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Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis.

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Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis.

This repository contains the code to analyze the data from the manuscript.

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Contents

  • src: Code for the analyses of FACS-based and Perturb-seq CRISPR screens. This folder contains a separate README file describing how to run the code.
  • metadata: Tables and annotations required for the analysis.
  • lockfiles: archived renv lockfiles
  • misc: archived scripts not required for the analysis
  • ATAC_ChIP: Code to analyze epigenomics datasets. This folder contains a separate README file that describes how to run the code.
  • CRISPR: Code to generate count matrices from FACS based CRISPR datasets. This folder contains a separate README file that describes how to run the code.
  • cellRanger: Code to generate CellRanger's output from Perturb-seq data. This folder contains a separate README file that describes how to run the code.

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Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis.

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