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Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
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Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain Res 891:106-115 The mosinit.hoc file generates traces similar to figure 2 in the paper. It takes about 5 minutes to generate this figure on a 800 MHz Win 2000 PC. The model adopted De Schutter and Bower's model as the starting point, then modified the descriptions of several ion channels, such as the P-type Ca channel and the delayed rectifier K channel, and added class-E Ca channels and D-type K channels to the model. Our new model reproduces most of our experimental results and supports the conclusions of our experimental study that class-E Ca channels and D-type K channels are present and functioning in the dendrites of Purkinje neurons. See above paper for more details and references. For more information on the model please contact Dr H. Miyakawa email address: miyakawa@ls.toyaku.ac.jp These model files were supplied by Dr. H. Miyakawa 20120110 CalciumP.mod updated solve method to derivimplicit as per http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592
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