Comprehensive in vitro Proarrhythmia Assay (CiPA)
in silico model
R code used to perform uncertainty quantification for the CiPA in silico model
Kelly Chang, Zhihua Li
This code was developed with R version 3.3 and uses the following packages:
- optparse (version 1.4.4)
- deSolve (version 1.14)
- cmaes (version 1.0-11)
- FME (version 1.3.5)
- rms (4.5-0)
- ggplot2 (version 1.14)
This software and documentation were developed by the authors in their capacities as Oak Ridge Institute for Science and Education (ORISE) research fellows at the U.S. Food and Drug Administration (FDA).
FDA assumes no responsibility whatsoever for use by other parties of the Software, its source code, documentation or compiled executables, and makes no guarantees, expressed or implied, about its quality, reliability, or any other characteristic. Further, FDA makes no representations that the use of the Software will not infringe any patent or proprietary rights of third parties. The use of this code in no way implies endorsement by the FDA or confers any advantage in regulatory decisions.