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Update 20.treatments.md #75

Merged
merged 60 commits into from
Mar 31, 2020
Merged

Update 20.treatments.md #75

merged 60 commits into from
Mar 31, 2020

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aadattoli
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Dear All,

I edited the section about treatments and I added the tolicizumab drug analysis/description with relative literature. I am now working on the antiviral section. Please let me know your feedback.

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@rando2
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rando2 commented Mar 27, 2020

@dianerafi based on your intro in #17 , I was wondering if you would be able to give @aadattoli some feedback on this section?

And @rishirajgoel I know you are already working on another section, but I wanted to tag you here as well in case you're interested in looking it over

@rishirajgoel
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@dianerafi based on your intro in #17 , I was wondering if you would be able to give @aadattoli some feedback on this section?

And @rishirajgoel I know you are already working on another section, but I wanted to tag you here as well in case you're interested in looking it over

Yep. Happy to read it over!

@dianerafi
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@dianerafi based on your intro in #17 , I was wondering if you would be able to give @aadattoli some feedback on this section?

And @rishirajgoel I know you are already working on another section, but I wanted to tag you here as well in case you're interested in looking it over

Sure! I'd be glad to look it over.

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@rando2 rando2 added pharmacology Text for Review Feedback on this text is welcome! labels Mar 27, 2020
@rando2
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rando2 commented Mar 27, 2020

@nilswellhausen I also wanted to tag you here and see if you have any thoughts, since you've been very involved in this section!

@nilswellhausen
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I think it would be useful to incorporate the text blocks into #95 to fit them into the updated overall structure.
Tocilizumab:
-can go into Treatment of symptoms or into Antibodies under Biological drugs.

  • Maybe a reference to that tocilizumab is used for example to treat CRS in CAR-T therapy and RA

Interferon-beta:
I would open another sub-section in the Biologicals for "Cytokines"
I think there is more data out there and approaches to use other soluble factors as well

Avigan and Remdesivir:
Move it into the nucleoside analog section and add a general intro followed by the specific examples. Might be able to trim some of the "less relevant " information about the details of each trial.

@aadattoli
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@nilswellhausen I added a bit of intro for the antivirals, see what you think. I'm not sure I am done with the intro of the antivirals, I might add more (please tell me if you have any suggestions). Once I feel I'm done I will Incorporate everything into #95. Btw, do you guys want me to be more specific in the mechanism of action of these drugs?
Best

@rando2
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rando2 commented Mar 29, 2020

@aadattoli we also have someone else adding some info on Remdesivir. Updated to say: it's in #111 , please feel free to add comments on that pull request!

Once he submits his Pull Request, his section will also get feedback from others (hopefully you!) and we will integrate it with your content. I just wanted to keep you in the loop about other work being done on this section!

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rando2 commented Mar 31, 2020

@aadattoli we are planning to merge this in this morning, unless we hear from you in the next few hours. I made some changes based on the references I could find, but you are definitely welcome to make suggestions of additional papers that should be referenced (let's save it for the draft so we can get this merged in)! Thanks for your work on this!

HM Rando and others added 12 commits March 31, 2020 07:29
Co-Authored-By: Casey Greene <cgreene@users.noreply.github.com>
Co-Authored-By: Casey Greene <cgreene@users.noreply.github.com>
Co-Authored-By: Casey Greene <cgreene@users.noreply.github.com>
Co-Authored-By: Casey Greene <cgreene@users.noreply.github.com>
Co-Authored-By: HM Rando <halie.rando@pennmedicine.upenn.edu>
Co-Authored-By: HM Rando <halie.rando@pennmedicine.upenn.edu>
Co-Authored-By: HM Rando <halie.rando@pennmedicine.upenn.edu>
Co-Authored-By: HM Rando <halie.rando@pennmedicine.upenn.edu>
Co-Authored-By: HM Rando <halie.rando@pennmedicine.upenn.edu>
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@rando2 rando2 merged commit aa5e8ba into greenelab:master Mar 31, 2020
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7 participants