A database driver to add Microsoft SQL Server and Azure support using pymssql and FreeTDS in Peewee and should run on most Unix-like systems, Microsoft Windows and Mac OS X.
In it's current state you should be able to access data and possibly do certain updates. You will not be able to create tables or introspect existing databases, so you will have to write your models manually. Offsets will also not work, since the query compiler will need some significant rewrite to support TSQL dialect, however limit will work (TOP).
Install the latest stable release from Pypi:
$ pip install peewee-mssql
Or alternatively, select a release or development version from Github and run:
$ python setup.py install
For help on installing and configuring FreeTDS I recommend taking a look at the guide in the pymssql documentation.
And then you should be able to instantiate a database as below and start building your models for accessing data:
from peewee_mssql import MssqlDatabase
db = MssqlDatabase('MyDatabase', host='host.example.com', user='domain\\username', password='password')
If you are using Microsoft SQL Server 2005 you will need to use the legacy datetime data types, simple pass use_legacy_datetime=True to the database driver when initializing.