h2 is negative -1.105

[argossy]

Hi
my h2 estimate is negative (shown below). I didn't have any issue during data munging. So I don't know what's wrong. BTW, my sample size is 300+, do you think is it too small for estimating heritability or genetic correlation? Thank you

Total Observed scale h2: -1.105 (1.5709)
Lambda GC: 1.0436
Mean Chi^2: 1.0409
Intercept: 1.0478 (0.0093)
Ratio: 1.1669 (0.2275)

[bneale]

Hi

Yes - with only 300 samples you're extremely underpowered for this kind of
analysis as you need sufficient sample size to start to expose the
polygenic effects on the trait in question.

Best
Ben

On Friday, October 23, 2015, argossy notifications@github.com wrote:

Hi
my h2 estimate is negative (shown below). I didn't have any issue during
data munging. So I don't know what's wrong. BTW, my sample size is 300+, do
you think is it too small for estimating heritability or genetic
correlation? Thank you

Total Observed scale h2: -1.105 (1.5709)
Lambda GC: 1.0436
Mean Chi^2: 1.0409
Intercept: 1.0478 (0.0093)
Ratio: 1.1669 (0.2275)

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