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            [Illustration: Part of the original title page.]

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Transcriber's Note: The original publication has been replicated
faithfully except as shown in the TRANSCRIBER'S AMENDMENTS near the end of
the text. To preserve the alignment of tables and headers, this etext
presumes a mono-spaced font on the user's device, such as Courier New.
Words in italics are indicated like _this_. But the publisher also wanted
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the regular font which is indicated here with: _The pirates then went to
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There are 20 grains to a scruple, 3 scruples to a dram (or "8-ball"), and
8 drams to the ounce. The following table shows the unusual symbols used
in the prescriptions:

  Symbol         Meaning
  [dram]     dram, or drachm
  [oz.]      ounce
  [scruple]  scruple
  [ss.]      semi (half measure)

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                             _LOIMOLOGIA_:

                                 OR, AN
                           Historical Account
                                 OF THE
                      Plague in _London_ in 1665:

                 With precautionary Directions against
                         the like _Contagion_.

                         By NATH. HODGES, M. D.
              And Fellow of the College of Physicians, who
                   resided in the City all that Time.

                         To which is added, An
                                 ESSAY

                On the different Causes of PESTILENTIAL
                     DISEASES, and how they become
                              Contagious:

                                  WITH
                                REMARKS

                  On the Infection now in FRANCE, and
                 the most probable Means to prevent its
                            Spreading here.

                         By JOHN QUINCY, M. D.

                               _LONDON_:

       Printed for _E. Bell_, at the _Cross Keys_ and _Bible_ in
           _Cornhill_; and _J. Osborn_, at the _Oxford-Arms_
                       in _Lombard-street_, 1720.


                            [Illustration]




                                  THE
                                PREFACE.


_IT may be needless to acquaint the +Reader+ why the following +Sheets+
are published at this Time, we being all but too justly apprised of the
Danger there may be, of wanting those Helps, which are here intended to be
supplied, as far as such Means as these can do it._

_THE +Treatise+ of Dr. +Hodges+ contains the best Account of the late
Visitation by a +Plague+ here in +England+, of any hitherto extant; and
though some Readers may indeed observe, that the Enthusiastick Strain of
the preceeding Times very much hurts his Style and Perspicuity; such an
Influence had the Spirit of Delusion even over Matters of Science:
However, the most affected Peculiarities and Luxuriancies of that kind are
here avoided._

_WHAT is hereunto added, hath been partly extracted from Papers wrote some
Years ago, and partly put together since our present Apprehensions from
Abroad. The Enumeration of so many Causes of a Pestilence, or like
Changes, as have no Relation to the present Case, may to some perhaps seem
superfluous; but my Design hereby, was only the better to inculcate a
right Understanding of a +Contagion+, which is the last Consequence, and
highest Degree of Aggravation they are capable of rising to; and gradually
to lead Persons, not well accustomed to such Matters, from the more
obvious, to the more secret Means of bringing such terrible Changes into
our Constitutions._

_WHAT relates to such precautionary Means for our Security against the
present Infection now Abroad, as concern the Magistrate, I have presumed
to say but very little to; because I understand such Instructions are now
waited for from a very great and able Physician: But, with Submission to
the wisest, I cannot but repeat it here again, that no humane Means seems
more absolutely necessary, than to remove the Infected immediately upon
their Seizure, out of all great Towns, and provide for their due Support
in all Things, in open Country Places; for the Distemper becomes not
infectious till some Time after Seizure._

_AS for what every Person may do for his private Safety, I have given
several additional Hints, either fuller or plainer than Dr. +Hodges+ hath
done. And because his Antidotes and precautionary Medicines are now
obsolete, and not by much so elegant or easie to be procured, as the
present Practice and Shops do supply, I have added some +Formulae+, to be
complied with, or altered, as different Exigencies, and better Judges may
think fit._

_IF the Reader should be curious enough to note any Incorrectnesses of
Style, or Typographical Errors, he is desired to excuse them, from the
great Hurry which these Sheets passed through the Press in, although there
hath been as much Care taken to prevent either, as so much Hast with which
they were called for would admit of._

[Illustration]




                           TABLE OF CONTENTS.


  LOIMOLOGIA: OR, AN HISTORICAL ACCOUNT OF THE PLAGUE IN LONDON IN 1665:

    SECTION I.   Of the Rise and Progress of the late Plague.          1

    SECTION II.  Of the Cause of a Pestilence, and a Contagion.       29

    SECTION III.    Of the primary Seat of a Pestilence; where,       66
                    by the Way, is considered the Nature of
                    the Spirits, and their Infection in an
                    humane Body from Poison.

    SECTION IV.   Of the Complication of a Pestilence with            76
                  other Distempers, and particularly with
                  the Scurvy.

    SECTION V.    Of the manifest Signs of the late Pestilence.       85

    SECTION VI.   The Prognostick Signs of the late Pestilence.      140

    SECTION VII.   Concerning the Cure of the late Pestilence.       152

    SECTION VIII.   Of Preservation from a Pestilence.               205

  OF THE DIFFERENT CAUSES OF PESTILENTIAL DISEASES,
    AND HOW THEY BECOME CONTAGIOUS:                                  231

  A TABLE OF THE FUNERALS IN THE SEVERAL PARISHES WITHIN
    THE BILLS OF MORTALITY OF THE CITY OF LONDON,
    FOR THE YEAR 1665:                                               289


[Illustration]




                             _LOIMOLOGIA_:

                                 OR, AN

                             ACCOUNT, _&c._




                               SECTION I.

                 _Of the Rise and Progress of the late_
                                PLAGUE.


THE Plague which we are now to give an Account of, discovered the
Beginnings of its future Cruelties, about the Close of the Year 1664; for
at that Season two or three Persons died suddenly in one Family at
_Westminster_, attended with like Symptoms, that manifestly declared
their Origin: Hereupon some timorous Neighbours, under Apprehensions of a
Contagion, removed into the City of _London_, who unfortunately carried
along with them the pestilential Taint; whereby that Disease, which was
before in its Infancy, in a Family or two, suddenly got Strength, and
spread Abroad its fatal Poisons; and meerly for Want of confining the
Persons first seized with it, the whole City was in a little Time
irrecoverably infected. Not unlike what happened the Year following, when
a small Spark, from an unknown Cause, for Want of timely Care, increased
to such a Flame, that neither the Tears of the People, nor the Profusion
of their _Thames_, could extinguish; and which laid Wast the greatest Part
of the City in three Days Time: And therefore as there happens to be no
great Difference between these two grievous Calamities, this Mention of
them together may not be improper; and the more especially, because by a
like irresistable Fate from a Fever and a Conflagration, both the
Inhabitants and their Houses were reduc'd to Ashes.

BUT as soon as it was rumoured amongst the common People, who are always
enough astonished at any Thing new, that the Plague was in the City, it is
impossible to relate what Accounts were spread of its Fatality, and well
were it, had not the Presages been so ominous; every one predicted its
future Devastations, and they terrified each other with Remembrances of a
former Pestilence; for it was a received Notion amongst the common People,
that the Plague visited _England_ once in Twenty Years; as if after a
certain Interval, by some inevitable Necessity, it must return again. But
although this Conceit, how well soever justify'd by past Experiences, did
not so much obtain with Persons of more Judgment, yet this may be
affirmed, that it greatly contributed, amongst the Populace, both to
propagate and inflame the Contagion, by the strong Impressions it made
upon their Minds.

AND these frightful Apprehensions were not a little increased by the
Predictions of Astrologers, from the Conjunctions of Stars, and the
Appearances of Comets; for although but little Regard was given to such
Things by Persons of Thought, yet Experience daily shewed, what Influence
they had with the meaner Sort, whose Spirits being manifestly sunk by such
Fears, rendered their Constitutions less able to resist the Contagion.
Whosoever duly considers it, can never imagine that this Pestilence had
its Origin from any Conjunction of _Saturn_ and _Jupiter_, in _Sagitarius_
on the Tenth of _October_, or from a Conjunction of _Saturn_ and _Mars_ in
the same Sign on the Twelfth of _November_, which was the common Opinion;
for all the Good that happens during the like Conjunctions is assignable
to the same Causes.

THE like Judgment is to be made of Comets, how terrible soever they may be
in their Aspects, and whether they are produced in the higher Regions from
a Conglomeration of many Stars, and returning at certain Periods; or
whether they are lower, and the Production of sulphureous Exhalations,
kindled in our own Atmosphere; For there is nothing strange in the
Accension of heterogeneous Particles into a Flame, upon their rapid
Occursions and Collisions against each other, howsoever terrible the
Tracks of such Light may be circumstanced. The People therefore were
frightned without Reason at such Things, and the Mischief was much more in
the Predictions of the Star-Gazers, than in the Stars themselves: Nothing
could however conquer these sad Impressions, so powerful were they amongst
the Populace, who anticipated their unhappy Fate with their Fears, and
precipitated their own Destruction.

BUT to pass by Things of less Moment, it is to be taken Notice, that a
very hard Frost set in on _December_, which continued three Months, and
seemed greatly to deaden the Contagion, and very few died during that
Season; although even then it was not extinguished, for in the Middle of
_Christmas_ Holy-days, I was called to a Young-Man in a Fever, who after
two Days Course of alexiterial Medicines, had two Risings about the
Bigness of a Nutmeg broke out, one on each Thigh; upon Examination of
which, I soon discovered the Malignity, both from their black Hue, and the
Circle round them, and pronounced it to be the Plague; in which Opinion I
was afterwards confirmed by subsequent Symptoms, although by God's
Blessing the Patient recovered.

THIS Case I insert, both to shew that this Season did not wholly destroy
the Distemper, although it greatly restrained it; but upon the Frost
breaking, the Contagion got Ground, and gradually got out of its
Confinements; like a Flame that for some Time seems smother'd, and
suddenly breaks out with aggravated Fury.

AS soon as the Magistracy, to whom belonged the publick Care, saw how the
Contagion daily increased, and had now extended it self to several
Parishes, an Order was immediately issued out to shut up all the infected
Houses, that neither Relations nor Acquaintance might unwarily receive it
from them, and to keep the infected from carrying it about with them.

BUT whether this Method proved of Service or not, is to this Day doubtful,
and much disputed; but it is my Business here however to adhere to Facts,
and relate the Arguments on both Sides with all possible Impartiality.

IN Order whereunto, it is to be observ'd, that a Law was made for marking
the Houses of infected Persons with a Red Cross, having with it this
Subscription, LORD HAVE MERCY UPON US: And that a Guard should there
continually attend, both to hand to the Sick the Necessaries of Food and
Medicine, and to restrain them from coming Abroad until Forty Days after
their Recovery. But although the _Lord Mayor_ and all inferior Officers
readily and effectually put these Orders in Execution, yet it was to no
Purpose, for the Plague more and more increased; and the Consternation of
those who were thus separated from all Society, unless with the infected,
was inexpressible; and the dismal Apprehensions it laid them under, made
them but an easier Prey to the devouring Enemy. And this Seclusion was on
this Account much the more intolerable, that if a fresh Person was seized
in the same House but a Day before another had finished the Quarentine, it
was to be performed over again; which occasion'd such tedious Confinements
of sick and well together, that sometimes caused the Loss of the whole.

BUT what greatly contributed to the Loss of People thus shut up, was the
wicked Practices of Nurses (for they are not to be mention'd but in the
most bitter Terms): These Wretches, out of Greediness to plunder the Dead,
would strangle their Patients, and charge it to the Distemper in their
Throats; others would secretly convey the pestilential Taint from Sores of
the infected to those who were well; and nothing indeed deterred these
abandoned Miscreants from prosecuting their avaritious Purposes by all the
Methods their Wickedness could invent; who, although they were without
Witnesses to accuse them, yet it is not doubted but divine Vengeance will
overtake such wicked Barbarities with due Punishment: Nay, some were
remarkably struck from Heaven in the Perpetration of their Crimes, and one
particularly amongst many, as she was leaving the House of a Family, all
dead, loaded with her Robberies, fell down dead under her Burden in the
Streets: And the Case of a worthy Citizen was very remarkable, who being
suspected dying by his Nurse, was before-hand stripped by her; but
recovering again, he came a second Time into the World naked. And so many
were the Artifices of these barbarous Wretches, that it is to be hoped,
Posterity will take Warning how they trust them again in like Cases; and
that their past Impunities will not be a Means of bringing on us again the
like Judgment.

MOREOVER, this shutting up infected Houses, made the Neighbours fly from
theirs, who otherwise might have been a Help to them on many Accounts; and
I verily believe that many who were lost might have now been alive, had
not the tragical Mark upon their Door drove proper Assistances from them.

AND this is confirmed by the Examples of other pestilential Contagions,
which have been observed not to cease, until the Doors of the Sick were
let open, and they had the Privilege of going Abroad; of the same
Authority is the Custom of other Nations, who have due Regard to that
Liberty that is necessary for the Comforts both of Body and Mind.

IT now remains that we take Notice of all that is of any Weight on the
other Side; as therefore it is not at all deemed cruel to take off a
mortify'd Limb to save the whole, by a Parity of Reason is the Conduct of
a Community justifyable, who, out of a Regard to the Publick Good, put
Hardships upon particular Persons; in a pestilential Contagion therefore,
what can be of more immediate Service than securing those that are well
from the Infection? And the more especially in a Disease that reaches not
only the Body, but taints the very Breath; for in this Case the infected
Breath poisons upon the healthful, and even at the Point of Death
endeavours to diffuse that Venom to others that conquer'd them. From this
delirious Pleasure arises those Tricks of transplanting the Corruption of
a pestilential Tumour to another; not to say any Thing of that Woman, who
with her Importunities drew her unhappy Husband into her Embraces, which
ended his Life with hers.

AGAIN, to take away all Doubtings in this Case, I am not ignorant of what
Moment it is, to shut up the Houses of all those who are infected,
according to Custom; for by this means a Contagion may at first be
stifled, which otherwise would go beyond any Remedy; and with equal
Advantage might Gun-Powder be fired, if too much Time is not wasted in
Deliberation, before these Things are put into Practice.

BUT if hereafter again a Plague should break out, (which God forbid) with
Submission to Superiors, I should think it not improper to appoint proper
Accommodations out of the City, for such as are yet untouched in infected
Families; and who should continue there for a certain Time; the Sick in
the mean time to be removed to convenient Apartments provided on Purpose
for them: For by this Means, that Practice so abhorrent to Religion and
Humanity, even in the Opinion of a _Mahometan_, of shutting up the sick
and well together, would be avoided.

BUT to return: The Infection had long doubtfully reign'd, and continued
through _May_ and _June_, with more or less Severity; sometimes raging in
one Part, and then in another, as in a running sort of Fight; as often as
the Number of Funerals decreased, great Hopes were conceived of its
Disappearance; then on a sudden again their Increase threw all into
Dejection, as if the whole City was soon to be unpeopled; which
Uncertainty gave Advantage to the Distemper; because Persons were more
remiss in their Provisions against it, during such Fluctuation.

IT must not however be omitted, with what Precipitation the trembling
Inhabitants left the City, and how they flocked in such Crowds out of
Town, as if _London_ had quite gone out of it self, like the Hurry of a
sudden Conflagration, all Doors and Passages are thronged for Escape: Yet
after the chief of the People were fled, and thereby the Nourishment of
this cruel Enemy had been in a great Measure taken away, yet it raged
still; and although it seemed once to slay as _Parthians_ in their Flight,
it soon returned with redoubled Fury, and kill'd not by slow Paces, but
almost immediately upon Seizure; not unlike what is often seen in Battle,
when after some Skirmishes of Wings, and separate Parties, the main Bodies
come to engage; so did this Contagion at first only scatter about its
Arrows, but at last covered the whole City with Death.

THUS therefore in the Space of one Week were eighty Persons cut off, and
when Things came to Extremity, all Helps were called in; so it began now
to be solely the Magistrates Business, how to put a Stop to this cruel
Devastation, and save some Part of the City at last from the Grave; first
then therefore were appointed a Monthly Fast for Publick Prayers, to
deprecate the Anger of Heaven; nor proved it in vain, or were their
Supplications altogether fruitless; for if we have any Regard to the
Temperature of the Season, the whole Summer was refreshed with moderate
Breezes, sufficient to prevent the Air's Stagnation and Corruption, and to
carry off the pestilential Steams; the Heat was likewise too mild to
encourage such Corruption and Fermentation, as helps to taint the animal
Fluids, and pervert them from their natural State.

THE Government however, to the Duty of Publick Prayers, neglected not to
add what Assistances might be had from Medicine; to which Purpose his
Majesty, with the divine Helps, called in also all that was humane; and by
his Royal Authority commanded the College of Physicians of _London_,
jointly to write somewhat in _English_ that might be a general Directory
in this calamitous Exigence: Nor was it satisfactory to that honoured
Society to discharge their Regards for the Publick with that only, but
some were chose out of their Number, and appointed particularly to attend
the infected on all Occasions; two also out of the Court of Aldermen were
required to see this hazardous Task executed; so that encouraged with all
proper Means, this Province was chearfully undertaken, and all possible
Caution was used fully to answer the Intention; but this Task was too much
for four Persons, and wanted rather the Concurrence of the whole Faculty;
we were however ashamed to give it up, and used our utmost Application
therein; but all our Care and Pains were eluded, for the Disease, like the
_Hydra_'s Heads, was no sooner extinguished in one Family, but it broke
out in many more with Aggravations; so that in a little Time we found our
Task too great, and despaired of putting an entire Stop to the Infection.

NOR was there at this Time wanting the Help of very great and worthy
Persons, who voluntarily contributed their Assistances in this dangerous
Work; amongst the Number of which, the learned Dr. _Glisson, Regius
+Professor at+ Cambridge_, Dr. _Nath. Paget_, Dr. _Wharton_, Dr.
_Berwick_, Dr. _Brookes_, and many others who are yet alive, deserve very
honourable Mention; but eight or nine fell in this Work, who were too much
loaded with the Spoils of the Enemy; and amongst whom was Dr. _Conyers_,
whose Goodness and Humanity claim an honourable Remembrance with all who
survive him.

AFTER then all Endeavours to restrain the Contagion proved of no Effect,
we applied our selves altogether to the Care of the diseased; and in the
Prosecution of which, it may be affirmed without Boasting, no Hazards to
our selves were avoided: But it is incredible to think how the Plague
raged amongst the common People, insomuch that it came by some to be
called the _Poors Plague_; yet although the more opulent had left the
Town, and that it was almost left uninhabited, the Commonalty that were
left felt little of Want; for their Necessities were relieved with a
Profusion of good Things from the Wealthy, and their Poverty was supported
with Plenty; a more manifest Cause therefore for such a Devastation
amongst them I shall assign in another Place.

IN the Months of _August_ and _September_, the Contagion chang'd its
former slow and languid Pace, and having as it were got Master of all,
made a most terrible Slaughter, so that three, four, or five Thousand died
in a Week, and once eight Thousand; who can express the Calamities of such
Times? The whole _British_ Nation wept for the Miseries of her Metropolis.
In some Houses Carcases lay waiting for Burial, and in others, Persons in
their last Agonies; in one Room might be heard dying Groans, in another
the Ravings of a Delirium, and not far off Relations and Friends bewailing
both their Loss, and the dismal Prospect of their own sudden Departure:
Death was the sure Midwife to all Children, and Infants passed immediately
from the Womb to the Grave; who would not burst with Grief, to see the
Stock for a future Generation hang upon the Breasts of a dead Mother? Or
the Marriage-Bed changed the first Night into a Sepulchre, and the unhappy
Pair meet with Death in their first Embraces? Some of the infected run
about staggering like drunken Men, and fall and expire in the Streets;
while others lie half-dead and comatous, but never to be waked but by the
last Trumpet, some lie vomiting as if they had drunk Poison; and others
fall dead in the Market, while they are buying Necessaries for the Support
of Life. Not much unlike was it in the following Conflagration; where the
Altars themselves became so many Victims, and the finest Churches in the
whole World carried up to Heaven Supplications in Flames, while their
Marble Pillars wet with Tears melted like Wax; nor were Monuments secure
from the inexorable Flames, where many of their venerable Remains passed a
second Martyrdom; the most august Palaces were soon laid Waste, and the
Flames seemed to be in a fatal Engagement to destroy the great Ornament of
Commerce; and the Burning of all the Commodities of the World together,
seemed a proper Epitome of this Conflagration; neither confederate Crowns,
nor the drawn Swords of Kings, could restrain its Phanatick and Rebellious
Rage; large Halls, stately Houses, and the Sheds of the Poor, were
together reduced to Ashes; the Sun blush'd to see himself set, and envied
those Flames the Government of the Night, which had rivalled him so many
Days; as the City, I say, was afterwards burnt without any Distinction,
in like Manner did this Plague spare no Order, Age, or Sex; The Divine was
taken in the very Exercise of his priestly Office, to be inrolled amongst
the Saints Above; and some Physicians, as before intimated, could not find
Assistance in their own Antidotes, but died in the Administration of them
to others; and although the Soldiery retreated from the Field of Death,
and encamped out of the City, the Contagion followed, and vanquish'd them;
many in their old Age, others in their Prime, sunk under its Cruelties; of
the Female Sex most died; and hardly any Children escaped; and it was not
uncommon to see an Inheritance pass successively to three or four Heirs in
as many Days; the Number of Sextons were not sufficient to bury the Dead;
the Bells seemed hoarse with continual tolling, until at last they quite
ceased; the burying Places would not hold the Dead, but they were thrown
into large Pits dug in waste Grounds, in Heaps, thirty or forty together;
and it often happened that those who attended the Funerals of their
Friends one Evening, were carried the next to their own long Home:

      -------- _Quis talia fundo
      Temperet a Lachrymis?_ --------

Even the Relation of this Calamity melts me into Tears, and yet the worst
was not certain, although the City was near drained by her Funerals; for
the Disease as yet had no Relaxation.

ABOUT the Beginning of _September_, the Disease was at the Height; in the
Course of which Month more than twelve Thousand died in a Week: But at
length, that nothing might go untried to divert the Contagion, it was
ordered by the Governours who were left to superintend those calamitous
Affairs, (for the Court was then removed to _Oxford_) to burn Fires in the
Streets for three Days together; yet while this was in Debate, the
Physicians concerned were diffident of the Success, as the Air in it self
was un-infected; and therefore rendred such a showy and expensive a
Project superfluous, and of no Effect; and these Conjectures we supported
by the Authority of Antiquity, and _Hippocrates_ himself; notwithstanding
which, the Fires were kindled in all the Streets. But alas! the
Controversie was soon decided; for before the three Days were quite
expired, the Heavens both mourned so many Funerals, and wept for the fatal
Mistake, so as to extinguish even the Fires with their Showers. I shall
not determine any other Person's Conjecture in this Case, whether these
Fires may more properly be deemed the ominous Forerunners of the ensuing
Conflagration, or the ensuing Funerals; but whether it was from the
suffocating Qualities of the Fuel, or the wet Constitution of Air that
immediately followed, the most fatal Night ensued, wherein more than four
Thousand expired. May Posterity by this Mistake be warned, and not, like
Empyricks, apply a Remedy where they are ignorant of the Cause.

THE Reader is by the Way to be advertised, that this Year was luxuriant in
most Fruits, especially Cherries and Grapes, which were at so low a Price,
that the common People surfeited with them; for this might very much
contribute to that Disposition of Body as made the pestilential Taint more
easily take Place.

NOR ought we here to pass by the benificent Assistances of the Rich, and
the Care of the Magistrates; for the Markets being open as usual, and a
greater Plenty of all Provisions, was a great Help to support the Sick; so
that there was the Reverse of a Famine, which hath been observed to be so
fatal to pestilential Contagions; and in this the Goodness of Heaven is
always to be remembred, in alleviating a common Misery by such a Profusion
of good Things from the Stores of Nature.

BUT as it were to balance this immediate Help of Providence, nothing was
otherwise wanting to aggravate the common Destruction; and to which
nothing more contributed than the Practice of Chymists and Quacks, and of
whose Audacity and Ignorance it is impossible to be altogether silent;
they were indefatigable in spreading their Antidotes; and although equal
Strangers to all Learning as well as Physick, they thrust into every Hand
some Trash or other under the Disguise of a pompous Title. No Country sure
ever abounded with such wicked Impostors; for all Events contradicted
their Pretensions, and hardly a Person escaped that trusted to their
Delusions: Their Medicines were more fatal than the Plague, and added to
the Numbers of the Dead: But these Blowers of the pestilential Flames were
caught in the common Ruin, and by their Death in some Measure excused the
Neglect of the Magistracy, in suffering their Practice:

      ------ _Nec Lex est justior ulla
      Quam necis Artifices Arte perire sua._

ABOUT this Time a Person of Distinction and great Humanity, going to
_France_ upon some Affairs of State, heard that some _Frenchmen_ were
Masters of an Antipestilential Remedy, and took Care to send some Doses of
it over here: By Command of the Government we were ordered to try it with
due Caution, which we did with Expectations of uncommon Success, but _the
Mountain brought forth Death_; for the Medicine, which was a Mineral
Preparation, threw the Patients into their last Sleep. May it never
hereafter be injoined to try Experiments with unknown and foreign
Medicines, upon the Lives even of the meanest Persons! For certainly
nothing is more abhorrent to Reason, than to impose a universal Remedy, in
Cases whose curative Intentions are different, and sometimes opposite; and
the various Indications of a Pestilence require very different Methods of
Remedy, as shall hereafter be further demonstrated.

TO this may be added, that many common Medicines were publickly Sold,
which by their extraordinary Heat and Disposition to inflame the Blood,
could never be fit for every Age, Sex, and Constitution indifferently, and
therefore in many Cases must undoubtedly do Harm. On this Account not only
the _Sacred Art_, but the _Publick Health_ also suffered; yet we who were
particularly employed in this Affair as Physicians, used all
Sollicitations with the Magistracy to restrain such Practices, in Order to
stop the Ruin they aggravated. Hence notwithstanding it was made a
Question, whether in a Plague, where so many Physicians retire, (not so
much for their own Preservation, as the Service of those whom they attend)
it is not expedient for every one, according to his Abilities, to do his
utmost in averting the common Ruin? In the same Manner as in a Fire all
Hands are required, even of the Croud as well as Workmen, to extinguish
it.

BUT in this Case my own Opinion is determined: In the Restauration of
Health, a Person must proceed with more Caution and Deliberation than in
the supposed Case of a Fire; for there are Difficulties occur in the
Practice of Medicine which are insuperable but by the unlearned; and the
fine Texture of a humane Body is not to be managed by as clumsie Hands as
the Materials of a House; in the former, if a Person makes a Mistake, it
is with great Difficulty repaired; and therefore upon a serious
Consideration of the whole Affair, I cannot make any Doubt, but that it is
much better even to want Physicians in such Calamities, than to have the
Sick under the Care and Management of the unlearned; for such Persons,
like those who fight blindfold, know not in what Parts to attack the
Enemy, nor with what Weapons to do it; besides which, they also are in
Hazard of obstructing these Efforts of Nature, which would many Times,
without Help, if not thus hindred, get the better of the Distemper.

NOR in this Account are we to neglect, that the Contagion spread its
Cruelties into the neighbouring Countries; for the Citizens, which crowded
in Multitudes into the adjacent Towns, carried the Infection along with
them, where it raged with equal Fury; so that the Plague, which at first
crept from one Street to another, now reigned over whole Counties, leaving
hardly any Place free from its Insults; and the Towns upon the _Thames_
were more severely handled, not perhaps from a great Moisture in the Air
from thence, but from the tainted Goods rather that were carried upon it:
Moreover, some Cities and Towns, of the most advantageous Situation for a
wholsome Air, did notwithstanding feel the common Ruine. Such was the
Rise, and such the Progress, of this cruel Destroyer, which first began at
_London_.

BUT the worst Part of the Year being now over, and the Height of the
Disease, the Plague by leisurely Degrees declined, as it had gradually
made its first Advances; and before the Number infected decreased, its
Malignity began to relax, insomuch that few died, and those chiefly such
as were ill managed; hereupon that Dread which had been upon the Minds of
the People wore off; and the Sick chearfully used all the Means directed
for their Recovery; and even the Nurses grew either more cautious, or more
faithful; insomuch that after some Time a Dawn of Health appeared, as
sudden, and as unexpected, as the Cessation of the following
Conflagration; wherein after blowing up of Houses, and using all Means for
its Extinction to little Purpose, the Flames stopped as it were of
themselves, for Want of Fuel, or out of Shame for having devoured so much.

THE Pestilence did not however stop for Want of Subjects to act upon, (as
then commonly rumoured) but from the Nature of the Distemper, its Decrease
was like its Beginning, moderate; nor is it less to be wondred at, that as
at the Rise of the Contagion all other Distempers went into that, so now
at its Declension that degenerated into others, as _Inflammations_,
_Head-achs_, _Quinseys_, _Dysenteries_, _Small-Pox_, _Measles_, _Fevers_,
and _Hecticks_; wherein that also yet predominated, as hereafter will be
further shewn.

ABOUT the Close of the Year, that is, on the Beginning of _November_,
People grew more healthful, and such a different Face was put upon the
Publick, that although the Funerals were yet frequent, yet many who had
made most Hast in retiring, made the most to return, and came into the
City without Fear; insomuch that in _December_ they crowded back as thick
as they fled: The Houses which before were full of the Dead, were now
again inhabited by the Living; and the Shops which had been most Part of
the Year shut up, were again opened, and the People again chearfully went
about their wonted Affairs of Trade and Employ; and even what is almost
beyond Belief, those Citizens, who before were afraid even of their
Friends and Relations, would without Fear venture into the Houses and
Rooms where infected Persons had but a little before breathed their Last:
Nay, such Comforts did inspire the languishing People, and such
Confidence, that many went into the Beds where Persons had died before
they were even cold, or cleansed from the Stench of the Diseased; they had
the Courage now to marry again, and betake to the Means of repairing the
past Mortality; and even Women before deemed barren, were said to prove
proliffick; so that although the Contagion had carried off, as some
computed, about one hundred thousand, after a few Months their Loss was
hardly discernable, and thus ended this fatal Year.

BUT the next Spring indeed appeared some Remains of the Contagion, which
was easily conquered by the Physicians, and like the Termination of a
common _Intermittent_, ended in a healthful Recovery: Whereupon the whole
Malignity ceasing, the City returned to a perfect Health; not unlike what
happened also after the last Conflagration, when a new City suddenly arose
out of the Ashes of the old, much better able to stand the like Flames
another Time.

[Illustration]




                              SECTION II.

            _Of the Cause of a Pestilence, and a Contagion._


AS it is our Purpose here to enquire into the Origin of the late Plague,
and find out both its manifest and hidden Causes; I cannot judge it
necessary to go into the usual Length of Writers, in a particular Recital
of all those remote Regards which they distinguish by Supernatural,
Preternatural, and Natural; because by such Means this Treatise would be
drawn out into an almost infinite needless Distinction.

THAT the Truth therefore may at once be brought into an open Light, and
the Pestilence appear in its genuine Affections, I think it proper to
premise this one Thing, because the whole depends upon it, _viz._ That the
Pestilence is the most notorious of all popular Diseases, and depends upon
some Cause equally common, and in every respect adequate to its extensive
Effects; which being granted, it naturally follows, that all particular
Causes which may accidentally intervene, (the Recital of which would be
very tedious) are resolvable into this one.

AND for what concerns that Pestilence now under Enquiry, this we have as
to its Origin, from the most irrefragable Authority, that it first came
into this Island by Contagion, and was imported to us from _Holland_, in
Packs of Merchandice; and if any one pleases to trace it further, he may
be satisfied by common Fame, it came thither from _Turkey_ in Bails of
Cotton or Silk, which is a strange Preserver of the pestilential Steams.
For that Part of the World is seldom free from such Infections, altho' it
is sometimes more severe than others, according to the Disposition of
Seasons and Temperature of Air in those Regions: But if any would yet more
intimately be acquainted with its Origin, it concerns him to know all the
Changes the Air in these Climates is subject to, and its various
Properties of Dryness, Moisture, Heat, Cold, _&c._

BUT least I should be thought too prolix in the Enumeration of such
Circumstances, and incur the Suspicion of Atheism, (a Charge too just upon
the Faculty) by ascribing too much to second Causes, as the Schools please
to call them, it may be convenient for me to declare, that the [Greek: to
theion] of a Pestilence is as much a Part of my Faith, as any others; the
sacred Pages clearly and demonstratively prove, that the Almighty, by his
Authority, and at his Pleasure, may draw the Sword, bend the Bow, or shoot
the Arrows of Death; and a Retrospection into Times past, shews many
convincing Proofs of this terrible Truth; and in this Contagion before us,
the Footsteps of an over-ruling Power are very legible, especially so far
as concerns his divine Permission: But the great God's Purposes are
Secrets too awful for Mortals to pry into, although we know that he
punishes as a Parent, and chides for our Good, which makes it our Duty to
kiss the Rod, and submit. But enough of this, least I should be thought to
invade anothers Province; and it is sufficient to the Purpose of a
Physician, to assign natural and obvious Causes; and where such are
discoverable, it is unworthy of him and the divine Art he professes, as
well as an Affront to good Sense, to have Recourse to any other.

BUT this being premised only to prevent Censure, our Way now lies open to
a Discovery of the Nature of this Pestilence. Wherein, for Method Sake, I
shall begin with a Description of a Pestilence in general; and which if it
doth not exactly agree with the Accounts given by the Ancients, yet I
doubt not but it will be found by every impartial Considerer, to be as
full and satisfactory.

THE Pestilence is a Disease arising from an _Aura_ that is poisonous, very
subtle, deadly, and contagious, affecting many Persons at the same Time
together in one Country, chiefly arising from a Corruption of the nitrous
Spirit in the Air, attended with a Fever, and other very grievous
Symptoms.

EVERY one of these Particulars are as clear as the Light at Noon-day; and
these Explications are so obvious to be met with in the Writings of the
Learned, that it would be lost Labour to insist upon any such Thing here;
we shall therefore proceed to explain only what more immediately stands in
need of it.

AND first of all it is said from an _Aura_, as distinguishing it from such
Poison as is more gross and earthy; for this is not to be confined in any
Inclosure, but is so rare, subtle, volatile, and fine, that it insinuates
into, and resides in the very Interstices, or Pores of the aerial
Particles; whereas that which is of a more fixed Nature, is confined
within certain Limits, and is incapable of such Progress.

IT is said to be poisonous also, from its Similitude to the Nature of a
Poison, and both being equally destructive to Life, and killing Persons
much after the same Manner, so that they seem to differ in Degree only;
for the deadly Quality of a Pestilence vastly exceeds either the arsenical
Minerals, the most poisonous Animals or Insects, or the killing
Vegetables; nay, the Pestilence seems to be a Composition of all the other
Poisons together, as well as in its fatal Efficacies to excel them, for in
this there is manifestly joined both the Height of Putrefaction and
Malignity. And as in a great man the Virulence of this Taint hath been
discoverable, so in one Youth for Instance it was so remarkable, that even
in the Point of Death the whole Body changed green, which so alarmed the
Mother, that she immediately hasted to my House, to know whether by
Mistake there had not been some Poison given him; whereas he had taken
nothing but mild and common Alexipharmicks; this green Hue therefore was a
Demonstration of the poisonous Vitriolick Nature of the pestilential
Taint.

IT is said to be very subtile both on Account of its Original and
Production, before it hath escaped from its native Seat; and that
wonderful Comminution which it cannot but undergo in its Progress through
so many Climates, whereby it is, as it were, sublimed to the highest
Degree of Volatility, beyond that of any Meteor, which is the Production
of gross, corporeal, and heterogeneous Particles; nay, it is more active
than Lightning, and in the Twinkling of an Eye carries to a Distance
Putrefaction, Mortification, and Death.

AS for the Manner whereby it kills, its approaches are generally so
secret, that Persons seized with it seem to be fallen into an Ambuscade,
or a Snare, of which there was no Manner of Suspicion; they are therefore
not to be credited or regarded, who affirm the Progress of a Pestilence to
be sensible, even to the Smell and Sight, and report (though who will may
believe them for me) the Infection to resemble the Fragrancy of Flowers in
_May_, or any other sweet Savour; or, on the contrary, to strike the Nose
like the Stench of a rotten Carcase; nay, some pretend to be so
sharp-sighted, as to discern Clouds in the Atmosphere big with
pestilential Poysons, and other such Conceits of a distempered
Imagination, that are chiefly the Products of Fear, which construes every
Thing for the worst: Although indeed I must confess, that sometimes this
very subtile _Aura_ may be so mixed or loaded with gross and sulphureous
Particles, as to be perceptible to the Senses.

FURTHER, as to the fatal Influences of a Plague, if the before recited
Account is not sufficient to shew it, it would not be a Task of any
Difficulty to produce many Instances of its Tyranny and Destruction: Hence
the Plague by the _Hebrews_ was called [Hebrew letters], or Perdition; as
if it was ordained on Purpose to destroy Mankind: It is also called
_Lues_, from [Greek: luo], to dissolve, a most certain Way of Destruction,
and whose fatal Property in the Plague is most remarkable, whereby it does
not so much prepare the Way, as immediately of its self destroy, and of
whose certain Ruin, through whole Regions together, we have too many
Testimonies upon Record, in the Writings both of Ancients and Moderns.

AGAIN, the Pestilence is said to be contagious; because some are come to
that Height of Boldness, (being blind with too much Light) to propagate
strange Conjectures to the contrary, as if the late Plague was begun and
continued by a foreign Influence; but to remove this Controversie, it may
be convenient to explain the Nature of a Contagion, and its supposed
Conditions of Exertion; but before I enter upon this, it will be necessary
to dispatch the other Members of this Definition.

IT is further added, that the Plague affects many Regions together at the
same Time, in Order to distinguish it both from _Endemick_ Diseases, that
is, such as are appropriate to one Place only; and also from _Sporadick_
Diseases, which although they rage amongst the Populace in this or that
Country or Climate indifferently, according to the Influence of their
procatarctick Causes, they are yet to be deemed particular, as well as
they are pernicious: But enough of these Matters.

AT length then it becomes necessary to change the Consideration, and
enquire how it comes that the Plague hath its chief Origin from a Change
or Corruption of the nitrous Spirits in the Air: This is the great
Difficulty! This is our Task! It is therefore to be hoped that the Novelty
of the Opinion will not occasion any one to receive it at first Sight
amiss, until by due Examination he hath brought it to Trial; but in Order
to erect this upon a sure Foundation, it is proper to premise some
Considerations.

AND first of all, the central nitrous Spirit does every where transpire
and exhale towards the Surface, to recruit the Consumptions of Nature, and
for other Purposes hereafter to be mentioned. From this saline Origin
straining through the Bowels of the Earth, it is by every one understood
Vegetation is carried on; and that the Light and vital Warmth of the Sun
is impregnated by it through the whole Region of Air; and the mutual
Intercourses or Operations upon one another between the Sun's Rays, and
these saline Exhalations, by a Kind of Magnetism between them, is too
obvious in a Multitude of Instances to want any Comment.

I know in nothing indeed where there is a greater Intercourse and
Sympathy; and a considerable Illustration of which may be made by the
following Experiment. If any one in the Spring-time, when the Sun is
approaching nearer to us, digs up a Piece of Earth, and after Infusion and
Filtration, evaporates the Liquor, he will find at the Bottom of the
Vessel a Sixth Part of Salt more than at any other Time of the Year, from
the same Quantity of Earth managed after the same Manner; the nitrous Salt
for many Reasons not arising in so great a Quantity for the Exigencies of
Nature, at any other Times; whence I conceive it manifestly to prove, that
there is such an Efflux of this Salt as before suggested, and a Kind of
Sublimation of it into the Air, and that this saline Spirit hath a Sort of
Sympathy with the superior Heat. But that we may not use more Arguments
than are necessary to prove the Energy of this Principle, every one who is
doubtful herein may observe, that not only Plants are produced and
nourished by its subtle and luxuriant Insinuation into their Fibres, but
that also from the same aerial Spirit the Life of Animals, and even the
humane Species is preserved. And I cannot see any Difficulty in the
Opinion, that the best Temperature of the Blood and animal Juices, the
Renewal of wasted Spirits, the Restauration of Strength, and the good and
healthful Constitution of the Viscera, Members, and whole Body, is
maintained by the Assistance of this nitro-aerial Spirit. Nor does any
Thing appear more congruous to Reason, than that from the same Cause does
the Racy Spirit of the Blood arise, as it is not derivable from any other;
nor is it my single Opinion, that from the same Principle it derives its
Colour; but as there are no Arguments even objected to this Doctrine, it
is needless to imploy more Time in its Vindication.

BUT further, it may happen that this nitro-aerial Spirit may various Ways
be changed in its Properties; that is, either with Regard to its
proliffick Influences, (if it may be so expressed) or, which much oftner
happens, in its accidental and adventitious Impurities.

SOMETIMES this universal Principle languishes and degenerates, and in its
own productive Womb is tainted with somewhat pernicious to Vitality, and
that natural balsamick Constitution of Blood that supports it; and as
often as this is the Case, the whole Orders of living Beings may look upon
it as War declared against them: But where any Alteration is made upon it
by particular and fortuitous Causes, it is generally from too much
Humidity diluting it, as in immoderate and unseasonable Rains, whence
moist, crude, and unwholsome Vapours exhale; for every one knows how much
Humidity is a Promoter of Putrefaction; whence Swarms of Insects, which is
a certain Forerunner of a Pestilence: It also sometimes happens, that this
vital Spirit, which so much delights in Dryness, is almost quite
extinguished by a rainy Season; in which Exigency, what Miseries may not
Mankind expect, when a small Change is of so fatal Consequence? This is
abundantly confirmed by the Experience of Marshy Countries, where the
Diseases recurring every Year are very fatal, by means of the putrid and
damp Exhalations.

FURTHERMORE, this nitrous Principle may be sometimes changed in its own
Repository by too intense a Heat from within, as well as without; for by
so precipitate a Sublimation its Spirit may be deadned; that is, being
robbed of its balsamick Quality, (which is no Absurdity to suppose) and
kindled into too rapid a Motion, it may receive a kind of _Empyreuma_; and
from which Adustion there may arise several Sorts of Distemperature; as
Blasts upon Trees, and Diseases amongst Cattle; and at last end in a
Pestilence amongst Mankind.

FOR further Illustration hereof it may be observed, that the nitrous
Spirit which circulates through the subterraneous Caverns may, instead of
Obtaining a further Purification, take along with it corrupt and poysonous
Vapours from arsenical or other Minerals; and loaded therewith, break out
into the open Air: And this we have confirmed from common Observation in
the Western Climes of _Africa_, that lye under the _Equator_, wherein the
very Showers seem to be endued with a Stiptick or Caustick Power, so as
to taint the Cloaths and Skin of the Travellers, and burn, as it were,
upon them pestilential Characters. From which Disposition it cannot be a
Wonder to any, that the Plague should reign after Earthquakes; because a
poysonous Spirit at such Times break out into the Air; as also that Nitre
thus loaded with an impure Mixture, and sometimes too that which is
deadly, should of it self, like the Occursion of an Acid, force out its
Way wherever there is Room, and leave behind in its Passage many Marks of
Malignity; so that subterraneous Animals, such as Moles, Mice, Serpents,
Conies, Foxes, _&c._ as conscious of approaching Mischief, leave their
Burrows, and lie open in the Air; which is also a certain Sign of a
Pestilence at Hand: Hence also a sudden Death of Fish; and a Departure of
the Birds of the Air, to secure their Safety in that which is more
wholesome.

AFTER these Observations, it remains to shew how the nitrous Spirit
frequently receives a Change like to that which may be termed Corruption,
although it is vulgarly accounted incorruptible in it self, and is
serviceable in Preserving other Things from Putrefaction.

TO the Solution of this uncommon Difficulty, it is to be taken Notice that
Corruption here is not in that Sense strictly as when it is the Produce of
Humidity, but somewhat more congruous to the peculiar Nature of a nitrous
Spirit; which although it cannot, like some other Bodies, putrifie, yet if
it can be changed from its Nature and Figure, so as not to be reducible
into them again, it does not seem improperly said that such a Change is
equivalent to Corruption, its Vitality or Essence being destroyed, and a
new Texture being obtained. And this I shall further endeavour to
illustrate by a double Argument.

FIRST, It is not at all to be doubted, but that what Art, which is the
Imatator of Nature, can do, may be done by the Efficiency of a more
powerful Agent; and the most expert Chymists do shew a certain Corruption
of Salt; nor would it be any great Labour to discover here the Method how
it is done, were it not a Crime to expose the Secrets of Nature on
trifling Occasions. But if my Authority is not sufficient to support an
Assertion of this Weight, I trust no one will reject the Conviction that
arises from Effects, and therefore I shall restrain the Proof hereof to as
short a Compass as possible. As then it is established by the concurrent
Authority of Antiquity, that as Fire, as it is an Element capable of
Degeneration, and seemingly of Corruption, may increase a pestilential
Malignity by Means of its great Subtilty, its prodigious Increase, and
swift Propagation; Qualities too which a Pestilence very much partakes of.
That which they conceited of Fire, seems to me to be applicable in a much
more philosophical Sense to that Spirit we are speaking of, and which so
nearly resembles it. I am indeed a Stranger to any Thing in the Universe
that makes so swift a Progress as a Pestilence, and therefore the
infectious _Miasmata_ are in the sacred Scriptures styled _Arrows that fly
in the Dark_; and howsoever certain are their Strokes, and tho' by Means
of their Fineness they penetrate into the very Marrow, they yet shun by
their Subtilty our Conceptions.

AS to the spreading of a Contagion from one to another, and so on to
Thousands, there is nothing can be possibly more swift in the Progress of
Fire; and it exceeds even _Antimony_ in the Retention of its Properties,
though that loses them not in a thousand Infusions: But the instantaneous
Progress of this Enemy to Mankind is best illustrated by the Rapidity of
Light, which is not greater. But more of this we pass by till we come
professedly to speak of a Contagion.

SECONDLY, the particular Nature of the pestilential _Miasmata_, may be
known from their peculiar Influence upon the saline Particles in a humane
Body; for nothing acts with more Efficacy and Energy upon a saline Body,
than another partaking of the same Quality; and nothing is more plain than
that this nitrous Spirit is of more Efficacy than the _Alkahest_ it self,
as by it the fibrous Parts of the Blood are immediately corroded and
dissolved; and therefore after dangerous Hemorrhages, very little
Coagulation can be obtained in the extravasated Blood, unless by its being
exposed to the Cold: but as often as that does happen, do not we
immediately find a Fixation of the Fluids, and a certain Congelation of
the Juices, which greatly <DW44>s their rapid Motions, and sometimes
brings even a total Stagnation: It's furthermore of considerable
Importance to our present Argument, that Spasms, the constant Attendants
of a Plague, have their Origin from an acrid vellicating Salt in the
nervous Fluid.

TO these it may likewise be added, that a Pestilence has a great
Similitude to a scorbutick Habit, having its Origin from a saline
Constitution of Blood; and the great Likeness there is in many
Circumstances of their Generation and Propagation, insomuch that after a
Pestilence is with others ceased, it will yet continue to infect
scorbutick Constitutions; as hereafter will further appear: From the same
Cause likewise does a pestilential Contagion reign most in Maritime
Countries, and near the Sea-Coasts; because such a saline Disposition does
there most abound; and the Truth of this, the Maritime Parts of our own
Country do by sad Experience too much testifie.

LASTLY, If Arguments taken to this Purpose from the Method of Cure were
valid, from thence it may be gathered, that a saline Spirit hath a great
share in giving Rise to a Pestilence; for in our curative Regards for this
Distemper, a skilful and upright Physician bends his whole Care at first
to prevent its Attack, which he does by the Use of oleaginous Substances,
by that Means expecting to cover over the Stomach as it were with a
Plaster, to guard it against sharp and corrosive _Effluvia_; the same
Intention is also pursued by Medicines, in endeavouring to defend against
the poysonous Taint, or throw it out when received by Alexipharmicks and
Diaphoreticks: For every one who is but tolerably conversant in such
Practice, very well knows that the saline Particles are thrown off this
Way much more effectually than by any other; and a further Demonstration
of this Matter is also, that the Sweat of infected Persons, as in the late
Sickness, gives extream pungent Pains by its Acrimony in its Exit; and
that the more brackish such Sweat comes out, the more serviceable it
proves; whereas when it happened to be soft and insipid, it was a sure
Forerunner of worse Symptoms, and even of Death.

FURTHERMORE, as to curative Intentions, all Diligence was used to preserve
and restore the internal Ferments from a Contagion; and this was chiefly
done by saline Preparations of various Kinds, which gave greater Energy to
the natural Spirits, so as to alter and renew them by Means of that
Similitude of Texture and Constitution naturally between them.

AGAIN, what was excreted did greatly establish this our Hypothesis; what
was thrown up by hard Vomiting discovered nothing more than a rancid
Brackishness, that vellicated the Stomach into Convulsions by its
acrimonious and corrosive Qualities; and the frothy and fermentative
Nature of what was ejected by Stool, fully showed its saline Mixture: But
we shall come more fully to talk of this hereafter: To conclude therefore
this Controversie; although the Hypothesis here laid down may at first
Appearance seem new, yet it does not so far differ from the Sentiments of
the Ancients upon the same Subject, as confirm and explain what they have
said: It comes down to us for the Opinion of some of them, that a
Putrefaction of Choler in an humane Body gives Rise to a Pestilence; and
of others, that Fire may be so corrupted, as to occasion the same; what
therefore the former conceived of Choler, and the latter of Fire, we judge
more justly ascribed here to a vitiated saline Spirit. But least we should
too long dwell upon this Argument, if it was needful to recite all the
Causes enumerated by Authors of this Malady, it would be difficult to find
any one which does not coincide with this our Hypothesis; so that
whosoever pleases to be at this Pains, must either assent with us, or
reject them; and he that does not like our Opinion, would do well to shew
a better.

IN the above-described Pestilence, as indeed in many others, Persons
frequently died, without any preceeding Symptoms of Horror, Thirst, or
concomitant Fever: For the Confirmation of which, I shall give an Instance
or two out of a great many; A Woman, who was the only one left alive of
the Family, and yet to her Thinking perfectly well, perceived upon her
Breast the pestilential Spots, which she looking upon to be the fatal
Tokens, in a very short Space died, without feeling any other Disorder, or
any other Forerunner of Death.

A Youth also of a good Constitution, after he had found himself on a
sudden marked with the Tokens of the Contagion, believed at first they
were not the genuine Marks, because he found himself so well, and yet he
was dead in less than four Hours after, as his Physician had before
prognosticated.

BUT how suddenly soever the Sickness killed some People, whether by
suddenly seizing the Brain, Heart, Lungs, or any other principal Part,
with a deadly Infection, or poisoning the vital Spirits at once, so that
no Appearance could be discerned, even of a lurking Fever, yet for the
most Part, some Fever did shew it self.

AND it cannot be thought strange, that most who took the Contagion should
have a Fever, to those who consider the Nature of a nitrous Spirit,
especially when degenerated, and that from the most slight Cause it will
take Fire, and excite Heat; and the Fever accompanying this present
Sickness was of the worst Kind, both on Account of its State and Periods,
sometimes imitating a Quotidian, and at others a Tertian; sometimes
seeming to retreat, and at others attacking again with redoubled Fury:
There was never a total Cessation, but sometimes a Remission for an Hour
or two, although every Exacerbation was worse than the former; but this I
pass by here, having Occasion hereafter to enlarge further thereupon.

AT length therefore, to discharge my Promise in giving a short Account of
a Contagion, as of a Disease that is communicable that Way only, and
killing most it seizes, it is to be taken Notice, that the Infection of
the pestilential Poison is not only transferrable from one Subject to
another, either by mediate or immediate Contact, and exciting the same
Symptoms; but all the Conditions likewise of its Exertion, are as
conspicuous as the Noon-day Sun; wherefore those Arguments to prove the
pestilential Corruption not to arise from Contagion, are trifling and not
worth Notice, as altogether disconsonant to Reason and Experience; as
after I have enumerated the Conditions of a contagious Exertion, I doubt
not but to make this Matter clear to every one.

FOUR Things chiefly are necessary to a Contagion:

_FIRST_, That there is an Efflux of the contagious _Seminium_.

_SECONDLY_, That there is a convenient _Medium_ for the contagious
Particles to move through, and be conveyed by.

_THIRDLY_, A Fitness in the Subject to receive and cherish the contagious
_Effluvia_. And,

_FOURTHLY_, A due Stay of this _Seminium_; of all which distinctly.

THE Quantity of Necessaries daily taken in for Refreshment does evidently
demonstrate, that insensible Perspiration is much larger than all other
Evacuations together: But where a Pestilence invades, a yet much greater
Wast is made that Way than in a Time of Health, by the intestine
Colluctation and Struggle of opposite Principles in the animal Fluids;
this is confirmed by the Observation of _Sanctorius_, who tells us, that
Persons taken with a pestilential Contagion, immediately become much
lighter, the _Effluvia_ of their Bodies breaking through on all Sides with
Rapidity; for such is the Energy of the pestilential Taint, that it
immediately subtilizes more thick Substances, and gives them such a
Sharpness, as to cut their Way like so many Needles, or Wedges, and very
often carry along with them those natural Spirits which should be a
Preservative to the whole Frame: Hence sometimes follow Swoonings and
Faintings that are fatal, and Indications of that Wast of Spirits that
hath been made by the pestilential Poison.

HENCE moreover it appears, of what a diffused Nature this Contagion may be
of, by the great Plenty that transpires from an infected Person; and which
Steam alone, as it is sufficient to communicate the Infection, so it is
also capable of vast Dilatation and Diffusion; not much unlike the Snuff
of a Candle, which not only emits a great deal of Smoak, but carries a
considerable Stench along with it into very distant Parts.

_SECONDLY_, A fit _Medium_ is very conducive to the Propagation of the
Plague; for according to the Disposition of that, in being more or less
open or confined, is the Infection sooner or slower communicated: Nor is
there any Doubt, but that the Air is this fit _Medium_, and whose Pores,
altho' very minute, are readily filled with it; and therein the noxious
_Effluvia_ lodge securely, unless expelled by any external Force.

THE Air is moreover the more convenient Recepticle and Conveyance of this
pestilential Poyson, on account of that nitrous Spirit with which it
abounds; hence it more easily receives the poisonous _Aura_, and
faithfully preserves it as in a proper Conservatory, and on this Account
the pernicious Qualities, (unless first destroyed by some uncommon Power)
sooner reach any Subject to act upon, and float about in Readiness for
Destruction: Sometimes also the pestilential _Miasmata_ may be broke and
destroyed by the Occursion of others, without any Perception of either
having been in this _Medium_.

HENCE it comes strongly to be conjectured, how the pestilential _Seminium_
comes to be hid so secretly in the Porosities of the Air, so as to be
conveyed from one Country to another, and to travel unperceived into very
distant Regions. Further, as this _Medium_ is more still, it is so much
the more capable to receive the pestilential Infection; whereupon Places
that are close, confined, and dark, as Prisons, and Houses in Vallies, are
much more liable to Contagion, than Situations upon Eminencies, where the
Air is frequently agitated by Winds; for the malignant _Effluvia_ cannot
so well fix in an Air so tumultuously hurried about; and they are likewise
rendred less hurtful by a continual Mixture of fresh Air with them.

_THIRDLY_, A suitable Disposition of the Subject is very necessary for the
Reception of the pestilential Taint; and this Disposition respects either
some Fitness in the Pores of the Body, or a long Accumulation of
distempered Humours. The more open the Pores are, and the wider, by so
much the more easily will the Infection penetrate into the Body; and the
more constringed they are, the better Security is there against it,
insomuch that hardly by any other Means can it enter.

A Turgescency of bad Humours greatly facilitates the Plague's Admission
into any Person, whether such a morbid Constitution arises from the
Suppression of usual Evacuations, or from an erroneous Use of the
Non-naturals; and most of all, a Load of bad Humours from an Excess or a
Surfeit, leaves so great a Similitude to the pestilential Poison, as
greatly to encourage its Admission. But besides these Dispositions of the
Subject, it is much to the Purpose to suggest this following Observation,
that the Plague is sometimes so much hereditary, and influenced by a
seminal Taint, that in a common Contagion it shall much exert it self in
some in the same Manner upon Children, as their Parents, as in the
_Small-Pox_, and other Affections of like Nature.

_FOURTHLY_, It is necessary that there should be a continual Lodgment of
the pestilential Poison; for if the noxious Steams were blown away as
soon as received, there would be but little Mischief done; but those which
meet with any glutinous Matter, and a certain _Lentor_ from the Viscidity
of the Humours, with which they lie entangled, until they are carried
through the larger Vessels with the Blood, begin to fuse and taint all the
animal Juices; and thus the pestiferous _Miasmata_ having got Possession,
are able to subvert the whole Machine, and bring all into Confusion,
without requiring any long Stay to execute their pernicious Effects; for
as soon as they once find a viscid and tenacious Substance, they eagerly
join with it, and are but with great Difficulty to be extricated. Yet
notwithstanding it is generally thus, I have sometimes found Instances of
a longer Stay of the pestilential Poison before its Exertion, where the
Symptoms of Infection have not appeared until a fit Time of Maturity for
Eruption into Action, and for the Confirmation of which several Instances
might be produced were it controverted; I have known many go into the
Country after Intercourses with the infected, and keep well for a Month or
two, when the Enemy that has lay hid so long, rushed out of its
Fastnesses, and by its Fury sufficiently compensated its foregoing Delays;
and this Eruption sooner might very probably have been hindred, partly by
the Viscosity of the Humours entangling the pestilential _Miasmata_, and
partly from an over-powerful balsamick Quality, natural to a good Blood,
and to a Plenty and Vigour of animal Spirit; but as I would not be tedious
upon Things so very obvious, this shall suffice concerning a Contagion.

BESIDES the Causes already recited, there may be others also worth
Consideration, _viz._ the eating corrupted, or rotten Flesh; and it is not
at all foreign to our Purpose here to take Notice, that on the Year before
the late pestilential Sickness, there was a great Mortality amongst the
Cattel, from a very wet Autumn, whereby their Carcases were sold amongst
the ordinary People at a very mean Price; and a great deal of putrid
Humours in all likelihood produced from thence: And this, in the Opinion
of many, was the Source of our last Calamities; and many knowing Persons
ascribe the Pestilence to this Origin, as the morbid Disposition which
such a Feeding must needs subject the People, could not but facilitate
both the Infection and Progress of that fatal Destroyer.

TO this I do not deny, but that the common People, who fed upon such a
Diet even to Gluttony, might treasure up Matter enough for so deadly an
Impression, and with which the Plague might naturally enough go into a
Co-operation; but such Provision, although very much corrupt, and liable
thereby to excite Symptoms like to those in a Pestilence; yet they were
not in Plenty enough to supply the whole Market, and therefore a Cause so
private and particular, could not be supposed to extend to so universal an
Effect.

HENCE it is further manifest, that a corrupt Diet can do no more in giving
a pestilential Impression, than a good one can in removing it; and
therefore, not to dwell too long upon this Matter, it is my Opinion that
such a Way of Living may raise the Humours to a Degree of Putrefaction, as
brings Fevers very malignant, and causes epidemical Diseases, but not a
true Pestilence.

AND the Conjecture that a Sickness amongst Cattle is transferable to the
humane Species, hath not yet appeared on any good Foundation; but to
remove this Difficulty, no one doubts but that a Plague amongst Cattle,
from some common Cause, as a Corruption of the aerial Nitre, and which
differs from a Plague amongst Men but in Degree, may also be transmitted
to the humane Species; that is, a feebler Degree of Poison, and a milder
_Aura_, may taint the Herbage, than that which is sufficient to destroy
the firmer Constitution of Animals; besides which, from the Diversity in
the Pores of Brutes, and their different Constitutions, and the Fortitude
in the Spirit of a Man, I cannot be induced to believe that the Pestilence
amongst Cattle from a private Cause, can ever obtain any Dominion over
Mankind. These Stories therefore have no Weight with me, that a certain
Leech, upon opening an Horse, that with a great many others had died of
some common Distemper, in Order to know what it was, and finding certain
pestilential Tokens upon his Inwards, both the Master and the Family soon
died of the Infection; which yet went no further than that Family, but
expired with them.

DURING the late Plague likewise at _London_, a Citizen travelling into the
Country, found his Horse of a sudden to tire and fall down, whereupon he
opened his Mouth to find out if possible the Cause of so sudden a Change;
when the good Man, upon Receipt of the Horse's Breath upon him,
immediately grew sick, and died in two Days Time.

BUT these and the like Instances certainly tend to prove no more than that
there may be Constitutions and malignant Steams, which, by agitating the
Mass of Humours, may excite putrid and irregular Orgasms, wherein the
Juices and Animal Fluids, according to the Quantity and Prevalency of the
Distemperature, and the Variety of the infused Taint, with the Diversity
of Putrefaction, goes into Corruption; but the forementioned
Transplantation of the Plague does not happen but where there is a
suitable Predisposition of Humours to admit it, as its Cause is not
general.

MOREOVER, although the Intemperature of the Year, sudden Change of Air,
Suppression of usual Evacuation, Diminution of Perspiration, Drunkenness,
Venery, and Passions of the Mind, especially Anger and Fear, are justly
reckoned amongst the remote Causes of a Pestilence; yet they regard rather
the Invasion of it, than its Origin; but of this we shall say more
hereafter. As to the above-mentioned Passions, it is almost incredible how
some, at the Height of the Infection, would from a very slight Cause
kindle into the utmost Rage, and rave at one another like meer Scolds,
until Death parted their Contentions.

NOR does Fear or Sorrow less prepare the Way for the Infection, by
deadning the Fancy and Memory, by Suffocating the Spirits, Suppressing the
natural Heat, breaking the Constitution, and Promoting Malignity: We have
manifold Instances of this kind in Readiness; but if, as some do, we
should be prolix in the Enumeration of Things that want not Proof, the
Reader would be quite tired with needless Stories.

BUT now it may be convenient to add a few Remarks concerning the
Translation of a Pestilence from an hot Country to a cold one; for
according to the different Effects of Heat and Cold, the one attenuating
and rarefying, the other condensing and constipating, the pestilential
Venom is strangely altered, insomuch that in a Thing so obvious, there
does not require much to be said: Every Thing of this kind prodigiously
spreads in hot Climates, as being more subtile than even the Air it self;
tho' the same in the Northern Countries is more restrained, and confined
in Fastnesses it cannot escape from; and from hence the Reason is very
obvious why there is so much Difference between the Diseases of different
Climates, which would be too tedious for us here to go into.

TO come nearer therefore to our Business; the same Affections that in an
hot Country heat the Blood and other Juices, so as in a great Measure to
put them into Fusion, when translated into the contrary Extream may give
contrary Properties to the same Fluids, and _e contra_; and this might be
demonstrated by innumerable Experiments, were there any Doubt about it.

IT being then granted, that this Plague first was brought from _Africa_,
or _Asia_, to _Holland_, and from thence into _Britain_, every one may
easily conjecture, how much Alteration it must undergo in such a Travel,
from a hot and dry Climate into a moist and cold one, not so much in its
own Nature, as from the Vehicle of Air which conveyed it, and thereby
producing different Degrees of Infection, and Series of Symptoms: But this
Variation would be most discernable in the Complication of the
pestilential _Seminium_, with the particular Diseases of each Country, and
those which are as it were peculiar to them: This in our Case is very well
worth Notice, for in _Holland_, where the Scurvy extreamly reigns, and
therefore, for Reasons before given, most liable to a pestilential
Infection, it obtained only as a more aggravated Scurvy, as shall
hereafter be further remarked.

AS for that Opinion of the famous _Kircher_, about animated Worms, I must
confess I never could come at any such Discovery with the Help of the
best Glasses, nor ever found the same discovered by any other; but perhaps
in our cloudy Island we are not so sharp-sighted as in the serene Air of
_Italy_; and with Submission to so great a Name, it seems to me very
disconsonant to Reason, that such a pestilential _Seminium_, which is both
of a nitrous and poisonous Nature, should produce a living Creature.

AS in putrid Fevers, so in a Pestilence, Malignity is a Destroyer of
Insects, and frightens them away as it were alive, so far is it from
giving Birth to them; indeed in some malignant Ulcers and Cancers, and in
the Blood of some People, sometimes _animalcula_ are found; which is
rather to be looked upon as the Effect of some Fault in the nutritious
Juice, than the Produce of any Poison; and therefore they are not to be
accounted amongst the Causes of a Pestilence.

[Illustration]




                              SECTION III.

              _Of the primary Seat of a Pestilence; where,
                by the Way, is considered the Nature of
                 the Spirits, and their Infection in an
                       humane Body from Poison._


IN Order to put an End to the Controversies about the Seat of a
Pestilence, which have from Antiquity even to this Day been warmly
maintained, many Authors putting the Heart for the Principle of Life and
Death, some the Brain, and others the Stomach, Lungs, or Liver: It will be
necessary here to discover the immediate Residence of the pestilential
_Seminium_. Since therefore the above-mentioned _Aura_, according to
Hypothesis, is very subtile and spirituous, for that Reason there must
necessarily be some conformable Property in the Matter which is fit to
receive it; as therefore there is not in the whole humane Machine any
Subject more apposite, and capable of its Union, than the animal Spirits,
we must fix its Residence there. But because I am sensible what Objections
this Opinion lies open to, with some Persons, who may not conceive how an
immediate Infection of the Spirits is communicable to the Viscera, and
all Parts of the Body, it will be necessary to go thro' this Matter in a
very particular Manner, by enquiring;

_FIRST_, What are the Spirits concerning which we are here speaking?

_SECONDLY_, What is that Disposition of Spirits which makes them fit to
receive the pestilential Impression? And,

_THIRDLY_, After what Manner the vitiated Spirits can affect the whole
Body with Disorders?

TO this Purpose we must know, that the Spirits are the most thin and
subtile Particles of the Aliment and other Juices, raised to the utmost
Perfection and Volatility by the innate Heat, and the nitro-aerial Spirit,
to serve in the Operations of the Mind, and all the Purposes of the animal
OEconomy.

THE Matter whence the Spirits are generated is the Chyle, and their
Restauration, Confirmation, and Vigour, from the Recruits of Food, as is
their Languor, Prostration, and utter Extinction from the Want of it; so
that howsoever they were first generated in the original, they owe their
Conservation and Vitality to the Nourishment continually brought in; and
although in a State of perfect Health _they_ are never changed by _that_,
yet they continually act upon that after various Ways, bringing it from a
crude, recrementicious State, into a noble Juice, or rich spiritual
Balsam, retaining its ideal Character: And hence it comes about, that
although there is a daily Waste of Spirits, there is no Want, because
Nature is continually, while Things are in Health, making more; insomuch
that after a due Constitution of Spirits is obtained, they of themselves
are the main Efficients in making more, as one Light is kindled by
another, and as the Blood it self is the chief Instrument in
Sanguification, or making more Blood.

IT is a Matter indeed of much more Difficulty to determine, how Particles
from a gross Origin, should be raised to so great Volatility and Fineness;
but this is very certain, that when they are elaborated in the most
perfect Manner, they exceed even the Light and Activity of the Sun-Beams;
and the brighter and more active they are, the better do they perform
their Offices in the OEconomy, as from their Efficiency is procured a
State of Health and Vigour both in Body and Mind.

IT is of no great Moment to enquire, what Quantity of Spirit is necessary
for the Conservation and Support of an humane Body, so that we do but know
they partake of the Source from whence they are generated, insomuch that
they are more or less perfect, according to the greater or lesser Degree
of Purity in their productive Juices.

BUT I must here acknowledge my self diffident in that Opinion of the
Spirits being prepared of a different Nature for particular Parts, for
according to the Influences of the Mind, and the Contiguity, Rectitude, or
Consent of the Vessels, they are by a voluntary Act determined the same
into this or that Limb or Part: Which is manifest enough in the Prick of a
Needle, or a venomous Bite, from the great Affluence of Spirits to that
Part; I have therefore no Notion of a continued Emanation of Spirits, but
that on such Occasions they are called, by the Sensation upon the affected
Part, from the nervous Origin where they are elaborated.

_SECONDLY_, It sometimes happens that the Spirits degenerate from their
native Purity, as also at others that they prove abortive, in not arriving
to their utmost Maturity, whereby they lie more open to foreign
Impressions of Distemperature.

BUT when the juices, or common Promptuary from whence the Spirits are
generated, is not uniform, genuine, and perfect in kind, it is impossible
that Spirits should be made from it in any tolerable Perfection; for one
may as well pretend to wash a Brick, or draw clear Water from a foul
Spring, as expect pure and natural Spirits from a corrupt and vitiated
Chyle; although even when the Chyle is in right Order, there may various
Errors happen in the Generation of Spirits, as from too great an Heat
agitating the Blood in a preternatural Manner, or from an imperfect or
unequal Separation of Particles, or from too much Cold causing an
Intermixture of Crudities; and again, although the Spirits are duly
elaborated, yet they may run into irregular Motions, and be the Occasion
of many Disorders: But what is most to the Purpose, they may sometimes
also receive a Taint from external Impressions.

AND this Aptitude, or Propensity of the Spirits to receive a pestilential
Taint, is manifest from their fiery, or rather saline Nature, for on
Account of that Subtilty which they acquire thereby, do they more
naturally attract the contagious _Aura_, than Bodies more gross and heavy:
For as these Spirits, as before observed, are nitrous, and inflammable, by
their Similitude to a pestilential _Aura_, they not only are fitted to
receive, but even attract it, and provoke it into Union; as the Snuff of a
Candle just blown out, if it is not too far off, will by an Affinity of
Qualities be soon rekindled by another lighted one at some Distance; and
how much soever the poisonous Qualities of the pestilential _Effluvia_ may
be destructive of the animal Spirits, yet there is nothing more certain,
than that their Taint is very easily impressed upon them.

AFTER the pestilential Poison is thus received by the Spirits, it is
impossible to express the fatal Consequences, and the cruel Havock that is
made in the whole OEconomy; for the same Instruments which before were
aery, lucid, and like the Rays of the Sun, immediately become vapid, dark,
and useless, neither able to invigorate the Constitution, nor defend it
against the Contagion.

_THIRDLY_, Having briefly passed over these Matters, it remains that we
shew by what Steps the humane Frame comes to be disordered by this
pestilential Invasion; and in Order to this, I know not a more fatal
Circumstance in Nature than to have the very Guards and tutelary
Preservers of Life, turn, as it were, Deserters and Betrayers. For there
is nothing more manifest, than that the whole Compage, and its several
Parts, run into Decay as soon as the pestilential Taint takes Place; for
immediately upon the first Seizure, the whole Effort of Nature, as at
_Rome_ when _Hannibal_ was at their Gates, is recollected against the
Enemy, as sensible that all is at Stake, but being unequal to the
Conflict, they retreat, and are taken Prisoners, leaving the whole Body
defenceless. Hence the Infection runs through all the Blood, whereby the
Heart and Lungs are principal Sufferers. Hence such a Corruption of the
nutritive Fluids, that the whole nervous System is disturbed, the burning
Heat of the _Pancreas_ produces the most extream Sickness, and hence
follows such a Depravation of the whole Machine, that all the vital
Faculties cease to act, and Death closes the fatal Scene.

BUT I do not at all see how such a noble Part as the Heart, should be
first affected by any particular specifick Quality in the Poison of a
Plague, to affect that more than any other; as if it was so frightful, as
some would have it, to attack the Principles of Life at once; for the
Heart seems at first to be affected chiefly from the Multiplicity of
Vessels, and the great Crowd of Circulation that Way, giving Opportunity
for the Venom sooner to arrive thither; concerning which we shall have
Occasion to say more under that Head of Symptoms.

UPON the strong, presumptive Proofs therefore that the pestilential Poison
chiefly resides in the Spirits, we cannot but much admire at the Weakness
of those, who expect to detect its Nature and Cause from what they can
find on the Dissection of morbid Bodies, and such like Circumstances: For
a very noted Person, and one of exquisite Skill in Anatomy, although he
himself at last fell in the general Calamity, affirmed, that the Seat of
the last Pestilence was in the extream Angles of the _Plexus Choroides_,
towards the _Cerebellum_, because he had found a small Vesicle there;
others have observed the Lungs to have been marked with the Tokens of
Infection; others report the Heart to have been tumefied, and burnt as it
were, to a Coal; whereas it is plain, that these Parts are only so many
Fields of Battle, where the Spirits and the Infection contend it with each
other; Nor will any one, who rightly considers these Things, wonder, that
such Marks of Devastation should every where be left by so cruel an Enemy.

THEREFORE, although it should be granted that the most obvious and open
Tokens of a Pestilence are from a spiritual and an invisible Cause, and
whose Effects may perhaps sometimes be laid open to Sight, yet I have no
Intention to discourage anatomical Dissections as a needless Trouble, for
by such Light, Medicine is recovered from the Reproach of Conjecture; but
when Bodies are opened which have been destroyed by such subtile Agents as
here spoke of, there is no Confidence to be given from thence to the
Nature of the Disease; and those who have been most knowing in the Nature,
Use, and Disorders of the Spirits, very well can direct how to recover
those Disorders, and avoid future Inconveniencies by immediate Application
thereunto.

AND Lastly, to conclude this Doctrine concerning the Spirits Infection,
this irrefragable Argument may be produced from the Intention of Cure; for
I have experienced by more than a thousand Instances, that the more
cardiack and alexipharmick Medicines are subtile and spirituous, the more
certainly do they encounter the pestilential Poison with Success; whereas,
on the contrary, those Medicines which are coarser and slower of
Exertion, do little or no Good. But this we refer to the curative Part
hereafter in another Section.




                              SECTION IV.

               _Of the Complication of a Pestilence with
                other Distempers, and particularly with
                              the Scurvy._


AS the Pestilence is the most powerful of all other Distempers, so it also
claims a particular Privilege of joining with all others; so that it does
not more excel in its own Contrariety and Antipathy to Nature, than it
asserts a Prerogative over all those various Evils which the humane Frame
is subjected to, and draws them into its Assistance in exercising its
cruel Power over Mankind.

THIS Assertion might be supported by a Multitude of Instances, if it were
not for taking up too much of the Reader's Time; for which Reason we shall
only take Notice, that amongst all those Distempers which are thus
inclined to join their Forces with this most powerful Enemy, some seem to
have a more particular Fitness for such a Union, from a common Affinity
in the Nature of their Infection, and the Energy of their Poison.

ONE of the First of this Class is the venereal Disease, with which the
pestilential Venom does in a very familiar Manner unite it self. At the
first breaking out indeed of the last Sickness it was given out by common
Fame, that those who were previously infected with any foul Distemper, as
the Pox in particular, would be secured thereby against the pestilential
Taint; but wicked and impious was the Consequence of such a Suggestion;
for many were hereby encouraged to seek the most lascivious and filthy
Prostitutions, on purpose to be secur'd by one previous Infection against
another: But besides the poisonous Quality peculiar to this nasty Disease,
besides that Expence of Spirit in the procuring it, and besides a lost
Force of the Constitution thereby, the greatest Aggravation to this
Misfortune was, that the very Taint which was to defend against another,
had it in its Nature to be more forcibly attracted by it; so that the rash
Adventurer was soon brought to a bitter Repentance for his Experiment, by
sinking immediately under the pestilential Contagion at its first Stroke;
and it was common to find, by a very easy Transition, the venereal Buboes
changed into pestilential Carbuncles, except in a few Instances where
Nature found out an uncommon Artifice against these united Powers, by
endeavouring an Ejectment of their joint Malignities by Salivation,
whereby sometimes the Patient was brought into some Chance for his Life,
both the Poisons being in a great Measure cast off together that way.

BUT here it may not be improper to admonish the young Physicians not to be
too forward Imitators of Nature in such a Circumstance; unless they will
run the same Hazard with a certain Empirick, who crouded his Powders upon
the Sick that raised an untimely spitting, and brought a great many into a
dangerous Condition, which by a regular Practice might have been, tho'
with Difficulty, saved.

Yet to set this whole Affair in a clear Light, there is great Reason to
suspect that in many Cases Mercury had for some time remained in the Body,
which, like a Snake in the Grass, being raised by the Pestilential
Infection, flew up into a Salivation; for the febrile Heat, assisted with
Medicines also of an hot Nature, throw up the Mercury, which had long lain
quiet, like a Sublimation; which should be a Caution, not only to young
Physicians, but those of more standing in Practice, not to be so buisy
with mercurial Medicines, to Children as well as grown Persons, as they
are too much apt to be; least besides the Inconveniencies already
mentioned they cause malignant Ulcers, and Rotenness upon the Bones, as it
is too commonly observed to be done in irregular Practice, to the
irreparable Detriment of the Patients.

I am not however ignorant that sometimes the Pestilential Venom may
tumifie the salival Glands without any other Assistance, and occasion
Ulcers in the Mouth as with Mercury; for it is a common Case in many
malignant Fevers.

BUT it is so clear a Matter that the Pestilential and venereal Poysons may
intimately join together by their Affinity with one another, to the great
Detriment of Mankind, as to want no further Proofs to confirm it; nor
does their Opinion at all obviate ours, who place the venereal Poyson in
Humidity, and that of a Pestilence in Dryness, as long as the Symptoms and
Affections of both discover one common Principle, that is, somewhat
saline; but yet if this should not be granted, they are naturally enough
joined together by their known Malignity and Destruction to human Nature.

BUT the Affinity between a Pestilence and a Scurvy is not a slight, and a
supposititious Conjecture, but strengthened and confirmed by a plain Union
between them, whereby they attack like confederate Troops; and both
confess the same Origin, _viz._ a saline Principle; as is most remarkably
obvious in their eager Coalition, whether we consider the forementioned
Transplantation of the like Plague from _Turky_ to _Holland_, where their
Alliance was first formed; Or whether we reflect upon them both as
Distempers equally epidemical, which when joined make such cruel Havock
among the human Species; as neighbouring Flames catch together from a like
Affinity of Parts, and burn with united Fury.

FOR although there is a great Difference in Salts of different Kinds, yet
there is a common Property amongst them all, that when joined together
they cannot hardly by any Means possibly be afterwards separated, for
which Reason when these two Enemies of Mankind were joined, the
complicated Evil was at first customarily distinguished by the _outlandish
Scurvy_, which by a confederate Power had increased its Malignity to so
great a Degree. But to give some apparent Facts, which irrefragably prove
the natural Union between these two Origins of Mischief, it may be proper
to recite some Symptoms common to them both, and first of all those Spots
which were their certain Characteristicks.

THE Spots of those in the Plague were sometimes so numerous, as to cover
all the Body, of which we shall say more hereafter; and if we consider the
Appearances and Conditions of the Spots in both, we shall find a very
great Agreement; the pestilential Spots sometimes break out broad, at
other Times more contracted, just in the same Manner as it happens in a
Scurvy; and as to their Duration, sometimes they are longer out than at
others in both; now also suddenly appear, and then again as suddenly turn
in, and sometimes remain out for two or three Days together; and their
Likeness in all Respects is frequently so great, that amongst the ignorant
Nurses and Empiricks, sometimes the fatal Tokens of a Pestilence have been
mistaken only for Scurvy Spots: As to their Colour in a Plague, as well as
in a Scurvy, they are sometimes florid, resembling fresh Flea-Bites, and
at others dusky and livid; and I met with them in a certain Youth
resembling Violet Flowers painted all over the Body; and in some I have
seen them almost quite black, which are with great Difficulty to be
distinguished from the true pestilential Tokens.

THERE are other Symptoms also that denote the Agreement herein, such as
large Stools, of a saline and fetid Nature, and which are with great
Difficulty restrained by the most powerful Medicines; but if such a Flux
continues, it threatens irretrievable Injuries, as Corrosion,
Inflammation, and sometimes even Sphacelation of the Bowels, with
intolerable Gripings, and sometimes Loss of Blood: Furthermore, the
Agreement that there is between the Ulcers and Tumours of both evidently
demonstrate the Affinity of both their Origins, as will hereafter more
fully appear in that Part about the Cure.

THE Pestilence likewise shews its Affinity with the Scurvy, by leaving
behind it a scorbutick Habit, even where a Person was not given to it in
the least before; and it is not indeed at all strange, that after such
Disorders, and Corruption of the animal Juices, and such an Exhalation or
Suffocation of subtile and spirituous Particles, an Habit should be
confirmed, that can be removed but by the most generous Remedies, and the
most powerful Antiscorbuticks.

IT remains now briefly to enquire, whether a Pestilence coming upon
another Disease, in any Instances proves of Service; and this I shall
dispatch in two Histories of Cases, one in a Consumption, and the other in
the _King's-Evil_.

A Girl of fifteen Years of Age was so emaciated, that she had left little
besides Skin and Bones, and taking no Nourishment for 14 Days together,
she was given over as gone, but being called to the same House, to see her
Mother, and two others who had the Infection, and recovered, the same
Distemper seized that Creature almost half-dead before, whom also I then
attended; but she who just before lay as expiring, seemed animated by the
feverish Heat, began to move her Limbs, and with the Help of Alexipharmick
Medicines, although before speechless, began to complain of painful
Swellings about her; but those Buboes, which I suppose would otherwise
have broke out, for Want of Matter to raise them, were dissipated by
Transpiration; so that she recovered, and in about two Weeks also
manifestly lost her former Distemper, and gathered Flesh and Strength.

ANOTHER Maid of about 16 Years of Age had been so scrophulous from her
Childhood, as to have many indurated Glands remain after all possible
Means had been used to dissipate them. She at last was seized with the
Contagion, and pestilential Buboes rose upon the strumous Glands, which
suppurated, and let out a great Quantity of Filth; and upon her Recovery
from thence, her former Distemper was quite lost.

SOME gouty Persons likewise, and others accustomed to very obstinate
Complaints, were, by a lucky Conjunction with this Infection, quite
restored: and indeed most who were rightly managed in the Plague, and
perfectly recovered of it, were afterwards, in many Respects, better in
their Health than before; so that this terrible Enemy, as it was commonly
fatal, so it also sometimes proved a Remedy. And thus much for the
Complication of the Pestilence with other Distempers. We shall now proceed
to its Symptoms.




                               SECTION V.

            _Of the manifest Signs of the late Pestilence._


IT is altogether foreign to my Design here, to enumerate all the
Appearances that belong to a pestilential Constitution, because a great
deal may be ascribed to Phantasie and Conjecture, as the Influence of
Comets, and the Conjunctions of Planets, with others of like Nature: For
what strange Notions have been broached concerning this Contagion, which
was imported to us from Abroad? Are the Tails of Comets always armed with
pestilential Arrows? Or is the Air the more impure and unhealthful? Had we
any Famine before the last Sickness? Or had we portentious Swarms of
Insects like Clouds over us? No, just the contrary, as we before observed;
all Things from Nature were promising and serene, and this Destroyer
invaded us on a sudden from strange Countries; it is therefore of more
Advantage to our Design here, to take all its concomitant Signs from its
manifest Effects.

AND indeed there are not many peculiar to a pestilential Fever, as that is
chiefly a Collection, or an Epitome of all other Fevers together, which in
such a Confederacy are not therefore without a tedious Work to be
enumerated in all their Affections; I shall therefore satisfie my self
with describing such only which are most obvious to common Observation,
and are met with in most infected Persons: And these for Method Sake I
shall distribute into two Classes.

_FIRST_, The manifest Signs of Infection.

_SECONDLY_, The Appearances after Infection.

BUT hereunto I think it necessary to premise, that a Pestilence puts on
sometimes one, and at others another Appearance, and sometimes even
contrary ones, according to the Constitution or Age of the Patient, the
Season of the Year, present or preceding Distempers, a faulty Way of
Living, and the different Means of Communication, both with Respect to
Virulence and Degree.

THE Symptoms of the first Class are Horror, Vomiting, Delirium, Dizziness,
Head-ach, and Stupefaction.

OF the second, a Fever, Watching, Palpitation of the Heart, Bleeding at
Nose, and a great Heat about the _Precordia_.

THE Signs more peculiar to a Pestilence, are those Pustules which the
common People call _Blains_, Buboes, Carbuncles, Spots, and those Marks
called _Tokens_; of all which distinctly.

I do not know indeed throughout the whole Compass of Nature, (as before it
hath been frequently hinted) any Thing so subtile as the pestilential
Poison, and what will penetrate the Body with so much Swiftness and
Secrecy, insomuch that it is not perceived sometimes till long after its
Entrance; what therefore is commonly said of its sensible Attack, and that
the infected feel its first Insult as from a sudden Blow, is more the
Effect of a deluded Imagination and Conjecture, than any solid Judgment;
as the Populace are apt enough to frame strange Conceits out of their own
Heads, and what hath long obtained amongst them is very difficult to
erace.

WHEN therefore such a kind of People hath received the Notion, as was
common in the late Sickness, concerning the forementioned Manner of
Infection, it is no great Wonder that others likewise in general go into
the Error, and take it for granted that this unmerciful Destroyer makes
its Seizure in this violent Way, and therefrom wait for it as for a hidden
Stroke.

ALTHOUGH I am not insensible, that some may have thus perceived its first
Impression, upon taking in ungrateful and filthy Smells; for the
pestilential _Seminium_, (as before observed) when it incorporates with
other Bodies that are gross, fat, and viscid, may strike the Organs of
Sensation very manifestly at its first Entrance.

AFTER the pestilential _Miasmata_ have thus seized a Person, and the
Spirits are overcome, the whole Mass of Blood, and other animal Juices,
partake of the Disorder; from whence proceed Struggles not to be born, and
a Train of Symptoms, of which quaking or shuddering is the chief, all of a
sudden, without any manifest Cause.

THIS Symptome owes its Origin to the Conflict of Nature with the infused
Malignity, whose Efforts of Resistance excite a Sense of Cold from the
pestilential _Seminium_; after the same Manner as Nitre put upon the
Tongue excites the same Sensation; it is also to be suspected that this
Rigor may be owing to a Quality in the poysonous _Effluvia_ of
extinguishing the native Heat: And the Spasmodick Affections of the
Nerves proceed from salt, sharp, malignant, and heterogeneous Particles
rushing into the sensible Fibres, and vellicating them into involuntary
Motions and Twitchings.

THE greatest Part indeed of the Infected perceived this Horror, but some
of them more vehemently than others; but of the immediate Impression upon
the Spirit there is no Room to doubt, nor of a consequent Degeneration of
the whole Mass of Blood; although I am sensible that the Subtilty of the
pestilential Taint took Place sooner or later, according to the different
Degrees of Strength and Texture in the Body to resist it.

IT is certain that the fine and exquisite Contexture of the nervous
System, and the Agreement and Consent of one Part with another, as well as
the extraordinary Perfection of the Animal Spirits, set as Guards over
such sensible Parts, could not but be affected with the Apprehensions of
Mischief, and shake and tremble, and use their Efforts to throw off the
Danger; and indeed I take it further to be probable, that the pestilential
Poison might be shook by such Means out of the Nerves into the Muscles,
and there cause Tention, Trembling, Vellication, Yawning, Stretching, and
all those other Concomitants of putrid and malignant Fevers.

THE Duration also of this Shuddering was as uncertain as its Degree, for
it went off sometimes sooner, and at others later; sometimes in half an
Hour, and at others, not till four or five Hours; which Difference I
conjecture owing to the Quantity and Intenseness of the Malignity, as to
the greater or lesser Struggles of Nature to resist it.

AS soon as this Horror could be said to terminate, for the most commonly a
Nauseousness and Reaching succeeded, from whence there was such an
excessive Loathing of Food, that even the Mention of it was irksome; a
certain and infallible Sign of Seizure.

BESIDES the Nauseousness and Loathing, some were followed by grievous
Vomitings, occasioned by the poisonous Quality of the Pestilence
irritating and subverting the Stomach; for that, by Means of its nervous
Coats, being endowed with an exquisite Sense, endeavours to throw off any
Thing offensive and corrosive with the utmost Efforts, and prevent the
saline, pestilential Venom, if possible, from taking Place; insomuch that
nothing is more certain, than that the Stomach, by this fine Contrivance
of Nature, is ready also to throw off any other Thing disagreeable to it,
as well as the Poison we are here speaking of.

SOME endure hereby such a vehement and continued Irritation, that cannot
be asswaged by any Remedies, how often soever repeated, and sometimes the
Reaching continues after the Strength of the Patient is too far spent to
throw any Thing up, whereby the Symptoms aggravate, and the pestilential
Venom takes deeper Root in the Constitution.

AFTER the principal Load of Humours at the Stomach are thrown up, a very
frothy Bile, fermenting like Yest, follows, that in its Colour is
greenish, and sometimes so fetid, that a Person cannot endure the Room
without holding his Nose, such is the prodigious Putrefaction and
Malignity in some of these Cases.

BUT where the Use of Medicines, otherwise effectual to stop the most
obstinate Vomiting, proves ineffectual, and there follows a great Thirst
and Heat, it gives strong Suspicion of Carbuncles in the Stomach, and
immediate Death, so that the infected as it were vomit up their Souls,
which (if we believe _Helmont_) have their Residence there; but this will
be further spoke of in the Prognosticks.

BUT before I proceed any further, the Health of my Country, and the
Concern of Posterity, oblige me to take Notice of the pernicious Practice
of Empiricks of all Orders, with whom it was a Custom to give Emeticks;
for certainly many were destroyed by this Practice, the convulsive
Reachings to vomit being carried beyond a Possibility to bear it. And
truly the best Deliberation and Thought I was able to take in such
Exigencies, where I happened to be called, was but of little Effect, and
after Administration of the best Medicines that the Rules of Physick could
invent, Things generally grew worse; which made it appear as impossible to
rectifie a rash and fatal Error in the Conduct of a violent Disease, as
in the Management of a military Engagement; but of this we shall have
Occasion to say more hereafter.

YET to satisfie any inquisitive Person how this primary Affection of the
Stomach does arise, and through what Passages the pestilential Poison
makes its Entrance, it is to be observed, that nothing is more plain than
that the pestilential _Miasmata_ not only enter at the larger Passages,
but also through the Pores of the Skin, even to the whole nervous System,
from whence they are communicated to all other Parts; for this is peculiar
to the Nerves, that they not only convey the first Impression to the
Stomach by its general Consent with all Parts, but also when that is after
any Manner whatsoever affected, they communicate it to the whole Frame, as
in the taking a Vomit.

SOMETIMES the pestilential _Aura_ is mixed with the Food, and swallowed
therewith, which after some Delay in the Stomach being digested and
dissolved, lets out the imprisoned Venom to vellicate the Fibres into
Reachings and convulsive Motions: And to put this altogether out of
Dispute, I have often observed Persons immediately to fall sick from a
State of perfect Health after eating, and to throw up their Food, in other
Respects good and wholsome, as somewhat corrupted and poisonous.

VOMITING also may be promoted by Scents, as well those which are fetid, as
such as are contrary, by some particular Antipathy to the Nature and
Constitution of the Patient; and this I conjecture happens from the
Harmony and Consent of the Organs of Smelling with the Coats of the
Stomach, insomuch that the Stomach immediately perceives any Thing that
ungratefully strikes the Nose, and rises up against it. In the mean Time I
would however transiently make this one Remark, that as in many Cases the
Administration of Emeticks was pernicious, whether or no Evacuation of the
first Putrefaction at Stomach, might not be much better encouraged upwards
by Scents; as, on the contrary, the Reachings at Stomach are sometimes
allayed by like Means, as by the Smell of Vinegar, _&c._ I do confess,
that this is a Practice I cannot attest the Success of by Experience, yet
it is not unworthy a rational Physician to attempt it.

ALL the Sick likewise quickly after Seizure grew delirious, running wildly
about the Streets, if they were not confined by Force; when some tired
with Rambling, on Increase of the Distemper, would fall down, ignorant of
their Condition, or where they were; and lastly, to repeat what hath been
already remarked, that sad Calamity seemed to have complicated in its
Production every Thing of a poisonous and a destroying Nature.

MANY were seized with a _Vertigo_, which, without any Motion of external
Objects, made them believe their Heads to turn round: Without doubt the
Brain grievously suffered from the pestilential Taint, not only because
the Spirits used to be clouded, but that all Things were done as if in
Sleep, which might arise from the inflammatory, caustick, and narcotick
Nature of the Venom, and the Texture and Consent of the Vessels with the
various Dispositions of the Fluids. This vertiginous Disposition also in
my Opinion might sometimes arise from the inordinate and anomolous
Motions of the Spirits.

A great many likewise much complained of the Head-ach, which was so
vehement, as if the Parts would have flown asunder; a Complaint the most
intolerable of all, because it continued without any Remission or
Intervals; the Enemy never retreating of it self, and only to be
vanquished by the Efforts of the Constitution, and apposite Medicines.
Indeed nothing was more plain, than that the _Meninges_ were stimulated by
the saline _Spicula_ of the Contagion; and from the Inflammation of the
Brain, and its Sphacelation in those who died, there is a strong Suspicion
that this cruel, shooting Pain continued to the last.

IN this Class of Symptoms, Stupefaction is also to be ranked; because from
the Moment of Seizure many were taken with a _Coma_, and slept as if they
were dozed with an Opiate; many in the middle of their Employ, with their
Friends in Conversation, or other Engagements, (as was before taken notice
of) would suddenly, without any Reluctance, fall into profound, and often
deadly Sleeps.

BUT by what Means this Venom does exert its narcotick Qualities, is not
with me so ready to be accounted for; that is to say, whether it be from
its original _Seminium_? Or from Its affinity and Complication with the
Scurvy? Or from its predominant Malignity, and Antipathy? Or from an
Obstruction of Circulation, or Coagulation, or Extravasation of Blood? Or
lastly, from some particular Impression made upon the Origin of the
Nerves? For this is a Difficulty reserved for another _Hippocrates_. In
the mean while it is by all confessed, that by such Stupefaction or
Sleeping, the pestilential Venom becomes not only more deeply rooted, but
also more cruelly affects the nervous System, and greatly weakens it.

THE first and most considerable Symptom of the second Class, is a Fever,
which (as was before said) was a constant Attendant upon the last
Pestilence; although indeed the Infection seemed to kill some before the
Blood and other Juices could rise into Fermentation; wherefore it may be
taken for granted, that most Persons were accompanied with a Fever. But
this Fever indeed was in some very low and concealed, though in others it
appeared openly; and he must be but little acquainted in physical
Practice, who hath not frequently observed, that in malignant Fevers their
Beginnings are hardly discernable, being accompanied with no Heat, no
Inequality of Pulse, and no Thirst, although secretly indicated by some
other lurking Symptoms; and the Manner in which such Patients expire,
demonstrates, that they could not be altogether free of a Fever. There are
many Circumstances indeed which make it thus difficult in the Accession to
discern its Approaches, as a Want of Turgescency of Blood in the Veins and
Arteries, through Defect of Room for such Commotion and Depuration, or
because the Blood is so thin, crude, and degenerate, that it cannot but
with Difficulty ferment and grow hot; or because the pestilential
_Miasmata_ seem at their first Insinuation so friendly to the
Constitution, as to stir up no remarkable Alteration in the Blood; or from
its cold and styptick Quality, retarding or suppressing such an
Agitation.

WHEREFORE no Body should conjecture, that there is no Fever at all, where
its manifest Symptoms do not immediately appear; but it most commonly
happened otherwise during the late Contagion, for that discovered Signs
apparent enough of its Presence, such as extream Inquietude, a most
intense Heat outwardly, attended with unquenchable Thirst within, Dryness,
Blackness of the Tongue, intolerable Heat of the _Praecordia_, and all
other usual Concomitants of a Fever's Accession.

AS to the Fever's Exacerbations and Remissions, it appeared by constant
Experience, that sometimes they were erratick and changeable, and at
others continued, without any Intervals; and it was also customary to meet
with some that wholly remitted for 8, 10, or 12 Hours. The Alternations
likewise of Heat and Cold were very various, and with some would change
several Times in one Hour, and with others the Periods would be at much
greater Distances; so also the recurring Accessions were sometimes milder,
and at others more severe. Those who with great Difficulty went through
the first Paroxysm, could bear the second with Ease, as being much
milder; whereas again the third or fourth Accession would be with
intolerable Vehemence and Fury: And at other Times the first Fit would be
gentle, and the subsequent very severe and intense; and truly such was the
Uncertainty and Disguise of this insidious Enemy, that nothing could be
prognosticated of its Attacks or Cruelty.

BUT to come at some tolerable Notion of the Reason for such Uncertainty;
it is to be enquired,

_FIRST_, What Cause can be assigned for such an uncertain Return of the
Paroxysms? And,

_SECONDLY_, What Reason can be given for the unequal Exacerbations when
the Fits do recur?

CAN any one doubt what Tumults and Disorders may be excited in the Blood,
and other animal Juices, by that saline _Seminium_ of a Pestilence, which
we have already described? The Uncertainty then of such Disorders must
regard either the morbifick Venom, or the Nature and Motion of the Fluids
upon which it operates: The morbifick Venom, in Proportion to its Energy,
and Disagreement in Figure, irritates Nature, always ready in her own
Preservation to expel the Enemy; but when her Exertions are slow, or
imperfect, or quite languid, such a Depuration is not obtained; but upon a
Remission of the Conflict, there is Space given for interval; and this
indeed happens, when the Nature and peculiar Figures of the noxious
Particles are such, as may in the first Struggle be broke and subdued, but
after some Truce insinuates its Virulence further into the Habit, and
imprints upon every Part the true Characteristicks of a fatal Pestilence.

BUT to subdue and throw out the Enemy, the Spirits are at continual
Strife, although their Efforts are not always successful; to dispatch this
Matter therefore in one Word, as the Assimulation and perfect Mixture of
the heterogeneous Particles procures a Motion regular and conformable to
the Blood, so from an Inequality and disproportionate Mixture, arises an
irregular Circulation and Fermentation, so that the Reason for that
Uncertainty in these Fevers, and their irregular Returns and
Exacerbations, is to be fought for in the Fluids and their circulating
Vessels, and not from any Corruption, or Degree of Putrefaction, according
to the Opinion of the Ancients.

AND as for my own Part, I can affirm, that I never could in any one single
Instance amongst the infected, find the least Impressions of Corruption in
the Blood; and this even those Empiricks, though unwillingly, confess,
who, to the vast Detriment of the Sick, let them Blood upon such a Notion;
none of them having been ever able to discover any Signs of Corruption in
their Blood, which as conscious of it self blushed for their fatal
Mistake, and in this Distemper commonly appeared more florid than at other
Times.

THAT the Times of the Paroxysms should be uncertain, I take owing to the
Inability of the Constitution to struggle with the pestilential Venom; for
as every Fever is accounted regular, where all its Changes are uniform and
distinct, by Reason of the managable and ductile Disposition of the
morbifick Matter; so, on the contrary, where the pestilential _Miasmata_
uncertainly exert themselves, and excite new Commotions, either by the
Obstinacy or Asperity of their Parts not yielding to Comminution, there a
Fever returns with inconstant and unexpected Exacerbations: But to hasten
to the subsequent Symptoms.

ALTHOUGH some (as before said) were buried in Sleep, yet others suffered
by a very different Extream, and kept continually waking, insomuch that
frequent Repetitions of the most efficacious Opiates could not procure the
least Composure; in which Case, it is my Opinion, that the Membranes of
the Brain are pricked and vellicated by poisonous _Spicula_; besides which
also those soft, dewy Moistures upon the Brain, necessary for its
Relaxation to sleep, are dissipated and exhaled by the burning Heat of the
Fever; so that the Spirits are, as it were, set on Fire, and Inflammations
raised, not to be again extinguished, and frequently likewise
Sphacelations of the Brain.

BUT the most remarkable Symptoms of this Class, is the Palpitation of the
Heart, the Ancients conjectur'd that Pestilential _Aura_ to have a
specifick Contrariety to the Nature of that Organ; and it must be
confessed that in the late Sickness this Complaint was very grievous; but
yet I cannot see how this Venom should more particularly be pointed
against the Heart than any other of the _Viscera_, unless in Consideration
to the greater Importance of its Office in the OEconomy.

As soon as the subtile Poison of a Contagion hath insinuated it self into
the Mass of Blood, either through the Pores of the Skin, or other more
open Passages, there is no doubt, but it imprints upon it very malignant
Qualities, which, according to the necessary Laws of Circulation, must
arrive at the Heart it self, and affect it with Uneasiness, so that its
Palpitation is nothing else than its Struggles to throw off what is
Offensive; and it is no wonder to me this happens, because the Heart is
composed of such a Contexture of Fibres; for as the Pestilential Venom
hath somewhat in it of a saline Nature, and what is acrid, it very
naturally stimulates the nervous Parts, and gives to this Organ even
convulsive Motions; but of this matter every one hath leave to judge for
himself.

BUT how vehemently the Heart may beat on this Occasion, appears very
manifest from a remarkable Instance; I was sent for to a Youth of about
fourteen Years of Age, who had continued free of the Infection, after his
Mother and the rest of the Family had been visited by it, when all on a
sudden he was seized with such a Palpitation at Heart, That I and several
others could hear it at some considerable Distance, and it continued so to
do till he died, which was soon after; many Medicines being given without
any manner of Success: But in so extraordinary a Case as this, I am apt to
conjecture it rather owing to a Pestilential Carbuncle seizing the Heart
it self, than from the Vellication and _Stimulus_ only of pungent
Particles passing through it.

BUT to go on in the Enumeration of Symptoms, Sweat deserves mention,
because sometimes it breaks out in such Profusion as if the whole
Constitution was dissolved, and with a vast Loss of Spirits and Strength,
to the imminent Danger of the Patient, by such a Dissipation of Spirits,
such a Colliquation of the Balsam of Life, and an Extinction of the
natural Heat. And indeed I know nothing that more powerfully attenuates
the Humours, and more suddenly puts all the animal Juices into Fusion, so
as to run them through the Pores of the Skin, and the pestilential
nitro-aereal Poyson; and by whose colliquative Quality even the fleshy
Parts are dissolved and exhaled in vapour.

THESE Sweats also of the Infected are not only profuse, but also variously
; in some of a citron Hue, in others Purple, in some green or
black, and in others like Blood; which I take to be from the various
Dispositions of the morbifick Venom, to give different Tinctures to the
Humours: And by this Means some experienced Nurses could prognosticate the
Event of the Distemper from the Colour of the Cloaths or Linen tinged with
the Sweat.

THE Sweat of some would be so fetid and intolerable, from a kind of
Empyreumatick Disposition, possibly, of the Juices, that no one could
endure his Nose within the Stench; sometimes it was sharp, and in a Manner
caustick; and hence it was easy to judge from what Origin the Pestilence
derived its Qualities, _viz._ From a sharp and burning _Ichor_, that would
even excoriate the Parts, and sometimes vesicate them, as if scalding
Water had been poured upon them.

SOMETIMES cold Sweats would break out, while the Heat raged inwardly, and
excited unquenchable Drought. Some continued in a Profusion of Sweat until
Life it self exhaled with it, while others had short Intervals of Truce
and Cessation; nay, some at the same time sweat on one Side, while the
other was quite parched with Dryness.

BUT the Benefit of this Evacuation, when it was regular, either natural or
by Art, was so manifest, that all the Infected that recovered were
sensible of it, and greatly rejoyced at its good Effects; for those
pestilential Particles, which eluded the Power of all other Means,
immediately upon a Sweat, as at a common Signal, made their Escape with
the transpiring Steam; but whensoever Diaphoreticks could not conquer the
Coagulation, Viscidity, or Obstinacy of the pestilential Poyson, it
always went very bad, being commonly followed by a Symptomatical Sweat,
and a fatal Separation of the animal Fluids.

YET the Energy of the pestilential Contagion not only freely discovered
its self in these Profusions amongst the Living, who (as already observed)
were dissolved as in an _Helodes_ and a _Typhodes_, but commonly the very
Carcases when dead, would weep out, as it were, the morbid Ferment, both
through the cutaneous Pores, and the common lachrymal Ducts of the Eyes.

THERE is no Occasion to say much concerning Hemorrhages at Nose; this
Symptom happening much more often from the Colliquative Nature of the
Poison, and its Erosion of the Vessels, than from a Plethora; as is
evident more from the ichorous Colour of the Blood than its continual
Distillation from those Vessels.

Were it not here that we study all possible Brevity, many other Symptoms
might be enumerated which commonly attended this pestilential Fever, as
Heat of the _Praecordia_, Hiccup, Gripings, _&c._ all which I at present
pass by, and close the whole with such as are more peculiar to it,
particularly those poisonous Vesications commonly called _Blains_.

THESE Vesications used commonly to rise with an exquisite and shooting
Pain, containing a serous Humour or _Ichor_, for the most part of a
Yellowish or Straw Colour, and encompassed with a variegated Circle,
generally Reddish.

THESE Pustules broke out in many Parts of the Body; and as their Station
was various, so their Number was also uncertain; in some they were few, in
others many, and a Woman I once met with covered all over with them; as to
their Bigness, they were also uncertain; for some were as a small Pea,
while others increased to the Magnitude of a Nutmeg.

THE included Matter (near perhaps to the Nature of Urine) was altogether
incapable of Suppuration, as it was saline and almost caustick; for very
soon after its Eruption it would corrode its Vesicle, and burst out, of a
Colour yellowish, livid, or black. Moreover, the surrounding Circle was
not always of the same Appearance, although at first coming out it was
continually inflamed.

BUT this is highly observable, that sometimes these Vesicles broke out
without any other previous Indications of Infection, and, as I imagine,
from the expeditious Separation of the pestilential Venom, and the sudden
Conquest of the Distemper by a strong Constitution: But whensoever the
Pain and Heat of the Part was so aggravated, that no proper Applications
would asswage it, there was commonly Danger of a Mortification from so
great a Concourse of pestilential Particles together; and once I remember
a Vesicle to change into a Carbuncle, from the continued Accession to it
of fresh morbifick Poison.

WE come now in Course to speak of Buboes, which were hard and painful
Tumours, with Inflammation and Gathering upon the Glands, behind the Ears,
Arm-Pits, or Groin.

THESE Tumors immediately upon Seizure are found so hard, that they will
not at all give Way to the Touch. In some these were moveable, and in
others fixed; but after some Time this great Tension remitted; and it was
common to prognosticate the Event of the Distemper from their sudden or
slow Increase, and from their genuine or untoward Suppuration, as also
from the Degrees of Virulence in their Contents.

THE Groans and unfeigned Tears of the Sick too plainly expressed the
Aggravations of their Miseries, and some seemed even to drown their Sense
of Pain with their Complainings; and this Intenseness of Pain cannot be a
Wonder to any, who duly consider either the Nature of the pestilential
Venom, or the Constitution of the Glands. I have already so largely
discoursed of the Virulence and corrosive Qualities of the pestilential
Poison, that no more need here be said about it; and whosoever examines
the Glands will find, that from the great Distention of the Vessels, in
this Case, the Buboes must chiefly owe their Rise to a Correspondence
between the Nerves and Lymphaticks, and the Juices they contain.

MANY Persons of publick Note have elegantly given the Anatomy and Use of
the Glands; it is therefore sufficient for my Purpose here to shew, how
from an Obstruction of those Juices, which flow through the larger Nerves,
particularly of the Arms and Thighs, and their subservient Vessels, and
their Impregnation with heterogeneous and poisonous Particles, Buboes do
arise.

IF any one makes it a Doubt, why these Tumors should rather come in the
above-mentioned Places, rather than on the _parotide_ Glands, let such
consider, that it is owing to the Magnitude and Capacity of the Nerves and
Vessels constituting the Glands of those Parts; as also that their
different Dispositions to Suppuration does proceed from the same Cause.

BUT that this Affair may more fully appear, it is to be discovered from
what Source that Matter flows, which degenerates into Matter, and
discharges from a Buboe in so great Plenty.

IN the Prosecution of this Enquiry, it shall not be without a Colour, at
least, of Reason, that I shall dissent from an Opinion both of Ancients
and Moderns, about the Blood alone being immediately changed into Matter;
for I rather think it to proceed from other Juices; and this I shall
endeavour to support by the following Arguments.

AND first of all, notwithstanding the Blood which runs in the Arteries and
Veins does sometimes, though very seldom, appear whitish; it then happens
from too great a Mixture either of nutritious Juice, or of a degenerate
Chyle, that will not easily change, and take its red Colour; but it never
passes into Matter, because the necessary Conditions of Circulation will
not admit of so much Rest as is requisite thereunto; besides, even the
extravasated Blood will not easily undergoe such an Alteration: For when
any Vessels, and chiefly the Capillaries, are so obstructed by Contusions,
or any other Means, that the neighbouring Parts swell, every Physician and
Surgeon too, I hope, knows that discutient Medicines and Cataplasms will
restore the former Motion and Fluxility to the Blood, ease the Pain, and
dissipate the Tumour.

IF the Blood be too fluid in the Arteries, it is apt to occasion
_Anareusms_, and in the capillary Veins an _Ecchymosis_; but nothing is
more commonly observed in Practice, that upon a Recovery of the Blood's
due Constitution and Circulation, the obstructed Matter in an _Ecchymosis_
will dissipate through the Pores of the Skin, or be absorbed by the
refluent Blood: But when the Blood happens to be too grumous and stagnate,
a Fever immediately arises, unless it be prevented by Evacuation; and in
such a Disorder every one knows that there is most Danger of a _Schirrus_,
or a Mortification.

AND as it hath been already observed that Blood could not be drawn from
the infected by Phlebotomy, without Loss of Strength, if not of Life,
whereas the greater Quantities of _Pus_ were obtained by Suppuration of
their Buboes, the Patient was so much the better for it; it seems
consonant to Reason, that if _Pus_ was generated immediately from the
Blood, the Strength would as much decay upon its Loss, as upon Phlebotomy:
But I have always found it, (as many Times already observed) that how
little soever the Quantity of Blood drawn away was, and although done at
several Times, yet it proved of more Prejudice to the Patient than an
hundred times as much Matter drawn from a Buboe; and that the whole
remaining Mass was not able to recruit the Loss sustained thereby.

IF they who espouse a contrary Opinion, should suggest that Blood may be
drawn from a Tumour imperfectly suppurated, and from thence conclude, that
its Origin was from the Arterial and Venal Fluids; it may be readily
answered, that on opening a fresh Tumour, a bloody _Ichor_ will flow out,
because in the Operation some Blood-Vessels will be cut; whereas when the
Tumour is in Maturation, the Quantity of Humour there collected obstructs
the Blood from flowing to it through its proper Vessels; and which Humour,
altho' in it self at first more thin and crude, yet by the Heat of its
neighbouring Parts, and its own natural Disposition, it will afterwards
thicken, and change into a white Colour of a laudable Consistence.

_THIRDLY_, To the foregoing it may be added, that so far as the Blood
partakes of a saline Quality, by so much the less will it be disposed to
change into Matter; for the same Reason that Sea-Water cannot be boiled
into a Gelly; for Salt adds to the Fluxility of Fluids, and thereby
prevents Incrassation, unless in those Instances where they of themselves
chrystallize, by Means of an Incapacity of the _Menstruum_ to keep them in
Solution, which is foreign to the Case before us.

LASTLY, Nothing is more known in Nature, than that Blood, by what Means
soever extravasated, if it cannot get back again into the Vessels, will,
after some Stagnation, run for the most Part into Grume; so that when a
Fluctuation requires opening, little else than a coagulated Blood flows
out: And if any one please to receive the Blood from an opened Vein into a
warm Porringer, and afterwards place it in a luted Vessel upon a Sand
Heat, as near as possible equal to that which is natural, he will find all
Labour lost in endeavouring to produce thereby any Appearances of _Pus_ in
it, either from its Colour, Smell, or any other of its requisite
Properties.

WHY then may we not conclude with some others of great Note, that _Pus_ is
generated immediately from the nutritious Juice, not in the Arteries and
Veins, but in other Vessels; in which Juice all the requisite Properties
are to be found, as a Disposition to grow thick, without Smell, white,
light, and of a smooth Consistence; and I take it to be very probable,
that the _Pus_ is made from hence by the Assistance of the natural Heat,
and the Conveyance of it by the forementioned Vessels into the Glands
whereinto they are complicated, and not by any Means from the Venal Blood,
and much less from the Arterial.

BUT least I should seem to digress too far; the _Sanies_ thrown out by a
Buboe is very different, sometimes thin and ichorous, at others thicker
and more laudable, as in Abscesses that are not malignant; in Respect of
its Smell, it is sometimes so extreamly fetid, as not to be endured by the
Nose; but always the more plentifully it discharges, the better does the
Patient fare afterwards: Nature finds a Vent this open Way to disengage
her self from a pernicious Enemy.

THE Number of Buboes was uncertain, sometimes one only appeared, at
others, which was most commonly, two broke out at once; nay, there were
met with Instances wherein all the Glands capable of it were tumified.
Many Buboes at a Time infallibly demonstrated the Aggravation, and
Dispersion of the virulent Taint; and on the contrary, but few shewed the
Poison to be not so prevalent, more contracted, and brought to a narrower
Compass for Expulsion.

The Places, and Manner of their Eruption was very uncertain, sometimes one
would appear in the right _Axilla_, and another on the contrary Side of
the Groin; these Tumours would likewise sometimes last but a Day, and
again insensibly vanish, that is, always when profuse Sweat arose; but
whensoever they were drawn in again by any Mismanagement or Casualty, they
would appear and vanish again many Times, and be very difficult afterwards
to be fixed; and sometimes when they could be brought to Suppuration, and
a plentiful Discharge, they would renew again, as we shall hereafter have
further Occasion to observe.

THE _Parotides_ borrow their Names from the Glands affected, which grow
behind the Ears; but these Tumours are not to be distinguished from others
but by their Situation, and therefore require not any particular
Description here, so that amongst many Instances I shall give but one to
discover their Nature; In a certain Youth there arose a _Parotis_ on each
Side, behind the Ears, which after Suppuration and Incision, let out great
Quantities of _Pus_, and were afterwards by a Surgeon healed up; but the
musculous Flesh was at this Time so wasted, as to discover a Sight as
pleasant as strange, _viz._ the external jugular Veins, with the Arteries
under them, the recurrent Nerves, the Tendons, the OEsophagus, and in
short all the Vessels quite bare and untouched; but upon the Patient's
Recovery all filled up as before with new Flesh.

A Conjecture of _Diemebrooeck_ comes here in our Way to examine; he will
have it that Buboes are produced from an Ebullition of a saline and an
acid Humour meeting together, like a Mixture of Salt of Tartar and Spirit
of Vitriol: But whence can such a vast Coagulation arise? Indeed I do not
deny but that a Tumult and Bustle may be occasioned by the Concourse of
such Principles, as also that from such a Colluctation some saline
Particles may be precipitated; and it must further be allowed, that a Part
will inflate and swell while such Fermentation continues; but yet I cannot
apprehend how _Pus_ can be generated by such Means; for by an Effusion of
such a Mixture the _Serum_ would be more changed into a _Lixivium_, than a
purulent Matter; after the Conflict likewise is over, the Tumour would
immediately subside and vanish; but, on the contrary, Buboes daily and
gradually come to their Height of Suppuration: But I shall not detain the
Reader on this Head any longer, but proceed to a Description of a
Carbuncle.

A Carbuncle then is a small Eruption, whose Contents are soon discharged,
after which it appears in a crusty Tubercle about the Bigness of a Millet
Seed, gradually spreading, and encompassed with a very red and fiery
Circle; arising first of all from an ichorous Humour, afterwards with
great Pain and Heat, from a lixivious and caustick Poison.

THAT I may dispatch as much as possible in a few Words, it now lies before
me to describe the common Method of its Eruption; in the Beginning is a
sharp pricking Pain upon the Part affected, which in a little Time grows
very hot, and then lifts up the Cuticle into a Blister, containing a thin
_Ichor_; but after the Vesicle is by rubbing or any other Accident broke,
and the contained Fluid by Heat dissipated, its caustick Quality leaves an
_Eschar_ behind, which crusts over, in some sooner, and in others later;
its Extension is various, sometimes more broad, and at others more
contracted; nor is its Colour more certain; in the greatest Degree of
Inflammation it is extreamly red, but for the most Part it is dusky, very
often livid, and sometimes, from the peculiar Virulence of the
pestilential Poison, even quite black.

BUT as there is a Quality in the pestilential Venom not yielding even to
an actual Cautery, and from which in the Production of Carbuncles
_Eschars_ are generated, I take it to be of Consequence to know how such a
sharp, burning, and caustick Humour comes to be bred in an humane Body;
and by what Contrivance of Nature it comes to be thus separated and thrown
out?

AND in an Affair of this Difficulty, I expect to be candidly set right by
any one who thinks me mistaken. The whole Tribe of Diseases an humane
Constitution is subject to, does undeniably prove that our Bodies are
capable of producing many venomous Taints, even equal to any Thing in the
Air or the Earth; nay, the Histories of Physick give many Instances of
poisonous Insects and Animals bred within us; and no one can be ignorant,
that besides the Disposition of corrupted Humours within us to generate
such Creatures, that their _Semina_ are often brought to us from without:
And this is very manifest in a _private_ Pestilence, (if that Term may be
allowed me) where, without any Help from external Contagion, not only a
poisonous _Seminium_ may be generated, but Carbuncles also may break out;
that is, from the peculiar caustick Quality of saline Particles in the
Body.

WHEREFORE if this can be done in a _private_ Pestilence, what may we not
expect from a Pestilence that is the Consequence of an Epidemick Cause;
for the additional Assistance of a more powerful saline Principle from
without, cannot but greatly actuate the animal Juices, and induce a
compound Malignity abundantly sufficient for the Production of
pestilential Carbuncles.

THE more aggravated therefore the saline Qualities of this foreign saline
Principles shall be, and in Proportion to the Quantities of it insinuated
into the animal Fluids, the Carbuncles will break out more or fewer,
sooner or later; although as long as the pestilential Poison flows in
Company with other Fluids within the Vessels, it seems more mild, because
then diluted, than when separated and thrown upon the Skin by the natural
Excretory Powers. And this Expulsion of it seems much to be assisted by
the common Tendency of serous Particles towards the Surface, and the
Congress of nitro-aereal Particles therewith; but nothing however is more
manifest than that when the pestilential Poison hath got to the Surface,
it exercises its Virulence upon all the Parts it touches, and leaves cruel
Marks of its Triumph behind; the same as which likewise obtains not only
from an epidemick Pestilence, but upon drinking any poisonous Draughts.

BUT it concerns us here to remove one Mistake; For it is laid down by
_Diemebrooeck_, in Opposition to the common Opinion, that a Carbuncle is
nothing else but an actual Gangrene; for if any Credit may be given to our
Experience, which we look upon to be as well founded as that of this great
Man, I do not remember any Carbuncles (unless where there hath some
manifest Error been committed in external Applications, or the Virulence
of the Pestilence hath been greater than ordinary) to have tended more to
a Sphacelation, than any other Consequences of the pestilential Poison.

And were there not innumerable Testimonies to the Truth of this, many
Arguments might be alledged in its Vindication; for while there is a free
Influx of vital Spirits, and other natural Fluids, into the Part affected;
while the native Heat is preserved from Suffocation, and Putrefaction is
prevented, what Person can imagine there to be any particular Disposition
to Mortification in a single Carbuncle? And the more especially when the
Spirits are so far from being intercepted by the Carbuncle's Eruption,
that they flow more plentifully to the Part; when the native Heat is so
far from being suffocated; that by its Assistance a salutary Separation is
made; and lastly, when the Part affected is so far from Putrefaction, and
rendered more humid than before, that these saline Particles of an
escharotick Quality, rather prevent Mortification, and by drying the Part
make it rather more able to resist such a Change: And according to the
best of my Remembrance, I never did meet with a Carbuncle that mortified,
unless from the Mismanagement or Carelesness of Surgeons, or when the
highest Degree of Virulence in the pestilential Poison had not occasioned
an immediate Sphacelation.

NO Part of an humane Body was free from the Eruption of the Carbuncles;
And I shall not exceed the Truth if I affirm that I have met with them at
one time or other in all Places. But this Matter will yet appear more
fully beyond Contradiction, when I shall have brought a few select
Instances out of a great Multitude, to put it quite out of Dispute.

A Girl of about 12 Years of Age, felt a grievous Pain about her Breast,
where quickly after the Appearance of a Pimple, there broke out a
Carbuncle; the _Eschar_ at last came off, and the Ulcer discharging some
Matter plentifully; after about twenty Days she was reckoned to be very
well, had not a Surgeon too rashly dressed her with the _red drying
Ointment_, in order to cicatrize it; for upon that the Pestilence appeared
again, and killed her in about three Days, undoubtedly from a Return of
the Venom inwards before it was all discharged.

ANOTHER Case, almost beyond Belief, were it not attested by many
Eye-Witnesses, was of a Woman, who immediately after Delivery had a
Carbuncle appear upon her Breasts, when the Infant sucked all the Time
without Harm, and the Woman, through the Favour of the Season, and exact
Care in all Respects, recovered. I was also another time called to a Man
of advanced Years, whose whole Thigh and Hip was over-run with a
Carbuncle, but the Vesication was made by such an ichorous _Serum_, that I
strongly suspected a Mortification; I complained of being called so late,
but however ordered a deep Scarification, and other Means suitable,
whereupon there grew some Hopes of Separation, but for Want of inward
Strength and Spirits, the Patient died; whereas another of a more vigorous
Habit, was recovered in the same Case, for no other Reason, but that there
was Strength enough to carry him through it. Moreover, I once met with a
Buboe and Carbuncle together in the Groin of a Boy, not above two Finger's
Breadth of each other; but by due Means, both medicinal and chirurgical,
the Lad got well from both his Ails together.

A certain Merchant had a Carbuncle upon his Arm, a little below the
Elbow, but what was most unhappy was, that at the Beginning he was so
Impatient of the Pain, that he applyed a Cooling Cataplasm to it of his
own ordering, for suddenly thereupon it changed into a Gangrene, to
obviate which, Scarrification was immediately had recourse to, in the
Execution of which, the Surgeon inadvertently cut a large Vein, which
caused such a Flux of Blood, as could not be stopped by either actual
Cautery, or any other Means; whereupon followed such a Sinking of his
Spirits, that the unfortunate Gentleman died in three Hours time.

LASTLY, A Carbuncle appeared on the Finger of a young Woman, to eradicate
which, we took all imaginable Care; and all Things at first seemed to
answer our Wishes; but the Uncertainty of humane Expectations! for the
Patient with her old Nurse Supping plentifully upon _French_ Beans, that
very Night the Distemper returned; and although she vomited as much as her
Strength would bear, by the Provocation of an Emetick given her, after
which were used the most Cordial Remedies, and the most warm
Alexipharmicks, early in the Morning, a fresh Carbuncle came in the Place
of the old one; she was delirious all that Day, and in the Evening she
expired. After the Bearers came that Night to bury her, and talked of
fetching away the old Woman next, as a Person dead, the poor Wretch, as
awakened from Sleep, cried out, she was not dead; but she disappointed not
their Agreement, and died time enough to be carried away the same Night to
the burying Place.

I might easily imploy a Volume in a Recital of all the particular
Circumstances of these Carbuncles; but however, before I dismiss this
Subject, I cannot omit that the pestilential Venom was in a very great
Manner communicable from one Carbuncle to another; or to speak perhaps
more properly, the saline Virulence of a Carbuncle would generate another
wheresoever it lodged.

THE Number of Carbuncles was undeterminate, sometimes two, three, four, or
more, would come out at once, the pestilential Venom being diffused to
many Parts at the same Time; but the rest we shall leave to that Section
concerning the Cure of Carbuncles; we shall here therefore subjoin
somewhat concerning pestilential Spots, called _Petechiae_.

THE _Petechiae_ then are little Spots upon the Skin, not easily
distinguishable from a Flea-Bite; though this Difference may be observed,
in a Flea-Bite there may be seen a Puncture in the middle, where the
little Creature had struck in its Teeth, and round it an Inflammation,
with a little extravasated Blood: But these Spots are more uniform in
their Colour, more fixed, and difficult to be removed, whereas upon any
Pressure with the Finger a Flea-Bite gives Way, except in the central
Puncture. Furthermore the pestilential _Petechiae_ are to be distinguished
from the Spots of a malignant Fever, as they are deeper ; and
likewise to be known (as before observed) from Scurvy Spots, which are
much broader, and not always exactly round; although these are likewise
sometimes intermixed with the pestilential ones, and by Means of the
aforementioned Affinities between them, hardly in some Cases to be
distinguished.

TO this it may be added, that the pestilential _Petechiae_ do not always
fix in the same Parts, and sometimes they disappear, after a short Stay
in one Place, and immediately rise in others: And indeed there is no Part
altogether exempted from them, although they chiefly come out in the Neck,
Breast, and Back; whereas those of the Scurvy come mostly in the extream
Parts. The Reason of this in the former Case may probably be from the
Proximity of the larger Vessels, and the Largeness of the Pores about the
Trunk of the Body; and in the Scurvy, the Legs particularly are most
spotted, from the Tendency and Precipitation of the saline Particles
downwards.

THE Spots were sometimes few, but most commonly very numerous; in some
they were so thick, as to cover in a manner the whole Skin. I saw a little
Girl that was all over full with them, but upon a large Sweat arising,
they all disappeared, and she recovered; yet sometimes the Distemper was
so delusory, that these Spots would arise, and disappear, and come out
again, for several Times; that is, when Nature gave its utmost Efforts to
expel the Poison, they might be seen upon the Surface; but when the
Spirits languished, or upon any external Cold, they would go in again.

I might here conveniently observe, that this Eruption was almost always
symptomatical, and very rarely critical; the Colour of them was not always
the same, sometimes they were red, or purple, at others yellow, and
sometimes livid or black, according to the Nature and Energy of the
morbifick Venom, and its Complication with other Contingencies; and hence
we naturally pass to the essential Characteristicks of a Pestilence.

THE genuine pestilential Characters, by the common People amongst us
called _Tokens_, as the Pledges or Fore-warnings of Death, are nothing
else than minute and distinct _Blasts_, which have their Origin from
within, and rise up with a little pyramidal Protuberance, having the
pestilential Poison chiefly collected at their Bases, and, according to
the accustomed Dispersion of such Agents, gradually tainting the
neighbouring Parts, and reaching to the Surface, as the Configuration of
Vessels and Pores are disposed to favour their Spreading.

MOREOVER these Blasts were derivable from external Causes, as from the
Injuries of Air, where the pestilential _Miasmata_ were pent up and
condensed, and by that Means their Virulence increased to that Degree,
that Life it self was immediately extinguished, upon coming within their
Reach. Nay, some were so suddenly marked with these fatal Characters, that
they did not before find themselves in any other Respect out of Order;
which is a Circumstance so well known, that there is little need to
confirm it by particular Instances, however, for the Reader's
Satisfaction, I shall recollect one or two Facts of this Kind.

I was called to a Girl the first Day of her Seizure, who breathed without
any Difficulty, her Warmth was moderate and natural, her Inwards free from
glowing and Pain, and her Pulse not unequal or irregular; but, on the
contrary, all Things genuine and well, as if she had ailed nothing; and
indeed I was rather inclined to think she counterfeited being sick, than
really to be out of Order, until examining her Breast, I found the certain
Characters of Death imprinted in many Places; and in that following Night
she died, before she her self, or any Person about her, could discern her
otherwise out of Order.

Some time after I visited a Widow of Sixty Years of Age, whom I met with
at Dinner, where she had eat heartily of Mutton, and filled besides her
Stomach with Broth; after I had enquired into several Particulars relating
to her Health, she affirmed her self to have never been better in her
Life, but upon feeling her Pulse, I perceived it to intermit, and upon
examining her Breast, I found an Abundance of Tokens, which proved too
true a Prognostick, that even after so good a Dinner she would by the
Evening be in another World.

AS to the Eruption of these fatal Characters, I judged them to be rather
the Effects of the pestilential corrosive Salt, than of any Putrefaction
of the Humours; for this Poison wanting room for Exhalation through the
Pores of the Skin, collected in Quantities upon the Surface, and for want
of Spirits to strive therewith, imprinted these Marks thereupon.

FURTHERMORE these external Parts not only grew dry from the Acrimony of
this Venom, but were also very liable to Sphacelation by an Extinction of
the vital Spirits; but enough of this, because it would be but adding
Light to the Noon-day Sun, to endeavour to confirm it by more Testimonies.

THESE _Tokens_ did differ in Regard to their Colour and Hardness; of their
Colour we shall speak hereafter: Their Hardness I used to try with a
Needle or Penknife, to see whether the Sense and Life was perished or not;
in which Trials I found a great deal of Difference, as some would be
penetrated with very little Trouble, when others were even callous and
horny, and difficult to be penetrated. The Origin of these I conjecture to
be from the nervous Juice, or some gelatinous Substance evaporated into a
gummy Consistence, not unlike those horny Excrescencies from the Bones;
their Colour and Affinity in many Respects with Wharts is also
remarkable.

AND here I cannot pass by an Instance worth Observation, of a Girl who
came to my House full of Sadness and Consternation, already even to sink
down; upon Examination she told me that she had broke out from an House
where she was shut up with a Nurse, all the rest of the Family being dead,
to shew me the certain Forerunner of Death upon her, saying she had the
_Tokens_ upon her Leg; but I soon found a Mistake that might have been
fatal to her, for it was only a Whart, which neither she nor the Nurse had
ever taken Notice of before; she was soon undeceiv'd, and by my
Encouragement shook off all her Fear; returning Home chearful to take
those Medicines which were directed to carry off the Disorders upon her,
and sweating her plentifully removed all Suspicion of the Contagion: But I
really believe, that had not her Mind been soon made easie, by what was
said to her, she would have died merely by the Force of her Imagination;
as such a Dread extreamly aggravates the least Complaints.

BUT some of these _Tokens_ were not only so like in Appearance to Wharts,
that they deceived this young Girl, for sometimes even the Surgeons
mistook them; and I was beholden to the Management beforementioned of
pricking through them to be satisfied sometimes my self, as well as to
know the Degrees of Malignity in the Venom of the true _Tokens_; where I
found quickly a Sensibility, I took it for a good Sign, and those which
went no further than the Skin, would oftentimes slough off; whereas when
they went deeper, they were deemed dangerous, especially when the Part
lost its Feeling, and threatned Sphacelation. There were likewise some
found so extreamly comatous, that the whole Body was deprived of Sense;
insomuch that if any Limb, or Part clear of the _Tokens_, was tried by
Puncture, or Incision, there would be no more felt than upon the deadly
Marks themselves; notwithstanding which Insensibility of Body, some
Faculties of the Mind would return and be perceived even till Death.

THE _Viscera_ also, as well as the external Parts, would sometimes be
marked with these Characters, nay, sometimes it appeared, that the Inwards
were affected, when nothing of the _Tokens_ were seen externally.

THE Magnitude of the _Tokens_ were various, sometimes as small as a Pin's
Head, and at others larger, and as broad as a Silver Peny; there were
indeed Instances of many running into one, but this was but seldom in the
late Sickness.

LASTLY, Some were depressed, and others prominent, and some did not appear
till the infected Person was dead; so that it did not suffice to kill, but
also to leave Marks of its Triumph; but some of the crafty Nurses would
put the dead Body immediately into wet Cloaths, whereby they stopped the
further Fermentation of the Juices, and restrained such Eruption, in Order
to elude the Magistrates Notice and Power, to shut up the Houses.

BUT how much soever these deep Marks were the sure Fore-warnings of Death,
yet sometimes they would be out from the fourth Day before, and remain all
that while as terrible Admonitions both to the Sick and others.




                              SECTION VI.

            _The Prognostick Signs of the late Pestilence._


AS that Pestilence which of late made so great Havock amongst Mankind, was
so full of Shiftings and Changes in its Attacks and Progress, that very
little Certainty could be had of its Event; it highly concerns the Credit
and Honour of the Faculty, not too hastily in such Cases to prognosticate
either Recovery or Death: In Order therefore to remove, as much as
possible, such Difficulties for the future, it is with Cheerfulness that I
can leave with Posterity those Observations which I have been able to make
in my daily Attendance upon the Infected, to the utmost Hazard of my Life,
through the Course of this late Sickness.

THE prognostick Signs then regard either the Pestilence it self, as to its
Origin, Heighth, and Declension, or the Recovery or Death of the Patient.

_FROM certain and undoubted Signs, for some time foregoing the manifest
Eruption of the Plague, may its Degrees of Severity be prognosticated._

AS sharp and immoderate Pains apparently denote a pestilential
Constitution, and likewise Tumours breaking out again upon Parts before
affected: For it is a Case that I have often met with, that those who have
had Buboes and Carbuncles in the Sickness well cured, to break out again
afterwards, from some Remains of the pestilential Venom yet lurking in the
Constitution, and not to be conquered.

WHENSOEVER chronick Diseases are changed into acute ones, it may be
concluded that the Infection is not far off; For Valetudinarians are more
sensible of any approaching Disorder than those who are strong and
healthful: And from a natural Cause may it be accounted why infirm
Constitutions can certainly foretel several Changes in the Air, and be
forewarn'd of other external Inconveniencies; and the more virulent any
Infectious _Miasmata_ are, the sooner do they affect such Habits; and it
seems peculiar to the Plague to be preceded by its pernicious _Effluvia_,
like so many Officers seizing the Weak and Helpless first; and such it
tyrannizes over by converting the morbid Humours into its own Nature, in
subtilizing those which are gross, acuating the dull, heating the cold,
changing the natural Ferments, and in short, by inducing opposite
Qualities into the whole Constitution.

MOREOVER, in this Regard we may consider the frequent Mortalities amongst
Cattle, which foregoe an Infection amongst Mankind; for these Creatures
living for the most Part, both Night and Day, in the open Air, not only
are more influenced by it when tainted, but are also hurt by the
infectious Venom which gathers upon the Herbage; as likewise they are more
liable, on other Accounts, to feel its first Approaches, because its
freest Progress is in open Places.

MOREOVER, when there is a general Sadness and Consternation upon the Minds
of the People from no manifest Cause, so that the whole Multitude are pale
and spiritless, who can think but that some general Calamity is at Hand?

AND certainly this will not appear a very difficult Conjecture, and remote
from Reason, when we duly consider the strange Intercourse and Familiarity
which the Spirits maintain with Things very occult, and at a Distance; for
whosoever rightly weighs this Matter, will perceive the Spirits capable of
very subtile Impressions, by Means of their Intercourses with the
Imagination, whereby they are capable of perceiving, though obscurely, any
approaching Evil, and consequently of exciting amongst the Populace a
general Apprehension concerning Futurity, without any miraculous
Influence.

LASTLY, All fore-bodings of any Kind denote the Malignancy of the
approaching Evil, because they are manifestly from the Influence of the
pestilential _Miasmata_; and the further off such Impressions are made,
the greater do they prognosticate the future Calamity will be; because
such Irradiations at a Distance, and propagated through a long Tract of
Air, denote the great Energy and Virulence of their Origin; when therefore
the Pestilence seldom appears without such Fore-warnings, and gradually
diffuses according to the greater or lesser Liberty for the nitro-aerial
Poison to move in, and the first Perceptions of it are so terrible, what
Miseries and Desolations may not be expected from it, when it is arrived
in its full Force?

_A Pestilence that is fierce and deadly in its first Attack, soon ceases._

I call such a Pestilence fierce, that immediately destroys the strongest
Constitutions, and which being every where diffused, seizes all at once;
for the sooner the venomous _Seminium_ is spread and wasted, the sooner
will its Fury be over.

_THE Times of a Pestilence in its Decrease, are in Proportion to the Times
of its Increase._

FOR the infectious Poison does not act precariously, but in a regular and
uniform Manner, as it fully appeared by the Course of the late Sickness
amongst us; (not to mention others at a greater Distance of Place and
Time) but this will be best made appear from the Tables of Mortality
hereunto annexed.

_The Cause of a Pestilence being removed, spent, or extinguished, its
Effects immediately cease._

AS Fire goes out when its Fuel is wanting, or spent, so the pestilential
Virulence continually wants somewhat to keep it up, and no longer than it
is supplied with that necessary _Pabulum_ will it last: Although I
acknowledge that sometimes these fatal Sparks will lie as it were
smothered in their own Ruins, for some Time, and after a certain Interval
break out again into its first Fury, from the original Cause that as yet
hath never been extinguished. And hence perhaps some may be led into an
Error about the Plague's being co-aeval with the World, and its continual
Subsistance in one Place or another, as external Circumstances favour its
Propagation or Hindrance; for the very Increase of the pestilential
_Seminium_, after every Interval of Recess, plainly shews it to take fresh
Root; and upon the total Extirpation of it, I cannot see how the same can
appear again: And this is confirmed by the almost continual Varieties in
different Infections.

WE now come in Course to speak of those Prognosticks, which regard the
Death or Recovery of the infected.

_Every Hemorrhage is bad, but a Flux of the Menses always fatal._

_A Looseness of the Bowels, especially in the Beginning, is commonly a
Sign of Death._

BECAUSE by this Evacuation a _Diaphoresis_ is prevented, the Strength is
wasted, and the Poison is so far thrown upon the Bowels, as sometimes to
induce Sphacelation; the Case if likewise not much better when the _Faeces_
are extreamly fetid, and there is no Relief thereby; or when they are
green, or black, or come away involuntarily, especially when attended with
a _Dysentery_.

_WHERE the Lungs are tender, weak, or distempered, it generally ends ill._

FOR I can hardly remember any one who had bad Lungs that escaped in the
late Sickness; and it was a constant Observation, that Asthmatick Persons,
not only by frequent and hard Inspiration drew in more of the poysonous
Steams than others, but also that the weakned Force of that Organ, gave
Opportunity to them to fix their Lodgment there.

_WHEN Persons grew no better for Sweating, but weaker, and the Distemper
higher, it was judged fatal._

FOR after Nature had made such an Effort to expel the Venom to no Purpose,
all Hopes of Recovery could not but vanish. A great Expence of Spirit, and
a general Decay of Strength, must be the Consequence of such a Wast; and a
Continuance of Sweat likewise brings on a dangerous Colliquatation, or is
a Sign of it; and those hot sharp Sweats, which vesicate the Skin, are
also to be suspected: Moreover, it is very hazardous when cold Sweats come
after such hot ones. But the most certain Fatality of all, is from such
Sweats as have a cadaverous Smell; altho' there was sometimes a very
disagreeable scented Sweat, with which they recovered, as with it exhaled
the pestilential Venom.

_A Loss of Appetite for a great while, proved most commonly but a
dangerous Prognostick._

IT appears, by what hath been already said, that a Loathing at Stomach was
a certain Sign of Infection; and upon a Continuance of it, it was
necessary that there should ensue a Defect of Nourishment and Strength,
which made a Person much more liable to the worst Influences of the
Distemper, and even to Erosion and Sphacelation of the Stomach.

_DEAFNESS joined with Drowsiness, were Signs the_ Parotides _would soon
appear_.

_WHEN Buboes went in again without due Evacuation, and while bad Symptoms
continued, Matters were generally doubtful, and for the most Part very
dangerous._

I always looked upon my Labours to be defeated, whensoever these Tumours
disappeared of a sudden without any manifest Cause; for it was owing to
the Retreat of the Venom inwards, where it made terrible Mischief, and was
extreamly difficult to be got again to the Surface; yet if Sweats broke
out, that the Patient could well bear, it was not uncommon for them to
return, and bring again Matters into an hopeful State.

_WHENSOEVER these Tumours are discoloured, especially tending to
Blackness, or do not suppurate, or are insensible, it may be pronounced
the Patient will be worse._

_THE more Buboes there are, so that they suppurate, the better._

_CARBUNCLES are always more dangerous than Buboes._

BOTH on Account of their sharper Pain, and greater Difficulty to cure.

_THE smaller the Carbuncles are in Compass, and their Situation remote
from the_ Viscera, _greater Vessels, Tendons, and Nerves, and the fewer
they are in Number, by so much it is the better; and, on the contrary,
when they spread like a Gangrene, and are near the principal Parts, as the
Breast or Belly, and also are numerous, or livid, the Fate of the Patient
may be pronounced desperate._

_THE pestilential_ Tokens, _especially when they are deep, are the sure
and speedy Messengers of Death_.

FOR a general Mortification commonly follows these particular ones:
although there is sometimes (as before observed) some Time given between
one and the other, as for two or three Days.

_A Complication of bad Symptoms, together, precipitates the Patient into
another World._

NAY, sometimes when there are many Symptoms of Recovery, the obstinate
Continuance of one bad is enough to determine the Patient's Fate.

_FROM the inconstant Appearance of the Urine, there can be no certain
Judgment made._

THE Urine indeed of these Patients is generally not to be distinguished
from that of healthful Persons, although sometimes its Stench is not to be
endured; this a certain Physician found to his Cost, who taking the
Urinal too near, was infected by the Scent, fell ill, and in three Days
died.

_THE Pulse, which in all other Diseases is almost a certain Index, in this
Sickness could not be at all trusted to._

_THOSE who were comatous in the Beginning or Height of the Disease, seldom
escaped._

These Prognosticks I thought my self obliged to take Notice of, by the
Method I proposed to my self herein; but that I have omitted many, is to
be excused by the Difficulty and Difference of Judgment in these Matters;
for such was the delusory Appearance of this Pestilence, that many
Patients were lost when they were thought in a safe Recovery; and when we
thought the Conquest quite obtained, Death run away with the Victory;
whereas others got over it, who were quite given over for lost; much to
the Disreputation of our Art.




                              SECTION VII.

             _Concerning the Cure of the late Pestilence._


ALTHOUGH a pestilential Infection is extreamly dangerous, and doubtful as
to its Consequences, very few being spared by it, when in its greatest
Height, yet we are by no Means to despair in so great a Difficulty, and
give up the whole Race of Mankind to Destruction as soon as it comes, but
be rather stimulated to greater Endeavours; and, like faithful Ministers
of Nature, study all Helps against such common and grievous Calamities.

BUT before we enter upon that Part which seeks Assistance from Medicine,
it may be necessary to exhort the infected, that they have due Regard to
the Almighty Power, not only in confessing, and seeking Forgiveness for
Sin, but in imploring his Blessing upon those Remedies and Means for
Recovery which even the most skilful Physician can prescribe.

THE Infected also ought to be admonished that they make their _Wills_,
and settle their worldly Affairs, so as to prevent Contention and
Law-Suits, least by the Severity of such a Distemper they should chance to
be carried off. But this is to be done before they are affected at all in
their Understandings by the Disease.

LASTLY, It is likewise to be enjoined the Sick, that they quietly,
submissively, and with a chearful Confidence, commit themselves to the
Care and Management of their Physicians; And hence appears the Difficulty
of that Task to watch over those who are in such imminent Danger; and what
variety of Cares lie upon him who undertakes it, and who often falls
himself by that Tyrant he is endeavouring to defend others from?

BUT to do Justice to the _Sacred_ Art, in its relieving Mankind in such
cruel Diseases, this must eternize the Sons of _Esculapius_, that they
seem to be born for the Publick Good, by their Usefulness even in a
Pestilence, as well as other more common Calamities of Life; but on this
Head I shall forbear saying more, knowing how unworthy I am to give due
Honour to so much Worth.

BUT in the Prosecution hereof, as some heretofore have taken a great deal
of Pains to no Purpose in finding an _universal specifick_ against the
Pestilence, and have imposed many palpable Falsities upon the World under
such Pretences; so our modern _Coal-Blowers_ have in like Manner cried up
their pernicious Secrets, and wickedly imposed them upon the credulous
Populace. Certainly these publick Cheats ought themselves to be deemed
pestilential, as their Notions and Practice is abhorrent to all sound
Reason: For if the Arguments on both Sides the Question be fairly stated,
and one will be convinced, that there never as yet hath been discovered in
Nature, the full and absolute Essence of a Pestilence, but that it still
remains a Mystery to Mankind; wherefore in this Distemper a Person must
proceed, as in all others, by a serious Attention to the manifest
Symptoms, and a rational Conformity of the Means of Cure thereunto; and
while we hold to this only Rule of Procedure, although the Severity of the
Distemper may conquer several, yet many also may be saved.

IT now comes to us to declare what a Physician has to do in this Calamity;
as therefore the Disease admits of no Delays, Help must be immediately
procured, and the Physician ought to fly to the Patient's Succour, least,
by any Omission, the Case should be got beyond Recovery, and a Person be
lost for Want of timely Assistance.

WHEN the Physician is come, he ought to address the Patient with
Chearfulness, and blame those Fears and melancholy Apprehensions which
give many over too much into the Power of the Distemper, by cutting off
all Hopes of Recovery.

LASTLY, according to the general Directory of our College beforementioned,
the most generous and efficacious Medicines must be contrived with the
utmost Care and Deliberation.

IN the first Place then, whether Phlebotomy is to be practiced or not is
justly to be questioned; and indeed I should pass it by here as fatal, but
that I know many unskilful and rash Persons, who not only let Blood
largely at one Time, but order it likewise to be repeated until the
Patient faints.

BUT if the Authority of the Ancients as well as the Experience of the
Moderns hath any Weight, and indeed if our own Practice may be regarded,
it is highly to be feared, from many Instances, that Bleeding in a genuine
Pestilence is not only to be suspected, but charged as pernicious; for we
have many times seen the Blood and Life drawn away together; which makes
it astonishing to see the Practisers in such Mischief dare to justifie the
fatal Error; what is it that indicates this Evacuation, is it intense
Heat; or any Turgescency of the Vessels? Or is it to give Vent to the
pestilential Poison to make its escape? Certainly nothing to me seems more
absurd; for if the other Symptoms do not remit with the Fever, the Patient
will be plunged into the utmost Hazard; for how can the Blood and other
Juices be depurated, if the febrile Heat is extinguished? not to say any
thing of a Suppression of salutary Breathings hereby, a Perversion of the
natural Secretions, and Sinking the Spirits.

THEY also are under as great an Error, who fetch their Reasons for this
Practice from the Turgescency of the Vessels; for while inordinate Hurries
are excited in the Blood, from disagreeing and heterogeneous Particles
striving to extricate themselves from one another, there is made thereby
only a seeming Plenitude; what Madness then must it be, in order to remove
an imaginary Fulness, to sink the necessary Strength by a rash Effusion of
Blood?

AND lastly, the morbifick Poison is not of that kind, as to seek an Escape
at the Orifice of a Vein, and run out with the flowing Blood; and which
(as before proved) affecting chiefly the Spirits, and residing in other
Vessels, makes this Method of Cure in a Pestilence impracticable. I will
not however deny but that there may possibly be Circumstances in malignant
and pestilential Fevers, which may justifie Phlebotomy, as when it is done
for Revulsion sake, in too great a Flux of the _Menses_: But in a genuine
Pestilence, it is not to be meddled with. There is but one, as I can
remember, who survived it in the late Sickness; but it is needless to say
any more upon a Subject so plain, and therefore I shall pass to what is
of more Consequence.

AS for what concerns the next Means of Remedy, an _Emetick_ may be given
in the Infancy of the Disease, where the Stomach is loaded either by
over-eating, or by a Crowd of bad Humours, or when there is a Loathing, or
a Bitterness in the Mouth; so that any particular Conformation of the
Breast and Neck doth not contra-indicate; and amongst these Remedies they
are preferrable which plentifully excite Vomiting, without working also
downwards.

OF this kind are the _Syr. Diasari Fernelij_, _Syr. Scabios. compos.
Oxymel. Scillit._ and chiefly the _Sal Vitrioli_; but the Antimonial
Preparations are not so advisable. The Dose of the _Emetick_ ought to be
large enough to Empty the Stomach soon; and the Posset-drink used in the
Operation, in order to rince off its Coats all Filthiness, is to be
impregnated with _Carduus_, _Scordium_, _Meadow-sweet_, _Butterbur_, &c.
boiled in it. In my own Practice, I have always found good Service from
large Draughts of the Posset-drink above-mentioned, sweetned with _simple
Oxymel_, without any other previous _Emetick_ given.

AFTER Vomiting is over, in order to enable the Stomach the better to keep
any Alexipharmick Medicines, its Force may be greatly strengthned by
adding Stomachicks to the Alexipharmicks: But if a Reaching to vomit prove
Symptomatical, _Emeticks_ are by all Means to be avoided; least the
Physician (like old Nurses, who are altogether ignorant of the Rules of
Practice) should promote that Symptom, which by fruitless Strains waste
the Spirits, and sollicit the pestilential Venom into the Stomach from
distant Parts; which when fixed there, still irritates into more violent
Reachings, that cannot be asswaged by any Remedies.

ALTHOUGH in other Cases a Vomiting may be removed by _Emeticks_, yet in a
Pestilence it is dangerous to follow such Practice; because the Malignity,
or rather Nitro-saline _Effluvia_, vellicate the Mouth of the Stomach, and
so invert its nervous Coats, although empty, as to bring on Convulsions:
And some Persons seem to have their Stomachs full, as overloaded with
Food, who crave to be freed by Vomiting, which it is by no Means safe to
indulge them in, because such a Sensation of Fulness proceeds only from
the pestilential Poyson vellicating the Membranes, while the Stomach is it
self free from Food, or bad Humours; but what further concerns this
Matter, will come to be further considered under the Cure of Symptoms.

MOREOVER, Purges are justly reckoned amongst Medicines of great Efficacy;
but whether or no they are to be used in the Case before us, is a
Difficulty, and full of Controversy amongst Physicians; and indeed the
Varieties in pestilential Diseases, the Differences of Constitutions, the
various Complication of Circumstances, the Uncertainty of Seasons, _&c._
do make it impossible to give any general Rules hereupon; wherefore I
shall go no further than what my own Practice hath enabled me to judge
concerning it.

A Turgescency or Distemperature of Humours do certainly call for an
Evacuation this Way; that is, when the Humours are troublesome more by
their Quantity than any stimulating Quality; when therefore the
Constitution is not able to conquer such a Burthen, neither by Digestion
nor Expulsion, Catharticks are certainly necessary to help away the Load,
and especially if a Person hath been before eating to Excess.

BUT if this Evacuation be delayed till the Juices have received the
pestilential Taint, the Humours are then rather to be depurated, then
purged away by Catharticks; and it is certainly better to trust to the
Strength of Nature, when Things are gone so far, to do the Work her own
Way: And whether or no the Blood is too much fused, or (according to some)
coagulated, purging Medicines are certainly to be avoided; for in the
first Case they further agitate and fuse the Blood, besides the Hazard of
breaking open such Vessels as may not without great Difficulty be again
closed; the same Medicines are also hurtful in the Blood's Coagulation,
because they evacuate only the serous Parts, and leave the Remainder more
viscid and tenacious, whereby Obstructions are rendred more perverse and
unconquerable, and the stagnant Matter without a Possibility of Dilution,
and Restitution to its pristine State of Fluidity, as also more strongly
inclosing the pestilential Poison at the same Time; it is also greatly to
be feared, that in so great an Agitation the morbifick Venom may be drawn
to the Bowels, and Sphacelation follow thereupon.

THAT Purging may be also practised with Success, the Strength of the
Patient is carefully to be consulted, for where the Spirits are low, or
deficient, it may not only prove unsafe, but fatal; and where the Bowels
are extreamly stimulated by the Cathartick, and the Humours greatly put
into Fusion by its rarifying Qualities, they will be apt to pass off in
too large a Profusion.

WHAT can a Person likewise expect to do with a Cathartick, in Disorders of
the Spirits? It certainly appears to me more likely to purge away all the
Humours of the Body, than re-kindle the Spirits that are oppressed,
cloudy, and almost extinct, by such Means; and further, as the Subtilty of
the pestilential Poison inclines it rather to escape by the superficial
Pores, than the larger Emunctories, this Method is contrary to that
natural Tendency, calling it back again from the Circumference to the
Center; I cannot imagine what they propose, who even repeat in these Cases
their purging Medicines, until they bring both intolerable Pains, and
Gripings into the Bowels, and Sphacelations, as beforementioned.

BUT if after all Considerations any Person thinks it proper to purge, it
ought to be certainly done in the Beginning of the Infection, and with
somewhat that operates speedily; and to which Purpose those in Liquid
Forms answer best, as for Example:

[rx] _Aq. Angelicae simpl. Tartarizatae +[oz.] ij.+ Syr. de spina Cervina
+[oz.] j.+ Elix. proprietatis Crollii vel Antipestilentialis +[scruple]
j.+ & interdum +[dram] [ss.]+ +dissolve+ salis absynthii gr. +viij.+ M. S.
Fiat haustus hora commoda, & typo remittendo dandus._

A Solution also of _Pil. Ruffi_ from [dram] [ss.] to [dram] j. may be made
in _Marigold Water_, by those who like that better. They who please
likewise may use the following:

[rx] _Extract. Pilularum Ruffi +[dram] ij.+ resin zalapii +[scruple] j.+
trochisc. de rhabarb. +[dram] j.+ gum. ammoniaci in aceto scillit. soluti
+[dram] j.+ salis Tartari, absynthii +ana+ gr. +viij.+ cum tinct.
Theriacali q. s. fiat massa, e cujus +[dram] j.+ conglobentur pilulae
+vij.+, vel +viij.+ Dos. in constitutione athletica ad +[scruple] ij.+
prout medico visum fuerit varianda._

IN a Disease that will admit of no Delay, it is best to evacuate but
little, yet that not slowly; so that the morbid Humours may be expelled at
the first Seizure, before they have received the pestilential Taint, and
before its Virulence hath reached to the whole Mass of Fluids: For it is
certain that no Digestion is to be expected in this Case, and therefore
can there be no Room for _Alterants_ or _Digestives_: But when the Body is
very costive, I judge it most convenient and safe to do this with
Suppositories.

BUT all Authors and practical Physicians agree in this, to throw out the
pestilential Malignity as soon as possible; which is expeditiously and
surprizingly done by _Alexipharmicks_; and to these, as soon as the Belly
is loosned, Recourse must speedily be had, as to a sacred Refuge: And
there is such Plenty of Remedies of this kind, that Nature seems to have
had more than an ordinary Indulgence and Forecast, in providing against
this destructive Enemy of Mankind; nor hath the medicinal Art been
likewise wanting in supplying us with many Preparations of _Simples_, that
are powerful against so grievous a Destroyer. But in this great Choice it
behoves us to select those which are most efficacious; for this Distemper,
which is certainly the most tyrannical of any that besets a humane Body,
may be sometimes conquered in its Infancy, which when got to a Head, is
not to be managed by the greatest Efforts of humane Skill.

AMONGST the Simples of the three Kingdoms, to begin with the Vegetable,
_Virginian Snake Root_, when fresh and fragrant, is the most efficacious;
insomuch indeed that I have often admired, that such great Vertue should
reside in such minute Fibres, having a Tast very pungent, and a quick
aromatick Scent, and discovering somewhat wonderful and almost
supernatural; so that it deservedly is accounted the most efficacious and
generous _Diaphoretick_ and _Alexipharmick_ for expelling the pestilential
Poison. Its Dose, finely powdered, is from _gr._ iv. or vi. to [scruple]
ij. in any proper Vehicle, due Regard being had to the Strength and Age
of the Patient.

THE next Place is justly given to the _Contrayerva-Root_, from which also
a compound Medicine, which I shall hereafter describe, is admirably
contrived: The Dose of this in fine Powder is from [scruple] i. to [dram]
i. in _Angelica_, or _Scordium_ Water, or in Wine, _&c._

THERE are other Roots likewise which daily Experience hath taught us to be
very good for the same Purposes; and with which, as Occasion requires,
many valuable Compounds are formed, in order to effect that with a united
Force which they could not do singly; in this Class are the Roots of
_Angelica_, _Scorzonera_, _Butterbur_, _Masterwort_, _Tormentil_,
_Zedoary_, _Garlick_, _Elicampane_, _Valerian_, _Birthwort_, _Gentian_,
_Bittany_, and many others, which any Person that loves Variety may find
in proper Authors.

BUT even Gratitude obliges me not to omit saying somewhat of _Ginger_,
which I have prescribed both in the Root powdered, and candied, many Times
with great Success, for it is very powerful both to raise a breathing
Sweat, and defend the Spirits against the Pestilential Impression.

FROM these Roots may be made Extracts, either with Spirit of Wine or
Vinegar; for it is agreed by all, that the more subtil Particles collected
together, and divested of their grosser and unprofitable Parts, become
more efficacious in Medicinal Cases.

THE Leaves of Vegetables most used in Practice, are _Scordium_, _Rue_,
_Sage_, _Veronica_, _Dragon_, the _lesser Centaury_, _Scabious_,
_Pimpinel_, _Marygolds_ and _Baum_, and from which, on Occasion, are
several _Formulae_ contrived.

GOOD Vehicles to wash down and facilitate the taking more efficacious
Medicines, are made of the Waters distilled from those Herbs while they
are fresh and fragrant (having not yet lost their volatile Salt;) for
those which are commonly kept for Ornament in the Shops are insipid, and
of little or no Worth.

A _Clyssus_ also of the same Herbs is preferrable to the Waters, made
after this Manner, let a Quantity of Water be drawn from the green and
succulent Plant, and the Juice be expressed from another Parcel of the
same Herb, and depurated by standing; let then both be evaporated to the
Consistence of _Honey_, and from it a Tincture drawn with some more
distilled Water and a little Spirit of Wine, which is again by Evaporation
to be reduced into an Extract; also from the dryed Plant draw its
essential Oil, and from the _Residium_ after Distillation the Salt. Of the
Extract take [dram] iv. of the _Salt_ [oz.] [ss.], and of the _Oil_ 50
drops, and mix them together, where let them lie to incorporate more
intimately with one another. The inspissated Juices likewise of these
Ingredients are of good Effect, and in the Winter, Decoctions may
conveniently be made of them for the same medical Purposes; and further,
that the Remedies in this Case may be yet the more efficacious, they may
be joined with _Alkaline-Salts_ dissolved in a proper _Menstruum_: For by
this Means the Tone of the Stomach will be strengthened, Putrefaction will
be prevented, the nitro-saline _Effluvia_ will be resisted, or at least
precipitated, and a _Diaphoresis_ promoted.

SOME Berries are also of great Use in Practice; as the Powder of
_Ivy-Berries_ given to the Quantity of one Dram in two Parts of _Elder
Vinegar_, and One Part of _White-Wine_; the Spirit likewise drawn from
_Elder-Berries_ would do the same in a Dose of [oz.] iij. or [oz.] iv. the
Spirit of _Juniper Berries_ given to [oz.] i. a Spirit drawn from green
_Walnuts_, with _Treacle-Water_, as also from the Seeds of _Carduus_,
_Citrons_, &c. had likewise their due Recommendations in powerfully
promoting Sweat.

BUT I know nothing amongst the _Simples_ that hath so obtained, for Ages
together, as the _Oriental Bezoar_, and which still hath so great a Name;
yet without having any Inclination to contradict a received Opinion, I
have been so confirmed by a Multitude of Trials, that the Truth will speak
for it self, which manifestly denies its Virtues to be at all equivalent
to its Value: And I have really given it in Powder many times to 40 or 50
Grains, without any manner of Effect; and I dare affirm that the _Bezoar_
with which I made these Trials was genuine.

THE Powder also of an _Unicorn_'s Horn, so much cried up for an Antidote,
never answered any good Expectations, although I had several Dozes of it
given me by a Merchant, on purpose to try its Virtues: But that which
would cure Pidgeons, Fowls, Cats and Dogs, from Arsenical Poisons, as the
worthy Gentleman assured me that did, had yet no Efficacy against the
pestilential Virulence: Yet if it was not controverted to this very Day,
whether or no there is such an Animal in Being as an _Unicorn_; and it
should moreover be granted that the Horn hath these stupendious Virtues;
the Price of it would make it purchaseable only by the Rich; whereas in
this dreadful Calamity the Populace were chiefly infected; and therefore
cheap and common Medicines should be contrived for them by the Physicians;
in the Number of which, first occur the _Troches_ of _Vipers_, given to
the Quantity of [scruple] iv. in compound _Scordium Water_, or the
volatile _Salt_ of _Vipers_ given to [dram] [ss.] in the same Vehicle. A
very worthy Person sent us from _New-England_ some Troches made of the
Flesh of a _Rattle-Snake_, from which I found more Success amongst the
Sick, than those we commonly have here.

THE _Powder of Toads_ was likewise prodigiously extolled by every Body;
but I found more Success in _Spirits of Hartshorn_, given from [scruple]
ij. to [dram] i. in _Plague-water_.

A Youth was seized with a great Difficulty of Breathing, and the Arteries
hardly beat, and, in short, all Things seem'd to bespeak him in his last
Moments; I prescribed him [dram] i. of the forementioned Spirits in [oz.]
iij. of _compound Scordium Water_; but the Symptoms continuing obstinate,
I again repeated the same in three Hours Time with Addition of [scruple]
i. more; and five Blisters were also forthwith applied, after which in
about half an Hour, he began to move his Limbs, and recollect himself, as
if risen from the Dead: but at last when all Things were hopeful, there
appeared a Discolouration upon one of his Legs, where a Blister had been
raised, with a Loss of Sense very near to a Sphacelation; upon this the
affected Part was deeply scarified and then fomented, which, with a
Repetition of the same Draught twice in a Day, by the Blessing of Heaven,
again restored every Thing into a hopeful Way. For this Spirit is of such
a fiery Nature, that it immediately disperses through the whole Body; and
on Account of its great Volatility, helps to encounter with, and correct
the saline, malignant Quality of the Pestilence: But I need say no more
than that it is the most powerful _Diaphoretick_ that can be given in any
Disease whatsoever.

WHENSOEVER Things are brought to Extremity, some have Recourse to Mineral
Preparations, in Order to drive out the Pestilence by mere Force; amongst
which the chief are _Mineral Bezoar_, _Sulphur Auratum_, and _Aurum Vitae_,
&c. the Preparations of which are to be met with in chymical Writers.

I am fearful indeed of being too prolix in the Enumeration of Remedies
under this Class; although I am very sensible that some _Simples_
prudently chosen may singly encounter a Pestilence with Success, as well
as some other Diseases: But because this Evil is usually attended with so
many Complications, the Contrivances to oppose it should also, in the
Opinion of some, be equally and proportionably complicated; and all Forces
drawn up in Battle against it with full Front, in Order to be equal to
the Encounter. To this Purpose some of the Sons of _Esculapius_ have
invented manifold Compositions; and some of them so prolix, as if they
intended a Sacrifice of an _Hecatomb_ to appease the Severity of this
tyrannical Destroyer.

IT would be entirely foreign to our Business here, to extract all the
Medicines which some Writers abound with for this End; and it is our
Business here only to take Notice of those which were made Use of with
Success in the late Sickness; and in this Performance both Gratitude and
Duty oblige me to begin with such as were ordered by the _College_,
amongst which first occurs their _Plague-water_.

[rx] _Radic, tormentillae, angelicae, p[oe]oniae, zedoariae, glycirrhizae,
helenii ana +[oz.] [ss.]+ sol. Salviae, Chelidoniae, rutae, summitat:
rorismarini, absynthii, roris solis, artemisiae, pimpinellae, dracunculi,
scabiosae, agrimoniae, melissae, cardui, betonicae, centaurii min. fol. &
flor. calendulae ana M +i.+ (alii addunt flor. papaveris errat: paralys.
ana p. +iij.+) incisa, & contusa infundantur per triduum in lib. +viij.+
vin. alb. opt. dein F. cauta distillatio & liquor usui reservetur_: But
here it is by the Way to be taken Notice, that in the Cure of a
Pestilence the medicinal Forms are not to be pompously contrived with a
long Catalogue of Ingredients, but carefully adapted in every Respect to
the Circumstances and Exigencies of the Infected. It is also to be
observed, that this Water is by no Means indifferently to be given to all;
or to every one in the same Manner; as for Instance, not at all to Women
under their menstrual Purgations, least it should provoke them to flow too
immoderately; nor is it to be allowed to Women with Child, for Fear of
Miscarriage.

MOREOVER the _College_ hath appropriated other Medicines for the same
Ends, from which we may extract the following:

[rx] _Diascordii, vel Mithridatii +[dram] j.+ vel +[oz.] [ss.]+ fiat
dissolutio in +lib. [ss.]+ possetalae alteratae cum partibus aeq. vini albi,
& aceti opt. Misce detur haec potio servefacta, aegro stragulis bene
cooperto._ Or,

[rx] _Radic. Angelicae +[oz.] ij.+ tormentillae +[oz.] j.+ infusis, &
decoctis in aq. font. q. s. ad tertiae p. consumptionem, adde succi limonum
+[oz.] iij.+ vel aceti +[oz.] j. [ss.]+ bibat correptus +[oz.] vij+, vel
+viij.+ hujus apozematis calefacti_: Or,

[rx] _Sem. paetasitidis +[scruple] j.+ sem. citri gr. +xxvj.+ cuchianellae
+[scruple] [ss.]+ caphurae gr. +xij.+ misce, fiat pulvis, ex haustu aq.
cardui, calendulae, vel scordii sumendus._ Or,

[rx] _Expressionem stercoris vaccini recentis in aceto acerrimo infusi ad
cochl. +vij.+ vel +viij.+_ Or,

[rx] _Theriacae Androm. +[scruple] ij.+ Elect. de ovo vulg. +[oz.] [ss.]+
facta dissolutione in haustu possetalae carduatae, fiat potio, bibatur
calefacta expectando sudoris exundationem._

WE shall hereafter come to take Notice of those Medicines which by the
_College_ were contrived for the Poor, now therefore take those which by
daily Experience were found of most Efficacy, and deserve to stand first
on that Account.


                _A Compound Antipestilential Decoction._

[rx] _Radic. Scorzonerae, petasitidis ana +[oz.] v.+ angelicae, tormentillae
C.C.C. ana +[oz.] j.+ fol. Scordii, ulmariae, melissae ana M +j.+ flor.
calendulae, borrag. ana M +fs.+ bacc. juniperi, hederae ana +[oz.] j.+ sem.
citri +[dram] ij.+ coriandri praep +[dram]+. +j. fs.+ caricas numero +iij.+
incisa, & praep. in duabus p. aqu. font. & tertia p. aceti opt.
infundantur, & decoquantur, sub finem addendo glycyr. taleolatim sectae
+[oz.] j.+ in expressionis +lib. iij.+ dissolve theriacae Androm. +[oz.]
iij.+ nitri purissimi +[dram] iij.+ & adms. interdum Spir. Vitrioli, vel
Sulph. guttas aliquot ad leviusculam aciditatem._ Sometimes also we add
hereunto Syrup of the Juice of _Citrons_, or _Baum_; but when Matters are
in the utmost Hazard, the Patient's Life is more to be consulted than his
Palate; and all _Sugars_ we often omit, as they are both a Load upon the
Medicin's Operation, and in no wise fit for a Stomach affected with a
Contagion. The Dose of this Decoction is from 8 to 10 Spoonfuls every 4
Hours.


                        _An Alexiterial Water._

[rx] _Radic. Contrayerva +[oz.] j.+ scorzonerae hispan. angelicae ana +[oz.]
j. [ss.]+ fol. Scordii galegae ana M +iij.+ fl. ros. rubr. calendulae ana p.
+iij.+ ras. C. C. eboris ana +[oz.] j.+ bacc. juniperi, hederae ana +[oz.]
ij.+ in aceto sambucino per triduum macerat: dictamni cretici, cortic.
limonum ana +[oz.] j.+ succ. melissae, cardui, angelicae ana lib. +[ss.]+
aceti opt. lib. +ij.+ distilla in organis humilioribus post. deb.
infusionem._ Or,

[rx] _Succ. Scordii, acetosae ana lib. +j.+ galegae lib. +[ss.]+ succ.
limonum, aceti opt. ana lib. +j.+ theriac. Androm. +[oz.] iij.+ digere &
distilla Dos. ad cochl. +vj.+ vel +viij.+_

                                  Or,

[rx] _Aquae Alexiteriae lib. +ij.+ theriac. Androm. +[oz.] iij.+ Elect. de
ovo +[oz.] j.+ digere, filtra, & usui serva, Dos. ad cochl. +vj.+ vel
+viij.+ phiaelam agitando._

                                  Or,

[rx] _Summit absynthij, rutae ana +M j.+ Scordii, dracunculi ana +M iij.+
aceti sambuc. +lib. iij.+ distilla in vesica, tum in liquore dissolve
salis fraxini, carduii, vel Scordii Vitriolat. +[dram] iij.+ Dos. ad
cochl. +iv.+ vel +v.+ efficaciter elicit sudorem haec Aqua._


                           _A Treacle-Water._

[rx] _Radic. Asari Virgin. +[oz.] [ss.]+ contrayerva +[oz.] j.+
tormentilla, scorzon. petasitidis ana +[oz.] j.+ p. sem. cardui,
calendulae, angelicae, citri ana +[dram] iij.+ quibus praep. affunde spir.
vini, aceti opt. ana +lib. [ss.]+ dissolve theriac. Ven. +lib. [ss.]+ adde
croci Ang. +[dram] ij.+ misce indantur organis vitreis, & post octiduanam
super cineres digestionem, distillae, in rostro Alembici suspendendo
caphurae +[dram] iij.+ Dos. ad cochl. +v.+ vel +vj.+_


                         _A Diaphoretick Oil._

[rx] _Salis Absynthii, vel Scordii, sive Rutae +[oz.] ij.+ flor. Sulphuris
ter, quaterve sublimat. +[oz.] j.+ ol. Juniperi +lib. j.+ invicem misc.,
per biduum calore mediocri bene occlusa relinque, dein per Retortam
distilla, etiam altera vice distilla, digerendo per biduum, addendo salis
absynthij +[oz.] j.+ Dos. ad cochl. unum, vel duo, ex aq. angelicae, vel
scordii, saccharata, ad olci +v.+ a. e. Commixtionem._


                      _An Alexipharmick Vinegar._

[rx] _Radic. Scorzon. Hispan. Chelidoniae mai. ana +[oz.] ij.+ contrayerva
+[oz.] i.+ angelicae, tormentillae ana +[oz.] i.+ p. fol. scordii, melissae,
scabiosae ana +M ij.+ summit. Rutae p. +ij.+ dictamni cret. +M [ss.]+ flor.
sambuci, calendulae ana p. +iij.+ gr. Junip. +[oz.] ij.+ ras. C. C. eboris
ana +[oz.] j.+ sem. rutae, cardui, citri ana +[dram] ij.+ portulacae +[dram]
v.+ cinam. opt. +[oz.] [ss.]+ caryophyll. +[dram] iij.+ Theriac. Androm.
+lib. [ss.]+ quibus s. a. praep. affunde Aceti ex vin. albo acerrimi +lib.
v.+ vitro opt. obaurato digere per triduum, bis, terve de die
conquassando, tum caute distilla, suspensis camphorae, & croci ana +[dram]
ij.+ in rostro Alemb. Dos. ad cochl. +v.+ vel +vj.+_

BUT sufficiently of these; from whence it is easie for any one to gather,
why liquid Medicines, and especially when warmed, are preferrable to
others in the Form of _Boles_ or _Electuaries_; that is, because of their
more expeditious and more effectual Operations.

BUT because many of the Infected have a Loathing at Stomach, and an
Inclination to vomit, in the same Manner as an Overload of Eating and
Drinking occasions, Medicines in solid Forms suit best with such, as they
are not so easily thrown up, and adhere better to the Sides of the
Stomach: Of this Kind we have the following Composition, which at taking
may be made into Boles of [dram] ij. each adding thereunto _Salt of
Carduus_, or _Wormwood_ [scruple] j. or more or less according to the
Exigency of Symptoms.

[rx] _Elect. de ovo mineralis +[oz.] j.+ theriac. Androm. +[oz.] [ss.]+
pulu: serpentariae virgin. +[dram] v.+ cuchianellae +[dram] iij.+ croci
pulveriz. +[dram] [ss.]+ cum Syr. e succo melissophyll. vel citri,
coagmentetur massa._


                  _The famous Sir +Theodore Mayerne+'s
                          Electuarium de Ovo_.

[rx] _Ovum vulgariter ut in Pharmacop[oe]ia +Londinensi+ praep. de quo
sume, & sem. sinapios, vel eruca ana +[oz.] j.+ Antidoti Saxonicae +[oz.]
[ss.]+ lapidis prunellae +[dram] v.+ Antimonii diaphoret. fixissimi, &
croci metallorum simul ustorum +[dram] iij.+ pulv. scordii, rutae, zedoariae
ana +[dram] ij.+ +[ss.]+ Theriacae ven. veteris +[oz.] iv.+ Philonii
Turneri +[scruple] vij.+ gr. +ij.+ misce & cum spir. Theriac. +[dram]
iij.+ & mellis de spumati q. s. Piat Elect. molle, Dos. ad +[scruple] iv.+
vel +[dram] ij.+ corroborand. adjiciendo corda, & jecinora +vj.+ viperarum
v. a. e. praep._ But it is to be observed in this likewise, as in other
Antidotes, that a long Fermentation of the Ingredients together in a Mass
is very necessary, because by that Means they more intimately mix with one
another.

BUT if the Body be too open, the _Lapis Contrayerva_ is very suitable, and
'tis thus made:

[rx] _Pulv. radic. contrayerva res. +[oz.] j.+ serpentariae virgin. +[dram]
ij.+ +[ss.]+ extract. radic. Angelicae, tormentillae ana +[dram] ij.+ pulv.
C. C. philosophice calcin. chelarum Cancrorum praep. pulv. Corall. rubr.
ana +[dram] j.+ +[ss.]+ Antimonii Diaphoret. vel potius Diaphor. Jovis
+[dram] iij.+ cuchianellae +[dram] [ss.]+ croci +[scruple] j.+ (aliqui
addurat lapid. bezoar. orien. +[scruple] ij.+) ambrae grys. +[scruple]
[ss.]+ cum gelatina spoliorum serpentum, vel C. C. fingantur globuli s. a.
exiccandi, Dos. ad +[scruple] ij.+ vel +[dram] j.+ e vehiculo idoneo,
+&c.+_

FOR the same Purpose also is the celebrated _Orvietan_ thus compounded,
and given [dram] ij. at a Dose.

[rx] _Cardui bened. totius eupatorii mai. & min. ana +[oz.] [ss.]+
scordii, aristolochiae utriusque ana +[dram] v.+ viperinae, h. e. echii,
gentianae, bacc. Junip. bistortae ana +[oz.] j.+ bacc. lauri, tormentillae,
dictamni albi ana +[oz.] [ss.]+ carlinae, angelicae ana +[oz.] j.+ +[ss.]+
rhabarb. imperatoriae, scorzon. hispan. valerianae ana +[oz.] [ss.]+ morsus
diaboli, calami aromat. ana +[oz.] iv.+ Theriac. Androm. opt. +[oz.] iij.+
corda, & jecinora 12 viperarum, terantur terenda subtilissime, & cum s. q.
mellis despumati fiat Elect. per tres menses fermentand._

IT is to be observed, that these and the like Medicines, whether
_Galenical_ or _Spagyrical_, which cannot be prepared as soon as
_Asparagus_ can be boiled, ought to be always in Readiness.

THE general Remedies being thus provided, the exact Way of Living and Diet
comes to be considered: And first of all whensoever the Patient is taken,
he must immediately be put to Bed; wherein we have found it much more
serviceable to be covered with Blankets, than Linen Sheets, because the
Woollen much better encourages Sweating, and also absorps it, and keeps
the Body cleaner all the while; for Linen being not suited to drink up the
Sweat, the Pores of the Body, at such Times as open as possible, will be
choaked up and obstructed by the Moisture hanging upon the Skin, and
giving also a Chilliness to the Flesh: To all therefore who sweat thus,
Change of Cloaths is to be denied, for the Patient takes Harm by clean
Coverings, not so much from any prejudicial Quality of the Soap abounding
in them, (according to the Opinion of _Diemebrooeck_) as from a Dampness
which is inseparable from them, and the Approach of Air which is
unavoidable in the Shifting; both which will check the Sweating.

UNLESS the Patient hath Occasion for a Vomit, or Purge, or a Clyster,
immediately upon his going to Bed, _Alexipharmicks_ ought to be given,
and if thrown up by Vomiting, repeated until the Stomach if strengthned,
and can retain them; and I have always observed, that such Nauseousness
goes off as soon as Sweat breaks out.

SOME indeed of a very dry Temperament, or from a Consumption of their
Humidities by the febrile Heat, do not easily get into a Sweat; such
therefore I ordered liberally to drink of a medicated Posset-Drink; in
order by this Means both to render the viscid Humours more fluid, and
contemper and asswage the feverish Heat.

THE Milk with which this Posset-Drink was made, was turned with two Parts
of Ale, and one Part of Vinegar, in which had been boiled the Roots of
_Scorzonera_ and _Butterbur_; the Leaves of _Baum_, _Scabius_, and
_Wood-sorrel_; the Flowers of _Borage_ and _Marygolds_; the Raspings of
_Ivory_ and _Hartshorn_, and _Carduus_ and _Coriander_ Seeds.

THESE Sweats we used to keep up for two or three Hours at a Time, as the
Strength would bear them; and until the morbifick Venom was rarified and
subtilized, so as to be exhaled quite away along with the viscid Humours:
Sleep also was industriously kept off, although sometimes, through meer
Weariness, the Patient would drop into a Doze.

AS much Care, besides that of Sweating them, was taken to support the
Strength and Spirits of the Infected, by such Aliments as the Stomach was
able to receive; for which End I ordered them Bread soaked in Wine,
poached Eggs with _Juice of Citrons_, _Pomegranates_, or _Elder Vinegar_,
as also cordial Waters, Broths, Gellies, and sometimes also generous
Wines.

THE Broths then used were made by boiling in Chicken-Broth the Roots of
_Scorzonera_; the Leaves of _Pimpinel_, _Meadow-sweet_, _Wood-Sorrel_,
_Borage_, Raspings of _Hartshorn_, and _Dactyls_, with a Piece of White
Bread, and a little _Saffron_ tied in a Nodule; and the Fat was not taken
off unless in a Loosness or Loathing at Stomach: Of the Usefulness of Gold
boiled in these Things I have nothing to say: Of this Broth was also
sometimes Emulsions made with the _Seeds of Citrons_, _Plantain_,
_blanched Almonds_, and _Pearl-Sugar_.


                _+Mayerne+'s celebrated Cordial-water._

[rx] _Radic. carlinae +[oz.] vj.+ zedoariae, scorzonerae, imperatoriae,
gentianae, vincetox. valerianae, tormentillae, bistortae, petasitid. dictamni,
bardanae, pimpinella totius ana +[oz.] iv.+ fol. cardui, oxytriphyll.
scordii, ana M +v.+ ulmariae, scabiosae, morsus diaboli, melissae,
pentaphyll. menthae, rutae, buglossae, flor. calendulae, hyperici ana M +iv.+
limones, & Aurant. cum corticibus ana numero +xx.+ flor. salviae, rorism.
ana M +ij.+ corda vervecina numero +vj.+ corda viper. numero +xx.+ vini
generosi +Hispan.+ lib. +xx.+ infusione deb. peracta, fiat Distillatio
cauta in B. M. hujus Aq. Dos. ad cochl. +iv.+ vel +v.+ dulcor. (si ita
visum) cum sacchari perl. q. s._

BUT the Patients were kept from Aliments of this Kind until some Relief
was found by _Alexipharmicks_; and then only so much was allowed of as
their Strength would admit of, for that was to be helped, and not loaded;
but as they grew better, more was allowed: Yet an Hour or two after such
Refreshment, notwithstanding the Distemper seemed to be extinguished,
_Alexipharmicks_ were repeated, until all Suspicion of its Remainder was
removed; because sometimes it would on a sudden recruit after it had
seemed to be quite gone.

THE Infected were kept close in their Beds the whole Time of the Disease;
and those who would not be thus governed, bitterly repented of their
Obstinacy; for upon Checking a _Diaphoresis_, and Confining the
pestilential Venom, most grievous Pains and Disorders ensued: And they who
were delirious, were tied in their Beds, to prevent their doing either
Injury to themselves, or those who attended upon them.

IF a Drowsiness came on at the first Attack of the Distemper, or in the
Beginning to Sweat, the Patient was forcibly kept awake; although, when
some Appearance came of Recovery, a little Sleep was indulged to recruit
the Spirits, but not beyond four Hours together; for if they slept longer,
they were waked to take their Medicines.

IF the Belly was costive, and the Distemper on its Declension, Clysters
were used with Benefit; made of a Decoction with the Roots of
_Scorzonera_, _Tormentil_, and _Marsh-Mallows_; the Leaves of _Scordium_,
_Meadow-sweet_, and _Violets_; Flowers of _Chamomil_ and _Elder_; _sweet
Fennil-Seeds_, and _Anniseeds_; and in it was dissolved the Yolk of an
_Egg_, _brown Sugar_, and [dram] iij. of _Diascordium_ or _London
Treacle_; and when more Haste was required for Evacuation, [oz.] j. or
[oz.] j. [ss.] was added of the Infusion of _Crocus Metallorum_. After the
Clyster came away, the Patient was allowed a Draught of generous Wine, or
of some Cordial Julap, or Broth, _&c._

AND whereas a Languor upon the Spirits very much contributed (as before
observed) both to the Propagation and Violence of the Contagion; to remove
such an Inconvenience, grateful Scents were made use of, such as are known
to comfort the Brain; sometimes _Vinegar of Roses_ was sprinkled upon live
Coals, and at others, were burnt such things as _Styrax_, _Labdanum_, &c.
of which more hereafter, and all things avoided which might give any
Offence to the Nose by its Smell.

HITHERTO we have treated of Antidotes, and the Regimen of our Patents;
next we come to external Helps, amongst which _Blisters_ demand the first
mention; and whose frequent and successful Application removed all
Controversie about their Usefulness.

_BLISTER-Plasters_ were applied to several Parts; as the Nape of the Neck,
within-side the Arms, the Thighs, and Legs; and by these the Vessels were
warmed, the Juices rendered more fluid, a _Stimulus_ given to the
Sluggishness of Nature, and Passage made sufficiently large, for the
Evacuation not only of superfluous Serosities and noxious Humours, but
also for the pestilential Poison, which by this Artifice seemed to be
turned out this Way; not to say any Thing of the Revulsion made hereby of
Venom from the nobler Parts.

FOR this Purpose, I once ordered a _Blister-Plaster_ to be applied
within-side the Thigh, a little below a Buboe in the Groin, but by the
Carelesness of the Nurse, it was laid upon the Buboe it self; which
happening to prove fortunate, after obtained in Practice, in Expectation
thereby to prevent the morbifick Humour from going back again, and to
forward its Suppuration; but altho' this was of Advantage in some Cases,
it was yet much suspected by the more cautious Physicians and Surgeons, as
for the most Part it brought too great an Inflammation all round it, and
promoted a Strangury, which, by Excess of Uneasiness, greatly wasted the
Spirits, and sunk the Patient's Strength.

THAT these Applications may certainly answer their End, the most sharp
ought to be used: The following Composition never failed me in all my
Practice; but before its Application, the Part was always rubbed with
Vinegar.

[rx] _Picis navalis +[oz.] v.+ galbani colat. +[oz.] j.+ cerae +[oz.] j.
[ss.]+ quibus simul liquatis, & ab igne semotis, adde pulv. cantharidum
praep. +[dram] vij.+ vel +[oz.] j.+ fermenti veteris, sem. ameos ana
+[dram] iij.+ euphorbii +[dram] j.+ cum aceti scillit. q. s.
incorporentur, assidue agitando, quousque cogantur in Emplastri massam._

THE Parts thus vesicated were never suffered to heal, till the Malignity
of the Disease was spent; and to prevent their suddain drying up, they
were continually stimulated by _Melilot_ Plasters sprinkled over with some
Powder of _Cantharides_; which kept up a constant Drein of noxious
Humours; but to asswage the great Heat and Inflammations, sometimes
occasioned hereby, _Cole-wort_ Leaves were applied to them.

YET although _Epispasticks_ did so much Service to the Infected, and
sufficiently made amends for the Trouble and Pain they gave; yet they were
not indifferently suitable to all Persons; As for Instance, where there
was an Heat of Urin, or a continual Inclination to piss, where the
_Sphincter_ of the Bladder was inflamed, or ulcerated, in an Hemorrhage,
or to Women with Child, or having the _Menses_; and lastly, where there
was a great _Languor_ upon the Spirits; it is also diligently to be
considered when _Epispasticks_ are applied to Buboes or Carbuncles near
upon Suppuration, that they do not fuse the Humours too much, to admit
them going into a laudible _Pus_, and give such a _Stimulus_ to the Parts,
as may sink the Spirits, and frustrate other Endeavours of Nature to help
her self.

BESIDES _Epispasticks_, it is not lost Labour to apply proper Things to
the Feet; I commonly used a Plaster made of the compound _Bettany_
Plaster, adding to it some _Euphorbium_, _Saffron_, and _London Treacle_;
And I found this to do more Good than _Cataplasms_, which some, however,
liked better to use, and were made of _Bryony_ Root steeped in Vinegar,
the Flesh of _pickled Herrings_, _black Soap_, _Rue_, _Scordium_, and
_Arum_, with a sufficient Quantity of Vinegar: Sometimes also Pidgeons
were applied to the Feet.

BUT these, and other Medicines of the same Rank, were not applied in any
Expectation to draw away by them the pestilential _Miasmata_ as by
Attraction; but because the Multitude of Pores, and their Largeness in the
Soles of the Feet, gave such Things an Opportunity of sending in that
warmth, as would keep the Animal Humours more fluxile, and cherish the
natural Heat that was almost extinct; and from thence the whole Body would
be refreshed by their Influence: Applications were likewise made to the
Wrist with the same View.

AND thus having gone through the curative Part of a Pestilence in general,
we now come to the Management of particular Symptoms; and first of all of
the Buboes.

IT highly concerns all who are concerned for the Sick in these Cases, both
Physicians and Surgeons, to attend with Diligence to the Nature of these
Tumours, and have their several Differences ready in their Minds, that at
their first Sight they may know their Condition, and use Means of treating
them accordingly. And first of all it is to be enquired, whether they are
moveable or fixt? whether soft or hard? whether depressed or prominent?
whether small or great? whether contracted or broad? whether with, or
without Pain? and lastly, whether inflamed or not?

WHENSOEVER a Buboe is uncertain and dodges, sometimes appearing and then
again going back, all Means is to be used to fix it; and this is very
successfully done by cupping upon the Glands, which will fix a permanent
Tumour upon them.

TO Buboes just in their first Formation, we have indeed applied
_Discutients_, and very powerful ones too, in Order to dissipate them; and
although they have several Times endeavoured to settle, yet we have not
despaired to conquer the Enemy this Way: But we always found it for
certain, that they who went through such Fluxes and Refluxes of the
pestilential Venom, never recovered in such a perfect Manner, as they
whose Buboes immediately fixed, and after Suppuration threw out a great
deal of Matter.

If the Tumour is hard and painful from too great a Tension upon the
glandulous Parts, not giving Room enough to receive the protruding
Humours, the Part affected may be anointed with _Oil of Lilies_, _Roses_,
_Elder_, &c. if no Inflammation forbids such a Method; in which
Circumstance all Oils and Ointments are to be suspected, as they obstruct
the Pores, and are no Ways suitable to the Nature of the nitro-saline
pestilential Venom. When an Inflammation therefore is upon any Part, which
is easie to be known by its Heat and Colour, it is better to make Use of
the _Mucelages of Linseed_ and _Fenugreek_, with _Elder Vinegar_, and
_London Treacle_; or a _Cataplasm of Wheat-Flower_, _Fenugreek_ and
_Linseed_, _Elder Flowers_, _white Bread Crumbs_, the _Yolk of Eggs_, and
_Powder of Saffron_.

THE _London_ Physicians at this Time spared no Trouble nor Application, to
manage the Buboes rightly; some of the Cataplasms therefore by them daily
used I shall here insert.

[rx] _C[oe]pam majusculam, quam v. a. e. excavatam imple summit. rutae dcb.
exiccat. & pulveriz. [dram]+ _+ij.+ indantur etiam theriac. +Lond.
[scruple] iv.+ foramen operculo suo obturetur, c[oe]pa deinde charta
bibula involuta sub cineribus assetur, cui adde ficum methodo eadem
assatam, cum ol. lini, liliorum alb. ana q. s. simul macerentur, &
conficiatur +cataplasma+, applicandum calide, bis de die immutandum_: This
is also good against the Bites of venomous Creatures.

                                  Or,

[rx] _Fol. rutae, scordii contus. ana M +[ss.]+ medullae carnis ficuum
+[oz.] ij.+ flor. meliloti p. +[ss.]+ salis marini pulveriz. +[dram] ii.+
fermenti veteris +[oz.] [ss.]+ cum s. q. aceti, paretur Cataplasma._

                                  Or,

[rx] _Rad. liliorum, althaeae, cum aceto macerat: ana lib. +[ss.]+ sem.
lini, faenugraeci ana +[oz.] [ss.]+ carnis ficuum +[oz.] iij.+ confectionis
sinapi, cum theriac. ana +[oz.] [ss.]+ axungiae suillae q. s. F.
cataplasma._ Or, according to _Mayerne_, from whom I learned the Rudiments
of Practice.

[rx] _Succ. apii +[oz.] ij.+ melissae +[oz.] j.+ pimpinellae +[oz.] j.+
+[ss.]+ caepas majores Numero duas, ad intenerationem, sive putrilaginem
sub cineribus caute assatas, alliorum bulbos Numero +vj.+ clavos
juglandium maj. vetust. Numero +iv.+ tritis alii bulbis, & clavis,
affunde succos, tum adde Caepas, in mortario marmoreo cum aceti scillit. q.
s. agitentur, & cogantur in Cataplasmatis consistentiam._

BUT the Hardness, pricking Pain, and intense Heat of the Tumour
continuing, Medicines were used to dissolve such Hardness, and asswage the
Pain and Heat: As,

[rx] _Rad. liliorum alb. +[oz.] ij.+ porrorum, medullae carnis ficuum ana
+[oz.] j.+ sem. lini +[oz.] [ss.]+ flor. Sambuci, meliloti ana p. +[ss.]+
micarum panis alb. +lib. [ss.]+ coq. in s. q. lactis, addendo sub finem
ol. ros. liliorum alb. vel sambuc ana q. s. ut F. +Cataplasma+._

                                  Or,

[rx] _Fol. Scabiosae, acetosae ana +M ij.+ charta bibula involut. &
cineribus scintillantibus subditorum, quibus adde fermenti veteris +[dram]
ij.+ salis tantillum, agitentur probe in mortario cum s. q. axungiae
suillae, ad usum praememoratum._ But that I may not be too tedious in
reciting particular Forms of this Kind, any necessary Variations are left
to the Discretion of every Physician in his own Practice.

WE do not wait for the Suppuration of a Buboe until it breaks of it self,
when the Pain and other Symptoms continue very severe without Remission;
besides, there would in doing so be Danger of wasting the Spirits too
much, and letting the morbifick Matter retreat, besides the Smalness of
the Orifice, which when they open themselves, is seldom large enough to
give due Vent; we therefore open them by Incision, or to prevent
Mortification, by a potential Cautery; and for the same Purpose it hath
also been many Times found reasonable to mix the milder Causticks with
Digestives.

YET although common Experience attests to the Advantage of Cataplasms, as
they wonderfully cherish the languid and almost extinguished natural Heat,
supple the neighbouring Parts, relax the Skin, and contemper and asswage
sharp Humours; yet, I say, because their frequent Repetition is sometimes
on many Accounts inconvenient and disagreeable, I used to substitute the
following _Cerate_ in their Room.

[rx] _Emp. Oxycrocci +[oz.] iij.+ galbani colat gum. curannae ana +[oz.]
j.+ picis navalis +[oz.] ij.+ e liquatis simul. cum ol. chamemeli, &
liliorum, v. a. e. F. massa pro empl._ And I am bold enough to affirm,
that with this I have prevented the Want of a Surgeon in more than a
thousand Instances: But when a Buboe is artificially opened, it is the
most proper to do it in some depending Part of the Tumour; taking Care not
to wound the larger Vessels and Muscles.

BUT whether a Buboe breaks of it self, or is opened by Incision, it is to
be washed and cleansed with a _Lixivium_ of _Ashes_, _Scordium_, _Betony_,
_Bugloss_, _Sanicle_, &c. in which also is dissolved some _London
Treacle_: And the following Mixture I have found very good for this
Purpose, consisting of _Birthwort Root_, _Myrrh_, _Aloes_, and _Saffron_,
infused in _Spirit of Wine_, and to the strained Tincture, adding a little
_Oil of Turpentine_. Furthermore, to promote Digestion, and prevent
Putrefaction, the following may be applied:

[rx] _Mellis ros. +[oz.] i.+ terebinth. cum vitello ovi solut. +[oz.]
[ss.]+ theriac. Lond. +[dram] iij.+ farinae tritici +[oz.] ij. [ss.]+ cum
ol. hyperici & sambuc. ana q. s. coq. in Cataplasmatis consistentiam._

                                  Or,

[rx] _Ung. basilic. p. duas, linimenti Arcaei p. Tertiam, ol. terebinth.
+[dram] [ss.]+ M. S._ But here it is to be observed, that Detergents are
by no Means to be used, unless the Ulcer is foul; as also that to appease
the Enormity of Pain and Inflammation, by Opiates and Repellers, is a most
pernicious Practice, because it drives back the Venom upon the nobler
Parts; and also by their frequent Continuation, is a Sphacelation
endangered upon the Extremities.

THESE Ulcers are likewise by no Means to be healed up until they are well
cleansed, and all the pestilential Symptoms quite disappear. But here I
cannot but remark, that these Ulcers do heal much easier than any other
when the Venom is fully conquered: And in the Cure, it chiefly concerns
the Surgeon to prevent the Lips growing callous, because sometimes that
Error is not easily again remedied; when the Ulcer is well cleansed, the
ordinary _Sarcoticks_ used in the common Method will soon fill up the lost
Substance: To prevent Repetition, the _Parotides_ are to be treated after
the same Manner as Buboes.

AFTER this transient View, our Method now brings us to the Cure of
Carbuncles; since therefore these Eruptions have their Rise from a
pestilential _Lixivium_, thrown upon several Parts of the Body, and there
burning them into an _Eschar_, the Business of a Surgeon herein is
directed to three main Intentions.

1. THAT the Carbuncle does not spread too far, like a Gangrene, knowing no
Bounds.

2. TO bring it as soon as possible to a Separation; and,

3. TO cure it as carefully as it can be done.

FOR the first Intention, such Remedies are suited which give a Restriction
to the Part, so that the venomous Particles cannot spread; and such also
as asswage the distempered Heat, and cherish and preserve that which is
natural.

BUT the Cure of a Carbuncle is varied by its Nature, Progress, and
Situation; and is accordingly to be treated sometimes with more, and at
others with less Severity. In this Case Benefit is sometimes received from
a Cataplasm with roasted _Garlick_, _Soot_, _London Treacle_, and _Oil of
Turpentine_; Or,

[rx] _Fermenti veteris +[oz.] [ss.]+ allii assati +[oz.] ij.+ stercoris
columbini +[oz.] j.+ confec. Sinapi +[dram] v.+ euphorbii +[dram] ij.+ cum
s. q. saponis nigri F. Cataplasma._ But it is to be observed, that in the
Application of these Cataplasms, which are very sharp, the utmost Caution
must be used, that a Pain is not aggravated thereby beyond the Patient's
Power to bear; that the Humours be not colliquated, and thrown upon weaker
Parts; and that an immoveable _Eschar_ be not made thereby.

WHEN the _Eschar_ does not fall off, nor any Signs of Separation appear,
Unguents and Oils are not to be blamed; but if the Carbuncle spreads
further, it will be necessary to have Recourse to more effectual Means; in
which Case neither the Tenderness of Sex or Age is to be regarded.
Sometimes the pestilential Venom is to be drawn out by Cupping, or
Scarrification, or _Epispasticks_: Sometimes also for the same Purpose is
applied the bare Rump of a Fowl, repeated until these Creatures appear not
to be hurt by it; for this natural Warmth sooths the vital Heat of the
Part it is applied to, and entices away the morbifick Venom through the
Pores; Pidgeons used alive, and warm Sheeps Lights, have likewise been
observed thus to asswage the Acrimony of this pestilential Virulence.

THE _Eschar_ is sometimes got off by burning, and sometimes by Incision; I
never indeed found any thing more effectual than the actual _Cautery_; and
in this Practice of ours we differ not from the celebrated _Concoregius_,
who tells us, _pag._ 39. that in his Time they were wont to burn the
Carbuncle with a red hot Iron. There are very convenient Instruments
amongst the Surgeons for this Operation, which they call the _Button_,
being so shaped; but they are of little Service, except the Burning
extends to the Compass of the Eruption; and the Iron is by no means to be
taken away, until the Patient is sensible of it; but to get off the
_Eschar_, the middle Part must be burnt deepest.

AMONGST many other Advantages, I shall mention but a few that are received
from the actual _Cautery_ in these Cases; for from hence the Parts
affected are rendred more firm and strong; hence the Vessels are more
astringed; hence the subtil _Miasmata_ are rarified and evaporated; hence
the Poison is corrected and dried up; and lastly, hence the languishing
Heat is quickned; and, not to use many Words, the pestilential Venom seems
to be destroyed by Burning, no otherwise than the Bites of poisonous
Creatures are cured after the same Manner.

AS for what is done by the Knife, the Infected are certainly as much
benefitted by it, as by the actual _Cautery_; especially if the Incision
be made deep, and goes to the Root at the Centre; for by this may be made
a very expeditious Elevation and Separation of the _Eschar_; and this
Means is more particularly to be used where a Gangreen is threatned; but
in doing it, great Care must be taken, as before hinted, that there is not
made any Effusion of Blood by cutting the larger Vessels, especially the
Arteries.

BUT when this Separation is once finished, whether it be by a Knife, or by
Burning, or of its own Accord; the next thing is to peal it off; and this
is frequently assisted by moistening it with new Butter, Oil of _Elder_,
or Oil of _Lilies_. The _Eschar_ is likewise to be loosened gradually, and
not too hastily; that is, a kind of Maturation is to be waited for. After
the Carbuncle is fallen off, Care must be taken to cleanse away the
_Sordes_ upon it, and promote Digestion by the Use of suitable
Applications; and every thing else carefully managed, as before directed
in the Cure of Buboes.

LASTLY, Incarning is gradually to be effected, and the Ulcer slowly healed
over; for by being too hastily closed, it is not uncommon to find some
pestilential _Miasmata_ lurking behind, which afterwards prove
mischievous, and often fatal, as may easily be gathered from a preceding
History, and many others not here mentioned.

BUT because sometimes the Parts where Carbuncles arise, cannot be cleansed
conveniently from the morbid Humours, whence the Cure proves slow, or
cannot be effected at all, the circumjacent Parts at first should be
guarded by Defensatives, which would astringe the Laxity upon those Parts,
keep the Passages clear, and give Room for the due Motions of the Juices
and Spirits, while at the same time they prevent the Exhalation of the
natural Heat; But if notwithstanding the utmost Care, Sphacelation comes
on, immediate Recourse is to be had to Embrocation, with the following.

[rx] _Cinerum absynthii, scordii, cardui, centaurii min. ana +[oz.] iij.+
e quibus paretur lixivium, indendo flor. chamemeli, sambuci, meliloti ana
+M j.+ liquoris limpidi +lib. ij.+ adde spir. vini opt. +lib. [ss.]+
dissolve theriac. Lond. +[oz.] ij.+ M. S. pro fotu p. affectae bis de die,
quam caladissime, exin Cataplasma conficiatur e theriac. Lond. cum Elix.
proprietatis_.

LASTLY, To put an End to this Section, wherein to prevent prolixity, I
have studiously avoided all Points of Controversy; I cannot altogether
omit the Mention of those skilful and faithful Surgeons, with due Honour,
whose Task in this raging Calamity was very hard and dangerous, how they
had the Care of all pestilential Tumours and Ulcers, _&c._ But although
some of these fell themselves in the Discharge of their Duty to others,
yet the Survivors went on chearfully in their Business; and they who lived
through the whole, owed a great deal to a Constancy of Mind, as well as to
the conservatory Power of Providence.




                             SECTION VIII.

                  _Of Preservation from a Pestilence._


IT is manifestly much more adviseable to keep off the Invasion of a
Pestilence, than to stand its violent and fatal Shocks; and
Self-Preservation, as well as the Example of all other wise People,
admonishes us to use all possible Endeavours to keep it from us, and guard
our selves against it while at a Distance. This Part therefore concerning
our Preservation from a Pestilence, regards both the Duty of the
Magistrate, and the Care of every Individual; that is to say, it is the
Magistrate's Duty, that when the Nature and peculiar Qualities of this
Disease are known, and reported by Physicians, such Laws should be
provided, as might best conduce to prevent its Spreading, if not to its
utter Extirpation.

_FIRST_ of all therefore, they ought to be deemed as a kind of Traitors,
who frighten the credulous Populace with the Apprehensions of an
approaching Plague, by idle and groundless Reports and Predictions; for
the Propagation of the late Sickness was too notoriously assisted by this
Means, to want any Arguments to prove it.

THE timely Separation also of the infected from the well, is absolutely
necessary to be done; because the most sure Way of spreading it, is
letting the sick and well converse together. Publick Funerals ought to be
forbid, as also all kinds of Meetings, and frequent Intercourses of
several Persons together: An Injunction also of Quarentine from infected
Places, according to the Custom of Trading Nations, is by any Means not to
be omitted, and carefully to be executed.

ALTHOUGH it is looked upon as almost impossible by the most artful
Contrivances, and the most prudent Councils, to avoid the Influence of a
common Cause; yet the Call of Nature, and the Laws of Self-preservation,
demand our utmost Diligence and Labour, both in publick and private, to
prevent the Encroachment of such a subtile and cruel Destroyer. And it was
certainly to this purpose a wise Contrivance of the Magistrates, to
constitute two in every Parish daily to visit every Family, and be
satisfied whether every one belonging thereunto was well, and free from
any Infection.

BUT both the Ancients and Moderns have taken the utmost Pains in
contriving to purge the Air, on a Supposition that, in a pestilential
Contagion, that is _substantially_ infected: But as the Air, as before
demonstrated, is only the Lodgment or Vehicle to the pestilential
_Miasmata_, which are every Way agitated in it, it does not seem so much
to want Depuration on its own Account, as that poisonous Mixture which is
joined with it. Indeed the pestilential Particles residing in the
Porosities of the Air, may often, without any Change of Figure, for Want
of due Agitation, remain and stagnate in it a long Time, so as to be drawn
in by the Lungs in Inspiration, and hence from the intimate Mixture and
Confusion as it were of both, a Suspicion may be entertained of the Taint
coming from a Corruption of Air; but of this we have said enough already;
and as howsoever this Matter is, a Purgation of the Air is by common
Consent called for on all Sides in these Cases, we shall consider this
Matter, chiefly in these two Respects.

_FIRST_, That the pestilential _Seminium_ be dislodged; and to this
Purpose contribute brisk Winds, especially from the _North_, and the
frequent Explosions of great Guns, in the Morning and Evening chiefly;
because such Concussions agitate the poisonous _Miasmata_, and not only
help to dissipate them; but to change and alter them in those particular
Configurations whereby they become so noxious; and it hath been attested
by Experience, that an intimate Combination of _Nitre_ and _Sulphur_
greatly alters the saline Qualities of the pestilential Taint.

_SECONDLY_, The utmost Diligence is to be used to prevent the pestilential
Particles from taking Effect; which is succesfully done by proper
Fumigations. _Hippocrates_, the Oracle in Physick, hath left it to
Posterity, to kindle Fires in the publick Streets; and these sometimes I
conceive may do good; but not as some will have it, by absorbing the
pestiferous Humidities, but by diffusing on all Sides a great deal of
_Nitre_, which gives a considerable Change to the venomous _Miasmata_; I
judge it best therefore that such Fires should be made of resinous Woods,
which throw out a clear and unctious Smell, such as _Juniper_, _Fir_,
_Oak_, _Ash_, _Elm_, _Chesnut_, &c. but by no Means Coals, which exhale an
impure, fetid, and suffocating Sulphur.

BY the Care of the Magistrate also the Streets, Sinks, and Canals, should
daily be cleared of all Filth; because Stench and Nastiness are justly
reckoned the Entertainers of Infection, and we find the Air to be
corrupted frequently from noisome Smells; so that the pestilential Venom
cannot but receive additional Strength from such Means.

BUT to be yet more particular about these Fumigations, both to mend the
Air, and refresh the Houses that have been infected, they must be composed
of such Things as raise and comfort the Spirits that were languishing,
with their grateful Flavours; for refreshing Smells are a kind of natural
_Pabulum_ to the animal Spirits; or they should be of such Substances as
by their gummy Viscidity entangle and cover the venomous _Spicula_, so
that they cannot act; or, lastly, of such Things as breath out such
nitrous Steams, which will either preserve our Bodies from receiving
Impurities, or change the Nature of the infectious Particles.

I do not indeed deny, but some ungrateful Smells may be sometimes more
convenient than sweet ones, as they fix those Spirits which would
otherwise exhale; and a copious Efflux of saline Particles will often keep
them from Infection and Injury. But to reduce these into Classes.

The _Simples_ of the first Class are _Musk_, _Civet_, _Amomum_,
_Lavender_, _Rosemary_, _Roses_, _Angelica_, _Marjoram_, _Cloves_,
_Rhodium Wood_, _Aloes Wood_, &c. Of the second, _Frankincense_,
_Benjamin_, _Storax_, _Bdellium_, _Labdanum_, _Pitch_, _Sagapenum_,
_Myrrh_, &c. Of the third Class, _Sulphur_ and _Nitre_, more of which
hereafter.

BUT further, that all the Means of propagating the Plague may be removed,
it is very wisely ordered by the Magistracy, to kill all Dogs, Cats, and
other domestick Brutes, lest these Creatures in their Passage from one
Place to another should carry along with them the pestilential Infection.

YET although both the Makers and Executors of the Laws were very diligent
in their Duty during the late Sickness, the Contagion notwithstanding
spread; when therefore all the Care and Skill of the Magistrate could
avail nothing in stopping the common Destroyer, the utmost Application was
made to preserve the Individuals under its Visitation: For which Purpose,
first of all were removed all Means of rendering our Bodies more subject
to take the Infection, and the best Care taken to fortifie the
Constitution against its Attacks, and to support it under its Tyranny.

I know not indeed a greater Neglect than in not keeping the Body clean,
and keeping at a Distance every Thing superfluous or offensive; and during
the pestilential Constitution nothing was worse than Evacuations of all
Kinds: But if a _Plethora_ required _Phlebotomy_, the Blood should be
taken away by a small Orifice, in but little Quantity, and at several
Times: A Person loaded with bad Humours, should be discharged of them, if
possible, immediately; if they glut the Stomach, and first Passages, they
ought to be thrown off by Vomiting, Drinking in the Operation good
Quantities of Posset-Drink, in which hath been boiled the Leaves of
_Carduus_ and _Scordium_; and also the Bowels should be cleansed, to which
Purpose the following is useful:

_Salis Tart. +[scruple] ij.+ F. Solutio in spir. vini opt. +[oz.] ij.+ tum
adde guttae gambi +[scruple] iv.+ peracta solutione evaporetur spir. tum
adde colocynth. cum urina praep. +[scruple] ij.+ scammaii, Sulphurati
+[scruple] j.+ Aloes, rosatae +[dram] ij.+ trochisc. de rhabarb. rec.
+[scruple] iv.+ gum. ammoniaci in aceto, scil. sobuti +[dram] j.+ salis
absynthii, cardui ana +[scruple] j.+ ol. carui gutt. +vij.+ cum s. q. Syr.
de rhamno F. massa, inde pilulae, min. formentur, Dos. ad +[scruple] ij.+_
And thus to throw off those Humours which join with and aggravate the
pestilential Venom, very much prevents the Want of Antidotes afterwards.

CARE must be taken that there be no Suppression of Urine; the Non-naturals
must be used with great Regularity; the Body must be kept transpirable;
the Tone of the _Viscera_ strengthened; Fasting avoided; Choice made of a
good Diet, such as will yield good Nourishment, make but little Excrement,
and be easy of Digestion; to which several Pickles and Sauces are to be
recommended; as _Juice of Sorrel_, _Lemons_, _Oranges_, _Pomegranates_,
_Barberries_, &c. and at every Meal Sack is to be allowed, whose Vertues
we shall hereafter have Occasion to speak of; and Care should be taken not
to be Abroad in the Evening.

AND to express all in a few Words, all the animal Fluids must be kept in a
natural State, in an Equality of Motion, and an equable Degree of Mixture
and Fluxility; they must not be put at any inordinate Hurries, nor be too
much rarified or exalted; nor must they be suffered to grow vapid and
languid, for Want of Depuration, and a Retention of excrementitious
Particles. But a proper Regimen is better to be had from other Writers, we
therefore hasten to proper Antidotes.


             _An Antipestilential Electuary of +Mayerne+._

[rx] _Juglandium virid. +lib. ij.+ ficuum, prunorum ana +lib. j.+
macerentur in aceto, & pulpa trajiciatur, cui adde pulv. subtiliss. rutae,
+lib. [ss.]+ viperinae Virginianae +[oz.] j. [ss.]+ rad. contrayerva +[oz.]
iij.+ petasitid. zedoariae, ana +[oz.] ij. [ss.]+ sacchari perlati +lib.
j.+ Syr e succo Kermes +[oz.] j.+ Syr. calendulae, caryophyll. ana q. s. ut
F. Elect. molle, addendo fol. Auri 40. Dos. ad quantitatem nucis Jugland.
maj. mane, & vesperi_.


                      _An Electuary for the Poor._

[rx] _Conserv. lujulae, galegae ana +lib. [ss.]+ calendulae +lib. j.+
Theriac. Londin. +[oz.] iij.+ boli armen. vitriol. +[oz.] iv.+ cum syr.
limonum q. s. conficiatur Elect. Dos. ad +[dram] ij.+ vel +iij.+_


                   _An Antipestilential Confection._

[rx] _Radic. scorzon. Hispan. petasitid. contrayerva ana +[oz.] ij.+
helenii, tormentillae ana +[oz.] [ss.]+ angelicae, chelidoniae, mai. ana
+[oz.] j. [ss.]+ bacc. Junip. praep. +lib. [ss.]+ summit. rutae +p. j.+ sem.
cardui, citri ana +[dram] ij.+ quibus praep. affunde p. duas aceti sambuc.
& tertiam spir. vini opt. infusione peracta & expressione, liquor igne
lento evaporetur fere ad mellaginem: extracti +lib. j.+ adde theriac.
Londin. +[oz.] ij. [ss.]+ boli arm. terrae sigillatae ana +[oz.] j.+ flor.
sulphuris +[dram] v.+ succi Kermes +[oz.] ij.+ conserv. lujulae +lib. j.+
cum syr. limon. q. s. F. Elect. molle, Dos. ad quantit. nucis myristicae
mai. ter, vel saepius de die._


                       _Antipestilential Pills._

[rx] _Extract. rad. helenii, angelicae, contrayerva ana +[oz.] j.+ adde
extract. alb. glycyrrh. +[dram] iij.+ flor. sulph. ad quatuor altem vices
sublim. +[dram] ij.+ C. C. philosoph. calcin. sem. citri pulveriz. ana
+[dram] j. [ss.]+ salis scordii, absynth. ana +[scruple] ij.+ cum s. q.
picis liquidae F. massa pro pilulis, Dos. ad +[dram] [ss.]+ vel +[scruple]
ij.+ mane, & hora somni._


               _Antipestilential +Elixir Proprietatis+._

[rx] _Croci Angl. opt. +[oz.] [ss.]+ extrah. tincturam cum aq. ulmariae,
scabiosae, cardui; vel melissae s. q. additis spir. sulphuris aliquot guttis
ad leviusculam aciditatem: liquor per chartam emporeticam agatur, in
colatura ad lentum B. calorem dissolve Aloes pellucidae e vesica +[oz.]
iv.+ per sataccum linteum haud ita rarum trajiciatur liquor; deinde F.
condensatio ad eundem calorem, acquisita pilularum molliuscularum
consistentia, adde myrrhae purissimae +[dram] vij.+ flor. vel. magisterii
praecipit. Benzoin +[dram] iij.+ salis C. C. +[dram] ij.+ cum syr. sambuc.
q. s. F. massa unde pilulae formentur, Dos. ad +[scruple] ij.+_


                     _Lozenges against the Plague._

[rx] _Extract. rad. angelicae, & contrayerva +[oz.] j.+ extr. alb.
liquiritiae +[dram] iij.+ flor. sulphuris myrrhat. h. e. cum myrrha sublim.
+[dram] v.+ ol. cinnam. gutt. +viij.+ saccharum crystallin. ad duplum
omnium pondus, cum mucilag. gum. tragacanth. aq. scordii parat. q. s. F.
Tabellae parvae subling._

SOME used every Morning to swallow a Clove or two of _Garlick_; and many
eat unripe _Walnuts_ pickled. The following Draught was of admirable
Service:

[rx] _Aq. rosar. rubr. camphoratae +[oz.] ij.+ aceti opt. +[oz.] j.+ in
quibus dissolve bol. arm. opt. +[scruple] ij.+ adde syr. scabiosae simpl.
+[dram] iij.+ M. S. F. haustus._

SOME old Nurses, as themselves have informed me, for an Antidote gave
human Excrements; but for the Efficacy of this Secret, I have nothing to
say. Some found Benefit by drinking of Urine; but many who have thought
themselves by these Means so well fortified, would venture themselves too
inadvertently into Danger, without any necessary Occasion, to the great
Hazard of their Lives.

BUT in these precautionary Directions, it is to be particularly
advertised, that Astringents of any Kind whatsoever, as _Bole_, _sealed
Earth_, _Lemnian Earth_, _Coral_, &c. are not to be given to Maidens, and
Women in their monthly Courses, for Fear they should occasion
Obstructions, and other bad Disorders: Those Remedies also are as much to
be blamed which force this Evacuation by thinning the Blood too much, and
irritating the Uterine Vessels: And lastly, in the Preservation as well as
the Cure, the Seasons of the Year, Sex, Constitution, Age, _&c._ are
carefully to be attended to.

BUT before I proceed further, Gratitude obliges me to do Justice to the
Vertues of _Sack_, as it deservedly is ranked amongst the principal
Antidotes, whether it be drank by it self, or impregnated with _Wormwood_,
_Angelica_, &c. for I have never yet met with any Thing so agreeable to
the Nerves and Spirits in all my Experience. That which is best is
middle-aged, neat, fine, bright, racy, and of a Walnut Flavour; and it is
certainly true, that during the late fatal Times, both the infected and
the well found vast Benefit from it, unless they who used it too
intemperately; many indeed medicated it with various _Alexipharmick
Simples_.

IT remains that we now say somewhat concerning the Use of _Tobacco_, whose
Vertues for this Purpose are extreamly cried up by _Diemebrooeck_, and
some others; but whether we regard the narcotick Quality of this
_American_ Henbane; or the poisonous Oil which exhales from it in
Smoaking; or that prodigious Discharge of Spittle which it occasions, and
which Nature wants for many other important Occasions; or, lastly, the
Exercise it gives to the Lungs in drawing it; besides the Aptitude of the
pestilential Poison to be taken down along with it, and the Irksomeness of
its Scent; I must confess my self at Uncertainties about it; though as to
my self, I am its professed Enemy, and was accustomed to supply its Place
as an Antidote with _Sack_.

WE now then come to external Remedies, amongst which _Amulets_, and
Characters, demand the first Notice: It must indeed be granted, that it is
no new Custom or Contrivance to hang these Charms, made various Ways,
about many Parts of the Body, but what Vertues these Things have, is worth
some Enquiry.

IT hath obtained with many, that Nature, or the Soul of the World, hath
impressed upon some certain Bodies a very diffusive magnetick Vertue;
whereupon some _Adepts_ have ascribed to many of these Bodies a Faculty of
expelling Poisons. Others conceit, that both artificial and natural
Poisons do, by a certain Sympathy, when outwardly applied, draw away every
Thing that is detrimental to the Constitution; after the Manner as _Amber_
attracks Straws, and (as they report of the _Snake-stone_) imbibe its
Venom: Some others again contrive _Amulets_ of Spices, to invigorate
Nature, and support her against the Enemy.

I think it proper to give my Opinion of this Matter; with Submission
therefore to these great Men, I cannot easily come into a Belief of any
Advantages to be had from this Practice; for most of the Efforts ascribed
to them, is rather from the Power of Imagination, or owing to some
manifest Property. Furthermore, it hath religiously obtained amongst many
People, that Diseases are to be driven away by painting Characters upon
the Body; but it is strongly to be suspected, that this Practice hath been
altogether owing to _Jugglers_, and Persons addicted to infernal Arts; for
what medicinal Virtue can there be in a Figure? It seems to me, that
because the _Sacred Mysteries_ of our _Art_ were anciently described by
_Hieroglyphicks_, the Populace, who were ignorant of their Significations,
mistook them for Charms against a _Plague_, and other grievous Diseases,
and they propagated their Delusion down to Posterity.

THERE are innumerable Preparations of these Charms or _Amulets_ to be met
with in the Writings of several Physicians; but I shall take it to have
sufficiently discharged my Duty here, to mention those only which were
used by our own Country People; the principal of which was a _Walnut_
filled with _Mercury_; for it is certain that many did promise to
themselves Security from the Dignity of this Metal, which to them seemed
to be the Parent of all others; others again expected great Matters from
its Volatility, notwithstanding it was thus inclosed, thinking that the
natural Heat of the Body would draw such Vertues, as would secure them
from the Infection. But much the greater Number were supplied with
arsenical _Amulets_, from Empiricks and Mountebanks; these were compounded
of _Arsenick_ alone, with Wax; or had many other Things added thereunto,
appropriated to the Disease. One of the chief Forms of this Kind is the
following:

[rx] _Dictamni cret. pulv. +[scruple] vij.+ pulv. sinapi +[dram] [ss.]+
Benzoin. +[dram] ij.+ Arsenici veri +[dram] iij.+ ol. cinnam. gutt. +vij.+
cerae opt. +[dram] v.+ cum mucilag. gum. tragacanth. aceto rosac. parat. F.
pasta, unde placentae multiformes depsaticae parentur, ad pondus +[dram]
ij.+ vel +iij.+ cordis regioni admovendae, linteo serico prius involutae._
For it commonly prevailed amongst the Populace, that _Arsenick_, by some
magnetick Vertue, draws away all Poison, especially that of a Pestilence.
The wearing also of a dried Toad was a mighty Secret with some.

BUT to give my Thoughts concerning the good or bad Effects of these
appended Remedies, I do not remember any one who had their Expectations
answered thereby; but many confiding too much in them, neglected other
more necessary Means of Preservation, and brought themselves into great
Hazard of their Lives by wearing them; a remarkable Instance of which I
met with in an elderly Lawyer, who upon wearing an Arsenical _Amulet_ upon
his Breast, had a pestilential Carbuncle rise under it, the third Day
after which he died. In some others large Vesications appeared, not from
any Venom drawn out, but from the Caustick Quality of the Charm it self,
and the Communication of its own Poison to the Part: What Madness was it,
in such a terrible Calamity, to put the Hazard of Life upon such idle and
ridiculous Experiments?

BUT to pass over such Baubles, and proceed to Means that are conformable
to Reason, and the Rules of Medicine, _Issues_ are not to be forgot; for
by these all kinds of Impurities are allowed to flow out along with the
pestilential Poison, as through an open and ready Passage; and the more of
these little Ulcers are made, the better, although their Largeness may
answer as well as more in Number; that is, if they are big enough to hold
4, 6 or 8 Peas together. If any one hath a Mind for two Issues, let one be
made in the left Arm, and the other in the opposite Leg. And as for the
Usefulness of these, I can speak it of my own Experience, that whensoever
I was most beset with pestilential Fumes, in the Course of my Business, I
could then immediately perceive a shooting Pain in my Issue, and had a
great deal of an ill conditioned Matter discharge from it; and this I
always looked upon as a sure Warning to have timely recourse to
_Alexipharmicks_.

GREAT Service was likewise found in the Preservation against the
Pestilence, as well as in its curative Part, by the Application of
_Blisters_, and keeping them open a good while.

HAVING thus come to a Conclusion, I think it not amiss to recite the Means
which I used to preserve my self from the Infection, during the continual
Course of my Business among the Sick.

AS soon as I rose in the Morning early, I took the Quantity of a Nutmeg of
the _Antipestilential Electuary_; then after the Dispatch of private
Concerns in my Family, I ventured into a large Room, where Crowds of
Citizens used to be in waiting for me; and there I commonly spent two or
three Hours, as in an Hospital, examining the several Conditions and
Circumstances of all who came thither; some of which had Ulcers yet
uncured, and others to be advised under the first Symptoms of Seizure; all
which I endeavoured to dispatch, with all possible Care to their various
Exigencies.

AS soon as this Crowd could be discharged, I judged it not proper to go
abroad fasting, and therefore got my Breakfast: After which, till
Dinner-time, I visited the Sick at their Houses; whereupon, entring their
Houses, I immediately had burnt some proper Thing upon Coals, and also
kept in my Mouth some Lozenges all the while I was examining them. But
they are in a Mistake who report that Physicians used, on such Occasions,
very hot Things, as _Myrrh_, _Zedoary_, _Angelica_, _Ginger_, &c. for
many, deceived thereby, raised Inflammations upon their Tonsils, and
greatly endangered their Lungs.

I further took Care not to go into the Rooms of the Sick when I sweated,
or were short-breathed with Walking; and kept my Mind as composed as
possible, being sufficiently warned by such, who had grievously suffered
by Uneasiness in that Respect. After some Hours Visiting in this Manner, I
returned Home. Before Dinner, I always drank a Glass of _Sack_, to warm
the Stomach, refresh the Spirits, and dissipate any beginning Lodgment of
the Infection. I chose Meats for my Table that yeilded an easie and
generous Nourishment, roasted before boiled, and Pickles not only suitable
to the Meats, but the Nature of the Distemper; (and indeed in this
melancholy Time, the City greatly abounded with Variety of all good Things
of that Nature) I seldom likewise rose from Dinner without drinking more
Wine. After this, I had always many Persons came for Advice; and as soon
as I could dispatch them, I again visited till Eight or Nine at Night, and
then concluded the Evening at Home, by drinking to Cheerfulness of my old
favourite Liquor, which encouraged Sleep, and an easie Breathing through
the Pores all Night. But if in the Day-time I found the least Approaches
of the Infection upon me, as by Giddiness, Loathing at Stomach, and
Faintness, I immediately had Recourse to a Glass of this Wine, which
easily drove these beginning Disorders away by Transpiration.

YET in the whole Course of the Infection, I found my self Ill but twice;
but was soon again cleared of its Approaches by these Means, and the Help
of such Antidotes as I kept always by me.

BUT to conclude, it may not be improper to take Notice, that the Citizens
much accustomed themselves to certain Compositions for keeping off the
Infection, by continual Smelling to them; the chief amongst which was the
following.

[rx] _Pulv. rad. angelicae, summit. rorism. & lavendulae cum floribus ana
+[dram] ij.+ caryophyll. +[dram] iiij.+ labdaeni puriss. Styracis ana
+[dram] iij.+ omnibus praep. in commixtione adde ol. nucis mosch. per
express. +[dram] j. [ss.]+ ol. ligni rhod. +[scruple] ij.+ camphorae
+[dram] [ss.]+ moschi +gr. viij.+ cum cerae opt. p. s. F. massa._ Some
likewise would smell to _Galbanum_, _Oil of Wormwood_, or _Rue_, as also
the Oil or Spirit drawn from _Pitch_, and dropped upon Cotton, to be kept
in a close Ivory Box. Yet I could not so much approve of these Things, as
they were used; because they so much dilated the Pores of the olfactory
Organs, as to give more Liberty for the pestilential _Miasmata_ to pass in
along with them.

THE Purification of Houses was contrived to be done several Ways; but what
I most approved of, was in placing a Chafing-dish in the Middle of a Room,
or the Entries, or Windows, where proper Things were burnt, and exhaled
all round. Quicklime was likewise thrown into the following Decoction.

[rx] _Fol. Scordii, Angelicae ana +M iij.+ summit. lauri, rutae, lavendulae
ana +M j. [ss.]+ flor. rosar. pallid. sambuci ana +p. ij.+ calami aromat.
+[dram] v.+ Caryophyll. Contus. +[dram] iij.+ F. decoctio in duabus p. aq.
font. & tertia aceti rosac. vel Sambuc. consimiliter ac lagenae, a mucore,
& setu calcis extinctione mundantur, ita ut liquorem inditum amplius
vitient, & corrumpant._ For as soon as the Lime is thrown in, it raises a
very penetrating Steam, which seemed very likely to destroy the Efficacy
of the pestilential _Miasmata_. For the same Purpose likewise were the
following very judiciously contrived.

[rx] _Salis petrae +lib. j.+ Sulphuris +[oz.] iij.+ benzoin. Styracis simul
liquati. ana q. s. ut formentur s. a. Trochisc. deb. exiccandi._

                                _FINIS._




                                 OF THE
                            Different Causes
                                   OF
                         PESTILENTIAL DISEASES,
                    And how they become Contagious.

                                  WITH
                                REMARKS
                       Upon the INFECTION now in
                               _FRANCE_,

                     And the most probable Means to
                       prevent its Spreading here.

                         By JOHN QUINCY, M. D.

                               _LONDON:_

      Printed for _E. Bell_, at the _Cross Keys_ in _Cornhill_; and
        _J. Osborn_, at the _Oxford-Arms_ in _Lombard-street_,
        1720.


[Illustration]




                                 OF THE

                            Different Causes

                                   OF

                      _Pestilential Diseases_, &c.


THERE is hardly any one Subject more largely treated of by Physical
Writers, than that of _Pestilential Diseases_; and the Reason of it I take
to be, the Frequency in all Ages and Countries, of Alarms from such
dreadful Destroyers; and the uncommon Impressions they are apt to make
upon the Minds of those, whose Profession naturally leads them to enquire
into their Causes. But in this it has fared as with all the other Branches
of that noble Science. The Conjectures and Opinions of Persons have at
all Times been too much influenced by the Philosophy in Vogue, insomuch
that it is almost an endless as well as an unprofitable Task, to examine
into them all: And as such an Enquiry is not consistent with the intended
Brevity of these Pages, I shall pass them by, only just taking Notice of
the most considerable Opinions, under which, most that has been advanced
to any Purpose may be reduced.

ALL Authors upon this Subject, may be reduced under these two Sorts: Such
as ascribe them to the immediate Wrath of Heaven, and account them as
Punishments inflicted by the immediate Exertion of a Supernatural Power;
and such as assign for their Origin some natural Cause.

ALTHOUGH too great a Regard cannot be had to the Author of our Beings, yet
Care should likewise be taken, not to ascribe every Calamity to the
immediate Exertion of the Almighty Power; for it seems much more worthy of
the Divine Being so to order it, that from the Course of second or natural
Causes, Punishments shall pursue Offenders, than to imagine the frequent
Exertion of his Power in a Way supernatural to inflict such Punishments.
But there is a great deal of Reason to suspect, that the Number of this
Sect was very much increased by such, as either out of Ignorance in other
Causes, or out of an affected Devotion, thought it their Interest to come
into this Opinion, and pretend to do greater Cures by certain religious
Performances, and their Intercession with Heaven, than was in the Power of
Medicine, of which they knew but very little.

OF those that assign some natural Cause, there are several Opinions: Some
ascribe them to astral Influences, to malign Conjunctions and Radiations
of the Heavenly Bodies. We find, from the most remote Antiquity, not only
_Pestilential Diseases_, but likewise a great many others, ascribed to the
same Causes: But all the Reasonings about this Conjecture have been very
obscure and perplexed until the present Age, when Sir _Isaac Newton_ first
taught Men to think justly, and talk intelligibly about the Motions and
Influences of those remote Bodies upon our _Atmosphere_: And upon his
Theory Dr. _Mead_ has since further proceeded to determine their
Efficacies upon humane Bodies. By which, as it does appear that they
affect us no otherwise than as they occasion the several Variations of the
Seasons, and different Constitutions of the Air, the Reader must be left
to the Consideration of such Causes.

ANOTHER Cause is charged upon Steams and Exhalations from putrefying
Bodies. There are Abundance of Instances to support this Opinion, that
manifestly discover very fatal Effects from such Causes. As Battels are
generally fought in Summer-Time, when by the Heat of the Season Things are
most disposed to Putrefaction, so it has often been observed, that the
Plague has appeared after great Slaughters of Men in Fight, as appears by
undoubted Testimony from _Julius Alexandrinus_[1], _Diodorus Siculus_, and
a great many others, too tedious to mention. _Ambrose Parrey_[2] gives a
Relation of a Plague, that laid waste almost a whole Country, which had
its Rise from the Stench of a great many human Carcases that were thrown
into one Pit, and left Rotting uncover'd. _Joannes Wolfius_[3],
_Forestus_[4], the above-mentioned _Parrey_[5], and _Agricola_[6], all
take Notice of Plagues arising from the Stench of putrifying Fish that
were thrown dead upon the Shores.

OTHER Steams of the same Efficacy frequently arise from the Putrefactions
of stagnant Waters, and other Bodies, which, in some particular
Constitutions of Air, are apt to corrupt and emit very offensive
_Effluvia_. Dr. _Mead_[7] relates from _Diogenes Laertius_[8], that
_Empedocles_ observed a pestilential Disease to afflict the _Salinuntij_,
from the Putrefaction of a certain River; to remedy which, he contrived to
have the Streams of two other neighbouring Rivers drained into it, which,
by their Increase of the Current, with an additional Weight and Pressure
of Water, brought the former to its usual Sweetness, and so put a Stop to
the Plague.

TO this Purpose Dr. _Plot_[9] observes, the Reasons why _Oxford_ is now
much more healthful than heretofore, to be the Enlargement of the City,
whereby the Inhabitants, who are not proportionably increased, and not so
close crowded together; and the Care of the Magistrates in keeping the
Streets clear from Filth: For formerly (he says) they used to kill all
Manner of Cattle within the Walls, and suffer their Dung and Offals to lie
in the Streets. Moreover, about those Times the _Isis_ and _Cherwell_,
thro' the Carelessness of the Townsmen, being filled with Mud, and the
Common-Shores by such Means stopped, did cause the Ascent of Malignant
Vapours whenever there happened to be a Flood. But since that, by the Care
and at the Charge of _Richard Fox_, Bishop of _Winchester_, in the Year
1517, those Rivers were cleansed, and more Trenches cut for the Water's
free Passage, the Town has continued in a very healthful Condition; and in
a particular Manner so free from Pestilential Diseases, that the Sickness
in 1665, which raged in most Parts of the Kingdom, never visited any
Person there, although the Terms were there kept, and the Court and both
Houses of Parliament did there reside.

TO this Cause, 'tis very probable, is owing the Frequency of the Plague at
_Grand Cairo_ in _Egypt_, and in the Island of _Sardinia_, as _Paeusanias_
and others relate: Although indeed _Prosper Alpinus_[10] charges a great
deal of the Cause of that at _Cairo_, upon their continual Commerce with
such Nations as are seldom without such infectious Diseases. And for this
Reason it is, that we find all those Countries, which most abound with
Swamps and Standing-Waters, to be most unhealthful, especially in the
hottest Seasons; except, as in several Parts of _Italy_, such Lakes have
any Communication with the Sea, or some large Rivers. To this purpose
_Piso_[11] frequently observes those Places to be most subject to such
Calamities, where there are constant Heat and settled Calms, as such a
Temperament of Air most disposes Bodies to Putrefaction and Corruption, as
in St. _Thomas Island_, and _Guinea_: And, on the contrary, that
notwithstanding the Intenseness of Heat, if the Fluids are but agitated by
Winds, Tides, and Currents, there is little Danger of such Diseases; and
the less still, the more regular and constant the Seasons are upon other
Accounts: By which Means it is, that between the _Tropicks_, and even
under the _Equator_, it is very healthful.

UNDER this Head it may not be improper to observe, that too scanty and
mean a Diet, and Feeding upon unripened and unsound Fruits, are frequently
charged with a Share in Mischiefs of this kind. _Josephus_[12] and _Julius
Caesar_[13], amongst Historians; _Forestus_,[14] and several other physical
Writers, give Accounts of Plagues from the like Causes. _Galen_[15] is
very positive in this Matter; and in one Place[16] accuses his great
Master _Hippocrates_ with Neglecting too much the Consequence of a bad
Diet, and ascribing some Mischiefs arising from thence to a bad Air. And
upon this is grounded the common Opinion of a _Plague_'s following a
_Famine_; in which Circumstances, the poorer sort, who feed meanest,
generally suffer most, as it frequently happens in long Sieges, and Armies
ill supplied with Provisions. Thus Travellers report, that _Surrat_ in
the _East-Indies_ is seldom or never free from a Plague, which is ascribed
to the mean Diet of the Natives, who are _Banians_, and feed on little
else than Herbs, Water, Rice, and such like pitiful Fare; for it is
observed, that the _Europeans_ who trade there, are in no Danger of being
infected, because they feed well on Flesh, and drink Wine, which secures
them against those malignant Diseases.

A Third Cause is ascribed to Mineral Eruptions and subterraneous
Exhalations. _Pestilences_ from this Cause are more infrequent than from
several others; because such Eruptions hardly ever happen but upon
Earthquakes, or Breaking into the Bowels of the Earth by Mines, Pits,
Wells, and the like; and then too, in Order to produce a _Pestilence_, it
is necessary that whatsoever exhales and mixes with the ambient Air, must
be of such a Nature, as to render it unrespirable; or to communicate by it
such Particles to the Animal Juices as will pervert their natural Crasis,
and disturb their due Secretions; which does not often happen, for there
are frequent Shocks of the Earth from intestine Fermentations, which are
not followed by any such Mischiefs, as they happen only from the Struggle
of such Principles, as when they have got Vent, neither of themselves, or
by any Thing emitted with them, are of that disagreeable Nature, as to
give any Disturbance to the Animal OEconomy.

_CAROLUS de la Font_,[17] indeed, as well as several others, lays great
Stress upon Causes of this kind, and charges _Pestilential Diseases_
chiefly to Mineral Exhalations of divers kinds; as _Arsenical_,
_Mercurial_, _Sulphurous_, &c. which he imagines the ambient Air often to
be overcharged with, either from the Heat of the Sun, Earthquakes, or
subterraneous Fires. To all this, Persons of different Opinion object, the
Infrequency of Plagues in _Calabria_, _Naples_, and several Parts of
_Sicily_, where there are manifestly very great subterraneous Fires, such
as occasion violent Earthquakes, and many furious and plentiful Eruptions
of metallick and mineral Fumes. A very distinct Relation of which, from
his own Knowledge, may be met with from Dr. _Bernard Connor_,[18] who has
been very curious in his Enquiries hereinto.

BUT however Authors differ upon this Head, several very odd Relations are
to be met with in History of malignant and deadly Sicknesses from these
Causes. That Story is very strange which is related by _Ammianus
Marcellinus_,[19] and taken Notice of by _Cardan_ and _Riolanus_, that a
most grievous Pestilence broke out in _Seleucia_, which, from thence to
_Parthia_, _Greece_, and _Italy_, spread it self thro' a great part of the
World, from the Opening an ancient Vault in the Temple of _Apollo_, and
that it raged with so much Fury, as to sweep away a third part of the
Inhabitants of those Countries it visited.

IT is needless to trouble the Reader with many Relations of the sudden and
strange Effects of some Steams arising from Mines and Pits, which are
generally termed by our Colliers _Damps_, because almost every Body has
already been acquainted with such Accounts.

DR. _Plot_[20] tells us, That about Twenty Years since, two Persons were
employed to dig a Well in the Parish of _North-Leigh_ in _Oxfordshire_,
but upon being taken ill, left off the Work: Whereupon it was undertaken
by two others of _Woodstock_; who, before they could do any thing
considerable in it, sunk down, and died irrecoverably in the Well: Which
being perceived by a Miller hard by, and he coming to their Assistance,
fell down dead upon them. Another also venturing to do the same, with a
Rope tied about him, fell from the Ladder just in the same Manner; and
though presently drawn up by the People above, yet he was scarcely
recover'd in an Hour or more. And since then, upon a Bucket's falling into
a Well in another Part of the Town, a Woman perswaded a strong lusty Man
to go down a Ladder to fetch it, who, by that Time he had got half way
down, fell from the Ladder into the Well; upon which, the Woman called
another of her Neighbours to his Assistance, who, much about the same
Place, met with the same Fate, without giving the least Sign of Change; so
fatal (says the Doctor) are the Damps of that Place. Dr. _Boot_[21] tells
a Story that happened at _Dublin_ in _Ireland_, just of the same Nature.
And in the _Philosophical Transactions_[22], there are the like Relations
of Damps in the Coal-Mines belonging to the Lord _Sinclair_ in _Scotland_.

THE most surprizing Effect of these subterraneous _Effluvia_ that I ever
met with, is in a Relation of Dr. _Bernard Connor_, of certain Persons in
_Paris_ digging deep in a Vault or Cellar, who were so suddenly transfixed
by some subtile Vapour, that when a Servant-Maid came down to speak with
them, she found them in Postures as if at Work; one with his Pick-Ax
advanced, another with his Shovel full of Earth, half lifted up, and a
Woman sitting by with her Arm upon her Knee, her Head leaning upon that
Hand, with manifest Expectations in her Countenance of what they were in
Search after.

THE same Author, from his own Knowledge, gives a very exact Account of a
_Grotta_ in _Italy_, much talked of, and commonly called _la Grotta de
cani_, by this Author, _Crypta_ [Greek: Kunichus]; But Dr. _Mead_ hath
since, from his own Knowledge also, given a very particular and rational
Account of this Place, and the Manner of its killing; to whom therefore
the Reader may turn for further Satisfaction.

ANOTHER, and more general Cause than any hitherto mentioned of these
Maladies, is some bad and unwholsome Constitution of Air. Such
Constitutions may arise from several Causes, which although they affect us
in different Manners, yet as they are equally fatal, we call them all
_Malignant_ or _Pestilential_: In Order therefore to understand the better
how we are differently affected by those different Constitutions, it will
be proper to consider them somewhat distinctly, under these general Heads,
_viz._ _A dry hot Air_, _hot and moist_, _cold and moist_, _and cold and
dry_; to which most Variations of Air may be reduced.

THAT from the several Constitutions of Air, our Bodies are differently
affected; and that most Diseases are in some Measure more or less
influenced thereby, is quite out of Dispute. _Hippocrates_, in a great
many Places declares himself of this Mind: His whole third section of
_Aphorisms_ is a Proof of it; and in several Places[23] he discovers his
Opinion, that _Pestilential Diseases_ have their Rise from hence. _Galen_,
his best Interpreter, understood his [Greek: to theion], which some will
have to be meant of somewhat Divine, or the immediate Hand of God, to be
nothing else but a particular Constitution of Air arising from natural
Causes; and that he was of the same Mind himself, is very plain from his
own Writings[24].

IT is almost endless, as well as altogether needless, to cite all the
Authorities for this Opinion, that might be collected from the most remote
Antiquity down to the present Age. We shall therefore proceed to consider
the different Constitutions of Air, according to the forementioned
Distinction; premising only, that the Terms _Hot_, _Cold_, &c. are used in
a twofold Sense, the one is _Absolute_, and the other _Relative_; by the
former, _viz._ _Absolute Heat_, _Cold_, &c. is understood one simple
Property of the Air only, as it is different not in Degree, but in Quality
from others: By the latter, that is, _Relative Heat_, &c. is meant certain
Degrees of those Properties: As the same Air may at the same Time be said
properly to be both Hot and Cold, or Dry and Moist, as it is compared with
another Air, either Hotter or Colder, Dryer, or Moister; for with Regard
to a hotter Air, it will be termed cold, when at the same Time if it be
compared to a colder Air, it would be accounted hot: And so of the rest.
To which Distinction, it is very necessary to have constant Regard to
avoid Confusion.

THOSE Countries where the Air is hot and dry for the greatest Part, are
related to be healthful, and free from _Pestilential Diseases_, except
where there are great Swamps and stagnant Waters, or by any accidental
Causes Bodies are exposed there to Putrefaction, the Steams of which
render Persons Diseased. In such Countries, for the most Part of the Year,
there is but very little Rain, and the Nights are comparatively colder
than elsewhere, from the great Dews which then fall. As _Piso_[25] informs
us, that the colder the Nights are in _Brasil_, and the more plentifully
the Dews fall, the Inhabitants account it most agreeable to their Soil,
and conducive to Vegetation; and Physicians reckon it much the most
healthful for the Inhabitants.

THE Heat of the Air alone, where it is constant and uniform, does not
appear to render Persons born in it, or long accustomed to it, any more
unhealthful, than that which is more temperate. _Aristotle_[26] indeed
says, a hot and dry _Southerly_ Wind will bring a _Pestilence_; but of
such we have very few Instances, especially on this Part of the Globe.
There is in _Livy_[27] an Account of a _Plague_ at _Rome_, from a great
Drought; and _Nicephorus_[28] relates such another: But these generally
come from some other manifest Causes besides Heat, and in Places not
accustomed to a dry Air.

BUT a hot and moist Air is very different. By _Moist_, is meant what
arises from sudden or long Rains. This is the Constitution of Air that
most Authors charge with being the greatest Instrument in _Pestilential
Distempers_. _Hippocrates_[29] ascribes a great deal to such an Air, and
relates a _Pestilence_ that had its Rise from great Heat, joined with
_Southerly_ Winds and much Rain. _Galen_ is of the same Mind, as appears
from several of his Writings[30], with many others too tedious to mention.
The Truth of this is likewise manifest from the Histories of those
Countries, where there are long settled Heats, and afterwards much Rain,
as in several Parts of the _East-Indies_, which are known at such Times to
be most grievously afflicted with Fevers and Diseases of a very malignant
Kind. The same we are informed of from some Places in _Africa_,[31],
_viz._ That if Showers fall soon upon the sultry Heats of _July_ and
_August_, pestilential Distempers certainly ensue. It may be generally
observed here too in our own Climate, that the most unhealthful Times are
after warm Rains, and the more if the Air is then agitated but little with
Winds.

FROM a cold and moist Air, we have little complained of, as to their
occasioning these Diseases, unless such a Constitution sets in immediately
upon a contrary Extream; for all sudden Changes of Weather are more or
less unhealthful, as well as in other Respects of living; for which Reason
particularly, _Corn. Celsus_ advises to be very slow in all Alterations of
Moment: And _Sanctorius_ frequently inculcates the same in his
_Aphorisms_, and tells us[32] how it is hurtful, both to go suddenly out
of a hot Air into a cold one, and out of a cold Air into a hot one; and is
also very particular[33] in the Inconveniencies of such a Constitution of
Air we are now speaking of, setting in after the Heat of Summer.
_Hippocrates_[34] does tell us of a _Pestilence_ from long continued cold
Rains, as likewise does _Fernelius_[35], but such Instances are not
common.

THE last Constitution of Air we are to take Notice of, is that which is
cold and dry, against which there are a great many very heavy Complaints.
_Galen_ writes of a most Raging Pestilence about _Aquileia_ in _Italy_,
that began in the very Middle of Winter, and had its manifest Cause in
extream Cold. _Fernelius_[36] asserts the Rise of several Pestilences from
the same Causes: As also does _Morellus_[37] observe great Malignities to
proceed from some _Northerly_ cold Winds. _Titus Livy_[38] likewise
mentions a _Pestilential Constitution_ arising from intense Cold, but
_Physical Histories_ abound with such Relations.

OF the strange and sudden Effects of intense Cold and dry Winds, we have
very surprizing Accounts from those who have travelled into Countries
where they are the most frequent. Dr. _Bernard Connor_[39]
beforementioned, relates, That when he was in _Poland_, it was asserted to
him by very creditable Testimonies, that it frequently happens in
_Lithuania_, and some of the _Northern_ Tracts of _Muscovy_ and _Tartary_;
that if sometimes, through the Neglect of the Shepherds, their small
Cattle, as _Sheep_, _Goats_, and the like, be left exposed in the
Night-time to the _Northerly Winds_, they are frequently found next
Morning perfectly stiff and dead, in the same Posture as they are wont to
be in at their Stalls and Cribs: And there are divers Accounts of Persons
in those Countries, who have been so suddenly transfixed, stiffened, and
killed by those _Blasts_, as to have continued on Horseback in the same
Posture as when Living, till the Horse, acquainted with the Road, has
brought them to their Journey's End: And the above-mentioned Physician[40]
tells us, that when he was at _Brussels_, he was informed by a _Spanish_
Captain, that of a Party of Horse that was sent out for Booty in a very
cold Season, one by Accident lost the rest of the Body; and Riding about
some time, before he could find his Way, or any Refreshment, he was so
transfixed with the Cold as to be quite killed, but continued on Horseback
in the Posture of a Live Person, until his Horse at last happened to find
the Way back to his Quarters, whither his Company had before got, and
missing him, feared he had fallen into the Enemies Hands; but when they
came to congratulate him upon his safe Return, they went so near as to
speak to him, and take hold of him, before they perceived him to be dead.

TO _Blasts_ of this kind it undoubtedly is, that Fruit Trees and Plants do
so frequently suffer, especially after a warm early Spring, after the
vegetable Juices have began to rise and shoot into Buds and Leaves.
Instances of this Nature we frequently find in our own Countrey; and I
have had Opportunity to observe, more than once, that upon such _Blasts_,
the Trees have, on that side towards the Wind, been in one Night's Time
quite changed in the Colour of the Leaves; and some, of the most tender
sort, almost stripped bare, their Leaves falling off dry, as in _Autumn_.

BUT there is something yet further, besides particular Constitutions of
Air, that is taken Notice of by Physicians, as a general Cause of Maladies
of this kind; and that is what is commonly called _Contagion_ or
_Infection_; by this Term _Contagion_, is understood a Disease arising
from the Contact of such Bodies or Particles as have in them a Power of
Altering the due Crasis of a healthful Person, and inducing still one
common Disease; these Particles are generally called by Physical Writers
[Greek: miasmata], _Contagiosa_, or _Contagij Seminia_; and the Difference
of Pestilences arising from these Causes seems much to differ from what
have been hitherto taken Notice of, as the former cannot be shunned but by
quite leaving the diseased Climate, or by such a Strength, or Turn of
Constitution, as resists, or yeilds not to the general Disorder; whereas
in this last Case, a Person seems to be equally safe in any Air that is
not impregnated with these contagious _Effluvia_, and the greatest Danger
arises from the Nearness to diseased Persons, or whatsoever else is
capable of harbouring those mischievous and secret Messengers, as the
Poet[41] takes Notice.

      _Quo proprior quisq; est, servitq; fidelius agro
      In partem Lethi citius venit.----_

THE Histories of Physick abound with Relations of Pestilences from no
other Cause than what arises from the Importation of the Disease, if it
may be so termed, from distant Countries; and sometimes not by Persons
themselves distempered, but by the Conveyance of these _Pestilential
Miasmas_ in their Cloaths or Wares imported in the Way of Trade.
_Fracastorius_,[42] an eminent _Italian_ Physician, tells us, That in the
Year Fifteen Hundred and Eleven, when the _Germans_ were in Possession of
_Verona_, there arose a deadly Disease amongst the Soldiers from the
Wearing only a Coat purchased for a small Value; for it was observed, that
every Owner of it soon sickened and died; until, at last, the Cause was so
manifestly from some Infection in the Coat, that it was ordered to be
burned. Ten Thousand Persons, he says, were computed to fall by this
Plague before it ceased.

FROM the same Cause, that is, infected Garments, and Merchandize,
_Mercurialis_ takes Notice of a Plague in his Time at _Venice_; and
_Appianus Alexandrinus_[43] assures us, that the _Celtae_, after a Conquest
over the _Illyrici_, and in Possession of their Plunder, were infected
with a grievous Plague, which the _Illyrici_ then laboured under.
_Thycidides_ also, in his Relation of the Plague at _Athens_, intimates,
That it was brought from some Part of _Ethiopia_ by the like Means. And
_Prosper Alpinus_[44], before mentioned, seems to lay the greatest Stress
for the Frequency of the Plague at _Grand Cairo_, to the Traffick with
those Countries as are hardly ever free from _Pestilential Diseases_. A
great many Physicians have charged the Plague in Sixteen hundred and sixty
three at _Amsterdam_, to the Infection of some _Pestilential Miasms_ which
were transported from _Smyrna_ and _Algiers_, then much infected with such
Diseases, with some Merchandize; by which Means likewise it was
conjectured soon afterwards to reach _London_, and several other Parts of
_England_, as it appears from the preceding Account of Dr. _Hodges_. To
this Purpose I remember to have read a strange Story, somewhere in
_Baker_'s Chronicle, of a great Rot amongst Sheep, which was not quite
rooted out until about Fourteen Years Time, that was brought into
_England_ by a Sheep bought for its uncommon Largeness, in a Country then
infected with the same Distemper: And upon this Account it is that the
Prudence of those Nations and States are to be justified, who enjoin all
Persons and Merchandize from infected Countries, to stay a certain Time
upon their Coasts and Borders before they are suffered to intermix with a
healthful People; having by such Instances as here mentioned been justly
alarmed at the Incroachment of such dreadful Destroyers.

THESE Historical Fragments are put together, in Order to apprize those
Readers who have not been very conversant with Things of this Kind, with
the various Ways by which the most dangerous Diseases, and even sudden
Death, may be introduced into our Constitutions, by the Agency of very
minute and unheeded Causes; and likewise the better to support the
Distinction necessary to be made between _Epidemic_ Diseases, and a
_Contagion_; as well as to illustrate the Manner whereby the latter
subsists, spreads, and proves fatal, when the Causes producing the former
are absent.

_Epidemic_ Diseases of all Kinds and Degrees of Exacerbation, have their
Rise from some common Cause, that affects all within its Extent more or
less, in Proportion to the particular Fitness of different Constitutions
to be affected by it: And by the _Bellinian_ Doctrine we are taught, how
all those Changes are made in the Blood, when thrown into a Fever by these
Causes, even from the most simple _Ephemera_, to the most complicated and
malignant Cases whatsoever; to which therefore the Reader must be
referred, for a clear Understanding of such Matters; it being sufficient
to our Purpose here to observe, that he demonstrates all Fevers to be
attended with some Fault in the Blood's Motion, Quantity, or Quality, or
in some or all of them together; and that its chief Fault in Quality,
(which is most to the present Case) consists in an unequable Fluidity,
some Parts of it being rendered thinner, and others thicker at the same
Time, than in a natural State; not unlike what happens to all coagulated
Liquors.

FROM this Condition of Blood, this great and wonderful Man goes on to
shew, through the whole Course of his Propositions, that the coagulated
Part, which he commonly distinguishes by the Name of _Lentor_, does
accumulate in the capillary Vessels until their Endeavours of Restitution,
as in all Elastick Bodies, are greater than the protruding Force, when by
the Arteries Re-action upon it, the _Lentor_ is shook, dislodged, and
washed away into the Veins, and ordinary Course of Circulation, there
continuing its Progress till it is either fitted for some Secretion and
Evacuation, or again lodged in the Capillaries, to bring on a new
Paroxysm.

THIS unequable Fluxility of the Blood arises from two general Causes,
either from such Means as diminish its Motion, or from the Mixture of such
Particles, as cannot only of themselves be reduced by the digestive Powers
into homogeneous Dispositions therewith; or as have a Faculty to put in
Fusion some Parts of the Mass, and leave the other thicker than before;
these are particularly enumerated, and their Ways of Operation distinctly
demonstrated by _Bellini_.

CONFORMABLE to this Change in the Blood, which is the common Promptuary of
all the other animal Fluids, every Thing separated from it hath some
correspondent Affections; and the nervous Fluid in particular, which is
separated from a Mass so unequally fluid, cannot but in it self have some
Parts too fine, and others too gross, besides the Inequalities in the
Times and Quantities of its Separation; from all which the same Author
accounts for those Affections, termed nervous, which are the
_Concomitants_ of Fevers: And in the Prosecution hereof he frequently
takes Occasion to speak of this Fluid to be thin, sharp, hot, fiery, dry,
_&c._ as the saline and rigid Parts in its Composition are by the
Distemper more or less subtilized, or more or less defrauded of its humid
Parts by Exhalation.

FURTHERMORE, in this great Disorder of the Constitution, and inordinate
Hurry and Colluctation of the Fluids, sometimes the Solids are maintained
in their Contractions and Motions, until the Particles either introduced
from Abroad, or generated in the Body, which cannot be assimulated into
homogeneous Qualities, are thrown out of the Course of Circulation by the
natural Discharges, by Transpiration, or by Abcesces; and the animal
Fluids restored to their natural State. But when Matters are brought to
this pass, it happens that the very Means of saving one Person, may prove
the Destruction of many others; because what is thus critically thrown
off by one, hath a Faculty of exciting the like Disorders in the Fluids of
another, when it is insinuated into them; as a very small Quantity of some
fermenting Substances will communicate its Efficacies a very great Way,
and put very great Parcels of Fluid into the like Agitation. And this is
the Way by which a malignant Fever comes to be infectious, and a
_Pestilence_ changes into a _Contagion_; as _Bellini_ more largely
explains it in his XXVIII_th Proposition_ of Fevers; from the whole of
which it is manifest, as Dr. _Mead_ hath expressed it in his fifth _Essay
of Poisons_, that _the Effects of the +one+ are the Cause and Beginning of
the +other+_.

TO bring then this nearer to the Matter under Examination, the Plague
which is described in the foregoing Pages, was strictly and properly a
_Contagion_, and by all Accounts of the best Authority, That which hath
made such vast Devastations in some Parts of _France_, and now continues
to rage amongst them, to the great Terror of their Neighbours, is also of
the same Kind; and was brought to them in Merchandize, and by a Ship's
Crew, who were sick of a pestilential Disease all their Voyage Home from
some Parts of _Turkey_; in neither of these there being any Manner of
Fault chargeable upon the Air, or to any other Causes before enumerated in
producing a _Pestilence_.

THE Symptoms of That now Abroad are reported by the best Physicians
amongst them to be _sudden Pains in the Head_, _great Loathing at
Stomach_, _Reaching to Vomit_, _Consternation_, _wild Looks_, _trembling
Voice_, _Coldness in the extreme Parts_, _low unequal Pulse_, _Paleness_,
_Delirium_, _Convulsions_, _Carbuncles_, _Buboes_, _livid Vesications_,
_purple Spots_, _and Hemorrhages_; _the last are certain Forerunners of
Death_. All which, more or less, are the constant Attendants of all
pestilential Fevers.

BECAUSE then there is such a vast Difference between a _Pestilence_
arising from assignable Causes in the Air, _&c._ and a _Pestilence_ from a
_Contagion_, as to the preservative Means especially against them; and
that what we are now in most Apprehension of, is of the latter Kind; it
most concerns us to be well acquainted with the Manner of Infection, as
far as we can reason about Agents so extreamly minute and subtle. How all
other _Antecedents_ to a _Pestilence_ exert themselves in their
Influences over the animal OEconomy, _Bellini_ has brought even to a
Demonstration; but as to a _Contagion_, he says little; which therefore,
as introductory to some following Remarks, we shall here insert.

    'As this Coagulation and Fusion may go on so far as to set at
    Liberty, and perspire through the Surface of the Body, or with
    the Breath in Respiration, many noxious Particles, which may be
    so subtil and active, as to enter the cutaneous Pores of other
    Persons, or mix with that Air which they draw in Respiration,
    and when got into the Body, be able to make the same Change in
    the Blood, both as to its Coagulation and Fusion; hence it comes
    that such a Fever proves _contagious_, which is an inseparable
    Requisite to a _pestilential_ Fever.

    'But this is not only thus brought about; but also the
    dissolved, and dispersed Particles may longer adhere to some
    inanimate Bodies than others, as to Woollen and Linen Cloaths,
    Papers, _&c._ and these Particles may, by the Steam of a living
    Body, or by the Means of any other Heat, be put into Motion, so
    as to breath out of those Lodgments, where they quietly resided,
    and obtain so much Liberty, and Action on all sides, as will
    carry them into the cutaneous Pores of any Persons within their
    Reach, and infect them; and on this Account a _Pestilence_ may
    be brought from very distant Countries, lying a long Time in
    such Manner concealed, and then suddenly breaking out; with many
    other Circumstances of like Nature.

    'BUT if these subtile and active Particles be of that Nature,
    that they can penetrate the Pores of other Animals, and occasion
    a like Coagulation of their Blood, not only Men, but Brutes
    also, will be seized with a _Pestilence_; but this does not
    always very necessarily happen; because the Blood of Animals is
    different from humane Blood, so that although these Particles
    are supposed to get into it, it does not therefore necessarily
    follow that they must vitiate it, any more than will _Aqua
    Regia_ dissolve all kinds of Metals; but yet Brutes of all
    kinds, or some of them only, will be seized equally with Men,
    when this subtile and active Ferment, which penetrates the
    Surface, is of that Nature, as will taint the Blood of other
    Animals with those _pestilential_ Requisites.

    'AS this kind of Contagion then can easily proceed from an
    infected Person at a great Distance, as often as the noxious
    Particles can reach another Person, and give that Degree of
    Coagulation and Fusion, as is necessary to a _Pestilence_; the
    more aggravated then will be this Calamity, and more easily
    spread, when a healthful Person is near to one already infected;
    and yet much more worse, if it is in Contact with those Parts,
    which more plentifully, and with a greater _Impetus_, breath out
    infected Steams, as if the Air arising from the Mouth and Lungs,
    which must be extreamly hot, or the Perspiration of a Carbuncle
    when it is greatly inflamed; for in this Case the exhaling
    Particles will be in their greatest Activity when nearest the
    recipient Body, and likewise more dense, that is, more numerous,
    and consequently of greatest Efficacy.

    'BUT it is not every one that is seized with a _Pestilence_ from
    Contagion, by Means of Steams exhaling from any particular Parts
    of the Body; but only when these Steams, and the Air it self,
    hath joined with, and interspersed through it Particles of
    vitiated Faculties; and then this Kind of Fever will easily be
    communicated, and necessarily ensue, not only on Account of what
    gets into the Body with the inspired Air, but because also the
    whole Body is surrounded with such an Infection, wherein the
    noxious Particles floating about on all Sides, will endeavour to
    penetrate through the Pores upon the Surface, and get that Way
    into the Blood; for although the Skin is thicker upon the
    Surface of the Body, than that Pellicle covering the Vessels in
    the Lungs, and for that Reason it requires longer Time for such
    Particles to get that Way into the Blood, and the Habit of the
    Body, yet it is no Argument that they cannot get that Way at
    all, and be admitted into the Juices.'

BY this we are able to gather, that when a Fever from some Faults in the
_Non-naturals_ comes to the highest Degree of Malignity, it makes such a
Change in the animal Fluids as renders some Parts of them poisonous, and
capable of exciting the like fermentative Motions, wheresoever they come
into a proper Subject, without any of those procatarctic Causes as gave
Rise to the Fever of the first Person seized.

OF what Nature then this Poison is we may conjecture from the
Circumstances of its Production. All animal Bodies do more or less
generate a Salt; or rather, in Proportion to the Strength of their
digestive Powers, do they more or less subtilize the saline Particles
which are taken in with their necessary Nourishment. This is abundantly
manifest in the Distillation of many animal Substances, which plentifully
yield a volatile Salt. But indeed in the Composition of this, in a natural
and healthful State, there is joined a very subtilized Sulphur or Oil;
which contempers and softens it into a Fitness for the Purposes of the
OEconomy: And under this Modification, it becomes the Principle of
Vitality, and the chief Instrument of animal Action; not unlike what this
is conceived to be, is the common _Sal volatile oleosum_, or any other
Spirits drawn from odorous Bodies.

IT matters not what Names Persons please to distinguish this by, in an
humane Body; but that somewhat of this Kind is naturally the Produce of
its digestive Powers, in the highest Degree of Comminution or
Subtilization they are capable of bringing any Thing to, no one will
question; and that those minute Threads or Fibres, of which the whole is a
Composition, are animated by it; or, to speak more strictly, owe to it
their Elasticity and motive Faculties.

IT is hoped, that no one who hath been accustomed to Reasonings of this
Nature, will find any Difficulty in conceiving such a Difference of
Principles, so finely blended together, as here suggested of a saline, and
an oleous, or humid Substance: And whosoever reads _Bellini_, or any
others who have wrote in the same Manner, will find continual Regard had
to those two Principles, even in the animal Spirits; for without it there
can be no Notion had of what is so frequently mentioned, and which by
their Effects we find must be true of them, that they are too dry, hot,
active, fiery, and the like; or too humid, vapid, sluggish, viscid, _&c._
And it is further equally manifest, that in Proportion to the greater or
lesser Degrees of Motion in those Fluids, from whence this subtile
Composition is generated, and the Concussions of those fine Threads into
which it is separated, will it err in one or other of the foregoing
Extremes.

IN a Fever therefore, where the animal Fluids are in the highest Degree of
Agitation, and from Causes too of a coagulating Nature, it ought to be no
Wonder that even this subtile Union should be in some Measure dissolved,
and the softer and more humid Parts broke and exhaled, so much as to leave
the more rigid and saline ones not only unfit to lubricate those Elastick
Threads, wherein they reside, but sharp and pointed enough to stimulate,
contract, and harden them into all Loss of Motion.

AS the Destruction likewise of this _Nexus_ in so subtile a Fluid leaves
the saline Parts capable of injuring even that OEconomy which gave it
Existence, so may its Volatility favour its Escape in a great Measure by
Transpiration, so as to affect also other Persons within its Reach; and
These with all other Particles of like Nature, which, by an
Over-Agitation, and fermentative Motion of the animal Fluids, are
separated from the softer and lubricating Compositions with which they
were naturally joined, and which by their Volatility transpire and float
in the Air, we take to be the true _contagious Miasmata_, that convey,
propagate, and continue a _Pestilence_, after the Cause first raising it
ceases.

NOR will this seem strange to any who are accustomed to reflect, how many
Substances are changeable into a poisonous Nature, which before were not
only inoffensive, but useful to the Purposes of Life. Some Minerals, whose
saline Parts in their Production are naturally blended with good
Quantities of Sulphur, are harmless, and good _Alterants_; but when by any
Means those Principles are separated, the saline Parts become strong
_Emeticks_ and _Catharticks_, even to the Degree of a Poison. Who does not
know that _Antimony_ may be taken crude in large Quantities without any
manifest Effect, but that the Chymist can take somewhat from it, that in
few Grains shall operate beyond the Power of a strong Constitution to
bear?

THOSE Arrows of Death therefore that make such dreadful Slaughter in a
_Contagion_, are the animal Salts of infected Persons, set loose from
their natural Combinations, and subtilized into the highest Degree of
Volatility, by the Agitation and fermentative Motion of a Fever. And the
Buboes, Carbuncles, _&c._ in a _Pestilence_, are nothing else but
Collections of Particles, or Coalescences, formed in such irregular
Motions, and thrown out of the Course of Circulation by those necessary
Laws whereby every Thing is rejected, that cannot be assimilated into
homogeneous and like Properties: The Matter of which Excretions is
likewise of so subtile and fermenting a Nature, that if introduced into
the Fluids of another well Person, it excites there the same Motion and
Disorder.

THIS change of animal Substances into a Poison, is too common a Truth to
want any Attestation to those who have been but indifferently conversant
in Natural Enquiries. And it is greatly to our Purpose, that even those
Creatures, which are generally deemed poisonous, do require certain
Degrees of Heat, and animal Action, to exalt their Juices to so high a
Degree of Volatility, as to put on the Properties of a Poison, and act as
such upon other living Creatures; insomuch that it is not only a common
Observation that these Animals lose their poisonous Nature when remov'd
into Climes colder than what is natural to them, but that also they are
not so venomous in their own Climates, at the cooler Seasons of the Year,
as in the most sultry.

BUT the Case of a mad Dog entirely comes up to that of a _Contagion_ from
a Fever. When the hotter Seasons of the Year throw that Creature into
Madness, it is manifestly from a great Increase of Velocity and Motion in
the Fluids, which brings on what is equivalent to a _Delirium_, by an
additional _Impetus_ upon the Brain, and for want of so much Room through
the Skin for Transpiration, as in other Animals; the chief Evacuation is
by the Glands of the Mouth: That is, in short, the Dog hath a Fever, which
breaks the natural Texture of the Juices, disengages and subtilizes the
more rigid or saline Parts, and critically discharges them by the most
convenient Outlets the Creature is furnished with, changed into such a
poisonous Nature, that wheresoever they come to mix with the Juices of
others, they excite in them the like inordinate and mischievous
Alterations.

THIS Theory likewise might be further illustrated by many Instances from
inanimated Fluids, which are capable of being put into Fermentation by a
very small Portion of Matter, and which shall by such an Agitation from
new Particles, or _Moleculae_ having Properties of communicating the same
Effects to another quiescent Fluid; not much unlike what we see in the
Communication and Propagation of Fire, which is excited and carried on in
proper Subjects from the minutest Beginnings, and increasing also in its
own Force as it spreads.

WHEN a Person therefore falls into a Fever from any epidemic, or other
more private Cause, and that Fever rises to such a Degree of Malignity as
is always supposed in a _Pestilence_, as far as any _Effluvia_ do exhale
from that Person, so far may he be said to have round him a contagious and
poisonous _Atmosphere_; because there transpires from him such Particles
as will excite in other Animals of like Constitution, the same
fermentative Motions as those to which they owe their own Origin.

ALTHOUGH therefore, in the Beginning of epidemical Diseases, and during
the Subsistence of their common Causes, particular Regard is to be had to
these Causes, and the Manner whereby they affect the People; yet when it
is come to this pass, that the Fever it self is productive of a Poison, or
somewhat intirely disagreeable, that communicates the same Impressions
upon others, without any Concurrence of the first Cause, then such a
Fever is truly a Pestilence by Contagion, and all precautionary Regards
ought peculiarly to be suited, to prevent its Infection or Spreading;
either by keeping the well Subjects clear from the sick, or destroying the
Influence of the poisonous Exhalations, or fortifying the sound against
it. But to these Ends, it is necessary to have some tolerable Notion of
the Manner how these secret Destroyers are continued, and conveyed to
great Distances.

THE most common Manner of conveying and spreading a Contagion, observable
in the preceding historical Collections, and which also is the Case of our
present Apprehensions from Abroad, is by infected Persons, and
Merchandize; it being attested by too many Facts to admit of the least
Doubt, that even Packs and Bails of Goods carry the poisonous _Miasmata_
about with them; and from the Nature that we here suppose this Poison to
be of, nothing is more likely to preserve it than animal Substances, as
Hair, Wool, Leather, Skins, _&c._ because the very Manner of its
Production, and the Nature of its Origin, seems to give it a greater
Affinity with such Substances than any other, and to dispose it to rest
therein until by Warmth, or any other Means of Dislodgement, it is put
into Motion, and raised again into the ambient Air.

TO know how these _Effluvia_ come to have such fatal Influences over
Mankind, and to understand their Progression from the first Seizure, to
the End of that Distemper they gave Birth to, requires too many
_Precognita_ from the Mechanism of the animal OEconomy, and the Agency of
such minute Instruments, to be particular about, in the Compass here
limited. And a Reader who is duly fitted for such Enquiries, will find the
utmost Satisfaction from _Bellini_ of _Fevers_, and Dr. _Mead_ of
_Poisons_; how the Blood, and all the Secretions therefrom, are affected,
and changed by such Causes.

WE shall here therefore only suggest some Hints concerning the Suddenness
of their Seizure, and their Energy of Operation. And this will not be
difficult to conceive by those who are acquainted with that universal
Property of Matter, whereby it is more or less determined to draw, and
unite again, when separated into Parcels, according to the greater or
lesser Affinities of their Figures, Solidities, and Quantities of Motion.
As nothing therefore in Nature is supposed to bear a greater Similitude,
than in this Case the natural animal Salts do with what hath been
subtilized and set on Float in the Air, it can be no Wonder that when the
Ambient is sated with the latter, they readily join with the former, as
soon as they are received into the Body. And this is supported by the
Authority even of _Bellini_, who allows, in the Beginning of his XXVIII_th
Proposition_, that the _Antecedents_ to a pestilential Fever do sometimes
vitiate the Spirits immediately in Quality.

AS the ordinary Course therefore of producing Fevers is by disordering the
Blood first in Quality, with such Mixtures as coagulate it, that is, as
make it unequally fluid, some Parts being thinner, and others thicker than
natural; so by these extreamly subtile _Effluvia_, in a _Contagion_, the
Spirits are destroyed in their natural Texture, and the more rigid and
saline Parts, by a Combination with the venomous _Spicula_, changed into
Dispositions destructive of that Constitution they were before destined to
preserve. Whosoever then considers what must be the necessary Consequences
of such an immediate Depravation and Change in that Fluid, which is an
absolute Requisite to all animal Action, will not at all wonder at any of
the Affections which are commonly enumerated as the _Concomitants_ of a
Contagion; and a tolerable Acquaintance with the OEconomy, by the Help
especially of the Authors before referred to on _Fevers_ and _Poisons_,
will enable any one to account severally for their Production.

THIS then being the Case of a _Contagion_, that a Person having a Fever,
critically throws off poisonous _Effluvia_, which were generated during
such irregular Motions of the animal Fluids, insomuch as to diffuse for
some Distance round, what will infect other Persons within their reach;
and that so many have got this Infection, that no Part of the Air, for
some Tract of the Country together, is free from them; the poisonous
_Atmospheres_, if they may be so termed, of the infected, extending and
mixing into one universal, common _Contagion_; this, I say, being the Case
here under Examination, why any at all survive, must be owing either to
the Goodness of their Constitution, or to proper Means to defend against
its Infection, or to conquer it when received; which naturally brings us
to consider these two important Ends, of _Preservation_ and _Cure_.

AS for the _First_ of these, the common Experience, of meaner People being
mostly carried off, admonishes all to live upon as nutritive and generous
a Diet as can be procured; and such Things as not only yeild due
Nourishment, but Plenty of Spirits, and what easily perspires. For there
are many Things of good Nourishment, that are not easily perspired; such
as all light and viscid Substances, as Pork, Fish, and the like, which
therefore are very apt to go into Fermentation, and generate Corruption;
in short, whatever even the common People have Notions of, as apt to bring
Surfeits, ought to be avoided, and such Means of Subsistance complied
with, as generate a warm, rich Blood; and in Proportion to the Ways of
Living at other Times, should every one, except those who accustom
themselves to Riot and Excess, indulge himself at a higher Rate.

ROASTED Meats are by all preferred to boiled, and if Pickles and high
Sauces are ever to be encouraged, it is on these Occasions; and _Garlick_,
_Shallot_, _Onions_, &c. are extreamly serviceable, and preferable to the
hot, dry, spicy Seasonings, because their pungent Volatility seems
naturally covered with a Softness, or balsamick Quality, more agreeable
to the Nature of animal Spirits. To which Purpose it is very remarkable,
that in the Histories of many Pestilences, Notice is frequently taken of
the Exemption of _Jews_, and People who deal much in such Fare, from
Infection. And it is customary with some experienced Sailors, to lay in
great Stores of such Things against their Arrival at infected, and
unwholsome Countries.

THERE is also a very strict Regard to be had to the Firmness and Strength
of the Solids, which is greatly assisted by moderate Exercises, but
carefully avoiding too much, and every Thing that occasions too great an
Expence of Spirits at a Time, and particularly by over-Warmth. But to this
Purpose I cannot conceive any Thing more serviceable than frequent
Immersion in cold Water, so that the Times of staying in are as short as
possible, the Good received hereby being chiefly in the first Shudder and
Constriction; and it is particularly to be remembred, tho' the preceding
Author hath omitted it, that Watermen, and others, whose Occasions
imployed them much upon the River, and in the Cold, suffered least in the
late Sickness. The Use of _Vinegar_, and other _Acids_, are also of
Service for the like Intention.

YET besides the Helps for this End from common Diet, and Way of Living,
Assistances may also be had from Medicinal Preservatives, such as those
commonly termed _Antidotes_, consisting of spicy volatile Particles, which
afford a natural _Pabulum_ to the animal Spirits, and by carrying into the
whole Habit a fine subtle Oil, the better secure them against those
Contagions _Spicula_ which are in Readiness to mix with them; and for this
Purpose, we are furnished with a most elegant and useful Medicine, since
many Authors of Note have wrote on this Subject, which is the _Sal
Volatile Oleosum_, if it be well loaded with the essential Oils of Spicy
Ingredients; although indeed with some Constitutions more fetid
Compositions are very suitable; but they all agree in carrying into the
Habit somewhat that both recruits, and guards the Spirits against any
foreign Mixture, or from unnatural Separations of their saline and humid
Parts. And to the same End, in robust Constitutions, who have been
accustomed to fare hard, the Spirit or Oil of Turpentine frequently drank
in small Doses might be a great Means to preserve the poorer Sort from
Infection.

BECAUSE former Writers on these Occasions have given _Formulae_ of things
of this kind, much more prolix and inelegant than the present Practice is
accustomed to, it may not perhaps be unacceptable to give two or three
Examples more conformable to the latter. But because I judge such general
Prescriptions rather of Prejudice than Service, when they come hastily and
inadvertently to be required by the common People, I cannot but think it
much better to leave such to be ordered and regulated according to
particular Persons Constitutions and Exigencies.

AS to those preservative Means which a Government only have the Power to
provide, they must likewise be left to those who have that Power, but,
with due Submission to such, it is conceived that removing infected
Persons is a much easier and safer Care, than shutting them up in great
Towns: And it was certainly the greatest Error committed in the late
_Plague_ here, as our Author above grievously complains, to confine the
sick and well together.

IT seems a Point yet in Dispute, whether great Fires at such a Time are of
Service or hurtful, which to me is somewhat wonderful, because whosoever
considers the Necessity for Air in Respiration, and by what Quality it
becomes of such real Service to the Preservation of Life, cannot think
such Fires proper, because they destroy that very Property in the Air,
which is demonstrable by innumerable Experiments. As to the Dissipation
indeed of pestilential Vapours, or their Destruction in any Manner, they
undoubtedly may do Service, but then that ought to be done at vast
Distances only from where People inhabit. And what Fires common Occasions
require at such Times, are rather to be made with such Substances as
abound with, and yield a nitrous Salt, because that seems to be the chief
Support of the vital Property in the Air, and such are our common Coals;
for every one knows how much more all Wood-Fires are suffocating, and give
a Languor, and Flatness to the Spirits.

PRESERVATIVE Fumigations are largely talked of by all, on these Occasions,
and they with good Reason deserve to be practised, because while the
Poison is on Float in the Air, it may undoubtedly be entangled so as to
lose its Power of acting as such; but then for this Purpose such Things
ought to be used as exhale very subtile Sulphurs, as the spicy Drugs and
Gums. And on this Account I suspect Wood-Fires to be bad, because they
raise into the Air a very gross and viscid Humidity, which is not only
very unfit to lay hold on, and unite with, the extreamly minute Agents
that are to be provided against, but also carry into the Lungs with the
Air in Respiration, such Particles, as dispose of themselves to
Viscidities, and such Changes in the Blood, as are the Production of the
worst Fevers, without any other co-operating Cause; for the Fire only
forces out that Moisture, which, while a Tree is in its Growth, naturally
perspires from it; and how an Air so impregnated is like to be of Service
against a Pestilence, any one may soon be a Judge, who considers those
Kinds of Fevers which are most commonly epidemical in wood-land Countries.

SUCH Drugs however as are from a vegetable Production, and abound with
subtile, volatile Parts, are of Service to be exhaled into the Air this
way, both by their Fitness to join with, and cover those venomous
_Spicula_ that are on float; and to mix with the Animal Fluids by
Respiration and Insinuation into the Pores, whereby they convey, as it
were, an _Antidote_, wheresoever the Poison is able to penetrate, and
which grosser Vapours can by no means do.

OF this kind are chiefly _Storax_, _Benjamin_, _Frankincense_, and all the
Aromatick Roots and Woods; and amongst them all, I cannot think the Smell
of _Tar_, _Pitch_, &c. is inferior in any Respects, where its Scent is not
particularly offensive. And these Things should be burnt at such Distances
of Time from each other, that the Air may be always sensibly impregnated
with them.

BUT as some have sad Apprehensions from the Air being still, and as it
were stagnant at such Times, and not without good Reason, as it favours
the Collection of poisonous _Effluvia_, and aggravates an Infection; for
the Prevention of which, it is proposed at certain Intervals to fire off
great Guns, and the like: I cannot but imagine, that for this End, it
would be much more effectual to let off small Parcels of the common
_Pulvis Fulminans_, in such Openings of a large Town, as Squares and
Market-Places; for whosoever hath been accustomed to any Experiments with
this Composition, must have perceived a much greater Shock given to the
Air by its Explosion, than by the largest Pieces of Ordnance; insomuch
that if any Objection can lie against the Practice of this in _London_,
should there be Occasion, it is the crasie Condition of the City
Buildings, which perhaps may not well stand its Shocks, were they to be
made with good Quantities of it at a time.

THE Matter likewise of this Composition in some Measure bespeaks its
Usefulness for these Purposes on other Accounts, besides its _Elastick_
Force, because it diffuses into the Air great Quantities of that nitrous
Salt, which is known to add much to its Serviceableness in Life: And
whosoever considers how much cheaper this is to be procured, and how much
easier practised than the firing off Guns, especially in the Middle of
great Towns, cannot but be desirous to try it, in Case of such Calamities
as are now with too much Reason feared; it may not therefore be
unacceptable to give its Composition here.

[rx] _Sal. Nitri Partes +iij.+ Sal. Tartari P. +ij.+ Sulphuris P. +j.+
optime misceantur in Mortario, parum tepefacto, & servetur ad usuum vase
bene obturato._

THIS is order'd in a warm Mortar, and to be kept close, because the _Salt
of Tartar_ is apt to imbibe a Moisture from the Air, which hinders its
Explosion. A Drachm or two put in as close a Heap as possible upon an
Iron Plate over any Fire, will in a little Time go off with a Report and
Concussion beyond that of any Gun whatsoever; so that in a calm Season,
and an infected Air, great Services may undoubtedly be had from its
frequent Practice.

AS to the curative Part in such a terrible Visitation, it cannot be
expected that Rules can be given suitable to every one's Case but by such
as attend upon them; and the most that can be in general laid down to this
Purpose, may be collected from the preceding Treatise of Dr. _Hodges_.
Although as to the Choice of _Alexipharmicks_, they are certainly best
that are most subtile, and capable of being carried by the Course of
Circulation into the finest Recesses of the Constitution, whereinto it is
manifest the extream Subtilty of the pestilential Poison is capable to
enter: And amongst all of this Class, I take _Camphire_ to be much the
more preferable; which therefore I would propose not only to be repeated
in proper Doses to an infected Person, till a due _Crisis_ is obtained,
but also now and then given to those who are well, by way of Prevention.
And because some Persons, notwithstanding what has been before said, will
be pleased with some general _Formulae_ to these Purposes, the following
are offered to be complied with, or varied, at every one's Discretion, who
is a Judge of such Matters.

[rx] _Conserv. Rutae, Flor. Rorismar. ana +[oz.] j.+ Species diambrae sine
odoratis +[dram] j.+ Balsam. e Mecha +[dram] [ss.]+ pulv. Croci angl.
+[scruple] j.+ Syr. Balsam. q. s. ut F. Electuarium, cujus sum.
quantitatem N. M. omni mane, & hora somni superbibendo Haustulum Vini albi
Lisbonensis, vel Hispanici, tepefacti._ To the Night Dose of this, may be
added sometimes 2 or 3 Grains of _Camphire_, especially if a Person feels
any Indisposition that requires a breathing Sweat, some may perhaps like
the following better.

[rx] _Cons. Rutae +[oz.] j.+ Mithrid. +[oz.] [ss.]+ Pulv. Fol. Scordij
+[dram] j.+ rad. Contrayerv. Serpentarij_ +Virgin.+ _ana +[dram] [ss.]+
Sal. volat. Viperar. Croci angl. ana +[scruple] j.+ Syr. Balsam. q. s. ut
f. Elect. sumend. codem modo._

                                  Or,

[rx] _Confect. +Tracastorij+ sine Melle, Mithrid. ana +[oz.] [ss.]+ Boli
veri, Terrae +Japon.+ ana +[dram] j.+ Castor. Salis succin. Croci angl. ana
+[scruple] j.+ Confect. Alkerm. sine odoratis q. s. ut F. Electuarium ad
usum praedictum, precipue h. somni._

BESIDES a precautionary Use of these with proper Diluters, and under the
Direction of those who are Judges; some Security may possibly be had from
odoriferous Substances to smell to, especially at a Time of conversing
with the infected; for which Purpose I know of nothing so grateful and
efficacious, as the _Volatile Sal Armoniac_, well impregnated with the
essential Oils of Aromatick Ingredients, and as it is to be procured dry,
to be kept in small Bottles, from a careful Distillation of the common
_Sal Volatile Oleosum_. But if in any Cases more fetid Substances are
preferable, Compositions may be easily made of such from _Rue_,
_Featherfew_, _Galbanum_, _Assa-faetida_, and the like; for these, with
some Persons agree better than more grateful Scents.

FREQUENTLY to dissolve in the Mouth the following _Lozenges_, or something
like them, I also imagine may be of Service; especially to those who are
conversant in infected Places.

[rx] _Boli veri opt. +[oz.] j.+ Terrae Japon. +[dram] ij.+ Coral. rub.
Margarit. opt. levigat. Flor. Benz. ana +[dram] j. [ss.]+ ol. Cinnam. gut.
+xij.+ Sacchar. albis. +lib. j.+ Mucelag. Gum. Tragacanth. in aq. Rosar.
Dam. q. s. form. in Troch. ad usum praedictum._ For those who like it, may
be added some _Ambergrease_; enough to give a light Scent of it.

PRESERVATORY Evacuations of all kinds are much disputed in these Cases,
and not worth our particular Regard in this Place; for thus much is plain
to all who are competent Judges in such Matters, that but very few
Circumstances can justifie them; because every Evacuation, unless that of
Perspiration, gives more Liberty for any Thing noxious without, to
insinuate into the Pores, as there is made thereby less Resistance to its
Admission; not to say any Thing of the Danger in such a Practice, by
lessening at the same Time the Quantities of Spirits and Strength, which
cannot but be mischievous: And particularly ought all Persons at such
Times to avoid too lax a Temper of Body; for which Purpose, these
preservatory Means just hinted at, mostly tend to astringe the Bowels, and
increase Perspiration.

                                _FINIS._




                        A Table of the Funerals

                                 IN THE

             Several Parishes within the Bills of Mortality
                        of the City of _LONDON_,
                           For the Year 1665.


                   _No. of Funerals_|_Plag._

  ST. Albans Woodstreet       | 200 | 121
  St. Alhallows Barkin        | 514 | 330
  St. Alhallows Bread-street  |  35 |  16
  St. Alhallows the Great     | 455 | 426
  St. Alhallows Honey-lane    |  10 |   5
  St. Alhallows the Less      | 239 | 175
  St. Alhallows Lombardstreet |  90 |  62
  St. Alhallows Staining      | 185 | 112
  St. Alhallows the Wall      | 500 | 356
  St. Alphage                 | 271 | 115
  St. Andrew Hubbard          |  71 |  25
  St. Andrew Undershaft       | 274 | 189
  St. Andrew Wardrobe         | 476 | 308
  St. Anne Aldersgate         | 282 | 197
  St. Anne Black-Friers       | 652 | 467
  St. Antholins               |  58 |  35
  St. Austins                 |  43 |  20
  St. Bartholomew Exchange    |  73 |  51
  St. Bennet Finch            |  47 |  22
  St. Bennet Grace-church     |  57 |  41
  St. Bennet Pauls Wharf      | 355 | 172
  St. Bennet Sherehog         |  11 |   1
  St. Botolph Billinsgate     |  83 |  50
  Christ Church               | 653 | 467
  St. Christophers            |  60 |  47
  St. Clements Eastcheap      |  38 |  20
  St. Dionys Back-church      |  78 |  27
  St. Dunstans in the East    | 265 | 150
  St. Edmunds Lombardstreet   |  70 |  36
  St. Ethelborough            | 195 | 106
  St. Faiths                  | 104 |  70
  St. Fosters                 | 144 | 105
  St. Gabriel Fenchurch       |  69 |  39
  St. George Botolph-lane     |  41 |  27
  St. Gregories by Pauls      | 376 | 232
  St. Helens                  | 108 |  75
  St. James Dukes-place       | 262 | 190
  St. James Garlickhith       | 189 | 118
  St. John Baptist Walbrook   | 138 |  83
  St. John Evangelist         |   9 |
  St. John Zachary            |  85 |  54
  St. Katherine Coleman-street| 299 | 213
  St. Katherine Cree-church   | 335 | 201
  St. Lawrence Jewry          |  94 |  48
  St. Lawrence Pountney       | 214 | 140
  St. Leonard Eastcheap       |  42 |  27
  St. Leonard Foster-lane     | 335 | 255
  St. Magnus                  | 103 |  30
  St. Margaret Lothbury       | 100 |  66
  St. Margaret Moses          |  38 |  25
  St. Margaret New Fishstreet | 114 |  66
  St. Margaret Pattons        |  49 |  24
  Sr. Mary Abchurch           |  99 |  54
  St. Mary Aldermanbury       | 181 | 109
  St. Mary Aldermary          | 105 |  75
  St. Mary-le-Bow             |  64 |  36
  St. Mary Bothaw             |  55 |  30
  St. Mary Colechurch         |  17 |   6
  St. Mary Hill               |  94 |  64
  St. Mary Mounthaw           |  56 |  37
  St. Mary Somerset           | 342 | 262
  St. Mary Stainings          |  47 |  27
  St. Mary Woolchurch         |  65 |  33
  St. Mary Woolnoth           |  75 |  38
  St. Martins Ironmonger-lane |  21 |  11
  St. Martins Ludgate         | 196 | 128
  St. Martins Orgars          | 110 |  71
  St. Martins Outwich         |  60 |  34
  St. Martins Vintrey         | 417 | 349
  St. Matthew Friday-street   |  24 |   6
  St. Maudlins Milk-street    |  44 |  22
  St. Maudlins Old Fish-street| 176 | 121
  St. Michael Bassishaw       | 253 | 164
  St. Michael Cornhil         | 104 |  52
  St. Michael Crooked-lane    | 179 | 133
  St. Michael Queenhith       | 203 | 122
  St. Michael Quern           |  44 |  18
  St. Michael Royal           | 152 | 116
  St. Michael Woodstreet      | 122 |  62
  St. Mildred Bread-street    |  59 |  26
  St. Mildred Poultrey        |  68 |  46
  St. Nicholas Acons          |  46 |  28
  St. Nicholas Coleabby       | 125 |  91
  St. Nicholas Olaves         |  90 |  62
  St. Olaves Hart-street      | 237 | 160
  St. Olaves Jewry            |  54 |  32
  St. Olaves Silver-street    | 250 | 132
  St. Pancras Soper-lane      |  30 |  15
  St. Olaves Jewry            |  54 |  32
  St. Olaves Silver-street    | 250 | 132
  St. Pancras Soper-lane      |  30 |  15
  St. Peters Cheap            |  61 |  35
  St. Peters Cornhil          | 136 |  76
  St. Peters Pauls Wharf      | 114 |  86
  St. Peters Poor             |  79 |  47
  St. Stephens Coleman-street | 560 | 391
  St. Stephens Walbrook       |  34 |  17
  St. Swithins                |  93 |  56
  St. Thomas Apostle          | 163 | 110
  Trinity Parish              | 115 |  79

         _In the 97 Parishes within the Walls,
   Total of the Funerals 15207; Died of the Plague 9887._

       *       *       *       *       *

  St. Andrew Holborn          |3958 |3103
  St. Bartholomew the Great   | 493 | 344
  St. Bartholomew the Less    | 193 | 139
  St. Bridget                 |2111 |1427
  Bridewel Precinct           | 230 | 179
  St. Botolph Aldersgate      | 997 | 755
  St. Botolph Aldgate         |4926 |4051
  St. Botolph Bishopsgate     |3464 |2500
  St. Dunstans in the West    | 958 | 665
  St. George Southwark        |1613 |1260
  St. Giles Cripplegate       |8069 |4838
  St. Olaves Southwark        |4793 |2785
  St. Saviours Southwark      |4235 |3446
  St. Sepulchres              |4509 |2746
  St. Thomas Southwark        | 475 | 371
  Trinity Minories            | 168 | 123
  At the Pesthouse            | 159 | 156

         _In the 16 Parishes without the Walls,
  Total of the Funerals 41351; Died of the Plague 28888._

       *       *       *       *       *

  St. Giles in the Fields     |4457 |3216
  Hackney Parish              | 232 | 132
  St. James Clerkenwel        |1863 |1377
  St. Katherines Tower        | 956 | 601
  Lambeth Parish              | 798 | 537
  St. Leonards Shoreditch     |2669 |1949
  St. Magdalens Bermondsey    |1943 |1363
  St. Mary Newington          |1272 |1004
  St. Mary Islington          | 696 | 593
  St. Mary Whitechappel       |4766 |3855
  Rotherhith Parish           | 304 | 210
  Stepney Parish              |8598 |6583

      _In the 12 Parishes in the outer Parts,
  Total of the Funerals 28554; Died of the Plague 21420._

       *       *       *       *       *

  St. Clements Danes          |1969 |1319
  St. Paul Covent Garden      | 408 | 261
  St. Martins in the Fields   |4804 |2883
  St. Mary Savoy              | 303 | 198
  St. Margarets Westminster   |4710 |3742
  Whereof at the Pesthouse    | --  | 156

  _In the 5 Parishes of the City and Liberties of +Westminster+,
     Total of the Funerals 12194; Died of the Plague 8403._

       *       *       *       *       *

                    Total of the Funerals -- 97306.

                      Died of the Plague -- 68596.

    _Besides many, of which no Account was given by the
       Parish-Clerks, and who were privately Buried._




                               FOOTNOTES:


[1] De Bello Punico.

[2] Lib. 10. Cap. 3.

[3] Tom. 1. memorab. Cent. 10.

[4] In his _Scholium_ upon Obs. 9. Lib. 6.

[5] De Peste, Lib. 6.

[6] De Peste, Lib. 1.

[7] Praef. de Imperio Solis ac Lunae, _&c._

[8] Lib. 8. Segon. 70.

[9] Nat. Hist. of _Oxfordshire_, Chap. 2.

[10] De Medicin. _Egypt_. Lib. 1. Cap. 15.

[11] Hist. _India_ and _Brasil_.

[12] De Bello _Judaico_, Lib. 7. Cap. 26.

[13] De Bello _Civili_, Lib. 2.

[14] Lib. 6. Obser. 9. and 26.

[15] Lib 1. de differ. Feb. Cap. 3. & de cibis mali & boni succi.

[16] Comment, in Lib. de natalium, text. 4.

[17] Dissert. de Peste.

[18] De montis Vesuvii Incendio.

[19] Hist. 73.

[20] Nat. Hist. of _Oxfordshire_, Chap. 3. Par. 31.

[21] Nat. Hist. Cap. 18. Sect. 4.

[22] No. 3.

[23] _Vid._ Epidem. _and_ de Aere, Aquis & Locis.

[24] _Vid._ Comment. in Epidem. _Hippocrates_.

[25] Hist. _Ind. & Brasil_.

[26] Probl. 1.

[27] Lib. 1. Decad. 4.

[28] Lib. 15. Cap. 10.

[29] Epidem. Lib. 2 & 3. de Aere Aquis & Locis. Aph. 11. Sect. 3.

[30] Comment. in Epidem. Lib. 3. de differ. Febr. Cap. 4. de Temperam Lib.
1. Cap. 4.

[31] Vid. _Purchas_ Pilgr. Lib. 6. C. 1. as also _Joan_. _Les +Hist.+
Afric._ Lib. 1. Cap. 1.

[32] Medicina Statica. Sect. 2. Aph. 18.

[33] Ibid. Aph. 6, and 29.

[34] Lib. 3. Epidem.

[35] De Abdit. Lib. 2. Cap. 12.

[36] Ibid.

[37] De Febr. purp. Cap. 2.

[38] Lib. 5. decad.

[39] De Antris Lethiferis, Art. 2.

[40] Loco cit.

[41] Ovid. Met. m. lib. 7.

[42] De morbis contag. lib. 2. cap. 7.

[43] De Bello Illyrico.

[44] De Medic. _Egypt._




                        TRANSCRIBER'S AMENDMENTS


Transcriber's Note: The Table of Contents was added. Blank pages have been
deleted. The illustrations may have been moved. Footnotes have been moved
to immediately above this note. When the author's preference could be
determined, we have rendered consistent on a per-word-pair basis the
hyphenation or spacing of such pairs when repeated in the same grammatical
context. The publisher's inadvertent omissions of important punctuation
have been corrected. The gesperrt letter spacing has been deleted.

The following list indicates any additional changes. The page number
represents that of the original publication.

  Page          Change

    4  whose Spirits being manifesty[manifestly] sunk
   30  from the most irrefrigable[irrefragable] Authority,
   67  and their Restautation[Restauration], Confirmation, and Vigour,
   67  in a very particlar[particular] Manner,
   91  Coats, being endewed[endowed] with an exquisite Sense,
  107  and by whose colliquitive[colliquative] Quality
  108  Some cotinued[continued] in a Profusion of Sweat
  116  its Origin was from the Arteral[Arterial] and Venal Fluids;
  117  where they of themselves chrvstallize,[chrystallize] by Means
  127  and killed her in a[delete] about three Days
  133  as the Cofiguration[Configuration] of Vessels
  138  went no further than the Skin, would oftentimes shough[slough] off
  146  the Case if likewise noc[not] much better when
  147  likewise brings on a dangerous Colliquitation[Colliquatation],
  152  Chapter VI[VII]
  152  a pestilential Infection is extreamely[extreamly] dangerous,
  156  for if the other Sumptoms[Symptoms] do not remit
  158  _Meadow-sweet_, _Butter-Burr[Butterbur]_, &c.
  168  Decoctions may coveniently[conveniently] be made
  176  _An Alexiteral[Alexiterial] Water._
  186  their doing eirther[either] Injury to themselves
  190  which some, however, liked better to ule[use]
  204  studiously avoided all Points of Con-[delete] Controversy;
  205  admoniihes[admonishes] us to use all possible Endeavours
  208  agitate the poisonous _Mismata[Miasmata]_,
  212  rosatae [dram] ij. trcchisc[trochisc]. de rhabarb.
  215  in colatura ad lentum B. calorenz[calorem] dissolve Aloes
  249  continued cold Rains, as likewise does _Fermelius[Fernelius]_
  252  that is taken Notice off[of] by Physicians
  260  small Quantity of some fermening[fermenting] Substances
  275  that the _Antecedents_ to a pestilenlential[pestilential] Fever
  283  this kind are cheifly[chiefly] _Storax_
  283  the like: I cannot but imagin[imagine], that for this
  288  is plain to all who who[delete] are competent Judges

       *       *       *       *       *







End of the Project Gutenberg EBook of Loimologia: Or, an Historical Account
of the Plague in London in 1665, by Nathaniel Hodges and John Quincy

*** 