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Vogue is Clinical Genomics solution for capturing data from various places in the data flow and to trend the data over a longer period of time.

Installation

git clone https://github.com/Clinical-Genomics/vogue.git
cd vogue
pip install -e .

Release model

Vogue development is organised on a flexible Git "Release Flow" branching system. This more or less means that we make releases in release branches which corresponds to stable versions of Vogue.

Steps to make a new release:

1. Create a release branch from master named version_X.X.X
2. Update change log with the new version.
3. Make a PR to master,
4. Merge release PR into master
5. Use bumpversion to change version accordingly: bumpversion major or bumpversion minor or bumpversion patch
6. Do git push and git push --tags

- Name PR `release version X.X.X`
- Justify if its a patch/minor/major version bump
- Paste the latest changelog to the text body
- get it approved and merge to master. **Dont delete the release branch!**

5. Make a new release.

- Name tag version as `vX.X.X`
- Set target to the release branch
- Make descriptive title
- Paste latest changelog to the text body
- Release!

Deploying to production

Use update-vogue-prod.sh script to update production both on Hasta and Clinical-db. Please follow the development guide and ``servers`` repo when doing so. It is also important to keep those involved informed.

Front End

All views in vogue should be self-explanatory. There should be no further documentation needed to be able to interpret the content of the web page.

Back End

The trending database is a Mongo database consisting of following collections:

• sample - holds LIMS specific data on sample level. Anchoring identifier are LIMS sample ids.
• sample_analysis - holds data from diferent pipeliens on sample level. Anchoring identifier are lims sample ids.
• flowcell - holds LIMS specific data on run level. Anchoring identifier are flowcell ids.
• application_tag - holds application tag specific data. Anchoring identifier are application tags.

The load command of each collection is described below.

Data Flow

CLI

The CLI has two base commands - load and run. The load command is for loading various data into the trending database, and the run command is for running the web application.

Load sample

Usage: vogue load sample [OPTIONS]

  Read and load lims data for one or all samples. When loading many
  samples, the different options -f, -n, -d are used to delimit the subset
  of samples to load.

Options:
  -s, --sample-lims-id TEXT  Input sample lims id
  -m, --many                 Load all LIMS samples if no other options are
                             selected
  --dry-run                  Load from sample or not. (dry-run)
  -f, --load-from TEXT       load from this sample LIMS id. Use if load all
                             broke. Start where it ended
  -n, --new                  Use this flag if you only want to load samples
                             that do not exist in the database
  -d, --date TEXT            Update only samples delivered after date
  --help                     Show this message and exit.

Load analysis

Usage: vogue load analysis [OPTIONS]

  Read and load analysis results. These are either QC or analysis output
  files.

  The inputs are unique ID with an analysis config file (JSON/YAML) which
  includes analysis results matching the analysis model. Analysis types
  recognize the following keys in the input file: QC:multiqc_picard_dups,
  multiqc_picard_HsMetrics, multiqc_picard_AlignmentSummaryMetrics,
  multiqc_picard_insertSize microsalt:blast_pubmlst, quast_assembly,
  blast_resfinder_resistence, picard_markduplicate, microsalt_samtools_stats

Options:
  -s, --sample-id TEXT            Input sample id.  [required]
  -a, --analysis-config PATH      Input config file. Accepted format: JSON,
                                  YAML  [required]
  -t, --analysis-type [QC|microsalt|all]
                                  Type of analysis results to load.
  -c, --analysis-case TEXT        The case that this sample belongs.
                                  It can be
                                  specified multiple times.  [required]
  -w, --analysis-workflow TEXT    Analysis workflow used.  [required]
  --workflow-version TEXT         Analysis workflow used.  [required]
  --is-case                       Specify this flag if input json is case
                                  level.
  --case-analysis-type [multiqc]  Specify the type for the case analysis. i.e.
                                  if it is multiqc output, then choose multiqc
  --dry                           Load from sample or not. (dry-run)
  --help                          Show this message and exit.                      Show this message and exit.

Load flowcell

Usage: vogue load flowcell [OPTIONS]

  Read and load LIMS data for one or all runs

Options:
  -r, --run-id TEXT  Run id for the run. Eg: 190510_A00689_0032_BHJLW2DSXX
  -a, --all-runs     Loads all flowcells found in LIMS.
  --dry              Load from flowcell or not. (dry-run)
  --help             Show this message and exit.

Load apptag

Usage: vogue load apptag [OPTIONS] APPLICATION_TAGS

  Reads json string with application tags. Eg:'[{"tag":"MELPCFR030",
  "category":"wgs",...},...]'

Options:
  --help  Show this message and exit.

Run

Usage: vogue run [OPTIONS]

  Run a local development server.

  This server is for development purposes only. It does not provide the
  stability, security, or performance of production WSGI servers.

  The reloader and debugger are enabled by default if FLASK_ENV=development
  or FLASK_DEBUG=1.

Options:
  -h, --host TEXT                 The interface to bind to.
  -p, --port INTEGER              The port to bind to.
  --cert PATH                     Specify a certificate file to use HTTPS.
  --key FILE                      The key file to use when specifying a
                                  certificate.
  --reload / --no-reload          Enable or disable the reloader. By default
                                  the reloader is active if debug is enabled.
  --debugger / --no-debugger      Enable or disable the debugger. By default
                                  the debugger is active if debug is enabled.
  --eager-loading / --lazy-loader
                                  Enable or disable eager loading. By default
                                  eager loading is enabled if the reloader is
                                  disabled.
  --with-threads / --without-threads
                                  Enable or disable multithreading.
  --help                          Show this message and exit.