Metabolic models of E. coli used to study metabolic changes under high ATP demand

This repository contains kinetic and stoichiometric models of the central carbon and energy metabolism of E. coli growing under anaerobic conditions.

The models have been used in the following study: Boecker et al., "Deciphering the Physiological Response of Escherichia coli Under High ATP Demand."

Repository content

1) Stoichiometric model

The stoichiometric model was used for metabolic flux analysis. The zip file contains the CellNetAnalyzer project and can be used to reproduce the calculations from the study (see also the ReadMe file within the zipped CNA project folder). The SBML file of this model is also provided.

2) Kinetic model

This repository contains the two versions of the kinetic models each in SBML and Copasi format (as described in the aforementioned paper), and the documentation to the model:

• SBML file Model Version 1
• Copasi file Model Version 1
• SBML file Model Version 2
• Copasi file Model Version 2
• Model documentation