MR.Corr2

MR.Corr2 is a package for two-sample Mendelian randomization using correlated instrumental variants accounting correlated horizontal pleiotropy.

Installation

Install the development version of MR.Corr2 by use of the 'devtools' package. Note that MR.Corr2 depends on the 'Rcpp' and 'RcppArmadillo' package, which also requires appropriate setting of Rtools and Xcode for Windows and Mac OS/X, respectively.

library(devtools)
install_github("QingCheng0218/MR.Corr2")

If you have errors installing this package on Linux, try the following commands in R:

Sys.setlocale(category = "LC_ALL", locale = "English_United States.1252") 
Sys.setenv(LANG="en_US.UTF-8")
Sys.setenv(LC_ALL="en_US.UTF-8")

library(devtools)
install_github("QingCheng0218/MR.Corr2")

Usage

The 'MR.Corr2' vignette will provide a good start point for two-sample Mendelian randomization analysis using MR.Corr2 package.

References

Qing Cheng, Tingting Qiu, Xiaoran Chai, Baoluo Sun, Yingcun Xia, Xingjie Shi⁺, Jin Liu⁺. (2021) MR-Corr²: a two-sample Mendelian randomization method that accounts for correlated horizontal pleiotropy using correlated instrumental variants.

Development

This package is developed and maintained by Qing Cheng (qingcheng0218@gmail.com).