The Survival-Inferred Fragility Index (SIFI) is a simple and intuitive fragility measure for survival analysis, based on real-life conditions, that captures the vulnerability of the data.
The SIFI is defined as the minimum number of reassignments of the best survivors from the experimental to the control arm resulting in loss of statistical significance.
This repository contains (1) the code used to generate SIFI for various studies investigating immune checkpoint inhibitors, (2) survival data reconstructed from Kaplan-Meier curves of respective publications, and (3) several examples of SIFI implementation.
If using SIFI or the data reproduced here, please cite:
Bomze D, Asher N, Ali OH, Flatz L, Azoulay D, Markel G, Meirson T. Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors. JAMA Network Open. 2020;3(10):e2017675. doi:10.1001/jamanetworkopen.2020.17675