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Create examine method for ordinal CRM models #763

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Puzzled-Face opened this issue Dec 4, 2023 · 1 comment
Open

Create examine method for ordinal CRM models #763

Puzzled-Face opened this issue Dec 4, 2023 · 1 comment
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enhancement New feature or request

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@Puzzled-Face
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An examine method for ordinal CRM models is required.

Consider modularising using S4 helper methods in preparation for creating a single generic examine method for all model types.

@Puzzled-Face Puzzled-Face added the enhancement New feature or request label Dec 4, 2023
@Puzzled-Face Puzzled-Face self-assigned this Dec 4, 2023
@Puzzled-Face
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Puzzled-Face commented Dec 6, 2023

This is a larger change than I first imagined. Therefore, break it down into sub-tasks:

  • Create RuleDesignOrdinal and DesignOrdinal classes, mimicking RuleDesign and Design classes. [Create RuleDesignOrdinal and DesignOrdinal classes #766]
  • Create generic helper functions to
    • h_examine_create_results_table: create an empty results table (columns dose, DLTs, nextDose, stop and increment for Designs and dose, Grade0, Grade1, ..., Grade<n>, nextDose, stop and increment for DesignOrdinals)
    • h_examine_get_toxicity_combos: generate all possible combinations of toxicity counts for a given cohort size
    • h_examine_update_basedata: add a new "no observed toxicity" cohort to baseData
    • h_examine_extract_no_tox_results: extract results for no obserbed toxicities in the current cohort
    • Possibly more
  • Create examine-DesignOrdinal method

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Labels
enhancement New feature or request
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