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You can use optunity with ipython, but optunity's built-in parallellization will not work due to this issue. As such, the simplest way to deal with it is to not use parallel features in IPython (that is don't use optunity.parallel.pmap.
If you really want parallel functionality in ipython, you would need to (i) setup an IPython cluster with a set of workers (can be on a single machine) and (ii) implement an alternative to optunity.parallel.pmap that uses IPython's parallel features.