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Reconcile Gene Aggregation Feature with Memory Footprint Overhaul #99
Commits on Jan 21, 2016
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Commits on Feb 25, 2016
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For sleuth_gene_table, sleuth_results, and sleuth_to_matrix
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Commits on Feb 26, 2016
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Updated sleuth_gene_table, sleuth_prep, sleuth_wt, sleuth_fit, and models.
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Commits on Feb 27, 2016
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Commits on Mar 2, 2016
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Commits on Jun 16, 2016
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gene aggregation #vc for most part
temporarily disable filtering at gene level #vc stash gene mode #vc work in progress #vc add functionality to filter by target id #vc update aggregation #vc comment out a section in aggregation #vc deal with intersection #vc first cut at empirical bayes #vc fix small bug in empirical bayes #vc testing out pmax #vc empirical bayes and propagate filter #vc norm by effective length massive cleanup more cleaning refactor out check target mapping remove filter by target_id update warnings in check_target_mapping more cleanup
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Commits on Jun 17, 2016
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Commits on Jun 20, 2016
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Merge pull request pachterlab#74 from pachterlab/hjp/geneagg
Gene aggregation
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Commits on Jun 21, 2016
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Merge pull request pachterlab#75 from pachterlab/hjp/geneagg
update vignette
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Commits on Mar 7, 2017
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Commits on Mar 8, 2017
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Commits on Mar 13, 2017
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modified mclapply usage in gene_summary to reduce memory footprint; a…
…dded sleuth_prep option to select number of cores for mclapply
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corrected default value for num_cores, and strengthened check conditi…
…ons for num_cores to throw informative error
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fixed 'give a design matrix' test, which failed because the design ma…
…trix did not have dim names that matched the formula or the sample ids
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add in code from pull request pachterlab#92, which adds in 'drop = F'…
… option into 'spread_abundance_by' to prevent downstream error when preparing just one sample
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Commits on Mar 14, 2017
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Commits on Mar 15, 2017
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Commits on Mar 16, 2017
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add grave accent ` to sample expressions for plot_scatter so any arbi…
…trary string can be used as a sample name; proposed solution for pachterlab#89
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Commits on Mar 23, 2017
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initialize the bootstrap matrix and other variables for gene summary
+ move over gene_summary code + sleuth object now reports gene-level info for obs_norm and obs_norm_filt
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add code to build an equivalent gene-level matrix within the bootstra…
…p for loop of sleuth_prep
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move bs_quant_tpm code to before the gene aggregation bs_mat code to …
…avoid a bug related to using the bs_mat in bs_quant_tpm
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switch to data.table dcast for significant speed boost of bs_quant_tp…
…m and bs_mat gene aggregation
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add in conditionals for code affected by choice of transcript vs gene…
…-level analysis +matrixStats (using which_agg_id vs which_transcript_id) +colnames of bs_mat +names of sigma_q_sq
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move gene_mode and aggregation_column to initial object definition
+ change gene-level conditionals to ret$gene_mode
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merge 'merge' branch that had merged the gene_aggregation and memory …
…savings features
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add transform_function argument to allow users to customize the trans…
…formation function used
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add 'transform_synced' item to sleuth_model, in case a user changes t…
…he transform function after fits have already been made
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Commits on Mar 24, 2017
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extend primitive '$<-' and add a replacement function for transform_fxn
+ any change to transform_fxn leads to all existing fits have 'FALSE' transform_synced statuses + the user is warned that all existing fits need to be redone.
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update documentation for transform argument and functions; also fix misc
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fix bugs that arose with transform function option
+ User is now warned to re-do both sleuth_prep and sleuth_fit, since changing transform_fxn also affects bootstrap summaries + Bug 1: transform function was applied twice; now only applied in sleuth_prep + Bug 2: checks for transform sync status in sleuth_lrt referred to wrong variable
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Commits on Apr 19, 2017
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fixed attribute bug introduced by reusing obs_norm; created a new var…
…iable for obs_norm_gene and tpm_norm_gene
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Commits on Apr 20, 2017
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speed boost by converting gene aggregation code to use just data.tabl…
…e syntax rather than dplyr
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improve memory usage by removing objects sooner, and switching to use…
… pared down target_mapping table
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fix bug where target_id names with non-synatically valid R column nam…
…es leads to downstream errors when doing gene aggregation
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fix bug introduced if aggregation column has NA values
+ make sure blank entries are treated as NA values + fix behavior of overall list of gene IDs for gene-level filter_bool
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add processed sleuth data for testing purposes
+ this processed data uses the full target mappings + also includes TPM calculations for the bootstraps and the extra_bootstrap_summary + update Ellahi dataset README with info on the preprocessed results
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Commits on Apr 21, 2017
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move bootstrap summary code to separate function in bootstrap.R in pr…
…eparation for parallelization
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Commits on Apr 22, 2017
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