The bioOED R package includes functions for Optimal Experiment Design (OED) of non-isothermal microbial inactivation data. It can be applied to the models implemented in the bioinactivation R package (https://CRAN.R-project.org/package=bioinactivation).
A full description of the mathematical basis of the project can be found in:
Garre, A., González-Tejedor, G., Peñalver-Soto, J. L., Fernández, P. S., & Egea, J. A. (2018). Optimal characterization of thermal microbial inactivation simulating non-isothermal processes. Food Research International, 107, 267–274. https://doi.org/10.1016/j.foodres.2018.02.040