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Disabling proxy buffering is necessary to use Server-sent events (SSE), which is what NextPush use.
Generally, proxy buffering can be used to reduce connection load on the backend server if you have clients with very poor connection. The proxy closes the connection to the server sooner and keep delivering data slowly to the client. The advantage is pretty limited without a load balancer (on the proxy).
Note that if a user has defined another reverse proxy in front, for example to add a load balancer, they will be able to add proxy buffering with an exception for certain paths if necessary there.
Another solution is to set flushpackets to auto with a very low flushwait, but in my opinion flushpackets=on is good enough.
Related issues and discussions:
https://codeberg.org/NextPush/nextpush-android/issues/4
https://codeberg.org/NextPush/uppush/issues/8 (probably)
UP-NextPush/android#58
#4295
#4303