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dterstege/README.md

Dylan Terstege

I am a neuroscience PhD candidate studying in the Epp Lab in the Hotchkiss Brain Institute at the University of Calgary.

Academic Interests

  • My primary academic interest is studying the brain-wide dynamics supporting learning and memory
    • My prefered techniques for these investigations include (but are not limited to - I'm always looking out for new techniques!):
      • Batteries of sophisticated behavioural analyses
      • Brain-wide mapping of immediate early gene expression and the graph theoretical analysis of these functional connectivity networks
      • In vivo monitoring of cell type specific activity in specific target regions, at both a single cell level and at the level of regional population activity
      • Advanced histology and microscopy techniques, including various tissue clearing approaches, and sophisticated analysis of these images
      • 3D CAD modelling and the prototyping of scientific hardware

Programming Languages

Tools

Publication Repository

  • GitHub Repositories with the code used for data analysis (when applicable).
  • Further information on these publications can be found at the linked profiles (click icons):
Directory Title Included Analyses
Scott, Terstege, Vu 2020 Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex N/A
Scott 2021 Adult neurogenesis mediates forgetting of multiple types of memory in the rat N/A
Terstege 2021 Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test N/A
Evans Terstege 2022 Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval #photometry #FASTMAP
Terstege 2022A Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes #wholebrain #pointmask #targeteddeletion
Terstege 2022B FASTMAP: Open-Source Flexible Atlas Segmentation Tool for Multi-Area Processing of Biological Images #FASTMAP
Terstege 2022C New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue N/A
Terstege 2022D Network neuroscience untethered: brain-wide immediate early gene expression for the analysis of functional connectivity in freely behaving animals #wholebrain #pointmask #wholebrainanalysis
Moretti Terstege 2022 Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated activity #wholebrain #pointmask #wholebrainanalysis #labelcoexpression #FASTMAP
Dawson 2022 Sex-dependent role of hypocretin/orexin neurons in social behavior #photometry
Terstege 2023A Sex-dependent impairments of parvalbumin expressing neurons in the retrosplenial cortex in Alzheimer’s disease #wholebrain #pointmask #wholebrainanalysis #photometry
Terstege 2023B Protocol for the integration of fiber photometry and social behavior in rodent models #photometry
Terstege 2023C Parvalbumin as a sex-specific target in Alzheimer’s disease research – A mini-review N/A
Terstege 2024A PAW, a cost-effective and open-source alternative to commercial rodent running wheels #PAW
Ramkumar Edge-Partington 2024 Long-term impact of early-life stress on serotonin connectivity N/A
Terstege 2024B Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay #PAW
Terstege 2024C Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer’s Disease N/A

Collaboration

  • Always open to collaboration on the following kinds of problems

    • Work automating and quantifying histology

      • Brain-wide regional label expression
      • Colocalization of fluorescent labels in 3D volumetric imaging sets
    • The analysis of time-course datasets

      • multi/single region fibre photometry
      • multi/single region fibre photometry
      • miniscope recordings
      • mesoscale imaging data
      • fMRI (human and rodent)
      • PET (human and rodent)
    • Transcriptomic analyses

Contact Me

Pinned Loading

  1. FASTMAP FASTMAP Public

    ImageJ Plugin for Flexible Atlas Segmentation Tool for Multi-Area Processing

    ImageJ Macro 20 5

  2. PublicationRepo PublicationRepo Public

    Repository for Analysis Scripts and Publications

    MATLAB 3