MPH (MINQUE for Partitioning Heritability)

MPH is a C++ program for fast REML estimation of genetic (co)variance components.

The method features:

• Effective implementation of Fisher-scoring REML (equivalent to iterative MINQUE)
• Fast and memory-efficient performance
• Robust convergence
• Support for analyses of dominance, epistasis, and genetic correlation
• Capability to perform complex genome-partitioning of quantitative genetic variation and covariation

Citation

Jiang J. MPH: fast REML for large-scale genome partitioning of quantitative genetic variation. Bioinformatics. 2024 May 2;40(5):btae298. doi: 10.1093/bioinformatics/btae298. PMID: 38688661; PMCID: PMC11093526.

License

MPH is distributed under the GPL-3.0 license.

Author and contact

Jicai Jiang

If you want to submit an issue concerning the software, please do so using the MPH GitHub repository.

Documentation

https://jiang18.github.io/mph/