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agitter committed Mar 5, 2021
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Expand Up @@ -118,7 +118,7 @@ Structural racism has been proposed as a driver of both obesity and severe impac
Dementia and other forms of cognitive decline are thought to be functionally related to diabetes [@doi:10/c3tm55], and both cancer and dementia are related to chronic inflammation [@doi:10.1038/nature01322; @doi:10.1186/s13195-015-0117-2].

It should be noted that such comorbid conditions are inextricably tied to age, as conditions tend to be accumulated over time, but that the prevalence of individual comorbidities or of population health overall can vary regionally [@doi:10.1073/pnas.2008760117].
Several comorbidities that are highly prevalent in older adults, such as COPD, hypertension, cardiovascular disease, and diabetes, have been associated with CFRs upwards of 8% compared to an estimate of 1.4% in people without comorbidities [@doi:10.1111/jgs.16472; @url:https://www.who.int/publications/i/item/report-of-the-who-china-joint-mission-on-coronavirus-disease-2019-(covid-19)]. <!--To Do: will this url work for Manubot?-->
Several comorbidities that are highly prevalent in older adults, such as COPD, hypertension, cardiovascular disease, and diabetes, have been associated with CFRs upwards of 8% compared to an estimate of 1.4% in people without comorbidities [@doi:10.1111/jgs.16472; @WHO-China-report-2020-02-28].
Therefore, both age and health are important considerations when predicting the impact of COVID-19 on a population [@doi:10.1073/pnas.2008760117].
Additionally, certain conditions are likely to be more prevalent under or exacerbated by social conditions, especially poverty, as is discussed further below.

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