This app prototype for displaying bNABs epitope data by participant
The following layout was used as a template for displaying data.
Data follows the structure below:
Epitope | Env location | Residues (amino acids/ regions) | References | epitopeID |
---|---|---|---|---|
CD4-binding site | 276-282 | Loop D; key contacts - PNGS (N*S/T) N279-280 | West et al, PNAS, 2012 | Loop D |
CD4-binding site | 365-371 | CD4-binding site (bs) loop; key contact - D368 | West et al, PNAS, 2012 | bs loop |
CD4-binding site | 456-469 | V5 loop; key contact – R456 | West et al, PNAS, 2012 | V5 loop |
V2-apex | 166 | Arginine (R) | Andrabi et al., Immunity, 2015 | V2-apex |
V2-apex | 168-171 | Lysine (K)-rich | Haynes et al., Nat Immunol Rev., 2022 | V2-apex |
V2-apex | 156, 160 | PNGS (N*S/T) | Haynes et al., Nat Immunol Rev., 2022 | V2-apex |
V3-glycan | 301, 332 | PNGS (N*S/T) | Haynes et al., Nat Immunol Rev., 2022 | V3-glycan |
V3-glycan | 324-327 | GDIR | Haynes et al., Nat Immunol Rev., 2022 | V3-glycan |
Gp41 MPER | 662-667 | ELDKWA | Munir, Haynes, et al. (Duke) | Gp41-1 |
Gp41 MPER | 671-676 | NWFNIT | Munir, Haynes, et al. (Duke) | Gp41-1 |
Gp41 fusion peptide | 512-527 | AVGIGAVFLGFLGAAG | Kong et al., Science, 2016 | Gp41-2 |
Gp120-gp41 interface | 611 (gp41) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-1 |
Gp120-gp41 interface | 637 (gp41) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-2 |
Gp120-gp41 interface | 276 (gp120) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Loop D |
Gp120-gp41 interface | 448 (gp120) | PNGS (N*S/T) | Falskowka et al., Immunity, 2014 | Interface-3 |
NB: (1) PNGS – potential N-linked glycosylation site; (2) residues are listed as amino acids
-
Ensure your Docker client is running
-
Run the following commands in this directory:
docker-compose v.1.xx
docker-compose build
docker-compose up
docker-compose v.2.xx
docker compose build
docker compose up
Note: This does not show changes made to the code without a rebuild.
- Open a webpage at localhost:3000
Run the following command in this directory:
docker-compose v.1.xx
docker-compose down
docker-compose v.2.xx
docker compose down