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Experimental partial reimplementation of Molassembler in Rust

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(in)orgmol

Overview

This is an experimental partial reimplementation of Molassembler with multiple aims:

  • Try out additional features missing from original
    • GPU-offload parts of conformer generation's distance geometry refinement
    • Parameterizeable shapes (e.g. symmetric distortions in octahedron or bipyramids)
  • Blank slate offers easy path to trying out fixes to high-level gripes
    • Fixed shape list could possibly be dynamic
    • Avoid enumerating all possible atom-centered stereo arrangements when interpreting 3D positions
    • Bond-centric stereo arrangements could be found with semiempirics instead of hamfisted attempts to find general solutions to arbitrary combinations of two shapes
    • Underlying graph is not stable (i.e. vertex removal invalidates vertex descriptors), leading to much index management and complex manipulation functions
  • Personal enrichment: Enjoy ergonomics of Rust and its ecosystem of crates

Plan

This is for fun. Parts of this might be split off and published as crates at some point.

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Experimental partial reimplementation of Molassembler in Rust

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