766, June 2023. 10.1097/MS9.0000000000000736 PMID: 3736357
30. Srichawla, B.S., Catton, R.M., Lichtenberg, A.A., Henninger, N. Clinical Characteristics and Risk Factors for Bilateral Lateral Geniculate Body Pathology: A Systematic Review of the Literature. Neurological Sciences. 2023. Oct;44(10):3481-3493 10.1007/s10072-023-06818-5 PMID: 37086352
31. Găman, M.-A., Cozma, E.-C., Srichawla, B.S., Cozma, M.-A., Varkaneh, H.K., Chen, Y., Găman, A.M., Diaconu, C.C. Bioactive Vitamins and Epigenetic Modifications in Diabetes: A Perspective. Current Diabetes Review. 2023. Mar 30 10.2174/1573399819666230330124035 PMID: 37005542
32. Găman, M.-A., Cozma, M.-A., Manan, M.R., Srichawla, B.S., Dhali, A., Ali, S., Nahian A., Elton, A.C., Kutikuppala, L.V.S., Suteja, R.C., Diebel, S., Găman, A.M., Diaconu, C.C. Budd-Chiari Syndrome in Myeloproliferative Neoplasms: A Review of Literature. World Journal of Clinical Oncology. 2023;14 (3):99-116. 10.5306/wjco.v14.i3.99 PMID: 37009257
33. Srichawla, B.S., Sekhon, M. Biventricular Impella (BiPella) Utilization in Fulminant COVID-19 Myopericarditis Mediated Cardiogenic Shock During Pregnancy. Clinical Research in Cardiology. 2023. Oct;112(10):1475-1478 10.1007/s00392-023-02170-y PMID: 36795134
34. Găman, M.-A., Kipkorir, V., Srichawla, B.S., Dhali, A., Găman, A.M., Diaconu, C.C. Primary Arterial Hypertension and Drug-Induced Hypertension in Philadelphia-Negative Classical Myeloproliferative Neoplasms: A Systematic Review. Biomedicines. 2023;11, 388. 10.3390/biomedicines11020388 PMID: 36830925
35. Srichawla, B.S., Polyarteritis Nodosa Following mRNA-1273 COVID-19 Vaccination: Case Study and Review of Immunological Mechanisms. Cureus Journal of Medical Science. 2023;15(1): e33620. 10.7759/cureus.33620 PMID: 36788908
36. Srichawla, B.S., Garcia-Dominguez, MA, Zia, S. Secondary Complications and Management Strategies in Human Monkeypox: A Case Series. Journal of Medical Virology. 2022; 95(2): e28449. 10.1002/jmv.28449 PMID: 36583470
37. Kipkorir, V., Cheruiyot, I., Ongidi, O., Nyaanga F.K., Neema, B., Otieno, E., Baskaran, R.R., Srichawla, B.S., Biswas, J., Dhali, G.K., Dhali, A. Prevalence of the Retro-Renal Colon: A systematic Review and Meta-Analysis with Implications for Percutaneous Nephrolithotomy. International Journal of General Medicine. 2022; 2022(15): 8275-8283. 10.2147/IJGM.S389682 PMID: 36438019
38. Srichawla, B.S., Mild Encephalopathy/Encephalitis with a Reversible Splenial Lesion (MERS) and Longitudinally Extensive Transverse Myelitis (LETM) in Influenza B: Neurotropic Mechanisms and Diagnostic Challenges. Cureus Journal of Medical Science. 2022; 14(10): e30681. 10.7759/cureus.30681. PMID: 36426329
39. Kipkorir, V., Dhali, A., Srichawla, B.S., Kutikuppala, S., Cox, M., Ochieng, D., Nyaanga, F., Găman, A.M. The Re-emerging Monkeypox Disease. Tropical Medicine & International Health. 2022; 10.1111/tmi.1382. 10.1111/tmi.13821. PMID: 36229989
40. Srichawla, B.S., Sporadic Creutzfeldt-Jakob Disease with Status Epilepticus: Molecular Mechanisms and a Scoping Review of Literature. Cureus Journal of Medical Science. 2022; 14(8) e28649. 10.7759/cureus.28649. PMID: 36196307
41. Srichawla, B.S., Plasma Microbial Cell-Free DNA (cf-DNA) Next-Generation Sequencing in Diagnosing Intracranial Abscesses: Pathophysiology and a Scoping Review of the Literature. Cureus Journal of Medical Science. 2022; 14(8) e28172. 10.7759/cureus.28172. PMID: 36148190
42. Srichawla, B.S., Susac Syndrome With Livedo Reticularis: Pathogenesis and Literature Review. Cureus Journal of Medical Science. 2022; 14(7): e27352. 10.7759/cureus.27352. PMID: 36046280
43. Srichawla, B.S., Sporadic Burkitt Lymphoma of the Thoracic and Lumbar Spinal Canal in an Adult: Oncogenicity, and Literature Review. Cureus Journal of Medical Science. 2022; 14(7): e26860. 10.7759/cureus.26860. PMID: 35978743
44. Srichawla, B.S., Neuroinvasive West Nile Virus Encephalitis with Anton Syndrome: Epidemiology, and Pathophysiology Review. Cureus Journal of Medical Science. 2022; 14(6): e26264. 10.7759/cureus.26264. PMID: 35911357
45. Srichawla, B.S., Autoimmune Voltage-Gated Potassium Channel Limbic Encephalitis with Auditory and Visual Hallucinations. Cureus Journal of Medical Science. 2022; 14(5): e25186. 10.7759/cureus.25186. PMID: 35747055
46. Srichawla, B.S., Nitrous Oxide/Whippits-Induced Thoracic Spinal Cord Myelopathy and Cognitive Decline With Normal Serum Vitamin B₁₂. Cureus Journal of Medical Science. 2022; 14(4): e24581. 10.7759/cureus.24581. PMID: 35664396
47. Srichawla, B.S.,, Telles, C., Schweitzer, M., Darwish, B. Attention Deficit Hyperactivity Disorder and Substance Use Disorder: A Narrative Review. Cureus Journal of Medical Science. 2022; 14(4): e24068. 10.7759/cureus.24068. PMID: 35573587
48. Srichawla, B.S., Dimethyl Fumarate-Induced Takotsubo Cardiomyopathy in a Patient with Relapsing-Remitting Multiple Sclerosis. Cureus Journal of Medical Science. 2022; 14(4): e23789. 10.7759/cureus.23789. PMID: 35518534
49. Srichawla, B.S., Khazeei T, Găman MA, Munoz-Valencia A, Bonilla-Escobar FJ. War on Ukraine: Impact on Ukrainian Medical Students. Int J Med Stud. 2022;10(1):15-17. 10.5195/ijms.2022.1468. PMID: 35433038