RIC: RNA interaction capture

RIC is a package that contains a number of functions to analyse RNA-bound proteins detected in on oligo-DT-mediated RNA capture experiments. The package contains published SILAC data published by Garcia-Moreno et al 2019 processed with MaxQuant and follows the analytical steps described by Perez-Perri et al 2020.

Install

Once installed, load the package by writing in the console

library(RIC)

Additional information

Please see the vignette for complete workflow description.

References:

For references about the software and how to use RIC data see:

• Joel I Perez-Perri, Marko Noerenberg, Wael Kamel, Caroline E Lenz, Shabaz Mohammed, Matthias W Hentze, Alfredo Castello. Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture Nat Protocol. 2021 Jan;16(1):27-60. Epub 2020 Nov 18. (https://doi.org/10.1038/s41596-020-00404-1)