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BRCA1.gb
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LOCUS NM_007294 7224 bp mRNA linear PRI 29-MAR-2018
DEFINITION Homo sapiens BRCA1, DNA repair associated (BRCA1), transcript
variant 1, mRNA.
ACCESSION NM_007294
VERSION NM_007294.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7224)
AUTHORS Orban TI and Olah E.
TITLE Emerging roles of BRCA1 alternative splicing
JOURNAL MP, Mol. Pathol. 56 (4), 191-197 (2003)
PUBMED 12890739
REMARK Review article
REFERENCE 2 (bases 1 to 7224)
AUTHORS Orban TI and Olah E.
TITLE Expression profiles of BRCA1 splice variants in asynchronous and in
G1/S synchronized tumor cell lines
JOURNAL Biochem. Biophys. Res. Commun. 280 (1), 32-38 (2001)
PUBMED 11162473
REFERENCE 3 (bases 1 to 7224)
AUTHORS Paterson JW.
TITLE BRCA1: a review of structure and putative functions
JOURNAL Dis. Markers 13 (4), 261-274 (1998)
PUBMED 9553742
REMARK Review article
REFERENCE 4 (bases 1 to 7224)
AUTHORS Xu CF, Chambers JA, Nicolai H, Brown MA, Hujeirat Y, Mohammed S,
Hodgson S, Kelsell DP, Spurr NK, Bishop DT and Solomon E.
TITLE Mutations and alternative splicing of the BRCA1 gene in UK
breast/ovarian cancer families
JOURNAL Genes Chromosomes Cancer 18 (2), 102-110 (1997)
PUBMED 9115959
REFERENCE 5 (bases 1 to 7224)
AUTHORS Wilson CA, Payton MN, Elliott GS, Buaas FW, Cajulis EE, Grosshans
D, Ramos L, Reese DM, Slamon DJ and Calzone FJ.
TITLE Differential subcellular localization, expression and biological
toxicity of BRCA1 and the splice variant BRCA1-delta11b
JOURNAL Oncogene 14 (1), 1-16 (1997)
PUBMED 9010228
REFERENCE 6 (bases 1 to 7224)
AUTHORS Thakur S, Zhang HB, Peng Y, Le H, Carroll B, Ward T, Yao J, Farid
LM, Couch FJ, Wilson RB and Weber BL.
TITLE Localization of BRCA1 and a splice variant identifies the nuclear
localization signal
JOURNAL Mol. Cell. Biol. 17 (1), 444-452 (1997)
PUBMED 8972225
REFERENCE 7 (bases 1 to 7224)
AUTHORS Lu M, Conzen SD, Cole CN and Arrick BA.
TITLE Characterization of functional messenger RNA splice variants of
BRCA1 expressed in nonmalignant and tumor-derived breast cells
JOURNAL Cancer Res. 56 (20), 4578-4581 (1996)
PUBMED 8840964
REFERENCE 8 (bases 1 to 7224)
AUTHORS Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King
MC and Jensen RA.
TITLE Growth retardation and tumour inhibition by BRCA1
JOURNAL Nat. Genet. 12 (3), 298-302 (1996)
PUBMED 8589721
REMARK Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE 9 (bases 1 to 7224)
AUTHORS Xu CF, Brown MA, Chambers JA, Griffiths B, Nicolai H and Solomon E.
TITLE Distinct transcription start sites generate two forms of BRCA1 mRNA
JOURNAL Hum. Mol. Genet. 4 (12), 2259-2264 (1995)
PUBMED 8634696
REFERENCE 10 (bases 1 to 7224)
AUTHORS Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K,
Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W et al.
TITLE A strong candidate for the breast and ovarian cancer susceptibility
gene BRCA1
JOURNAL Science 266 (5182), 66-71 (1994)
PUBMED 7545954
REFERENCE 11 (bases 1 to 7224)
AUTHORS Petrucelli,N., Daly,M.B. and Pal,T.
TITLE BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
JOURNAL (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
K and Amemiya A (Eds.);
GENEREVIEWS((R));
(1993)
PUBMED 20301425
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL701927.1, U14680.1,
BC072418.1, BU617173.1 and BU679389.1.
This sequence is a reference standard in the RefSeqGene project.
On May 19, 2009 this sequence version replaced NM_007294.2.
Summary: This gene encodes a nuclear phosphoprotein that plays a
role in maintaining genomic stability, and it also acts as a tumor
suppressor. The encoded protein combines with other tumor
suppressors, DNA damage sensors, and signal transducers to form a
large multi-subunit protein complex known as the BRCA1-associated
genome surveillance complex (BASC). This gene product associates
with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus
plays a role in transcription, DNA repair of double-stranded
breaks, and recombination. Mutations in this gene are responsible
for approximately 40% of inherited breast cancers and more than 80%
of inherited breast and ovarian cancers. Alternative splicing plays
a role in modulating the subcellular localization and physiological
function of this gene. Many alternatively spliced transcript
variants, some of which are disease-associated mutations, have been
described for this gene, but the full-length natures of only some
of these variants has been described. A related pseudogene, which
is also located on chromosome 17, has been identified. [provided by
RefSeq, May 2009].
Transcript Variant: This variant (1, also known as BRCA1a)
represents the more frequently occurring transcript. It encodes the
full-length BRCA1 protein (isoform 1), which is also known as p220.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U14680.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-143 AL701927.1 1-143
144-5824 U14680.1 31-5711
5825-6573 BC072418.1 2401-3149
6574-7205 BU617173.1 19-650 c
7206-7224 BU679389.1 1-19 c
FEATURES Location/Qualifiers
source 1..7224
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.31"
gene 1..7224
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="BRCA1, DNA repair associated"
/db_xref="GeneID:672"
/db_xref="HGNC:HGNC:1100"
/db_xref="MIM:113705"
exon 1..213
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
misc_feature 93
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="alternative transcription start site"
STS 184..1651
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/db_xref="UniSTS:482866"
misc_feature 209..211
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/note="upstream in-frame stop codon"
exon 214..312
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
CDS 233..5824
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/EC_number="2.3.2.27"
/note="isoform 1 is encoded by transcript variant 1;
BRCA1/BRCA2-containing complex, subunit 1; RING finger
protein 53; breast cancer type 1 susceptibility protein;
breast and ovarian cancer susceptibility protein 1;
protein phosphatase 1, regulatory subunit 53; Fanconi
anemia, complementation group S; early onset breast cancer
1; breast cancer 1, early onset"
/codon_start=1
/product="breast cancer type 1 susceptibility protein
isoform 1"
/protein_id="NP_009225.1"
/db_xref="CCDS:CCDS11453.1"
/db_xref="GeneID:672"
/db_xref="HGNC:HGNC:1100"
/db_xref="MIM:113705"
/translation="MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFC
KFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYA
NSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLG
TVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISL
DSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGT
NTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTP
STEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDEL
LGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSK
SVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRP
TSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEK
NPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALE
LVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSN
KPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKV
SNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEP
NKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQY
LQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNE
SNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHG
LLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNN
IRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGV
LQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVC
SETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRR
GAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLS
LKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS
SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSV
SEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDS
SALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVE
RSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSY
LPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES
AQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKF
ARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKER
KMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMV
QLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSV
ALYQCQELDTYLIPQIPHSHY"
misc_feature 233..235
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine. {ECO:0000244|PubMed:22814378};
propagated from UniProtKB/Swiss-Prot (P38398.2);
acetylation site"
misc_feature 572..574
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 1154..1156
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by AURKA.
{ECO:0000269|PubMed:14990569}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 1415..1417
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 1424..1426
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 1499..1501
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 1532..1534
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 1883..1885
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 2312..2314
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 2354..2356
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 2405..2407
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P48754};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 2489..2491
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 2750..2752
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:P48754};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3194..3196
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CHEK2.
{ECO:0000269|PubMed:10724175,
ECO:0000269|PubMed:20364141}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 3257..3259
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3659..3661
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 3797..3799
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3803..3805
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3863..3865
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3881..3883
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 3884..3886
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4070..4072
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4214..4216
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 4238..4240
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
misc_feature 4256..4258
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4391..4393
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4412..4414
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by ATR, in vitro.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4421..4504
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P38398.2);
Region: Interaction with PALB2.
{ECO:0000269|PubMed:19369211}"
misc_feature 4499..4501
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4601..4603
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR, in vitro.
{ECO:0000269|PubMed:11114888}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4802..4804
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM.
{ECO:0000269|PubMed:21144835}; propagated from
UniProtKB/Swiss-Prot (P38398.2); phosphorylation site"
misc_feature 4856..4858
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (P38398.2);
phosphorylation site"
exon 313..366
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 367..444
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 445..533
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 534..673
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 674..779
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 780..825
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 826..902
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 903..4328
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
STS 909..1077
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454227"
/db_xref="UniSTS:157424"
STS 996..1234
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454278"
/db_xref="UniSTS:157425"
STS 1159..1436
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454349"
/db_xref="UniSTS:157426"
STS 1299..1543
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454353"
/db_xref="UniSTS:157427"
STS 1465..1730
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454372"
/db_xref="UniSTS:157428"
STS 1685..1947
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454381"
/db_xref="UniSTS:157429"
STS 1844..2087
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454417"
/db_xref="UniSTS:157430"
STS 2031..2329
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454421"
/db_xref="UniSTS:157431"
STS 2255..2510
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454425"
/db_xref="UniSTS:157432"
STS 2394..2617
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454429"
/db_xref="UniSTS:157433"
STS 2561..2830
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454433"
/db_xref="UniSTS:157434"
STS 2748..3061
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454437"
/db_xref="UniSTS:157435"
STS 2774..3016
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC13918P1"
/db_xref="UniSTS:270877"
STS 3013..3318
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454441"
/db_xref="UniSTS:157436"
STS 3284..3661
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454446"
/db_xref="UniSTS:157437"
STS 3526..3850
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454450"
/db_xref="UniSTS:157438"
STS 3796..4084
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1"
/db_xref="UniSTS:262743"
STS 3799..4072
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454454"
/db_xref="UniSTS:157439"
STS 3808..4067
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P3"
/db_xref="UniSTS:272805"
STS 3901..4196
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="G60034"
/db_xref="UniSTS:137300"
STS 3909..4067
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P2"
/db_xref="UniSTS:272804"
STS 3973..4181
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454458"
/db_xref="UniSTS:157440"
STS 4109..4326
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="GDB:454462"
/db_xref="UniSTS:157441"
exon 4329..4417
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 4418..4589
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 4590..4716
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 4717..4907
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 4908..5218
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5219..5306
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5307..5384
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5385..5425
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5426..5509
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5510..5564
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5565..5638
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5639..5699
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
exon 5700..7207
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/inference="alignment:Splign:2.1.0"
STS 5746..5881
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="PMC310899P11"
/db_xref="UniSTS:272801"
STS 5872..6109
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="RH79896"
/db_xref="UniSTS:90392"
STS 6374..7203
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="BRCA1_4046"
/db_xref="UniSTS:464465"
STS 6554..6633
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
/standard_name="D5S1597E"
/db_xref="UniSTS:151019"
regulatory 7182..7187
/regulatory_class="polyA_signal_sequence"
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
polyA_site 7207
/gene="BRCA1"
/gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
PPP1R53; PSCP; RNF53"
ORIGIN
1 gtaccttgat ttcgtattct gagaggctgc tgcttagcgg tagccccttg gtttccgtgg
61 caacggaaaa gcgcgggaat tacagataaa ttaaaactgc gactgcgcgg cgtgagctcg
121 ctgagacttc ctggacgggg gacaggctgt ggggtttctc agataactgg gcccctgcgc
181 tcaggaggcc ttcaccctct gctctgggta aagttcattg gaacagaaag aaatggattt
241 atctgctctt cgcgttgaag aagtacaaaa tgtcattaat gctatgcaga aaatcttaga
301 gtgtcccatc tgtctggagt tgatcaagga acctgtctcc acaaagtgtg accacatatt
361 ttgcaaattt tgcatgctga aacttctcaa ccagaagaaa gggccttcac agtgtccttt
421 atgtaagaat gatataacca aaaggagcct acaagaaagt acgagattta gtcaacttgt
481 tgaagagcta ttgaaaatca tttgtgcttt tcagcttgac acaggtttgg agtatgcaaa
541 cagctataat tttgcaaaaa aggaaaataa ctctcctgaa catctaaaag atgaagtttc
601 tatcatccaa agtatgggct acagaaaccg tgccaaaaga cttctacaga gtgaacccga
661 aaatccttcc ttgcaggaaa ccagtctcag tgtccaactc tctaaccttg gaactgtgag
721 aactctgagg acaaagcagc ggatacaacc tcaaaagacg tctgtctaca ttgaattggg
781 atctgattct tctgaagata ccgttaataa ggcaacttat tgcagtgtgg gagatcaaga
841 attgttacaa atcacccctc aaggaaccag ggatgaaatc agtttggatt ctgcaaaaaa
901 ggctgcttgt gaattttctg agacggatgt aacaaatact gaacatcatc aacccagtaa
961 taatgatttg aacaccactg agaagcgtgc agctgagagg catccagaaa agtatcaggg
1021 tagttctgtt tcaaacttgc atgtggagcc atgtggcaca aatactcatg ccagctcatt
1081 acagcatgag aacagcagtt tattactcac taaagacaga atgaatgtag aaaaggctga
1141 attctgtaat aaaagcaaac agcctggctt agcaaggagc caacataaca gatgggctgg
1201 aagtaaggaa acatgtaatg ataggcggac tcccagcaca gaaaaaaagg tagatctgaa
1261 tgctgatccc ctgtgtgaga gaaaagaatg gaataagcag aaactgccat gctcagagaa
1321 tcctagagat actgaagatg ttccttggat aacactaaat agcagcattc agaaagttaa
1381 tgagtggttt tccagaagtg atgaactgtt aggttctgat gactcacatg atggggagtc
1441 tgaatcaaat gccaaagtag ctgatgtatt ggacgttcta aatgaggtag atgaatattc
1501 tggttcttca gagaaaatag acttactggc cagtgatcct catgaggctt taatatgtaa
1561 aagtgaaaga gttcactcca aatcagtaga gagtaatatt gaagacaaaa tatttgggaa
1621 aacctatcgg aagaaggcaa gcctccccaa cttaagccat gtaactgaaa atctaattat
1681 aggagcattt gttactgagc cacagataat acaagagcgt cccctcacaa ataaattaaa
1741 gcgtaaaagg agacctacat caggccttca tcctgaggat tttatcaaga aagcagattt
1801 ggcagttcaa aagactcctg aaatgataaa tcagggaact aaccaaacgg agcagaatgg
1861 tcaagtgatg aatattacta atagtggtca tgagaataaa acaaaaggtg attctattca
1921 gaatgagaaa aatcctaacc caatagaatc actcgaaaaa gaatctgctt tcaaaacgaa
1981 agctgaacct ataagcagca gtataagcaa tatggaactc gaattaaata tccacaattc
2041 aaaagcacct aaaaagaata ggctgaggag gaagtcttct accaggcata ttcatgcgct
2101 tgaactagta gtcagtagaa atctaagccc acctaattgt actgaattgc aaattgatag
2161 ttgttctagc agtgaagaga taaagaaaaa aaagtacaac caaatgccag tcaggcacag
2221 cagaaaccta caactcatgg aaggtaaaga acctgcaact ggagccaaga agagtaacaa
2281 gccaaatgaa cagacaagta aaagacatga cagcgatact ttcccagagc tgaagttaac
2341 aaatgcacct ggttctttta ctaagtgttc aaataccagt gaacttaaag aatttgtcaa
2401 tcctagcctt ccaagagaag aaaaagaaga gaaactagaa acagttaaag tgtctaataa
2461 tgctgaagac cccaaagatc tcatgttaag tggagaaagg gttttgcaaa ctgaaagatc
2521 tgtagagagt agcagtattt cattggtacc tggtactgat tatggcactc aggaaagtat
2581 ctcgttactg gaagttagca ctctagggaa ggcaaaaaca gaaccaaata aatgtgtgag
2641 tcagtgtgca gcatttgaaa accccaaggg actaattcat ggttgttcca aagataatag
2701 aaatgacaca gaaggcttta agtatccatt gggacatgaa gttaaccaca gtcgggaaac
2761 aagcatagaa atggaagaaa gtgaacttga tgctcagtat ttgcagaata cattcaaggt
2821 ttcaaagcgc cagtcatttg ctccgttttc aaatccagga aatgcagaag aggaatgtgc
2881 aacattctct gcccactctg ggtccttaaa gaaacaaagt ccaaaagtca cttttgaatg
2941 tgaacaaaag gaagaaaatc aaggaaagaa tgagtctaat atcaagcctg tacagacagt
3001 taatatcact gcaggctttc ctgtggttgg tcagaaagat aagccagttg ataatgccaa
3061 atgtagtatc aaaggaggct ctaggttttg tctatcatct cagttcagag gcaacgaaac
3121 tggactcatt actccaaata aacatggact tttacaaaac ccatatcgta taccaccact
3181 ttttcccatc aagtcatttg ttaaaactaa atgtaagaaa aatctgctag aggaaaactt
3241 tgaggaacat tcaatgtcac ctgaaagaga aatgggaaat gagaacattc caagtacagt
3301 gagcacaatt agccgtaata acattagaga aaatgttttt aaagaagcca gctcaagcaa
3361 tattaatgaa gtaggttcca gtactaatga agtgggctcc agtattaatg aaataggttc
3421 cagtgatgaa aacattcaag cagaactagg tagaaacaga gggccaaaat tgaatgctat
3481 gcttagatta ggggttttgc aacctgaggt ctataaacaa agtcttcctg gaagtaattg
3541 taagcatcct gaaataaaaa agcaagaata tgaagaagta gttcagactg ttaatacaga
3601 tttctctcca tatctgattt cagataactt agaacagcct atgggaagta gtcatgcatc
3661 tcaggtttgt tctgagacac ctgatgacct gttagatgat ggtgaaataa aggaagatac
3721 tagttttgct gaaaatgaca ttaaggaaag ttctgctgtt tttagcaaaa gcgtccagaa
3781 aggagagctt agcaggagtc ctagcccttt cacccataca catttggctc agggttaccg
3841 aagaggggcc aagaaattag agtcctcaga agagaactta tctagtgagg atgaagagct
3901 tccctgcttc caacacttgt tatttggtaa agtaaacaat ataccttctc agtctactag
3961 gcatagcacc gttgctaccg agtgtctgtc taagaacaca gaggagaatt tattatcatt
4021 gaagaatagc ttaaatgact gcagtaacca ggtaatattg gcaaaggcat ctcaggaaca
4081 tcaccttagt gaggaaacaa aatgttctgc tagcttgttt tcttcacagt gcagtgaatt
4141 ggaagacttg actgcaaata caaacaccca ggatcctttc ttgattggtt cttccaaaca
4201 aatgaggcat cagtctgaaa gccagggagt tggtctgagt gacaaggaat tggtttcaga
4261 tgatgaagaa agaggaacgg gcttggaaga aaataatcaa gaagagcaaa gcatggattc
4321 aaacttaggt gaagcagcat ctgggtgtga gagtgaaaca agcgtctctg aagactgctc
4381 agggctatcc tctcagagtg acattttaac cactcagcag agggatacca tgcaacataa
4441 cctgataaag ctccagcagg aaatggctga actagaagct gtgttagaac agcatgggag
4501 ccagccttct aacagctacc cttccatcat aagtgactct tctgcccttg aggacctgcg
4561 aaatccagaa caaagcacat cagaaaaagc agtattaact tcacagaaaa gtagtgaata
4621 ccctataagc cagaatccag aaggcctttc tgctgacaag tttgaggtgt ctgcagatag
4681 ttctaccagt aaaaataaag aaccaggagt ggaaaggtca tccccttcta aatgcccatc
4741 attagatgat aggtggtaca tgcacagttg ctctgggagt cttcagaata gaaactaccc
4801 atctcaagag gagctcatta aggttgttga tgtggaggag caacagctgg aagagtctgg
4861 gccacacgat ttgacggaaa catcttactt gccaaggcaa gatctagagg gaacccctta
4921 cctggaatct ggaatcagcc tcttctctga tgaccctgaa tctgatcctt ctgaagacag
4981 agccccagag tcagctcgtg ttggcaacat accatcttca acctctgcat tgaaagttcc
5041 ccaattgaaa gttgcagaat ctgcccagag tccagctgct gctcatacta ctgatactgc
5101 tgggtataat gcaatggaag aaagtgtgag cagggagaag ccagaattga cagcttcaac
5161 agaaagggtc aacaaaagaa tgtccatggt ggtgtctggc ctgaccccag aagaatttat
5221 gctcgtgtac aagtttgcca gaaaacacca catcacttta actaatctaa ttactgaaga
5281 gactactcat gttgttatga aaacagatgc tgagtttgtg tgtgaacgga cactgaaata
5341 ttttctagga attgcgggag gaaaatgggt agttagctat ttctgggtga cccagtctat
5401 taaagaaaga aaaatgctga atgagcatga ttttgaagtc agaggagatg tggtcaatgg
5461 aagaaaccac caaggtccaa agcgagcaag agaatcccag gacagaaaga tcttcagggg
5521 gctagaaatc tgttgctatg ggcccttcac caacatgccc acagatcaac tggaatggat
5581 ggtacagctg tgtggtgctt ctgtggtgaa ggagctttca tcattcaccc ttggcacagg
5641 tgtccaccca attgtggttg tgcagccaga tgcctggaca gaggacaatg gcttccatgc
5701 aattgggcag atgtgtgagg cacctgtggt gacccgagag tgggtgttgg acagtgtagc
5761 actctaccag tgccaggagc tggacaccta cctgataccc cagatccccc acagccacta
5821 ctgactgcag ccagccacag gtacagagcc acaggacccc aagaatgagc ttacaaagtg
5881 gcctttccag gccctgggag ctcctctcac tcttcagtcc ttctactgtc ctggctacta
5941 aatattttat gtacatcagc ctgaaaagga cttctggcta tgcaagggtc ccttaaagat
6001 tttctgcttg aagtctccct tggaaatctg ccatgagcac aaaattatgg taatttttca
6061 cctgagaaga ttttaaaacc atttaaacgc caccaattga gcaagatgct gattcattat
6121 ttatcagccc tattctttct attcaggctg ttgttggctt agggctggaa gcacagagtg
6181 gcttggcctc aagagaatag ctggtttccc taagtttact tctctaaaac cctgtgttca
6241 caaaggcaga gagtcagacc cttcaatgga aggagagtgc ttgggatcga ttatgtgact
6301 taaagtcaga atagtccttg ggcagttctc aaatgttgga gtggaacatt ggggaggaaa
6361 ttctgaggca ggtattagaa atgaaaagga aacttgaaac ctgggcatgg tggctcacgc
6421 ctgtaatccc agcactttgg gaggccaagg tgggcagatc actggaggtc aggagttcga
6481 aaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacagaa attagccggt
6541 catggtggtg gacacctgta atcccagcta ctcaggtggc taaggcagga gaatcacttc
6601 agcccgggag gtggaggttg cagtgagcca agatcatacc acggcactcc agcctgggtg
6661 acagtgagac tgtggctcaa aaaaaaaaaa aaaaaaagga aaatgaaact agaagagatt
6721 tctaaaagtc tgagatatat ttgctagatt tctaaagaat gtgttctaaa acagcagaag
6781 attttcaaga accggtttcc aaagacagtc ttctaattcc tcattagtaa taagtaaaat
6841 gtttattgtt gtagctctgg tatataatcc attcctctta aaatataaga cctctggcat
6901 gaatatttca tatctataaa atgacagatc ccaccaggaa ggaagctgtt gctttctttg
6961 aggtgatttt tttcctttgc tccctgttgc tgaaaccata cagcttcata aataattttg
7021 cttgctgaag gaagaaaaag tgtttttcat aaacccatta tccaggactg tttatagctg
7081 ttggaaggac taggtcttcc ctagcccccc cagtgtgcaa gggcagtgaa gacttgattg
7141 tacaaaatac gttttgtaaa tgttgtgctg ttaacactgc aaataaactt ggtagcaaac
7201 acttccaaaa aaaaaaaaaa aaaa
//