SIFT-seq data for patient MR4050

R data package related to

Chandran et al. Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA Nat Medicine (2022).

This package contains access to the processed TCR-seq and scRNA-seq data of T cells obtained from patient MR4050.

How to use it

## install
devtools::install_github("abcwcm/KlebanoffMR4050")

Upon installation, the processed data, e.g. in the form of SingleCellExperiment objects, can be loaded thus:

## load SingleCellExperiment objects
sce.mr4050 <- KlebanoffMR4050::load_MR4050shared()

## load results of differential gene expression comparisons
## see 
KlebanoffMR4050::load_DE_results() # loads an object named `delist.both`
de.mr4050 <- delist.both; rm(delist.both)

For more details, see the code repository and the Rmd files detailing how the data underlying the figures were obtained.