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Database for rat #429
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Dear @anafunguetto, We are currently working on such a database. However, it will still take a while till we make it publicly available. Kind regards, |
Hi! thanks for the return.
Good to know you´re making this information possible!
We´re looking for pgP expressions in rat (brain, liver and intestine).
We are also looking for rat enzyme activities (CYP3A4 and CYP1A2)
Kind regards,
Em seg., 2 de dez. de 2019 às 14:00, HeCo <notifications@github.com>
escreveu:
… Dear @anafunguetto <https://github.com/anafunguetto>,
We are currently working on such a database. However, it will still take a
while till we make it publicly available.
In the mean time you could enter the data manually.
What CYP are you looking for?
Kind regards,
Henrik
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*Ana Cláudia Funguetto Ribeiro*
Farmacêutica
Mestranda no Programa de Pós Graduação em Ciências Farmacêuticas - Universidade
Federal do Pampa - Unipampa
Membro do Laboratório de Farmacologia - LabFar
Integrante do Grupo de Pesquisa em Nanobiotecnologia e Nanotoxicologia -
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Dear @anafunguetto, sorry for the late response. In our data base, the expression pattern of P-gp (Abcb1a) (https://www.ncbi.nlm.nih.gov/gene/170913) in the rat look like: For CYP3A4 it is a bit more tricky, since there are several homologs in the rat and sex specific differences in expression: Further reading: https://www.tandfonline.com/doi/full/10.1517/17425255.2.6.875 Here you should consider liver and intestinal activity. Hope this helps! Kind regards, |
Thanks!!!!
Em seg., 16 de dez. de 2019 às 08:16, HeCo <notifications@github.com>
escreveu:
… Dear @anafunguetto <https://github.com/anafunguetto>,
sorry for the late response.
The Cyp1a2 should only be present in the liver.
In our data base, the expression pattern of P-gp (Abcb1a) (
https://www.ncbi.nlm.nih.gov/gene/170913) in the rat look like:
[image: image]
<https://user-images.githubusercontent.com/4817133/70902755-bc9fd600-1ffd-11ea-98c8-dc1f900fa187.png>
For CYP3A4 it is a bit more tricky, since there are several homologs in
the rat and sex specific differences in expression:
[image: image]
<https://user-images.githubusercontent.com/4817133/70902085-51a1cf80-1ffc-11ea-99b9-f6c5dcb448b4.png>
Further reading:
https://www.tandfonline.com/doi/full/10.1517/17425255.2.6.875
Here you should consider liver and intestinal activity.
Hope this helps!
Kind regards,
Henrik
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*Ana Cláudia Funguetto Ribeiro*
Farmacêutica
Mestranda no Programa de Pós Graduação em Ciências Farmacêuticas - Universidade
Federal do Pampa - Unipampa
Membro do Laboratório de Farmacologia - LabFar
Integrante do Grupo de Pesquisa em Nanobiotecnologia e Nanotoxicologia -
GPNanoFar
(55) 9 9158 - 4063 (Claro)
|
hey, everyone!
would anyone have a database for rat (with cyp/PgP expession)? I need to simulate IP concentrations...
Tks!
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