Add this suggestion to a batch that can be applied as a single commit.
This suggestion is invalid because no changes were made to the code.
Suggestions cannot be applied while the pull request is closed.
Suggestions cannot be applied while viewing a subset of changes.
Only one suggestion per line can be applied in a batch.
Add this suggestion to a batch that can be applied as a single commit.
Applying suggestions on deleted lines is not supported.
You must change the existing code in this line in order to create a valid suggestion.
Outdated suggestions cannot be applied.
This suggestion has been applied or marked resolved.
Suggestions cannot be applied from pending reviews.
Suggestions cannot be applied on multi-line comments.
Suggestions cannot be applied while the pull request is queued to merge.
Suggestion cannot be applied right now. Please check back later.
Reference Issue or PRs
Fixes #237, closes #238
What does your PR implement? Be specific.
This PR fixes a bug arising when all genes whose Cooks outliers are replaced lead to all-zero values (cf #237).
To fix this, it introduces (similarly to DESeq2) a new
varm
field,"refitted"
, which complements"replaced"
by indicating whether dispersions and LFCs were refitted for that gene (on top of its having values replaced).Finally, the faulty example presented in #237 was added to the test suite.